RNA-binding proteins are emerging as critical modulators of oncogenic cell transformation, malignancy and therapy resistance. We have previously found that the RNA-binding protein Cold Shock Domain containing protein E1 (CSDE1) promotes invasion and metastasis of melanoma, the deadliest form of skin cancer and also a highly heterogeneous disease in need of predictive biomarkers and druggable targets. Here, we design a monoclonal antibody useful for IHC in the clinical setting and use it to evaluate the prognosis potential of CSDE1 in an exploratory cohort of 149 whole tissue sections including benign nevi and primary tumors and metastasis from melanoma patients. Contrary to expectations for an oncoprotein, we observed a global decrease in CSDE1 levels with increasing malignancy. However, the CSDE1 cytoplasmic/nuclear ratio exhibited a positive correlation with adverse clinical features of primary tumors and emerged as a robust indicator of progression free survival in cutaneous melanoma, highlighting the potential of CSDE1 as a biomarker of prognosis. Our findings provide a novel feature for prognosis assessment and highlight the intricacies of RNA-binding protein dynamics in cancer progression.

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 21, Issue 12 p. 1560-1562 CLINICAL LETTER Refraktärer IgA-Pemphigus erfolgreich mit Adalimumab als Monotherapie behandelt Juan José Lluch-Galcerá, Corresponding Author Juan José Lluch-Galcerá [email protected] orcid.org/0000-0003-0005-0318 Department of Dermatology, Hospital Universitari Germans Trias i Pujol | Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, Spain Korrespondenzanschrift Juan José Lluch Galcerá, Dermatology department, Hospital Universitari Germans Trias i Pujol, C/ Carretera de Canyet, s/n, 08916 Badalona, | Departament de Medicina, Universitat Autonoma de Barcelona, Spain. Email: [email protected]Search for more papers by this authorCarmen Alcoverro, Carmen Alcoverro Department of Dermatology, Hospital Universitari Germans Trias i Pujol | Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorEugeni Prat, Eugeni Prat Department of Dermatology, Hospital Universitari Germans Trias i Pujol | Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorManel Martinez-Molina, Manel Martinez-Molina Department of Dermatology, Hospital Universitari Germans Trias i Pujol | Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorIsabel Bielsa, Isabel Bielsa Department of Dermatology, Hospital Universitari Germans Trias i Pujol | Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, SpainSearch for more papers by this authorJulio Bassas, Julio Bassas Department of Dermatology, Hospital Universitari Germans Trias i Pujol | Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this author Juan José Lluch-Galcerá, Corresponding Author Juan José Lluch-Galcerá [email protected] orcid.org/0000-0003-0005-0318 Department of Dermatology, Hospital Universitari Germans Trias i Pujol | Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, Spain Korrespondenzanschrift Juan José Lluch Galcerá, Dermatology department, Hospital Universitari Germans Trias i Pujol, C/ Carretera de Canyet, s/n, 08916 Badalona, | Departament de Medicina, Universitat Autonoma de Barcelona, Spain. Email: [email protected]Search for more papers by this authorCarmen Alcoverro, Carmen Alcoverro Department of Dermatology, Hospital Universitari Germans Trias i Pujol | Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorEugeni Prat, Eugeni Prat Department of Dermatology, Hospital Universitari Germans Trias i Pujol | Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorManel Martinez-Molina, Manel Martinez-Molina Department of Dermatology, Hospital Universitari Germans Trias i Pujol | Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorIsabel Bielsa, Isabel Bielsa Department of Dermatology, Hospital Universitari Germans Trias i Pujol | Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, SpainSearch for more papers by this authorJulio Bassas, Julio Bassas Department of Dermatology, Hospital Universitari Germans Trias i Pujol | Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this author First published: 11 December 2023 https://doi.org/10.1111/ddg.15232_gRead the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. LITERATUR 1Kridin K, Patel PM, Jones VA, et al. IgA pemphigus: A systematic review. J Am Acad Dermatol. 2020; 82(6): 1386-1392. 