Conference Abstract| January 01 1987 The Optimal Dose of Glyceryl Trinitrate (GTN) in the Treatment of Stable Angina is 20μG/Minute A.L. Kemp; A.L. Kemp 1Department of Medicine One, St George's Hospital Medical School, London SW17. Search for other works by this author on: This Site PubMed Google Scholar D. Mannering; D. Mannering 1Department of Medicine One, St George's Hospital Medical School, London SW17. Search for other works by this author on: This Site PubMed Google Scholar E.D. Bennett E.D. Bennett 1Department of Medicine One, St George's Hospital Medical School, London SW17. Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1987) 72 (s16): 61P–62P. https://doi.org/10.1042/cs072061Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation A.L. Kemp, D. Mannering, E.D. Bennett; The Optimal Dose of Glyceryl Trinitrate (GTN) in the Treatment of Stable Angina is 20μG/Minute. Clin Sci (Lond) 1 January 1987; 72 (s16): 61P–62P. doi: https://doi.org/10.1042/cs072061Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1987 The Biochemical Society and the Medical Research Society1987 Article PDF first page preview Close Modal You do not currently have access to this content.

There has been recent controversy over the efficacy of transdermal glyceryl trinitrate (GTN) preparations in the treatment of angina and their effects on exercise tolerance. To determine the dose of GTN that produces significant anti-anginal effects, symptom limited exercise testing has been undertaken in seven patients with stable angina. Doses of 10, 20, 40 and 80 micrograms min-1 of GTN or placebo were infused during treadmill exercise until symptom limiting chest pain or greater than or equal to 3 mm ST segment depression occurred. Compared with placebo, total exercise time increased by 47% at 20 micrograms min-1 (P less than 0.05) with no further change at the higher doses. Duration of exercise before the onset of significant ST segment depression increased by 51% at 20 micrograms min-1 (P less than 0.05) with no further increase at the higher doses. These changes were accompanied by a 21% increase in double product (heart rate X systolic blood pressure) at 20 micrograms min-1 (P less than 0.05) reflecting a higher heart rate achieved as a result of the increased duration of exercise. These results suggest that 20 micrograms min-1 may be the optimal dose of GTN to achieve significant antianginal effects as demonstrated by the improved exercise tolerance and reduction of myocardial ischaemia. This implies that the dose of GTN delivered by transdermal preparations may be below the therapeutic level.

Conference Abstract| January 01 1986 Dobotamine as an Alternative to Exercise Testing in Post Infarction Assessment D. Mannering; D. Mannering 1Departments of Medicine One and Cardiology, St George's Hospital and Medical School London SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar E.D. Bennett; E.D. Bennett 1Departments of Medicine One and Cardiology, St George's Hospital and Medical School London SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar G. Leech; G. Leech 1Departments of Medicine One and Cardiology, St George's Hospital and Medical School London SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar G. Boyle; G. Boyle 1Departments of Medicine One and Cardiology, St George's Hospital and Medical School London SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar H. Valantine; H. Valantine 1Departments of Medicine One and Cardiology, St George's Hospital and Medical School London SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar N. Mehta; N. Mehta 1Departments of Medicine One and Cardiology, St George's Hospital and Medical School London SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar A. Kemp A. Kemp 1Departments of Medicine One and Cardiology, St George's Hospital and Medical School London SW17 ORE Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1986) 71 (s15): 54P. https://doi.org/10.1042/cs071054P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation D. Mannering, E.D. Bennett, G. Leech, G. Boyle, H. Valantine, N. Mehta, A. Kemp; Dobotamine as an Alternative to Exercise Testing in Post Infarction Assessment. Clin Sci (Lond) 1 January 1986; 71 (s15): 54P. doi: https://doi.org/10.1042/cs071054P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1986 The Biochemical Society and the Medical Research Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.