Elite athletic performance is linked to advanced cognitive functioning, yet cognition's role in motor skill acquisition among novices remains underexplored. This study examined how cognition influences learning a complex field hockey skill in participants with minimal prior experience. Forty novices (mean age = 20.04 years) completed a hockey ball control task assessed across six timepoints, three before and three after viewing a coaching video of an expert performing the task. Cognitive measures included fluid intelligence (Raven's Progressive Matrices), crystallized intelligence (Spot-the-Word), working memory (OSpan), perceptual speed (Inspection Time), and psychomotor ability (Fitts's task). Declarative and procedural knowledge were also recorded. Performance was evaluated using positional and technical scoring systems. Gains through repetition were modeled via linear regression. No overall significant improvement occurred during uncoached repetition. However, crystallized intelligence predicted individual differences in pre-coaching gains while fluid intelligence was positively associated with immediate coaching effects. Post-intervention improvements were predicted by working memory capacity and number of practice attempts. Psychomotor ability predicted gains through repetition both before and after intervention. Distinct cognitive domains support different phases of motor learning. Cognitive profiling may inform talent identification in early skill acquisition.

Persistent COVID-19 symptoms post-acute state have been shown to have a significant negative impact on brain structure and function. In this study, we conducted magnetic resonance imaging (MRI) of the whole brain in 43 working-age adults (mean age: 44.79+10.80; +10.80; range: 24-65 years) with a history of COVID-19 (731.17+312.41 +312.41 days post-diagnosis), and also assessed their cognitive function (processing speed, attention, working memory, executive function, and recognition memory), mental health, and sleep quality. MRI data were processed using FSL to derive regional volumes for bilateral nucleus accumbens, caudate, pallidum, putamen, thalamus, amygdala, and hippocampus, and total grey matter, white matter, and cerebral spinal fluid volume, and analysed in relation to persistent COVID-19 symptom load, mental health, and sleep quality. Higher persistent COVID-19 symptom load was significantly associated with smaller putamen volume, lower response accuracy on working memory, executive function, and recognition memory tasks, as well as a longer time to complete the executive function task, and poorer mental health and sleep quality. Smaller putamen fully mediated the relationship between persistent COVID-19 symptom load and lower executive function. Further research is required to confirm whether reduced putamen volume and its association with poor executive function persists in COVID-19 survivors in the long term.

Introduction:Although working memory (WM) deficits are well established in schizophrenia (SZ), their underlying source is still unclear. It has been proposed that these WM deficits may depend on an imbalance between cortical excitation and inhibition (E/I), but its importance for SZ remains unclear. A potential biomarker for E/I is visual Surround Suppression (SS), where the apparent contrast of a central grating is typically suppressed by a surround with parallel orientation (versus orthogonal). Here we exploited the SS phenomenon to test whether E/I contributes to WM impairments in schizophrenia. Methods:Using centre-surround gratings, we measured psychophysical thresholds for contrast matching, detection and orientation discrimination, in 21 SZ patients and 20 matched controls. Using the same stimuli, we also measured WM accuracy and event-related potentials (ERPs) in a delayed-match-to-sample task. Results:In SZ participants, reduced SS predicted impaired WM performance as well as general cognitive measures (CANTAB). Similar relationships were also observed between other early visual measures (impaired contrast detection and orientation discrimination), WM and general cognition. In response to SS, there was reduced amplitude visual ERPs (P1, N1 and P2) in patients compared with controls. Furthermore, across both groups the P1 amplitude correlated with visual SS. Conclusion:Together, these findings provide evidence that imbalances in cortical excitation and inhibition may contribute to visual and some cognitive deficits in schizophrenia, and that SS may provide a behavioural and electrophysiological biomarker.

