In 17-year cohort p1rospective study, the dynamics of arterial hypertension (AH) and arterial pressure (AP) levels has been examined as functions of the boy mass. The cohort included 630 men and 916 women aged from 20 to 59. The overweight was diagnosed at the Body Mass Index index no lower than 25 kg/m 2 . In the primary research, the AH prevalence rate was 35,7% among overweighted people and 12,5% ( р < 0,001) among people with normal weight. In the 17-year observation, the increase of the body mass up to overweight was accompanied by an increase in the AH rate and AP levels, while the decrease of the body mass down to the normal one was accompanied by a decrease of these indices (except only for men aged from 40 to 59). Among overweighted people revealed at the I and II stages of the study, the systolic ((155,71 ± 28,59) mmHg) and diastolic ((93,68 ± 13,77) mm Hg) AH was higher than that in people, who became overweighted the observation: (137,08 ± 23,02) and (86,73 ± 12,19) mm Hg, respectively ( р < 0,001).

In 17-year cohort p1rospective study, the dynamics of arterial hypertension (AH) and arterial pressure (AP) levels has been examined as functions of the boy mass. The cohort included 630 men and 916 women aged from 20 to 59. The overweight was diagnosed at the Body Mass Index index no lower than 25 kg/m(2). In the primary research, the AH prevalence rate was 35,7% among overweighted people and 12,5% (p< 0,001) among people with normal weight. In the 17-year observation, the increase of the body mass up to overweight was accompanied by an increase in the AH rate and AP levels, while the decrease of the body mass down to the normal one was accompanied by a decrease of these indices (except only for men aged from 40 to 59). Among overweighted people revealed at the I and II stages of the study, the systolic ((155,71 +/- 28,59) mmHg) and diastolic ((93,68 +/- 13,77) mm Hg) AH was higher than that in people, who became overweighted the observation: (137,08 +/- 23,02) and (86,73 +/- 12,19) mm Hg, respectively (p< 0,001).

In 17-year cohort p1rospective study, the dynamics of arterial hypertension (AH) and arterial pressure (AP) levels has been examined as functions of the boy mass. The cohort included 630 men and 916 women aged from 20 to 59. The overweight was diagnosed at the Body Mass Index index no lower than 25 kg/m 2 . In the primary research, the AH prevalence rate was 35,7% among overweighted people and 12,5% ( р < 0,001) among people with normal weight. In the 17-year observation, the increase of the body mass up to overweight was accompanied by an increase in the AH rate and AP levels, while the decrease of the body mass down to the normal one was accompanied by a decrease of these indices (except only for men aged from 40 to 59). Among overweighted people revealed at the I and II stages of the study, the systolic ((155,71 ± 28,59) mmHg) and diastolic ((93,68 ± 13,77) mm Hg) AH was higher than that in people, who became overweighted the observation: (137,08 ± 23,02) and (86,73 ± 12,19) mm Hg, respectively ( р < 0,001).

The aim: to explore natural dynamics of overweight (development of new cases, regression), mortality from cardiovascular diseases and all causes among people with overweight in seventeenyear prospective cohort study. Primary screening study on the basis of random doortodoor samples was conducted in the years 1988-1991, repeated in 2002-2005. There are 1546 people (630 men and 916 women) in a cohort at the age from 20 to 59 years. The observation was being carried out during 1 to 17 years, on the average during 15.47 years. Overweight was registered when body mass index was 25 kg/m2 or higher. In seventeenyear supervision high frequency of new cases of overweight 12.36 cases on 1000 personyears of observation (PYO) is revealed. Among women the indicator of incidence of overweight was higher (13.71 on 1000 PYO), than among men (10,88 on 1000 PYO). In a man"s part of a cohort the highest level of incident of overweight is revealed in younger age group 20-29 years (15.71 cases on 1000 PYO). Among women the highest point of this indicator is revealed in more advanced age of 30-39 years (18.55 cases on 1000 PYO) and 40-49 years (21.1 on 1000 PYO). Less often overweight developed among people of the senior age group 50-59 years (5.18 on 1000 PYO). According to the results of study high stability of course of overweight was found out, and also it was found out that regression level (4.7 on 1000 PYO) does not depend neither on sex, nor on age. It is revealed that mortality from cardiovascular diseases (3.16 on 1000 PYO) and all causes (6.52 on 1000 PYO) is higher among women with overweight, than among women with initially normal weight of body (0.61 and 2.82 on 1000 PYO accordingly). For men overweight was not a significant risk factor concerning mortality from cardiovascular diseases and all causes.

