This work is devoted to preformulation and preclinical studies of a new endolysin preparations in the form of gel and spray, effective against wound infections caused by gram-negative bacteria, including those with multidrug resistance.

Бактериофаги пробиотические средства регуляции мик робиоценозов и деконтаминации микроорганизмами продуктов питания, животных и растений В обзоре рассматриваются вопросы безопасного и эффек тивного применения бактериофагов в качестве пищевых добавок средств деконтаминации пищевых продуктов (на всех стадиях производства), животных, растений и пробиотических биологически активных добавок к пище, служащих дополнительным источником бактериофагов для организма человека, присутствие которых в нормоф лоре позволяет снизить риск развития у индивидуума та ких высококонтагиозных пищевых

Background Probiotic bacterial lectins (PBL) isolated by us from industrial strains of human origin are important regulators of microbiocenoses. The Aim is to evaluate potential of PBL in medicine. Results The data obtained indicate that preparations of PBL imitate general functions of probiotics, increase or create new useful activities. In biotopes PBL act as intrinsic tool of microbial selection, factor of supporting probiotic compartment. PBL can be used for screening probiotic microbes, sensitive and resistant clinical strains, and also for monitoring balance of biocenosis in directions “Microbes - Microbes” and “Microbes - Organism”. Application of PBL (combinations of L of lactobacilli and bifidobacteria [LL and LB] as the model functional imitator of biotope probiotic compartment) is multidirected and use antipathogen cascade multisynergism of PBL in time and in space. Results indicate that PBL are able to destruct biofilms of pathogen combinations “Staphylococcus > or < Candida” (synergistic contribution: LL > or < LB). LL+LB possess advantages of probiotic action in cases of biotopes where bifidobacteria or lactobacilli are currently absent. It seems, being delivered into organism, PBL will complete cell system “Lactobacillus + Bifidobacterium + Other probiotic-like microbes” and increase synbiotic biotope ingredients. The data on synergistic action between PBL and antibiotics allow using PBL in cases of non-effectiveness of antibiotics or for decreasing antibiotic doses. Conclusions Results indicate prospects of PBL in supporting probiotic and synbiotic systems of organism for example during chemotherapy and radiotherapy of tumors, or as ingredients of anti-infectives against eukaryotic pathogens (microfungi and protozoans).

© 2012 Lakhtin et al., licensee InTech. This is an open access chapter distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Lectin Systems Imitating Probiotics: Potential and Prospects for Biotechnology and Medical Microbiology