Objective. To develop a standard determination of a clinical case of measles in conditions of its elimination. Materials and methods. The study included 28 patients with measles (main group) and 30 with infectious mononucleosis (comparison group). By means of correlation analysis, among clinicolaboratory indicators there was determined a list of clinical signs, which statistically significantly were more often identified in patients with measles compared to patients with infectious mononucleosis. The mathematical model was developed using the method of logistic regression, which helped to single out the most qualitative binary classifiers directly connected with diagnostic probability of measles. Sensitivity and specificity of the obtained model were calculated. For statistical processing IBM SPSS Statistics 26 was used. Results. To carry out a standard determination of a clinical case of measles with the presence of combined clinicolaboratory symptoms, the mathematical model was developed, described by the following equation: р=1/(1+е-z) 100, where z=71,7+36,8 Х dry cough +53,5 Х maculo-papular rash +17,6 Х damages of eyes in the form of conjunctivitis and/or sclerite. Taking into account the regression coefficient values, such clinicolaboratory symptoms as maculo-papular rash, damages of eyes in the form of conjunctivitis and/or sclerite were directly connected with diagnostic probability of the diagnosis Measles. The determination coefficient of the obtained model was R2 = 0,97, p 0,001. The sensitivity of the model was 96.4 %, specificity 100 %, efficiency 98 %. Conclusions. In conditions of measles elimination, the combination of maculo-papular rash, damages of eyes in the form of conjunctivitis and/or sclerite allows confirming the clinical diagnosis of measles with the probability of 98 %.

The article presents results of a prospective randomized study of reactogenicity, safety and immunogenicity of the polysaccharide pneumococcal vaccine "Pneumo 23" in the group of medical workers. The vaccine was characterized by the high profile of safety (absence of clinical symptoms of allergy, changes in blood and urine), low reactogenicity and sufficient immunogenicity.

The article presents the characteristic of laboratory test results on micromycetes of objects of the environment in the medical infectious institution. 76 samples were investigated. The high micromycetes contamination level of the hospital premises was found, positive samples accounted for 97,36%. In the etiological structure of micromycetes mold fungi prevailed. The most unfavourable premises of the hospital on micromycetes dissemination were twenty-four hour stay wards and the procedure unit.