Numerous studies have examined executive function (EF) abilities in cognitively healthy older adults and those living with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Currently, there are no standard accepted protocols for testing specific EFs; thus, researchers have used their preferred tool, which leads to variability in assessments of decline in a particular ability across studies. Therefore, there is a need for guidance as to the most sensitive tests for assessing EF decline. A search of the most current literature published between 2000 and 2022 on EF studies assessing cognitively healthy older adults and individuals living with MCI and AD was conducted using PubMed/Medline, PsycINFO, Embase, Web of Science, and Google Scholar. Emphasis was placed on the EF's dual-tasking, inhibition, shifting or switching, and working memory updating. Many tasks and their outcomes were reviewed. Of particular importance was the difference in outcomes for tasks applied to the same group of participants. These various EF assessment tools demonstrate differences in effectively identifying decline in EF ability due to the aging process and neurodegenerative conditions, such as MCI and AD. This review identifies various factors to consider in using particular EF tasks in particular populations, including task demand and stimuli factors, and also when comparing differing results across studies.

Control of limb movements may be impaired after stroke due to the loss of connectivity between the cerebral cortex and spinal cord. A notion to improve motor function in stroke survivors is to use alternate motor fibers, such as the reticulospinal tract (RST), which originate from the brainstem and terminate at different levels of spinal cord. One way of targeting the RST is to use a "StartReact" protocol to foster premature release of a preplanned movement in response to a startling stimulus. Our aim was to find support for the preservation of such StartReact effect in stroke survivors. We conducted a systematic review with meta-analysis of literature published in English up to September 2020, to explore differences in motor responses to startling stimuli in StartReact effects. Protocol of the study was registered (PROSPERO Registration No. CRD42020191581). PubMed, Google Scholar, Web of Science, PsycINFO, and Science Direct were searched for relevant literature. The meta-analysis contained six studies involving a total of 151 stroke and healthy participants. Muscle onset latency data were extracted from the qualifying studies and compared using RevMan. StartReact effect was present in both stroke and healthy groups, represented by shortened muscle onset latency when startling stimulus was present. There was considerable heterogeneity of the outcome measures, which was attributed to the range of motor impairments among stroke survivors and methodologies used. Our findings support the notion of preservation of preprogramming ability and suitability of RST and StartReact effect for motor rehabilitation following stroke.

When two (or more) tasks, each requiring a rapid response, are performed at the same time then serial processing may occur at certain processing stages, such as the response selection. There is accumulating evidence that such serial processing involves additional control processes, such as inhibition, switching, and scheduling (termed the active scheduling account). The present study tested whether the existence of serial processing in multitasking leads to a requirement for processes that coordinate processing in this way (active scheduling account) and, furthermore, whether such control processes are linked to the executive functions (EF) of working memory (WM). To test this question, we merged the psychological refractory period (PRP) paradigm with a WM task, creating a complex WM span task. Participants were presented with a sequence of letters to remember, followed by a processing block in which they had to perform either a single task or a dual task, and finally were asked to recall the letters. Results showed that WM performance, i.e. the amount of letters recalled in the correct order, decreased when performing a dual task as compared to performing a single task during the retention interval. Two further experiments supported this finding using manipulations of the dual task difficulty. We conclude that the existence of serial processing in multitasking demands additional control processes (active scheduling) and that these processes are strongly linked to the executive functions of working memory.

The aim of this study was to compare two methodologies employed by the British Cycling talent identification program. Specifically, the authors investigated cyclists selected to represent GB cycling team at the London 2012 Olympics using (a) a traditional talent identification methodology (British Cycling Olympic Development Program), where selection is based upon race results and (b) a detection talent identification methodology (U.K. Sport Talent Team Program), which is a multi-Olympic event initiative that identifies athletic potential from physical and skill-based tests. To facilitate this comparison, the authors calculated the speed with which expertise was acquired. A Mann–Whitney U test ( U = 16.0, p = .031) indicated that the speed of acquiring expertise was quicker in detection talent identification ( Mdn = 5.4) than traditional talent identification ( Mdn = 7.2). Practice started later with detection talent identification than with traditional talent identification (14.12 years vs. 11.23 years, respectively), which affected the period to excellence. Thus, detection talent identification resulted in an absence of early specialization, which suggests a critical period for attaining cycling expertise. The authors hypothesize a genetic basis of talent and propose that critical periods are important in detection talent identification programs.

