Complex investigation of the peculiarities of landscape formation and sedimentation is an important component of regional paleogeographical reconstructions. The geomorphological and lithological maps compiled by the authors demonstrate the regularities of spatial differentiation and trends of age changeability of morpholitosystems. These trends served as the basis for mapping the paleogeographical zones of the East-European Plain with the history of regions’ development taking into account. The separation of the territory into paleogeographical zones, provinces, regions was fulfilled with the following estimation of landforms stability. Paleogeographical approach based on the purposive zoning gives the possibility of complex assessment of natural environment stability and regions of ecological risk. Paleogeographical expertise improves reliability of forecast for the morpholithosystems development in extreme situations.