10.1016/j.jaad.2019.11.059 CASPubMedWeb of Science®Google Scholar 2Hendrix JD, Mangum KL, Zone JJ, et al. Cutaneous IgA deposits in bullous diseases function as ligands to mediate adherence of activated neutrophils. J Invest Dermatol. 1990; 94(5): 667-672. 10.1111/1523-1747.ep12876246 CASPubMedWeb of Science®Google Scholar 3Kridin K, Schmidt E. Epidemiology of Pemphigus. JID Innov. 2021; 1(1):100004. 10.1016/j.xjidi.2021.100004 PubMedGoogle Scholar 4Aslanova M, Yarrarapu SNS, Zito PM. IgA Pemphigus. [Updated 2023 Mar 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK519063/#_NBK519063_pubdet_ [Last accessed April 1, 2023]. Google Scholar 5Porro AM, de Caetano LVN, de Maehara LSN, dos Enokihara MMS. Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus. An Bras Dermatol. 2014; 89(1): 96-106. 10.1590/abd1806-4841.20142459 PubMedWeb of Science®Google Scholar 6Hashimoto T, Teye K, Ishii N. Clinical and immunological studies of 49 cases of various types of intercellular IgA dermatosis and 13 cases of classical subcorneal pustular dermatosis examined at Kurume University. Br J Dermatol. 2017; 176(1): 168-175. 10.1111/bjd.14780 CASPubMedWeb of Science®Google Scholar 7Howell SM, Bessinger GT, Altman CE, Belnap CM. Rapid response of IgA pemphigus of the subcorneal pustular dermatosis subtype to treatment with adalimumab and mycophenolate mofetil. J Am Acad Dermatol. 2005; 53(3): 541-543. 10.1016/j.jaad.2005.02.051 PubMedWeb of Science®Google Scholar 8Moreno ACL, Santi CG, Gabbi TVB, et al. IgA pemphigus: case series with emphasis on therapeutic response. J Am Acad Dermatol. 2014; 70(1): 200-201. 10.1016/j.jaad.2013.09.037 PubMedWeb of Science®Google Scholar 9Cross A, Moots RJ, Edwards SW. The dual effects of TNFalpha on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1. Blood. 2008; 111(2): 878-884. 10.1182/blood-2007-05-087833 CASPubMedWeb of Science®Google Scholar 10Lokuta MA, Huttenlocher A. TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway. J Leukoc Biol. 2005; 78(1): 210-219. 10.1189/jlb.0205067 CASPubMedWeb of Science®Google Scholar Volume21, Issue12December 2023Pages 1560-1562 ReferencesRelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 21, Issue 12 p. 1560-1562 CLINICAL LETTER Refractory IgA pemphigus successfully managed with adalimumab as monotherapy Juan José Lluch-Galcerá, Corresponding Author Juan José Lluch-Galcerá [email protected] orcid.org/0000-0003-0005-0318 Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, Spain Correspondence Juan José Lluch Galcerá, Dermatology department, Hospital Universitari Germans Trias i Pujol, C/ Carretera de Canyet, s/n, 08916 Badalona, Barcelona, Spain. Email: [email protected]Search for more papers by this authorCarmen Alcoverro, Carmen Alcoverro Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorEugeni Prat, Eugeni Prat Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorManel Martinez-Molina, Manel Martinez-Molina Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorIsabel Bielsa, Isabel Bielsa Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, SpainSearch for more papers by this authorJulio Bassas, Julio Bassas Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this author Juan José Lluch-Galcerá, Corresponding Author Juan José Lluch-Galcerá [email protected] orcid.org/0000-0003-0005-0318 Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, Spain Correspondence Juan José Lluch Galcerá, Dermatology department, Hospital Universitari Germans Trias i Pujol, C/ Carretera de Canyet, s/n, 08916 Badalona, Barcelona, Spain. Email: [email protected]Search for more papers by this authorCarmen Alcoverro, Carmen Alcoverro Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorEugeni Prat, Eugeni Prat Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorManel Martinez-Molina, Manel Martinez-Molina Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorIsabel Bielsa, Isabel Bielsa Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, SpainSearch for more papers by this authorJulio Bassas, Julio Bassas Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Departament de Medicina, Universitat Autonoma de Barcelona (UAB), Badalona, Barcelona, SpainSearch for more papers by this author First published: 24 October 2023 https://doi.org/10.1111/ddg.15232Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Kridin K, Patel PM, Jones VA, et al. IgA pemphigus: A systematic review. J Am Acad Dermatol. 2020; 82(6): 1386-1392. 