The influence of optical radiation of various spectral ranges on the morphofunctional state of the skin under conditions of experimental dermatitis was studied. It was demonstrated that the effectiveness of the light depends on the radiation wavelength. The clinical, histochemical, and morphological data obtained give evidence that the application of blue and red optical radiation to the skin affected by experimental dermatitis is likely to produce the most pronounced therapeutic effect.

Multiple injections of conotoxin MII, a blocker of alfa3-ß2 and alfa6-containing subtypes of nicotinic acetylcholine receptors (n-AChRs), as well as conotoxin ArIB11L16D, a blocker of alfa7 subtype n-AChR, at a dose of 1 nmol/kg reduce both the lactate dehydrogenase level in tumor cells and the inflammatory leukocyte infiltration in tumor tissue in mice bearing Ehrlich carcinoma. The first stage of pathomorphism was detected in the tumor tissue after the treatment with the ArIB11L16D conotoxin, whereas the second stage was observed after the treatment with conotoxins RgIA and MII. Only MII injections led to a significant reduction in tumor growth. Our results show the involvement of n-AChRs in the regulation of metabolic processes and cell–cell interactions related to carcinogenesis and tumor-associated inflammation.

Многократное введение в дозе 1 нмоль/кг мышам-носителям карциномы Эрлиха конотоксинов MII, блокирующего альфа3бета2- и альфа6-содержащие рецепторы, или ArIB11L16D, ингибирующего с высокой эффективностью альфа7-подтип н-АХР, сопровождается снижением активности лактатдегидрогеназы в опухолевых клетках и уменьшением лейкоцитарного воспалительного инфильтрата в опухолевой ткани. При воздействии конотоксином ArIB11L16D отмечался патоморфоз в опухолевой ткани первой степени, а конотоксинами RgIA и MII – второй степени. Только введение конотоксина MII достоверно привело к торможению роста опухоли. Результаты свидетельствуют об участии никотиновых ацетилхолиновых рецепторов в регуляции метаболических процессов и межклеточных взаимодействий, связанных с онкогенезом и опухольассоциированным воспалением.

We undertook the ultrastructural analysis of liver parenchyma taken from male rats with experimental hepatitis induced by the administration of paracetamol at a dose of 1000 mg per 1 kg body weight either following a course of drinking mineral water containing humic acids at a concentration of 20 mg/sq. decimeter) or 14 days after the termination of the drug action (the after-effect phase). It was shown that the consumption of mineral water during 21 days resulted in the modification of the ultrastructural organization of hepatocytes apparent as the increased amount of cisterns in the granulosa endoplasmic system, glycogen rosettes, and mitochondrial polymorphism. These changes give evidence of the restoration of the energy, glycogen and protein synthesizing functions disturbed by paracetamol administration. The after-effect phase was characterized by the further strengthening of reparative processes and the functional activity of hepatic cells.