The study included 196 breast cancer patients with stages T1-3N0-3M0. The comprehensive therapy for breast cancer included surgical operation, chemotherapy, and radiotherapy. Multivariate analysis showed that multifocality growth of tumor (p = 0.004), high grade III (p = 0.008), two metastatic lymph nodes (p = 0.02) were associated with an increased risk of regional node failure in the patients with one to three positive lymph nodes. The prognostic models describing the probability of local recurrences of breast cancer were developed for individualization of the radiation therapy tactics. Postmastectomy radiation therapy in the patients with high-risk breast cancer treated with modified radical mastectomy improves locoregional control, breast cancer-specific survival, does not increase late toxicity.

This review about the application of radiotherapy in breast cancer patients after radical mastectomy. Emphasizes the need for a differentiated approach to radiation therapy, which should be based on the definition of clinical morphological factors that determine the risk of loco-regional recurrence of breast cancer.

ель исследования. Отметить клинические особенности и возможности магнитно-резонансной томографии (МРТ) в диагностике острой лучевой реакции у больных раком молочной железы. Материалы и методы. Представлен клинический случай МРТ диагностики выраженной острой лучевой реакции у больной раком левой молочной железы после органосохраняющей операции с интраоперационной лучевой терапией (ИОЛТ) однократной дозой 10 Гр, что составляет 24,8 Гр стандартного курса лучевой терапии. Результаты. Детальное обследование с применением MРT позволило выявить и подробно описать признаки острой лучевой реакции тканей оставшейся молочной железы (лучевого поражения кожи, мягких тканей и сосудов в оставшейся молочной железе), скорректировать дальнейшую тактику лечения пациентки. Выводы. Большая роль отводится MРT в диагностике лучевых реакций и повреждений оставшихся тканей молочной железы в условиях проведения высокодозной лучевой терапии, поскольку данный метод позволяет выявить изменения и проследить их динамику.

A clinical case with acute radiation reaction of the left breast after organ-preserving surgery with 10 Gy IORT (24.8 Gy) conventional radiation therapy has been presented. Comprehensive MRI examination showed signs of radiation- induced damage to skin, soft tissues and vessels of the residual breast.

This review about the application of radiotherapy in breast cancer patients after radical mastectomy. Emphasizes the need for a differentiated approach to radiation therapy, which should be based on the definition of clinical morphological factors that determine the risk of loco-regional recurrence of breast cancer.

The review aimed to assess the role of local hyperthermia in combined modality treatment of soft tissue sarcoma. The recent randomized trials have shown significant benefits from local hyperthermia in patients with soft tissue sarcoma. When combined with radiotherapy, hyperthermia has a complementary and additive effect. Extensive researches have also shown that hyperthermia improves the efficacy of many chemotherapeutic agents. Besides the increased effectiveness of radiotherapy and chemotherapy, hyperthermia has many anti-cancer effects and improves treatment results in patients with soft tissue sarcomas.

The study included 103 patients with stage T1–3N0–3M0 breast cancer who received multimodality treatment including neo- and adjuvant chemotherapy according to CMF and CAF schedules, hormonal therapy, radical mastectomy and adjuvant radiation therapy. All patients were divided into two groups depending on the volume of postoperative radiation therapy. Group I patients (n=48) received 40–44 Gy external radiation therapy to the areas of potential regional spread. Group II patients (n-55) additionally received radiation therapy delivered to postoperative scar area at a total dose of 38–44 isoGy. The comparative analysis of long-term results showed a significant decrease in the rate of local recurrences and increase in the 5-year recurrence-free and overall survival rates in the group of breast cancer patients who received adjuvant radiation therapy to the areas of potential regional spread and postoperative scar. In order to plan adequate radiotherapyand to minimize local radiation-induced reactions, it is necessary to consider clinical and morphological prognostic factors.

В лечении больных раком молочной железы (РМЖ) применяется комплексный подход, неотъемлемым компонентом которого является лучевая терапия. Эффективность адъювантной лучевой терапии (АЛТ) после радикальной мастэктомии подтверждена результатами многих исследований [4, 29, 37, 41]. Представлены данные, свидетельствующие о том, что максимальный локальный контроль имеет большое значение в достижении высоких показателей не только безрецидивной, но и общей выживаемости [5, 14]. В настоящее время среди радиационных онкологов существует единая точка зрения, согласно которой адъювантную лучевую терапию следует проводить больным РМЖ с исходно большими размерами первичной опухоли (Т3–4) вне зависимости от поражения лимфоузлов, а также с наличием 4 и более метастатических аксиллярных лимфатических узлов [15, 41, 43, 48]. Спорным остается вопрос, касающийся целесоУДК: 618.19-006.6-08:615.849.1

The article discusses the problem of radiation complications from normal tissues in patients after therapy with fast neutrons of 6.3 MeV. The methods of treatment using ozone technologies in patients with radiation reactions and skin lesions on the areas of irradiation after neutron and neutron-photon therapy have been worked out. Ozone therapy showed its harmlessness and increased efficiency of complex treatment of these patients.

The study included 103 patients with stage T1–3N0–3M0 breast cancer who received multimodality treatment including neo- and adjuvant chemotherapy according to CMF and CAF schedules, hormonal therapy, radical mastectomy and adjuvant radiation therapy. All patients were divided into two groups depending on the volume of postoperative radiation therapy. Group I patients (n=48) received 40–44 Gy external radiation therapy to the areas of potential regional spread. Group II patients (n-55) additionally received radiation therapy delivered to postoperative scar area at a total dose of 38–44 isoGy. The comparative analysis of long-term results showed a significant decrease in the rate of local recurrences and increase in the 5-year recurrence-free and overall survival rates in the group of breast cancer patients who received adjuvant radiation therapy to the areas of potential regional spread and postoperative scar. In order to plan adequate radiotherapy and to minimize local radiation-induced reactions, it is necessary to consider clinical and morphological prognostic factors.