10.1016/j.jaad.2019.11.059 CASPubMedWeb of Science®Google Scholar 2Hendrix JD, Mangum KL, Zone JJ, et al. Cutaneous IgA deposits in bullous diseases function as ligands to mediate adherence of activated neutrophils. J Invest Dermatol. 1990; 94(5): 667-672. 10.1111/1523-1747.ep12876246 CASPubMedWeb of Science®Google Scholar 3Kridin K, Schmidt E. Epidemiology of Pemphigus. JID Innov. 2021; 1(1):100004. 10.1016/j.xjidi.2021.100004 PubMedGoogle Scholar 4Aslanova M, Yarrarapu SNS, Zito PM. IgA Pemphigus. [Updated 2023 Mar 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK519063/#_NBK519063_pubdet_ [Last accessed April 1, 2023]. Google Scholar 5Porro AM, de Caetano LVN, de Maehara LSN, dos Enokihara MMS. Non-classical forms of pemphigus: pemphigus herpetiformis, IgA pemphigus, paraneoplastic pemphigus and IgG/IgA pemphigus. An Bras Dermatol. 2014; 89(1): 96-106. 10.1590/abd1806-4841.20142459 PubMedWeb of Science®Google Scholar 6Hashimoto T, Teye K, Ishii N. Clinical and immunological studies of 49 cases of various types of intercellular IgA dermatosis and 13 cases of classical subcorneal pustular dermatosis examined at Kurume University. Br J Dermatol. 2017; 176(1): 168-175. 10.1111/bjd.14780 CASPubMedWeb of Science®Google Scholar 7Howell SM, Bessinger GT, Altman CE, Belnap CM. Rapid response of IgA pemphigus of the subcorneal pustular dermatosis subtype to treatment with adalimumab and mycophenolate mofetil. J Am Acad Dermatol. 2005; 53(3): 541-543. 10.1016/j.jaad.2005.02.051 PubMedWeb of Science®Google Scholar 8Moreno ACL, Santi CG, Gabbi TVB, et al. IgA pemphigus: case series with emphasis on therapeutic response. J Am Acad Dermatol. 2014; 70(1): 200-201. 10.1016/j.jaad.2013.09.037 PubMedWeb of Science®Google Scholar 9Cross A, Moots RJ, Edwards SW. The dual effects of TNFalpha on neutrophil apoptosis are mediated via differential effects on expression of Mcl-1 and Bfl-1. Blood. 2008; 111(2): 878-884. 10.1182/blood-2007-05-087833 CASPubMedWeb of Science®Google Scholar 10Lokuta MA, Huttenlocher A. TNF-alpha promotes a stop signal that inhibits neutrophil polarization and migration via a p38 MAPK pathway. J Leukoc Biol. 2005; 78(1): 210-219. 10.1189/jlb.0205067 CASPubMedWeb of Science®Google Scholar Volume21, Issue12December 2023Pages 1560-1562 ReferencesRelatedInformation

Pediatric DermatologyVolume 39, Issue 6 p. 973-975 PHOTOQUIZ White hyperkeratotic plaque in a patient with infantile spasms Verónica Mora-Fernández MD, Verónica Mora-Fernández MD Dermatology Department, Hospital Universitari Germans Trias I Pujol (HUGTiP), Barcelona, Spain Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, SpainSearch for more papers by this authorAdrià Plana-Pla MD, Adrià Plana-Pla MD orcid.org/0000-0003-2241-5664 Dermatology Department, Hospital Universitari Germans Trias I Pujol (HUGTiP), Barcelona, Spain Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, SpainSearch for more papers by this authorAriadna Quer MD, Ariadna Quer MD Pathology Department, Hospital Universitari Germans Trias I Pujol (HUGTIP), Universitat Autònoma de Barcelona, Barcelona, SpainSearch for more papers by this authorIgnacio Blanco PhD, Ignacio Blanco PhD Clinical Genetics and Genetic Counseling Unit, Clinical Genetics Service, Northern Metropolitan Clinical Laboratory, Germans Trias i Pujol University Hospital (HUGTiP), Can Ruti Campus, Barcelona, Spain Clinical Genomics Research Unit, Germans Trias i Pujol Research Institute (IGTP-PMPPC), Can Ruti Campus, Barcelona, SpainSearch for more papers by this authorIsabel Bielsa PhD, Corresponding Author Isabel Bielsa PhD ibielsa.germanstrias@gencat.cat Dermatology Department, Hospital Universitari Germans Trias I Pujol (HUGTiP), Barcelona, Spain Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain Correspondence Isabel Bielsa, Dermatology Department, Hospital Universitari Germans Trias I Pujol (HUGTiP), Carretera del Canyet s/n, Badalona, Barcelona, Spain. CP 08916. Email: ibielsa.germanstrias@gencat.catSearch for more papers by this author Verónica Mora-Fernández MD, Verónica Mora-Fernández MD Dermatology Department, Hospital Universitari Germans Trias I Pujol (HUGTiP), Barcelona, Spain Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, SpainSearch for more papers by this authorAdrià Plana-Pla MD, Adrià Plana-Pla MD orcid.org/0000-0003-2241-5664 Dermatology Department, Hospital Universitari Germans Trias I Pujol (HUGTiP), Barcelona, Spain Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, SpainSearch for more papers by this authorAriadna Quer MD, Ariadna Quer MD Pathology