A means of assessing hepatitis NANB virus infection, via blood transfusion, as a cause of chronic liver disease was investigated in a hospital in each of two cities in England. Patients with chronic liver disease were matched for age and sex with other patients in the same hospital and histories taken included details of previous operations and blood transfusions; if these were within ten years of the study enquiries were made of hospital records officers. All positive histories were found correct, but about one third of previous transfusions had been omitted by both case and control patients. Sixty-seven male and 35 female patients with chronic liver disease and their controls were included in analyses. The only clear difference which emerged related to residence for more than a year in the Middle or Far East by male case- (40%) or control- (21%) patients (P less than 0.05). The exclusion of patients with this history left only 34 pairs in which five (15%) of the case patients and one (3%) of the control patients had a transfusion history: this difference was not statistically significant. Although the study results have shown no clear evidence of blood transfusion as a major cause of chronic liver disease in Britain, the study method, with sufficient numbers to allow analyses of newly diagnosed patients with confirmed transfusion histories, could be used to provide an ongoing assessment of the risk.

Conference Abstract| December 01 1987 Changes in Lipoprotein Profile in Patients with Acute Alcoholic Liver Disease During Recovery C.H. Bolton; C.H. Bolton 1University Department of Medicine, Bristol Royal Infirmary, Bristol, BS2 8HW Search for other works by this author on: This Site PubMed Google Scholar M. Khalil; M. Khalil 1University Department of Medicine, Bristol Royal Infirmary, Bristol, BS2 8HW Search for other works by this author on: This Site PubMed Google Scholar A.E. Read A.E. Read 1University Department of Medicine, Bristol Royal Infirmary, Bristol, BS2 8HW Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Online ISSN: 1470-8736 Print ISSN: 0143-5221 © 1987 The Biochemical Society and the Medical Research Society1987 Clin Sci (Lond) (1987) 73 (s17): 14P. https://doi.org/10.1042/cs073014Pa Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation C.H. Bolton, M. Khalil, A.E. Read; Changes in Lipoprotein Profile in Patients with Acute Alcoholic Liver Disease During Recovery. Clin Sci (Lond) 1 December 1987; 73 (s17): 14P. doi: https://doi.org/10.1042/cs073014Pa Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1987 The Biochemical Society and the Medical Research Society1987 Article PDF first page preview Close Modal You do not currently have access to this content.

Conference Abstract| December 01 1987 The Effects of Various Concentrations of Glucose Solutions on Human Mesenteric Blood Flow M.I. Qamar; M.I. Qamar 1University Department of Medicine, Bristol Royal Infirmary Search for other works by this author on: This Site PubMed Google Scholar R. Mountford; R. Mountford 1University Department of Medicine, Bristol Royal Infirmary Search for other works by this author on: This Site PubMed Google Scholar A.E. Read A.E. Read 1University Department of Medicine, Bristol Royal Infirmary Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1987) 73 (s17): 31P. https://doi.org/10.1042/cs073031Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation M.I. Qamar, R. Mountford, A.E. Read; The Effects of Various Concentrations of Glucose Solutions on Human Mesenteric Blood Flow. Clin Sci (Lond) 1 December 1987; 73 (s17): 31P. doi: https://doi.org/10.1042/cs073031Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1987 The Biochemical Society and the Medical Research Society1987 Article PDF first page preview Close Modal You do not currently have access to this content.

Transcutaneous Doppler ultrasound was used to assess the effects of exercise on both fasting and postprandial superior mesenteric artery blood flow. After treadmill exercise (speed 5 km/h, gradient 20%, duration 15 min) in 16 subjects, superior mesenteric artery blood flow decreased by 43% immediately after the end of the exercise and by 29% at five minutes and 24% at 10 minutes postexercise. The superior mesenteric artery blood flow response to a combination of a treadmill exercise and a liquid meal in 15 volunteers was significantly smaller at five minutes from the end of the stimuli, than the response to the meal alone (15 controls) (635 +/- 51 ml/min v 846 +/- 72 ml/min) (p less than 0.025), but not different at any other time. Thus exercise reduces mesenteric blood flow in both the fasting and postprandial state in normal subjects.