Deliberate practice theory argues that expertise can be acquired only after 10 years of domain-specific deliberate practice. To assess this prediction, we examined data from track ( n = 57) and field ( n = 15) athletes representing Great Britain Track and Field team (Team GB) at the 2012 Olympics. We defined the period to excellence as the difference in age between achieving expertise (the first selection for an international senior outdoor athletic championship) and starting age (joining a club, being coached, or engaging in competition). Results indicated that elite track (75.4%) and field (93.3%) athletes acquired expertise in significantly less than 10 years ( M = 7.20, SD = 3.20 , p < .001). Expertise mostly relying on the anaerobic pathway ( n = 51) was acquired significantly faster than expertise mostly utilizing the aerobic pathway ( n = 21), 6.15 ± 2.84 years vs. 9.78 ± 2.52 years ( p < .001). Those who did not specialize early ( n = 40) were faster in acquiring expertise in a new sport than those who specialized early ( n = 32), 6.27 ± 2.78 vs. 8.38 ± 3.34 years ( p = .005), contrary to deliberate-practice contention that early specialization is critical.

AbstractBackgroundDecline in cognitive ability is well understood to occur due to advanced age and pathological impairment. However, not all affected aspects of cognitive ability deteriorate at the same rate (Petersen, RC, et al., 1997; Craik, FI, and Salthouse TA, 2000, 2008, 2011; Salthouse, TA, 2009, 2012).In this study, we research how executive function abilities (mental processes that regulate and control our cognition) differ between cognitively healthy older adults and individuals living with Mild Cognitive Impairment (MCI) and early‐stage Alzheimer's disease (AD). Assessment was focused on four areas of executive functions dual‐tasking, inhibition, shifting and updating commonly utilised in everyday life (Miyake, A, et al., 2000; Alvarez, JA, and Emory, E, 2006; Suchy, Y, 2009; Baddeley, A., 2012). The aim is to better understand the nature and rate of deterioration as a means to aid in early detection and intervention for both conditions.MethodWe aim to assess approximately 30 cognitively healthy older adults, and a combination of 30 individuals living with MCI and early‐stage AD on four different aspects of executive functions, i.e. dual‐tasking, inhibition, shifting and updating. Two separate tasks will be utilised to measure each EF, dual‐tasking (the Test of Everyday Attention dual‐task telephone search subtest and Psychological Refractory Period paradigm task), inhibition (the Hayling Sentence Completion test and Stroop task), shifting (the Trail Making Test and a task switching test), and updating (the backward digit recall span test and a N‐back task).ResultData collection is ongoing.ConclusionWe predict better cognitive ability will be evident in the healthy older adult group, followed by the MCI and then the early‐stage AD groups. However, we expect dual‐tasking and updating ability to be most severely affected in individuals living with early‐stage AD and then shifting with inhibition showing most preservation.

ObjectiveUnilateral neglect is a poststroke disorder that impacts negatively on functional outcome and lacks established, effective treatment. This multicomponent syndrome is characterised by a directional bias of attention away from contralesional space, together with impairments in several cognitive domains, including sustained attention and spatial working memory. This study aimed to test the effects of guanfacine, a noradrenergic alpha-2A agonist, on ameliorating aspects of neglect.MethodsThirteen right hemisphere stroke patients with leftward neglect were included in a randomised, double-blind, placebo-controlled proof-of-concept crossover study that examined the effects of a single dose of guanfacine. Patients were tested on a computerised, time-limited cancellation paradigm, as well as tasks that independently assessed sustained attention and spatial working memory.ResultsOn guanfacine, there was a statistically significant improvement in the total number of targets found on the cancellation task when compared with placebo (mean improvement of 5, out of a possible 64). However, there was no evidence of a change in neglect patients’ directional attention bias. Furthermore, Bayesian statistical analysis revealed reliable evidence against any effects of guanfacine on search organisation and performance on our sustained attention and spatial working memory tasks.ConclusionsGuanfacine improves search in neglect by boosting the number of targets found but had no effects on directional bias or search organisation, nor did it improve sustained attention or working memory on independent tasks. Further work is necessary to determine whether longer term treatment with guanfacine may be effective for some neglect patients and whether it affects functional outcome measures.Trial registration numberNCT00955253.