Department, Hospital Universitari Germans Trias I Pujol (HUGTIP), Universitat Autònoma de Barcelona, Barcelona, SpainSearch for more papers by this authorIgnacio Blanco PhD, Ignacio Blanco PhD Clinical Genetics and Genetic Counseling Unit, Clinical Genetics Service, Northern Metropolitan Clinical Laboratory, Germans Trias i Pujol University Hospital (HUGTiP), Can Ruti Campus, Barcelona, Spain Clinical Genomics Research Unit, Germans Trias i Pujol Research Institute (IGTP-PMPPC), Can Ruti Campus, Barcelona, SpainSearch for more papers by this authorIsabel Bielsa PhD, Corresponding Author Isabel Bielsa PhD ibielsa.germanstrias@gencat.cat Dermatology Department, Hospital Universitari Germans Trias I Pujol (HUGTiP), Barcelona, Spain Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain Correspondence Isabel Bielsa, Dermatology Department, Hospital Universitari Germans Trias I Pujol (HUGTiP), Carretera del Canyet s/n, Badalona, Barcelona, Spain. CP 08916. Email: ibielsa.germanstrias@gencat.catSearch for more papers by this author First published: 28 November 2022 https://doi.org/10.1111/pde.15104Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume39, Issue6November/December 2022Pages 973-975 RelatedInformation

Transl Lung Cancer Res 2020;9(2):421-423 | http://dx.doi.org/10.21037/tlcr.2020.03.01 A 64-year-old man, former smoker with no prior relevant medical history was diagnosed with squamous cell carcinoma of the lung and underwent right bilobectomy (MRL and LRL) and mediastinal lymphadenectomy. The histopathology report confirmed the tumor to be pT1aN1M0. The patient was offered adjuvant chemotherapy with cisplatin and vinorelbine followed by adjuvant treatment with durvalumab (anti-PD-L1) 20 mg/kg/28 d in a clinical trial (NCT02273375). After 5 cycles of durvalumab, he presented at the emergency department with a 48-hour history of inflammatory pain in shoulders and pelvis, as well as low-grade fever. Physical examination revealed functional limitation of scapular and pelvic girdle. Laboratory analysis revealed increased acutephase reactants (CRP 52 mg/L; ESR 92 mm/h). Ultrasound of the shoulders showed bilateral bicipital tenosynovitis and subacromial bursitis, thus confirming the diagnosis of polymyalgia rheumatica (PMR), which was associated with durvalumab. Treatment with methylprednisolone 12 mg/d led to a good clinical and laboratory response; therefore, immunotherapy was maintained. Three weeks later, while the patient was undergoing methylprednisolone 8 mg/d, he presented with erythematous macules and papules and edema on the lower limbs and was admitted for further assessment. Skin biopsy revealed leukocytoclastic vasculitis. The results of an immunological study based on antinuclear antibodies, antineutrophil cytoplasmic antibodies, rheumatoid factor and cryoglobulins were negative. Complement levels were normal. Twenty-fourhour urine test revealed proteinuria (539 mg/24 h) and hematuria (90% dysmorphic red blood cells). PET-CT ruled out recurrence of the lung tumor. Kidney biopsy eventually revealed IgA vasculitis. In summary, we present the case of a patient receiving durvalumab who presented with symptoms compatible with PMR and IgA vasculitis. Given the second immune related adverse event (IRAE) induced by durvalumab, we decided to withdraw immunotherapy and start treatment with angiotensin converting enzyme inhibitors and 0.5 mg/kg/d prednisone. The symptoms were completely resolved and it was possible to taper glucocorticoids dose till its withdrawal 1 year later. The patient is currently being followed at the oncology and rheumatology clinics, is not receiving cancer treatment nor rheumatic, and remains symptom-free. The advent of the immune check-point inhibitors (ICI) in the clinical scenario has meant a relevant change in the therapeutic approach for several solid tumors. They have changed dramatically the prognosis of these tumors with a substantial improvement of survival and even with longlasting responders to such therapies. Despite this, ICI have come together with a new spectrum of toxicities. Generally, the incidence of the IR-AE is low with a mild or moderate symptomatic burden at presentation. Usually, they can be well controlled with steroids, requiring dose delays and occasionally drug withhold. Occasionally, these IRAE may be life-threatening with permanent and disabling Letter to the Editor