Conference Article| June 01 1987 Apolipoprotein A abnormalities in patients with liver disease COLIN H. BOLTON; COLIN H. BOLTON 1Department of Medicine Laboratories, Bristol Royal Infirmary, Bristol BS2 8HW, U.K. Search for other works by this author on: This Site PubMed Google Scholar MAHMOUD KHALIL; MAHMOUD KHALIL 1Department of Medicine Laboratories, Bristol Royal Infirmary, Bristol BS2 8HW, U.K. Search for other works by this author on: This Site PubMed Google Scholar ALAN E. READ ALAN E. READ 1Department of Medicine Laboratories, Bristol Royal Infirmary, Bristol BS2 8HW, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1987) 15 (3): 409–410. https://doi.org/10.1042/bst0150409 Article history Received: November 17 1986 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation COLIN H. BOLTON, MAHMOUD KHALIL, ALAN E. READ; Apolipoprotein A abnormalities in patients with liver disease. Biochem Soc Trans 1 June 1987; 15 (3): 409–410. doi: https://doi.org/10.1042/bst0150409 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: apo, apolipoprotein, HDL. high-density lipo-protein, LCAT. lecithin: cholesterol acyltransferase This content is only available as a PDF. © 1987 Biochemical Society1987 Article PDF first page preview Close Modal You do not currently have access to this content.

A duplex scanner which consists of a real time two dimensional scanner and a pulsed Doppler flowmeter was used to measure superior mesenteric blood flow in 70 healthy subjects. By processing the Doppler shift signals, the instantaneous average Doppler shift frequency and then the instantaneous average velocity of the flow rate were calculated. Both diameter of the vessel and angle between vessel and beam were measured from real time imaging. The mean (+/- standard error of the mean) of the superior mesenteric blood flow was 517 +/- 19 ml/min. There was neither significant difference in flow between sexes, nor correlation between flow and age (r = 0.042). The mean of coefficients of variability were 6.8% over the short term, and 8.2% in long term studies.

The extent of biliary excretion of paracetamol and its principal metabolites was studied in 10 healthy adults. Duodenal intubation was performed approximately 12 h after an oral dose of 1 g paracetamol. Duodenal fluid was aspirated following intravenous cholecystokinin, and urine was collected for 12 h after dosing. The mean concentration of the cysteine and glucuronide conjugates in the bile was 253.7 +/- 39.0 micrograms ml-1 (s.e. mean) and 69.3 +/- 15.3 micrograms ml-1, respectively. The mean recoveries of the cysteine and glucuronide conjugates in the bile were 6.0 +/- 1.5 mg and 1.2 +/- 0.41 mg, respectively. The bile is an important route of elimination for the cysteine conjugate and accounts for 19.4 +/- 4.4% of the total excretion of the metabolite. The fate of the biliary excreted conjugates is not known, and needs further investigation.

Conference Abstract| January 01 1986 High Density Lipoprotein Abnormalities in Patients with Acute Liver Disease M. Khalil; M. Khalil 1University Dept. of Medicine, Bristol Royal Infirmary, Bristol, BS2 8HW Search for other works by this author on: This Site PubMed Google Scholar C.H. Bolton; C.H. Bolton 1University Dept. of Medicine, Bristol Royal Infirmary, Bristol, BS2 8HW Search for other works by this author on: This Site PubMed Google Scholar A.E. Read A.E. Read 1University Dept. of Medicine, Bristol Royal Infirmary, Bristol, BS2 8HW Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1986) 71 (s15): 71P. https://doi.org/10.1042/cs071071P Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation M. Khalil, C.H. Bolton, A.E. Read; High Density Lipoprotein Abnormalities in Patients with Acute Liver Disease. Clin Sci (Lond) 1 January 1986; 71 (s15): 71P. doi: https://doi.org/10.1042/cs071071P Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1986 The Biochemical Society and the Medical Research Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.

