Background: Erectile dysfunction (ED) is an early manifestation of a generalized arterial disease. The association between penile vascular disease progression and total atherosclerotic burden was investigated using a classification that incorporates ultrasonographic assessments of intima media thickness (IMT) and plaques from both the carotid and femoral arteries.Methods: Sixty-five ED patients (mean age, 56 +/- 10 yrs) were evaluated for cavernous vascular disease severity using penile Doppler ultrasound. Ultrasonographic assessments of IMT, lumen diameter, and plaques in the carotid and femoral arteries were evaluated, and patients were classified according to an ultrasound-based morphological system.Results: Based on the results of ultrasonic assessments, patients were divided into two groups-a high-score group and a low-score group. Patients in the high-score group had increased intima-media (>1.0 mm) and/or plaque in any of the four arteries. Patients in the low-score group had normal carotid and femoral IMT and an absence of plaques in all four arteries. While the two groups did not differ in blood pressure parameters, metabolic profile, and smoking status, high-score patients (n = 31) had significantly decreased age-adjusted peak systolic velocity (25.2 cm versus 32.3 cm/s, P < 0.01) and a longer duration of ED (3.8 years versus 2 years, P < 0.05), compared with low-score patients (n = 34). In the high-score group, score level was inversely correlated with peak systolic velocity after adjusting for age and systolic blood pressure (b = -0.322, P = 0.025). There also was a positive linear relation of ED duration with prevalence of high score (P < 0.05).Conclusions: In patients with vasculogenic ED, ultrasound findings of penile vasculature damage and long-standing ED correlate significantly with increasing carotid and femoral atherosclerotic burden. These data suggest a close interrelationship between progression of vasculogenic ED and peripheral atherosclerosis.

You have accessJournal of UrologyModerated Poster 20, Monday, May 21, 2007, 8:00 - 10:00 am1 Apr 2007689: Correlation between Penile Doppler Findings and C-Reactive Protein Levels in Patients with Erectile Dysfunction of Vascular Origin Konstantinos Rokkas, Nikolaos Loakeimidis, Charalambos Vlachopoulos, Carmen Vasiliadou, Athanasios Tsokanis, George Antoniou, Athanasios Askitis, and Christodoulos Stefanadis Konstantinos RokkasKonstantinos Rokkas More articles by this author , Nikolaos LoakeimidisNikolaos Loakeimidis More articles by this author , Charalambos VlachopoulosCharalambos Vlachopoulos More articles by this author , Carmen VasiliadouCarmen Vasiliadou More articles by this author , Athanasios TsokanisAthanasios Tsokanis More articles by this author , George AntoniouGeorge Antoniou More articles by this author , Athanasios AskitisAthanasios Askitis More articles by this author , and Christodoulos StefanadisChristodoulos Stefanadis More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)30929-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "689: Correlation between Penile Doppler Findings and C-Reactive Protein Levels in Patients with Erectile Dysfunction of Vascular Origin." The Journal of Urology, 177(4S), p. 231 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 177Issue 4SApril 2007Page: 231 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Konstantinos Rokkas More articles by this author Nikolaos Loakeimidis More articles by this author Charalambos Vlachopoulos More articles by this author Carmen Vasiliadou More articles by this author Athanasios Tsokanis More articles by this author George Antoniou More articles by this author Athanasios Askitis More articles by this author Christodoulos Stefanadis More articles by this author Expand All Advertisement PDF DownloadLoading ...

Objective: Aortic stiffness and wave reflections are markers of subclinical atherosclerosis and prognosticators of cardiovascular risk. Erectile dysfunction (ED) may be the early manifestation of a generalized vascular disease. We investigated the association between aortic stiffness, wave reflections and duration of ED. Methods: A total of 244 men with ED (detected with a validated questionnaire) were studied: 75 men (62±9 yrs, mean time interval of ED = 3 years) with coronary artery disease (ED-CAD) and 169 men (59±11 yrs) without CAD. Men without CAD were divided into three groups, according to ED duration: Group A ( 3 yrs, n=45). Aortic stiffness was evaluated with carotid-femoral pulse wave velocity (PWV) and wave reflections with augmentation index (AIx) of the aortic pressure waveform. Results: PWV and AIx values were comparable among ED-CAD patients and patients with time interval longer than 3 years (group C) and higher of those in men of groups...