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 18, Issue 7 p. 743-747 Clinical Letter Ichthyosiform eruption and facial erythema secondary to ponatinib therapy Mónica Munera-Campos, Corresponding Author Mónica Munera-Campos monicamunera@hotmail.com Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain Correspondence to Mónica Munera-Campos, MD Department of Dermatology Hospital Universitari Germans Trias i Pujol Carretera de Canyet, S/N 08916 Badalona, Barcelona, Spain E-mail: monicamunera@hotmail.comSearch for more papers by this authorJose Manuel Carrascosa, Jose Manuel Carrascosa Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorCarlos Ferrándiz, Carlos Ferrándiz Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this author Mónica Munera-Campos, Corresponding Author Mónica Munera-Campos monicamunera@hotmail.com Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain Correspondence to Mónica Munera-Campos, MD Department of Dermatology Hospital Universitari Germans Trias i Pujol Carretera de Canyet, S/N 08916 Badalona, Barcelona, Spain E-mail: monicamunera@hotmail.comSearch for more papers by this authorJose Manuel Carrascosa, Jose Manuel Carrascosa Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorCarlos Ferrándiz, Carlos Ferrándiz Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this author First published: 26 June 2020 https://doi.org/10.1111/ddg.14154Citations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume18, Issue7July 2020Pages 743-747 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 18, Issue 9 p. 1039-1043 Clinical Letter Genitale lymphoplasmazelluläre Mukositis mit kristallinen Einschlüssen: eine histomorphologische Variante, die nicht mit lymphoproliferativen Erkrankungen assoziiert ist Mar Llamas-Velasco, Corresponding Author Mar Llamas-Velasco mar.llamasvelasco@gmail.com Department of Dermatology, Hospital Universitario de la Princesa, Fundación de Investigación de La Princesa, Madrid, Spain Korrespondenzanschrift Mar Llamas-Velasco, MD c/o Diego de León 62 CP 28006 Madrid, Spain E-Mail: mar.llamasvelasco@gmail.comSearch for more papers by this authorJavier Fraga, Javier Fraga Pathology, Hospital Universitario de la Princesa, Fundación de Investigación de La Princesa, Madrid, SpainSearch for more papers by this authorTeresa Zulueta, Teresa Zulueta Department of Pathology, Hospital Universitario Virgen del Rocío, Sevilla, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, SpainSearch for more papers by this authorMaría Jose Concha-Garzón, María Jose Concha-Garzón Department of Dermatology, Hospital Universitario de la Princesa, Fundación de Investigación de La Princesa, Madrid, SpainSearch for more papers by this authorMaria Teresa Fernández-Figueras, Maria Teresa Fernández-Figueras Hospital Universitari General de Catalunya, Universitat Internacional de Catalunya, Sant Cugat, Barcelona, SpainSearch for more papers by this author Mar Llamas-Velasco, Corresponding Author Mar Llamas-Velasco mar.llamasvelasco@gmail.com Department of Dermatology, Hospital Universitario de la Princesa, Fundación de Investigación de La Princesa, Madrid, Spain Korrespondenzanschrift Mar Llamas-Velasco, MD c/o Diego de León 62 CP 28006 Madrid, Spain E-Mail: mar.llamasvelasco@gmail.comSearch for more papers by this authorJavier Fraga, Javier Fraga Pathology, Hospital Universitario de la Princesa, Fundación de Investigación de La Princesa, Madrid, SpainSearch for more papers by this authorTeresa Zulueta, Teresa Zulueta Department of Pathology, Hospital Universitario Virgen del Rocío, Sevilla, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, SpainSearch for more papers by this authorMaría Jose Concha-Garzón, María Jose Concha-Garzón Department of Dermatology, Hospital Universitario de la Princesa, Fundación de Investigación de La Princesa, Madrid, SpainSearch for more papers by this authorMaria Teresa Fernández-Figueras, Maria Teresa Fernández-Figueras Hospital Universitari General de Catalunya, Universitat Internacional de Catalunya, Sant Cugat, Barcelona, SpainSearch for more papers by this author First published: 28 September 2020 https://doi.org/10.1111/ddg.14250_gAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume18, Issue9September 2020Pages 1039-1043 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 18, Issue 9 p. 1039-1043 Clinical Letter Genital lymphoplasmacellular mucositis with crystalline inclusions: a histomorphological variant not related to lymphoproliferative disorders Mar Llamas-Velasco, Corresponding Author Mar Llamas-Velasco