The opening of the thiazoline ring upon the action of amino alcohols was studied. The effects of the reagent ratio and structures of the heterocycles and amino alcohols on aminolysis were investigated. A new method was developed for the preparative synthesis of a series of N'-(hydroxyalkyl)-2-guanidinoalkanethiols.
ChemInformVolume 21, Issue 5 Heterocyclic Compounds ChemInform Abstract: Synthesis and Radioprotective Activity of 2-Amino-4-oxo-5-aminomethylthiazoline and 2-Amino-4-oxo-5-aminoethylthiazoline. A. A. MANDRUGIN, A. A. MANDRUGIN Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorA. A. RODYUNIN, A. A. RODYUNIN Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorV. M. FEDOSEEV, V. M. FEDOSEEV Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorM. M. KONSTANTINOVA, M. M. KONSTANTINOVA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorG. V. DONTSOVA, G. V. DONTSOVA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorO. N. RAKHMANINA, O. N. RAKHMANINA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this author A. A. MANDRUGIN, A. A. MANDRUGIN Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorA. A. RODYUNIN, A. A. RODYUNIN Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorV. M. FEDOSEEV, V. M. FEDOSEEV Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorM. M. KONSTANTINOVA, M. M. KONSTANTINOVA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorG. V. DONTSOVA, G. V. DONTSOVA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorO. N. RAKHMANINA, O. N. RAKHMANINA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this author First published: January 30, 1990 https://doi.org/10.1002/chin.199005182Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume21, Issue5January 30, 1990 RelatedInformation
We have demonstrated the basic possibility of cyclizing guanidinoalkanethiols of different structure to thiazolines and thiazines. The rate of reaction depends on the pH of the medium. The concentration of buffer and the addition of heavy water and α-D,L-alanine have virtually no effect on the rate of reaction.