Abstract. The article presents data about blood serum cytokine profile in patients with chronic widespread dermatoses, associated with increase in blood markers of endogenous intoxication (EI) syndrome, i.e., lowand medium-molecular mass substances (LMWS). A close interrelation has been revealed between EI levels, and cytokine profiles. In the patients with high amounts of blood LMWS, increased levels of anti-inflammatory IL have been shown. Correlation analysis of clinical and laboratory parameters has demonstrated a leading role of EI in pathogenetic mechanisms of chronic extended dermatoses, and brings about altered regulation of metabolic processes. A severe clinical course of dermatoses (i.e., therapy resistance) was associated with a considerable decrease in blood IL-8 and IL-10 levels, along with high IgE and LMWS amounts. (Med. Immunol., 2011, vol. 13, N 2-3, pp 205-210)
The level of 8-OH-2-desoxiguanosin in blood serum of patients with severe chronic dermatitis was analyzed. It is demonstrated that in comparison with healthy patients in examined group of patients this indicator is increased mainly in patients with atopic dermatitis (up to 62%) and least of all with psoriasis (up to 25%) and bullous dermatitis (up to 18%). The statistically reliable differences of this indicator from control values under endogenic intoxication and different degree of severity of disease are determined. The detection of level of 8-OH-2-desoxiguanosin in blood serum is an informative technique of analysis to increase quality of laboratory monitoring of oxidizing stress.
The level of 8-OH-2-desoxiguanosin in blood serum of patients with severe chronic dermatitis was analyzed. It is demonstrated that in comparison with healthy patients in examined group of patients this indicator is increased mainly in patients with atopic dermatitis (up to 62%) and least of all with psoriasis (up to 25%) and bullous dermatitis (up to 18%). The statistically reliable differences of this indicator from control values under endogenic intoxication and different degree of severity of disease are determined. The detection of level of 8-OH-2-desoxiguanosin in blood serum is an informative technique of analysis to increase quality of laboratory monitoring of oxidizing stress.
Представлены данные об уровне окислительной модификации белков в крови больных тяжелыми распространенными дерматозами на фоне развития синдрома эндогенной интоксикации. Показано, что наличие в крови больных большого количества веществ низкой и средней молекулярной массы сопровождается повышением уровня общей окислительной модификации белков и снижением уровня окислительной модификации олигопептидов. На основании полученных данных в комплексную терапию распространенных тяжелых дерматозов предлагается включать лекарственные препараты дезинтоксикационного действия.