mar.llamasvelasco@gmail.com Department of Dermatology, Hospital Universitario de la Princesa, Fundación de Investigación de La Princesa, Madrid, Spain Correspondence to Mar Llamas-Velasco, MD c/o Diego de León 62 CP 28006 Madrid, Spain E-mail: mar.llamasvelasco@gmail.comSearch for more papers by this authorJavier Fraga, Javier Fraga Pathology, Hospital Universitario de la Princesa, Fundación de Investigación de La Princesa, Madrid, SpainSearch for more papers by this authorTeresa Zulueta, Teresa Zulueta Department of Pathology, Hospital Universitario Virgen del Rocío, Sevilla, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, SpainSearch for more papers by this authorMaría Jose Concha-Garzón, María Jose Concha-Garzón Department of Dermatology, Hospital Universitario de la Princesa, Fundación de Investigación de La Princesa, Madrid, SpainSearch for more papers by this authorMaria Teresa Fernández-Figueras, Maria Teresa Fernández-Figueras Hospital Universitari General de Catalunya, Universitat Internacional de Catalunya, Sant Cugat, Barcelona, SpainSearch for more papers by this author Mar Llamas-Velasco, Corresponding Author Mar Llamas-Velasco mar.llamasvelasco@gmail.com Department of Dermatology, Hospital Universitario de la Princesa, Fundación de Investigación de La Princesa, Madrid, Spain Correspondence to Mar Llamas-Velasco, MD c/o Diego de León 62 CP 28006 Madrid, Spain E-mail: mar.llamasvelasco@gmail.comSearch for more papers by this authorJavier Fraga, Javier Fraga Pathology, Hospital Universitario de la Princesa, Fundación de Investigación de La Princesa, Madrid, SpainSearch for more papers by this authorTeresa Zulueta, Teresa Zulueta Department of Pathology, Hospital Universitario Virgen del Rocío, Sevilla, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, SpainSearch for more papers by this authorMaría Jose Concha-Garzón, María Jose Concha-Garzón Department of Dermatology, Hospital Universitario de la Princesa, Fundación de Investigación de La Princesa, Madrid, SpainSearch for more papers by this authorMaria Teresa Fernández-Figueras, Maria Teresa Fernández-Figueras Hospital Universitari General de Catalunya, Universitat Internacional de Catalunya, Sant Cugat, Barcelona, SpainSearch for more papers by this author First published: 13 September 2020 https://doi.org/10.1111/ddg.14250AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume18, Issue9September 2020Pages 1039-1043 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 18, Issue 7 p. 743-748 Clinical Letter Ichthyosiforme Hautveränderungen und Gesichtserythem nach Behandlung mit Ponatinib Mónica Munera-Campos, Corresponding Author Mónica Munera-Campos monicamunera@hotmail.com orcid.org/0000-0002-2227-2993 Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain Korrespondenzanschrift Mónica Munera-Campos, MD Department of Dermatology Hospital Universitari Germans Trias i Pujol Carretera de Canyet, S/N 08916 Badalona, Barcelona, Spanien E-Mail: monicamunera@hotmail.comSearch for more papers by this authorJose Manuel Carrascosa, Jose Manuel Carrascosa Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorCarlos Ferrándiz, Carlos Ferrándiz Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this author Mónica Munera-Campos, Corresponding Author Mónica Munera-Campos monicamunera@hotmail.com orcid.org/0000-0002-2227-2993 Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain Korrespondenzanschrift Mónica Munera-Campos, MD Department of Dermatology Hospital Universitari Germans Trias i Pujol Carretera de Canyet, S/N 08916 Badalona, Barcelona, Spanien E-Mail: monicamunera@hotmail.comSearch for more papers by this authorJose Manuel Carrascosa, Jose Manuel Carrascosa Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorCarlos Ferrándiz, Carlos Ferrándiz Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this author First published: 26 July 2020 https://doi.org/10.1111/ddg.14154_gCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume18, Issue7July 2020Pages 743-748 RelatedInformation

Prostate cancer accounts for almost 1 in 5 new diagnoses of cancer and is the second most common cause of death in men in Western societies. This article is protected by copyright. All rights reserved.

A 60-year-old man with a history of IgA kappa multiple myeloma was referred for evaluation of an indolent, erythematous papule on his glans penis of 2 weeks’ duration; he denied sexual risk behavior and reported no recent changes in medication. What is your diagnosis?

