Chagas disease caused by the protozoan Trypanosoma cruzi is an endemic parasitic disease in Central and South America. The chemotherapic agents against Trypnosoma cruzi (imidazol compounds, lampit and benznidazol) are not very convenient products. Since it is known that protozoan Trypanosoma are close to Leishmania we studied the action of 14 bisbenzylisoquinoline alkaloids, in vitro, on three strains of T. cruzi (Tulahuen, C8C11, and 1979 CL1). As in the case of Leishmania, gyrocarpine, daphnandrine and obaberine showed an interesting activity and we judge them to be worthy of in vivo assays.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlcaloïdes des Annonacées, 77. Alcaloïdes de Duguetia spixianaDominique Debourges, François Roblot, Reynald Hocquemiller, and André CavéCite this: J. Nat. Prod. 1987, 50, 4, 664–673Publication Date (Print):July 1, 1987Publication History Published online1 July 2004Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/np50052a015https://doi.org/10.1021/np50052a015research-articleACS PublicationsRequest reuse permissionsArticle Views146Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlcaloïdes de Annona hayesiiSabine Rasamizafy, Reynald Hocquemiller, Bruce K. Cassels, and André CavéCite this: J. Nat. Prod. 1987, 50, 4, 759–761Publication Date (Print):July 1, 1987Publication History Published online1 July 2004Published inissue 1 July 1987https://pubs.acs.org/doi/10.1021/np50052a036https://doi.org/10.1021/np50052a036research-articleACS PublicationsRequest reuse permissionsArticle Views172Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlcaloïdes des Annonacées, 84. Bisaporphinoïdes de l'Unonopsis spectabilisOlivier Laprévote, François Roblot, Reynald Hocquemiller, and André CavéCite this: J. Nat. Prod. 1987, 50, 5, 984–988Publication Date (Print):September 1, 1987Publication History Published online1 July 2004Published inissue 1 September 1987https://pubs.acs.org/doi/10.1021/np50053a044https://doi.org/10.1021/np50053a044research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlcaloëdes du Petchia ceylanicaAndré Cavé, Nicole Kunesch, Jean Bruneton, Robert Goutarel, and Gladwin Percy WannigamaCite this: J. Nat. Prod. 1987, 50, 6, 1178–1182Publication Date (Print):November 1, 1987Publication History Published online1 July 2004Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/np50054a034https://doi.org/10.1021/np50054a034research-articleACS PublicationsRequest reuse permissionsArticle Views69Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

The alkaloids pseudoxandrine, pseudoxandrinine, oxandrine, and oxandrinine have been isolated from a Colombian Annonaceous, Pseudoxandra aff. lucida. These bases belong to the small group of bisbenzyisoquinolines with a C(11)—C(11′) biphenyl bond, and are the first α or α′ mono-keto-bisbenzyltetrahydroisoquinolines. These structures were elucidated by ms, 1H nmr (including double resonance and nOe experiments), and 13C nmr.

Pentouregine, isolated from the leaves of Guatteria ouregou, is the first aporphine alkaloid with a 1, 11-methyleneoxy bridge found in an Annonaceae. Its structure has been elucidated by means of spectral analysis.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLa Saülatine, Alcaloïde Isoquinoléique Original Isolé de Abuta bullataR. Hocquemiller, A. Cavé, and A. FournetCite this: J. Nat. Prod. 1984, 47, 3, 539–540Publication Date (Print):May 1, 1984Publication History Published online1 July 2004Published inissue 1 May 1984https://pubs.acs.org/doi/10.1021/np50033a026https://doi.org/10.1021/np50033a026research-articleACS PublicationsRequest reuse permissionsArticle Views72Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Two new alkaloids, which we have named annomontine (1) and methoxyannomontine (2), have been isolated from the trunk- and root-barks of Annona montana Macf. (Annonaceae). Their structures have been deduced by spectral analysis and confirmed by an X-ray structure determination of (2). They are the first members of the new class of 1-(2′-aminopyrimidin-4-yl)-β-carboline alkaloids.

Le contenu alcaloïdique des écorces de tronc et des feuilles de l'Enantia polycarpa, Annonacées, a été étudié et comparé à celui d'autres Enantia. Les principaux alcaloïdes sont des protoberbérines, des tétrabydroprotoberbérines et des aporpbinoïdes (aporphines quaternaires, aporphines, nor-aporphines, oxo-aporpbines). Une isoquinolone, la corydaldine, a été isolée, ainsi qu'un alcaloïde nouveau, la polycarpine.