24 recipients after ortotopic liver transplantation (9 women and 5 men) 18–57 years aged were studied in 1–2 and then through 4–18 months following operation. Bone mineral density (BMD) in repeated estimation in 13 recipients was elevated on 14 ± 10,5% and in 11 recipients was decreased on 2,5 ± 2,56%. BMD elevation was associated with bone remodelling normalization. BMD lowering followed transplant dysfunction, glucocorticoid therapy, bone resorption increasing and bone formation suppression.

Aim. Comparative evaluation of two biochemical markers of bone resorption and hormonal regulation of bone metabolism in liver recipients. Methods and results. B о ne densitometry of L2–L4 and neck of femur, serum level of some hormones (PTH, vitamin D 3 , estradiol, testosterone) regulating osteoclastogenesis as well as com- parative analyses of two bone resorption markers β -crosslaps and tartrate-resistant acid phosphatase type 5b (TRAP-5b) were ful fi lled in patients after orthotopic liver transplantation (OLT). In 1 month after OLT bone density reduction of L2–L4 and neck of femur; decrease of vitamin D 3 , estradiol in women, testosterone in men and increase levels of bone resorption markers were observed. In 1 and 2 years after OLT the rise of bone density, increased levels of PTH, estradiol, testosterone and decreased β -crosslaps levels were revealed, while vitamin D 3 and TRAP-5b levels remained stable. Conclusion. TRAP-5b was found to be a more specif fi c marker of bone resorption, independent from collagen metabolism in liver. Osteoporosis de fi ned in long-term period after OLT was associated with higher TRAP-5b and revialed in women with low estradiol level.

Biochemical markers of bone formation [osteocalcin (OC), N-terminal propeptid of type 1 procollagen (P1NP), bone isoferment of alkaline phosphatase (BALP)] were estimated in 34 recipients after liver transplantation. Three types of deviation have been demonstrated: combination elevated circulating levels OC and P1NP with normal levels BALP in recipients without clinical postoperative complication; combination lower levels OC and BALP with normal levels P1NP in recipients as a result of corticosteroid therapy prior/ following transplantation; superior levels P1NP with normal levels OC and BALP which results excessive accumulation hepatic collagen formation in recipients with postoperative clinical complication.