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 17, Issue 5 p. 558-561 Diagnosequiz Dermatoskopischer Fallstrick bei einem langjährig bestehenden Tumor Mónica Munera-Campos, Corresponding Author Mónica Munera-Campos monicamunera@hotmail.com Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain Korrespondenzanschrift Mónica Munera-Campos, MD Dermatology Department Hospital Universitari Germans Trias i Pujol Universitat Autònoma de Barcelona Carretera de Canyet, S/N 08916 Badalona, Barcelona, Spain E-Mail: monicamunera@hotmail.comSearch for more papers by this authorAram Boada, Aram Boada Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorAdrià Plana-Pla, Adrià Plana-Pla Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorCarlos Ferrándiz, Carlos Ferrándiz Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this author Mónica Munera-Campos, Corresponding Author Mónica Munera-Campos monicamunera@hotmail.com Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain Korrespondenzanschrift Mónica Munera-Campos, MD Dermatology Department Hospital Universitari Germans Trias i Pujol Universitat Autònoma de Barcelona Carretera de Canyet, S/N 08916 Badalona, Barcelona, Spain E-Mail: monicamunera@hotmail.comSearch for more papers by this authorAram Boada, Aram Boada Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorAdrià Plana-Pla, Adrià Plana-Pla Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorCarlos Ferrándiz, Carlos Ferrándiz Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this author First published: 22 May 2019 https://doi.org/10.1111/ddg.13835_gAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume17, Issue5May 2019Pages 558-561 RelatedInformation

JDDG: Journal der Deutschen Dermatologischen GesellschaftVolume 17, Issue 5 p. 558-561 Case for Diagnosis A dermoscopic pitfall in a long-standing tumor Mónica Munera-Campos, Corresponding Author Mónica Munera-Campos monicamunera@hotmail.com Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain Correspondence to Mónica Munera-Campos, MD Dermatology Department Hospital Universitari Germans Trias i Pujol Universitat Autònoma de Barcelona Carretera de Canyet, S/N 08916 Badalona, Barcelona, Spain E-mail: monicamunera@hotmail.comSearch for more papers by this authorAram Boada, Aram Boada Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorAdrià Plana-Pla, Adrià Plana-Pla Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorCarlos Ferrándiz, Carlos Ferrándiz Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this author Mónica Munera-Campos, Corresponding Author Mónica Munera-Campos monicamunera@hotmail.com Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain Correspondence to Mónica Munera-Campos, MD Dermatology Department Hospital Universitari Germans Trias i Pujol Universitat Autònoma de Barcelona Carretera de Canyet, S/N 08916 Badalona, Barcelona, Spain E-mail: monicamunera@hotmail.comSearch for more papers by this authorAram Boada, Aram Boada Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorAdrià Plana-Pla, Adrià Plana-Pla Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorAriadna Quer, Ariadna Quer Department of Pathology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this authorCarlos Ferrándiz, Carlos Ferrándiz Department of Dermatology, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Badalona, Barcelona, SpainSearch for more papers by this author First published: 23 April 2019 https://doi.org/10.1111/ddg.13835AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume17, Issue5May 2019Pages 558-561 RelatedInformation

Importance Neurofibromatosis type 2 (NF2) is a devastating genetic condition characterized by the development of multiple tumors of the nervous system. An early diagnosis of individuals with NF2 would facilitate treatment and reduction of disease impact because most severe effects of the disease do not usually develop before adolescence. Little attention has traditionally been paid to dermatological signs in NF2. However, skin plaques are commonly seen in patients with NF2, normally appearing either at birth or early childhood, providing an opportunity for early NF2 detection and testing. Objective To determine the clinical utility of skin plaque identification and characterization in children for reaching an early diagnosis of patients with NF2 and to evaluate their molecular pathogenesis and their use in the genetic diagnostics of NF2. Design, Setting, and Participants Diagnostic test study by the histological and genetic characterization of skin plaques from patients with NF2. Patients were 7 individuals with NF2 or clinical suspicion of NF2 treated at the Spanish Reference Center on Phakomatoses. Main Outcomes and Measures Histological evaluation of all skin plaques was performed. Fresh skin plaques were cultured to obtain Schwann cells and theNF2gene was genetically analyzed. For all 7 patients, NF2 clinical history was reviewed. Results In all 7 patients (4 male and 3 female), all skin plaques analyzed were histologically characterized as plexiform schwannomas. Genetic analysis of primary Schwann cell cultures derived from them allowed the identification of a constitutional and a somaticNF2mutation. Genetic testing allowed the early diagnosis of NF2 in a child only exhibiting the presence of skin plaques. Most of the patients with NF2 analyzed had an early presentation of skin plaques and a severe NF2 phenotype. Conclusions and Relevance This work emphasizes the clinical utility of a careful dermatological inspection and the correct identification of skin plaques in children for an early diagnosis of NF2. We show for the first time that Schwann cells derived from skin plaque plexiform schwannomas bear the double inactivation of theNF2gene and thus constitute an excellent source of tissue for genetic testing, especially in the context of mosaicism.