Conference Abstract| December 01 1985 Effect of Secretin and Cholecystokinin on the Superior Mesenteric Artery Blood Flow in Man M I Qamar; M I Qamar 1University of Bristol Department of Medicine Bristol Royal Infirmary, Bristol BS2 8HW Search for other works by this author on: This Site PubMed Google Scholar R Mountford; R Mountford 1University of Bristol Department of Medicine Bristol Royal Infirmary, Bristol BS2 8HW Search for other works by this author on: This Site PubMed Google Scholar R Harvey; R Harvey 1University of Bristol Department of Medicine Bristol Royal Infirmary, Bristol BS2 8HW Search for other works by this author on: This Site PubMed Google Scholar A E Read A E Read 1University of Bristol Department of Medicine Bristol Royal Infirmary, Bristol BS2 8HW Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1985) 69 (s12): 37P. https://doi.org/10.1042/cs069037Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation M I Qamar, R Mountford, R Harvey, A E Read; Effect of Secretin and Cholecystokinin on the Superior Mesenteric Artery Blood Flow in Man. Clin Sci (Lond) 1 December 1985; 69 (s12): 37P. doi: https://doi.org/10.1042/cs069037Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1985 The Biochemical Society and the Medical Research Society1985 Article PDF first page preview Close Modal You do not currently have access to this content.

Transcutaneous Doppler ultrasound was used to measure coeliac axis blood flow in 42 normal subjects in the fasting state and in 10 subjects following a liquid meal. A Duplex scanner was used and coeliac axis blood flow was estimated by calculating the instantaneous average velocity of blood flow over the cardiac cycle. Both the diameter of the vessel and the angle between the vessel and the beam were measured from real time imaging. The mean (+/- s.e.m.) of coeliac axis blood flow was 703 +/- 24 ml/min. There was no difference in the results between the sexes nor any correlation between flow and age. The mean coefficient of variability was 7.8 per cent in a 1 day test and 9.2 per cent in a 2 day test. Coeliac axis blood flow increased by 38 per cent immediately after the end of ingestion of the meal and declined to 29 per cent 5 min and 24 per cent 10 min later.

Conference Abstract| January 01 1985 Combined Effects of Meal and Exercise on Superior Mesenteric Artery Blood Flow in Man M.I. Qamar; M.I. Qamar 1University of Bristol Department of Medicine, Bristol Royal Infirmary, Bristol, U.K. Search for other works by this author on: This Site PubMed Google Scholar A.E. Read A.E. Read 1University of Bristol Department of Medicine, Bristol Royal Infirmary, Bristol, U.K. Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1985) 68 (s11): 37P–38P. https://doi.org/10.1042/cs068037Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation M.I. Qamar, A.E. Read; Combined Effects of Meal and Exercise on Superior Mesenteric Artery Blood Flow in Man. Clin Sci (Lond) 1 January 1985; 68 (s11): 37P–38P. doi: https://doi.org/10.1042/cs068037Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1985 The Biochemical Society and the Medical Research Society1985 Article PDF first page preview Close Modal You do not currently have access to this content.

This paper reviews small intestinal lymphoma. Although a major emphasis is placed on primary small intestinal lymphoma of the “Western” type, the important topic of lymphoma in celiac disease is discussed. Our own recent experience of 7 patients with lymphoma in celiac disease is presented. The lymphoma of immunoproliferative small intestinal disease (“Mediterranean” lymphoma) and the associated α-chain disease are also reviewed, with emphasis on the differences from the “Western” type of primary small intestinal lymphoma.

Transcutaneous Doppler ultrasound was used to measure resting and postprandial blood flow in the superior mesenteric artery (SMABF) in nine patients with dumping syndrome and in ten normal volunteers of matching age and sex. All nine patients experienced signs and symptoms of dumping during the investigation, but none of the controls did so. At rest, SMABF in the dumping patients (567 +/- 47 ml/min) (mean +/- s.e.m.) did not significantly differ from that of the normal volunteers (493 +/- 72 ml/min). Five minutes from the end of a balanced liquid meal, flow had approximately doubled in each group (1232 +/- 140 and 941 +/- 128 ml/min). Compared with controls, increased SMABF was observed in patients with dumping syndrome at 10 min (76 per cent), 15 min (66 per cent), 30 min (55 per cent) and 45 min (42 per cent) (P = 0.05-0.01). Splanchnic pooling and abnormal redistribution of blood probably contribute to the pathogenesis of the early dumping syndrome.