Under the control of the total cardiovascular risk means the possibility of targeted reduction of its absolute and relative values through exposure to risk factors that have been proven to affect the progression of atherosclerosis and the development of its clinical complications. The study included 81 people of socially homogeneous group of men working at the same enterprise and being on dispensary dynamic supervision within 10 years who did not have clinical manifestations of atherosclerosis according to the data of primary inspection. The median age was 45.6±2.94 years. The statistical calculations were based on the method of status measurement, which allows to analyze and assess the state of human health by a complex of genetic, immunological, physiological, biochemical, anamnetic and socio-hygienic indicators. The obtained result made it possible to propose an algorithm for assessing the risk of developing clinical manifestations of atherosclerosis for a single sample of individuals, which is simple for use in clinical practice. Thus, the classification capabilities statustitle in the separation of the men surveyed limited sample to alternative on combined endpoints for the subgroup is significantly higher than the possibility of stratification according to the SCORE model for European countries with high risk (sensitivity 73.9 per cent, a specificity of 74.7%).

The information content of Framingham, SCORE model and, statusmetriya in the evaluation of the total ten-year cardiovascular risk in an isolated sample of 207 males without clinical manifestations of atherosclerosis was investigated. Detected that most of the observations from persons who had attained over a 10-year period of the combined end point, the models qualified incorrectly, which didn’t meet the requirements of individual risk assessment in a limited sample group of males. Statusmetrichesky algorithm, in contrast to the accepted system of risk stratification, significantly more of the entities attributed to high-risk and significantly less - to the low-risk category. Sensitivity of the model was 73,9%, specificity - 74,7%, the total information value - 74,5%.

Evidence that has been progressively gathered implicates an important role of the immune system in the course of heart failure. In the majority of heart disease patients, disturbances of humoral immunity with production of cardiodepressant antibodies may play a functional role in cardiac dysfunction. This study evaluates the role of autoantibodies to the cardiac myosin. We examined 52 patients (from 14 till 61 years) with chronic myocarditis. The main examination methods were clinical and biochemical blood tests, ECG, ambulatory Holter ECG monitoring, echocardiography. Autoantibodies to the cardiac myosin were determined by ELISA. These autoantibodies correlate with myocardial inflammation. Also they are associated with structural changes of the heart (hypertrophy, dilation) and cardiac dysfunction (contractility, rhythm and conduction). The degree of expression of these disorders is related to the severity of chronic heart failure.

Имеющиеся в настоящее время доказательства предполагают важную роль ответа иммунной системы в прогрессировании клинических проявлений заболеваний сердца. У большинства пациентов с заболеваниями сердца нарушения гуморального иммунитета с образованием кардиодепрессорных аутоантител могут играть существенную роль в сердечной дисфункции и аритмогенном потенциале. Данные, что различные аутоантитела повышены у больных с сердечной недостаточностью разной этиологии, были получены из ряда исследований. Данное исследование оценивает влияние аутоантител к кардиомиозину на клинические проявления у больных коронарогенной и некоронарогенной патологией сердца. Было обследовано 77 больных хроническим миокардитом и ИБС с острым коронарным синдромом (ОКС БП ST) (возраст от 26 до 64 лет, мужчины и женщины). Основными методами обследования были клинический и биохимический анализы крови, ЭКГ, суточное мониторирование ЭКГ по Холтеру, эхокардиография. Для выявления аутоантител к кардиомиозину использовался иммуноферментный анализ в модификации ELISA. Данные аутоантитела коррелируют с миокардиальным воспалением, что приводит к прогрессированию хронической сердечной недостаточности. У больных с острым коронарным синдромом установлена значимая связь аутоантител с преимущественно аритмическими событиями.

To study the sympathetic myocardial innervation in coronary artery disease patients with chronic atrial fibrillation, 20patients aged 69.2±8.3 years (62 78 years) and 14 healthy subjects aged 45.85±2.67 years were examined.

Pathogenetic mechanisms of inter- and intraventricular synchronism influence on chronic heart failure (CHF) progression, as well as cardiac resynchronization (CR) mechanisms, are discussed. CH indications, based on multicenter trials' results, are presented. CR technique and methods ofCR effectiveness assessment are described. CR beneficial effects on clinical status and prognosis in CHF patients are emphasized.

The study included 45 patients with coronary heart disease (CHD) and chronic heart failure (CHF) of functional class I-IV. Increased cardiac troponin T(cTnT) level could be used in verification and assessment of CHF decompensation severity. In CHF, increase in cTnT level was influenced by CHF decompensation, left ventricular systolic dysfunction and remodeling. At the same time, essential arterial hypertension, post-infarctial cardiosclerosis, permanent atrial fibrillation, left ventricular diastolic dysfunction, left atrium pathologic remodeling did not significantly influence cTnT concentration in patients with CHD and CHF.