Empirical evidence suggests that levodopa medication used to treat the motor symptoms of Parkinson's disease (PD) may either improve, impair or not affect specific cognitive processes. This evidence led to the 'dopamine overdose' hypothesis that levodopa medication impairs performance on cognitive tasks if they recruit fronto-striatal circuits which are not yet dopamine-depleted in early PD and as a result the medication leads to an excess of dopamine. This hypothesis has been supported for various learning tasks including conditional associative learning, reversal learning, classification learning and intentional deterministic sequence learning, on all of which PD patients demonstrated significantly worse performance when tested on relative to off dopamine medication. Incidental sequence learning is impaired in PD, but how such learning is affected by dopaminergic therapy remains undetermined. The aim of the current study was to investigate the effect of dopaminergic medication on incidental sequence learning in PD. We used a probabilistic serial reaction time task (SRTT), a sequence learning paradigm considered to make the sequence less apparent and more likely to be learned incidentally rather than intentionally. We compared learning by the same group of PD patients (n=15) on two separate occasions following oral administration of levodopa medication (on state) and after overnight withdrawal of medication (off state). Our results demonstrate for the first time that levodopa medication enhances incidental learning of a probabilistic sequence on the serial reaction time task in PD. However, neither group significantly differed from performance of a control group without a neurological disease, which indicates the importance of within group comparisons for identifying deficits. Levodopa medication enhanced incidental learning by patients with PD on a probabilistic sequence learning paradigm even though the patients were not aware of the existence of the sequence or their acquired knowledge. The results suggest a role in acquiring incidental motor sequence learning for dorsal striatal areas strongly affected by dopamine depletion in early PD.

It is known that neuroticism impairs cognitive performance mostly in difficult tasks, but not so much in easier tasks. One pervasive situation of this type is multitasking, in which the combination of two simple tasks creates a highly demanding dual-task, and consequently high neurotics show higher dual-task costs than low neurotics. However, the functional neuroanatomical correlates of these additional performance impairments in high neurotics are unknown. To test for this, we assessed brain activity by means of functional magnetic resonance imaging (fMRI) in 17 low and 15 high neurotics while they were performing a demanding dual-task and the less demanding component tasks as single-tasks. Behavioural results showed that performance (response times and error rates) was lower in the dual-task than in the single-tasks (dual-task costs), and that these dual-task costs were significantly higher in high neurotics. Imaging data showed that high neurotics showed less dual-task specific activation in lateral (mainly middle frontal gyrus) and medial prefrontal cortices. We conclude that high levels of neuroticism impair behavioural performance in demanding tasks, and that this impairment is accompanied by reduced activation of the task-associated brain areas.

Objectives: Neuromodulation of the immune system has been proposed to be influenced by hemispheric lateralisation (HL). The present study tested whether HL predicted CD4+ levels, statistically controlling for confounders. Methods: Employing two assessments of HL, 68 human immunodeficiency virus (HIV)-1+ patients were followed prospectively. Numerous exclusion criteria and confounder assessments were employed (e.g. age/medication). Results: Left HL significantly positively predicted CD4+ levels at follow-up, and this was qualified by medication (HAART) status: only in HAART-naïve patients did HL predict CD4 levels. Furthermore, HL significantly predicted whether patients had clinically significantly high/low CD4+ counts. Conclusions: Using a more rigorous methodology than a previous study, the present work partly corroborated the theory of HL influences on immunity, extended it to HIV immunity and identified a possible moderator: HAART medication. Implications for future research and treatments are provided.

Communication from the brain to the immune system is influenced by hemispheric lateralisation (HL). Left-HL is immunopotentiating, right-HL is immunosuppressive. Only one study has examined the effects of HL on the progression of HIV (Gruzelier et al., 1996). That study included a small sample with very little control over third variables. The present study tested whether left HL predicted higher CD4 and CD8 levels, statistically controlling for confounders.