The article presents comparative evaluation of serum total oxidizing and total anti-oxidizing activity in reanimation patients with severe cranio-cerebral injury and ischemic and hemorrhagic strokes. Due to irregularity of experimental groups in a number of demographic and clinical indicators the new estimated indicator was proposed. The normalized coefficient of oxidation made it possible to apply comparative evaluation of expression of oxidative anti-oxidative imbalance in these groups. The characteristics are presented concerning the oxidative derangements in the studied groups during acute period of disease.
The article presents comparative evaluation of serum total oxidizing and total anti-oxidizing activity in reanimation patients with severe cranio-cerebral injury and ischemic and hemorrhagic strokes. Due to irregularity of experimental groups in a number of demographic and clinical indicators the new estimated indicator was proposed. The normalized coefficient of oxidation made it possible to apply comparative evaluation of expression of oxidative anti-oxidative imbalance in these groups. The characteristics are presented concerning the oxidative derangements in the studied groups during acute period of disease.
Objective: to study the state of systemic microcirculation and endothelial function in comas induced by acute cerebrovascular accident (ACA). Subjects and methods. The study was conducted within the first 7 days of ACA in 38 coma patients, who were divided into groups according to the etiology of stroke: Group 1 comprised 20 patients with hemorrhagic stroke; their mean age was 56.6±2.3 years; Group 2 consisted of 18 patients with ischemic stroke; their mean age was 58.5±2.2 years. A control group included 34 apparently healthy individuals; their mean age was 55.1±2.1 years. The microcirculatory bed was evaluated within 7 days, by applying cutaneous laser Doppler flowmetry using a LAKK-02 capillary blood flow laser analyzer made in Russia (LAZMA Research-and-Production Association, the Russian Federation). Coincidentally with recording of the microcirculatory blood flow, blood samples were collected to explore the serum concentrations of endothelin-1, stable nitric oxide metabolites, van Willebrand factor, and thrombomodulin. Results. Throughout the study, the patients with coma induced by ACA were found to have microcirculatory disorders consisting in higher microperfusion along with the markedly increased influence of active modulators of vascular tone, as well as endothelial functional structural changes. Conclusion. The data obtained in the study suggest that there were uniform changes in the state and regulation of systemic microcirculation in patients with ACA irrespective of the type of stroke (hemorrhagic or ischemic). Key words: stroke, microcirculation, microvascular bed, micro blood flow, tissue perfusion, endothelium.
Objective: to evaluate the microcirculation system in critical conditions caused by abdominal sepsis for a further differentiated approach to intensive care. Subjects and methods. Twenty-four patients with abdominal sepsis (mean age 42.9±0.9 years) were examined; a control group consisted of 35 apparently healthy individuals (mean age 40.1±2.1 years). Over 11 days, the microcirculatory bed was evaluated by cutaneous laser Doppler flowmetry by means of a ЛАКК-02 laser capillary blood flow analyzer made in the Russian Federation (LAZMA Research-and-Production Association), by using a basic light guide for percutaneous microcirculation studies. Results. Throughout the study, tissue blood perfusion remained in the patients with sepsis due to the higher effect of mainly active components of vascular tone regulation on the microvascular bed. In a poor outcome, there was a reduction in both active and passive regulatory effects on tissue perfusion chiefly due to local (myogenic) factors. Conclusion. The findings suggest that the patients with sepsis have microcirculatory regulation changes aimed at maintaining tissue perfusion. A follow-up of the microcirculation may be useful in choosing intensive care tactics and predicting disease outcome. Key words: sepsis, microcirculation, microvascular bed, micro blood flow, tissue perfusion.