In 17-year nested prospective study, the natural dynamics of hypertriglyceridemia (HTG) (development of new cases, regress), cardiovascular mortality and other mortality of patients with HTG have been examined. The nest included 630 men and 916 women from 20 to 59 years old. The HTG incident in the nest was 8.24 cases per 1000 people*years of observation. Among people 20—29 years old, new HTG cases were observed more often in men, while in the age interval of 30—59 years, new cases were more often observed in women. For the period of observation, the HTG occurrence increased 1.6 times in men and 2.1 times in women. HTG is characterized by the low course stability, and the regress level is independent of sex. Among men and women, Among men and women with HTG, brain stroke and cardiovascular mortality is higher than that among people with the normal triglyceride (TG) level. The TG level did not affect the total men mortality.

Aim. To study the effects of social factors (marital status, the number of children born and raised in the family) on the incidence of body weight (BW) increase.Material and methods. The 15-year follow-up focussed on BW dynamic's in men and women, in regard to the changes in their martial status. At baseline, all participants were married (n=845; 327 men and 518 women). To evaluate the effects of the children's number on increased BW incidence, 238 women aged 40-59 years and having at least one child before the baseline, were examined 2 children in 163 women, 1 child in 75 women). Increased BW was registered if body mass index (BM I) was 25 kg/m2 or higher.Results. In widowed participants, the incidence of BW increase was lower (1,9 %) than in those married (10,5 %; p<0,01) or divorced (21,4 %; p<0,01). In widowed women, the normalisation of initially increased BW was registered more often (13,5 %), compared to their still married peers (4,3 %; p<0,05). In those still married, BMI increased from 26,95 +/- 0,09 to 27,91 +/- 0,09 kg/m2 (p<0,001), while in those widowed, it decreased from 29,92 +/- 0,24 to 29,34 +/- 0,24 kg/m2 (p<0,05). In women with 2 or more children, the incidence of BW increase was higher (85,3 %) than in women with only one child (73,3 %; p<0,05).Conclusion. The change in marital status could affect BW dynamics. Spouse death is an important cause of BW reduction. In women with 2 or more children, increased BW was more common than in women with only one child.

Aim. To study the cross-sectional prevalence of overweight (OW) in men and women, in regard to their spouses' body weight (BW), as well as to assess the BW dynamics in participants and their spouses over 15 years of the prospective follow-up.Material and methods. In the screening study, body mass index (BM I) was assessed in 425 married couples. The repeat assessment, performed 15 years later, included 232 couples who were still married. OW was diagnosed in subjects with BMI >= 25 kg/m2.Results. In the wives of OW men, OW prevalence was higher (76,2%) than in the spouses of non-OW men (61,3%; p<0,001). In the husbands of OW women, OW prevalence was also higher (61,3%) than in the spouses of non-OW women (43,8%; p<0,001). In the prospective study, the participants with no OW at baseline, whose spouses developed OW, the incidence of OW was significantly higher (60,9%) than in participants whose spouses remained non-OW (16,4%; p<0,001), or in participants whose spouses remained OW (31,7%; p<0,05). Among men and women with OW at baseline, whose spouses reduced their BW and became non-OW, BW normalization was more frequent (32,0%) than in the participants whose spouses either remained OW (9,1%; p<0,001), or remained non-OW (3,4%; p<0,001), or increased BW and became OW (6,9%; p<0,05).Conclusion. BW dynamics in spouses was characterized by parallel increases or decreases, due to shared social and intra-familial factors.

Variation of seven biochemical gene markers (Tf, Gc, Hp, ACP1, PGM1, PGD, and EsD) in the population of Tomsk was examined. The genetic structure of this population is compared to that of other urban populations from different regions of Russia.

Results of the investigation of the genetic-demographic structure of Tomsk city are presented. It was shown that the Russians constitute about 90% population Tomsk. This population is characterized by intensive migration processes: only 30% of the investigated residents were born in Tomsk; maximal migration flow was observed from Western Siberia, Eastern Siberia, Kazakhstan and Ukraine. The population of Tomsk reproduces only 10% of its gene pool, while 40% of it is formed by the migrants from remote regions of the country. Dynamics of the portion of offsprings of heterolocal marriages in age groups was observed. Comparative analysis of genetical demographic structure of Tomsk's population and other previously studied urbanized populations of CIS was made.