Background Chronic immunosuppression promotes nonmelanocytic squamous cell carcinoma (SCC) after kidney transplantation. Adaptive and innate immunity play a key role controlling tumor growth and are influenced by different immunosuppressive agents. We hypothesized that functional impairment of tumor-specific T cell responses due to calcineurin inhibitors (CNI) could contribute to SCC development, whereas conversion to mammalian target of rapamycin inhibitors (mTOR-i) could recover this protective immune response. Methods Peripheral tumor-specific T cell responses against main SCC-derived antigens using the IFN-&ggr; enzyme-linked immunospot assay and intratumor (IT) and circulating immune phenotypes (CD4 + T, CD8 + T, CD20 + B, CD56 + NK, FOXP3 + regulatory T [Treg] cells) were explored in a cross-sectional analysis in 59 kidney transplant patients with SCC on CNI (KT-CNI-SCC) or mTOR-i (KT-mTORi-SCC), 25 nontransplants developing SCC (NoKT-SCC) and 6 healthy controls. Moreover, 25 KT-CNI-SCC were switched to mTOR-i and evaluated after 12 months. Results Kidney transplant patients showed lower IT infiltrates and tumor-specific T cell responses than NoKT-SCC, and intratumoral and circulating FOXP3 + Treg cells were higher in KT-mTORi-SCC (P < 0.05). Tumor-specific T cell responses were significantly lower in KT-CNI-SCC than KT-mTORi-SCC and NoKT-SCC and predicted SCC relapses (area under the curve = 0.837; P < 0.05). One-year after mTOR-i conversion, a significant increase in FOXP3 + Treg cell numbers and tumor-specific T cell responses were observed, reaching similar levels than KT-mTORi-SCC and NoKT-SCC patients. Conclusions Tumor-specific T cell responses are strongly impaired in CNI-treated patients but recover after mTOR-i conversion, reducing SCC relapses.

BACKGROUND:Mixed adenoneuroendocrine carcinoma is a rare tumor recently recognized as a new category in the last World Health Organization (WHO) classification of appendiceal tumors (2010). This term has been proposed to designate carcinomas of the appendix that arise by progression from a pre-existing goblet cell carcinoid. Mixed adenoneuroendocrine carcinomas are more aggressive tumors than typical goblet cell carcinoids and usually present with peritoneal spreading and ovarian masses. Staging, some histological features, and completeness of surgery are factors that determine its evolution.CASE PRESENTATION:We report the case of a mixed adenoneuroendocrine carcinoma--signet ring cell subtype--that presented as a Krukenberg tumor of unknown primary.CONCLUSION:The review of literature is focused on the most recent WHO pathologic classification of appendiceal tumors containing goblet cell clusters, which seems to correlate with prognosis. A management proposal for mixed adenoneuroendocrine carcinomas reported in previous literature is also discussed. This ranges from right hemicolectomy to cytoreduction plus hyperthermic intraperitoneal chemotherapy, in both cases usually followed by intravenous chemotherapy.

Grover disease (GD) is a rather common papular pruritic dermatosis that can be transient, persistent, or asymptomatic. The microscopic diagnosis of clinically suspected lesions can be challenging because GD can adopt different patterns, and involved areas are generally admitted to be mostly focal. The histopathologic hallmark of the disease is acantholysis, frequently combined with dyskeratosis, which confers the lesions an appearance similar to Darier disease, Hailey-Hailey disease, or pemphigus. Eczematous features can be observed as well. In this study of 120 consecutive cases of GD, we have found a sex and age incidence similar to what has been previously described, with no obvious seasonal influence, but careful evaluation of their microscopic features suggests that the histopathological diagnostic criteria of GD should be expanded. Specifically, in addition to the commonly described GD findings, we have detected cases with porokeratosis-like oblique columns of parakeratosis, lesions showing a nevoid or lentiginous silhouette, intraepidermal vesicular lesions, lichenoid changes with basal vacuolization and dyskeratosis, and dysmaturative foci with keratinocyte atypia. Moreover, quite often the dermal infiltrate was composed not only of lymphocytes intermingled with eosinophils, but also of neutrophils. In many cases, the capillary vessels showed hints of vascular damage including endothelial tumefaction due to cytoplasmatic edema and erythrocyte extravasation. Finally, because involved areas were larger than 2 mm in more than 50% of our cases, we should assume that GD lesions are not always as small as commonly claimed. Awareness of the patterns newly described herein may be important to avoid underdiagnosis of GD and may contribute to understand the pathogenesis of this acantholytic disease.