In experiments with mice radioprotective properties and toxicity of 2(3)-guanidinoalkanethiols were investigated by exposure to gamma-irradiation in the dose of 6.4 Gy. The obtained results allow to find an association between radioprotective activity of 2(3)-guanidinoalkanethiol compounds and their structure and toxicity.
In the experiments with Ehrlich ascites tumor cells it was shown that specific oxidation of cellular glutathione after irradiation produced no effect on the degree of radiation injury in the air, but resulted in a decrease of radioprotective effect of beta-mercaptoethylamine. From these results it follows that for a complete realization of radioprotective effect normal level of cellular glutathione is necessary.
ChemInformVolume 21, Issue 5 Heterocyclic Compounds ChemInform Abstract: Synthesis and Radioprotective Activity of 2-Amino-4-oxo-5-aminomethylthiazoline and 2-Amino-4-oxo-5-aminoethylthiazoline. A. A. MANDRUGIN, A. A. MANDRUGIN Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorA. A. RODYUNIN, A. A. RODYUNIN Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorV. M. FEDOSEEV, V. M. FEDOSEEV Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorM. M. KONSTANTINOVA, M. M. KONSTANTINOVA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorG. V. DONTSOVA, G. V. DONTSOVA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorO. N. RAKHMANINA, O. N. RAKHMANINA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this author A. A. MANDRUGIN, A. A. MANDRUGIN Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorA. A. RODYUNIN, A. A. RODYUNIN Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorV. M. FEDOSEEV, V. M. FEDOSEEV Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorM. M. KONSTANTINOVA, M. M. KONSTANTINOVA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorG. V. DONTSOVA, G. V. DONTSOVA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this authorO. N. RAKHMANINA, O. N. RAKHMANINA Khim. fak. Mosk. gos. univ. im. LomonosovaSearch for more papers by this author First published: January 30, 1990 https://doi.org/10.1002/chin.199005182Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume21, Issue5January 30, 1990 RelatedInformation
In experiments with Ehrlich ascites tumor cells with the use of a specific thiol blocker, 6,6'-dithiodinicotinic acid, it was shown that thiols of a cell plasmic membrane are necessary for the radioprotective effect of mercaptoethylamine to be realized.