Abstract Aim to evaluate the prevalence of heart rhythm disorders among hospitalized patients with acromegaly Methods we enrolled patients with acromegaly hospitalized in our Endocrinology Research Center in 2018. Acromegaly was established based on the clinical signs and symptoms, elevated levels of insulin-like growth factor-1 (IGF-1) and presence of pituitary adenoma. All patients underwent clinical examination, routine electrocardiogram (ECG). In patients with changes in the resting ECG and/or complaints of heart rhythm disorders, echocardiography and Holter ECG monitoring were performed. We also performed cardiac magnetic resonance imaging (MRI) with contrast in cases of arrhythmia confirmation. Results Among 107 enrolled patients with acromegaly (61 women, mediana of age 51 [40; 58] years) arrhythmia was first diagnosed in 21 (19,6%) patients: 7 patients had sick sinus syndrome, 5 patients suffered from atrial fibrillation, 4 patients had AV block, 5 patients - ventricular arrhythmias (1 patient had sustained ventricular tachycardia). The median level of the GH was 1,77 [0,8; 5,4] ng/ml, and the median of IGF-1 - 348,95 [233,4; 557,4] ng/ml, 16 (76,1%) patients with arrhythmia had active acromegaly. 21 patients underwent MRI of the heart: median of ejection fraction 54 [48; 60] %, in 8 patients we revealed focal fibrosis of left ventricle myocardium. Diffuse accumulation of contrast agent was observed in 11 patients of different severity and localization, mainly endocardium of mitral and tricuspid valves. We didn’t find a clear correlation between the levels of hormones, changes in the MRI of the heart and the type of cardiac arrhythmia. We implanted pacemakers in 4 patients, 1 patient – implantable cardioverter defibrillator. Conclusion The prevalence of cardiac arrhythmia in hospitalized patients with acromegaly is about 20%. New cases of arrhythmia could occur despite normal level of GH and IGF-1 in patients with acromegaly. Patients with acromegaly and cardiac arrhythmia often have abnormalities in MRI of the heart, which requires further investigation.

The paper deals with subject concerning MRI and definition of its capacities in estimation of brain and pituitary condition in athletes. It was performed MRI of 70 persons (43 males and 27 females, aged 18-35) which were divided into 2 groups: the 1st group consisted of 44 athletes and the 2nd – of 26 healthy volunteers. All examined persons in both groups had normal blood indexes results, electrocardiogram, arterial pressure but during the physical stress some of the athletes had transitory arterial hypertension. MRI identified different changes in brain and pituitary (a small hydrocephalus, arachnoidal and unilocular cysts, microadenomas, «Empty cellar syndrome», etc.), more in athletes. It’s shown that MRI gives important information about the condition of brain and pituitary in athletes at the preclinical stage, which may play an important role in addressing issues as training mode, conditions of training, as well as opportunities of selected sports and preventive measures.

Belichenko, O.1; Smolenskiy, A.3; Vorontsov, A.2; Vladimirova, V.2; Averkieva, E.2; Mikhailova, A.3 Author Information

Objectives: To evaluate MRI diagnostic possibilities dynamic examination of patients (pts) with adrenal tumors and arterial hypertension. Methods: Study included 291 pts (106 pts with aldosteroma, 95 pts with pheochromocytoma, 71 pts with corticosteroma, 19 pts with incidentaloma). MRI was performed with Magnetom Avanto, Siemens, 1.5T. Standard MRI included T1-, T2-weighted, fat saturation sequence; 137 pts underwent MRI with contrast enhancement (Gd-DTPA-BMA 0.2 mgkg). Duration of arterial hypertension before treatment was 1–6 years. Period after surgical treatment of adrenal tumors was 0.5–4 years. Control group included 25 healthy volunteers. Results: In 52% pts after surgical treatment of aldosteroma some enlargement of contra- lateral adrenal was found as a result of vicar hypertrophy; in 28% pts we determined inhomogeneity of adrenal structure, possibly because the small nodes or areas of dysplasia present in adrenal gland. In all pts after surgical treatment of pheochromocytoma we marked enlargement of contra- lateral adrenal gland. In 19% pts after 1–2 year new tumors (size less than 3 cm) of the second adrenal gland was found. Majority of pts did not show any changes in renals in comparison with first examination, but in 20% pts we determined pyelectasis. MRI after surgical treatment of corticosteroma showed no changes in the contra- lateral adrenal gland in 30% of pts, in 15% - reduction in size and 40% - enlargement compared with the data obtained before treatment. In 12 pts on the basis of clinical status and laboratory data presence another adrenal tumor data was suspected, which was confirmed by MRI. In pts with incidentaloma were present the same date. In all cases MRI allowed to estimate structure, shape, and size of contra- lateral adrenal gland, find tumor of adrenal or extra adrenal localization. Conclusion: MRI is method of high effectiveness dynamic examination of pts after surgical treatment of adrenal tumors and arterial hypertension. MRI with contrast enhancement gives the important additional information.

Objectives: To evaluate MRI diagnostic possibilities in patients with metastasis in adrenal gland and arterial hypertension. Methods: MRI performed in 23 patients with metastatic adrenal lesions. Standard MRI included T1-, T2-weighted, fat saturation sequences, MRI with contrast enhancement (Gd-DTPA-BMA 0.2 mgkg). In all cases MRI results were proved with histological findings. Results: Our study includes 23 cases of metastatic adrenal lesions from different sources. On T1-WI metastases usually had signal intensity equal to or less than the liver, sometimes heterogeneous structure. On T2-WI heterogeneity of the structure of metastasis was seen better due to hyperintensity relatively to normal liver, often isointense or even hyperintense in comparison with fat,. However, we did not reveal the criteria that precisely distinguish metastasis from adenoma. After the gadolinium injection metastasis intensively and inhomogeneousely collected and kept it which was different from usual adenoma's pattern. MRI showed local invasion due to the high contrast between normal tissue and malignant neoplasm, especially on T2-WI with fat suppression. Conclusion: MRI is a high effective method in patients with metastasis in adrenal gland and arterial hypertension. MRI with contrast enhancement gives the important additional information.

: Wednesday, June 16, 2004: POSTER SESSIONS: Poster Session 48: Vasoactive Substances and Neurohormones

The authors propose an integrated Tooth Contact Analysis (TCA) computer program for simulation of meshing and contact of gear drives that enables to determine transmission errors and shift of bearing contact for misaligned gear drives. The developed computer program combines numerical solutions for the problems above and their graphical interpretation. The program is applicable for various gear drives but needs derivation of tooth surface equations specified for the considered gear drive. The computer program represents a set of integrated operations such as the development of required algorithms, storing in database, copying, deleting, printing, design correction from the database, etc. The proposed computer program is based on application of the Java programming language. Examples of application for a spiral bevel gear drive and a worm gear drive are provided.

OBJECTIVE:The aim of this study was to clarify the relationship between morphologic changes of the pituitary gland and the genotype of Prophet of Pit-1 (PROP1), a newly discovered gene responsible for congenital combined pituitary hormone deficiency, in a series of eight humans with this disorder.CONCLUSION:Congenital hypoplasia of the anterior pituitary gland is the most common MR imaging finding in patients with combined pituitary hormone deficiency. Our findings suggest a crucial role for PROP1 in pituitary organogenesis as well as anterior pituitary cell differentiation.

was obtained experimentally, and simulation results suggest that even better performance could be obtained by replacing