Neoadjuvant chemotherapy followed by local therapy as surgery and/or radiation therapy is the current standard for Ewing's sarcomas. Surgery is the treatment of choice in the cases that R0 resection is possible - mostly cases with tumors located at extremities. R0 resection is not possible in many non-extremity cases where radiation therapy replaces surgery in the curative setting, or radiation therapy is used after R1-2 resections in the adjuvant setting. We evaluated the results of radiation therapy and the prognostic factors affecting the local control in non-extremity Ewing's sarcomas. Between 1995 and 2011, 44 patients with non-extremity Ewing's sarcomas were treated with radiation therapy. The median age was 17 years (4 - 41). M/F ratio was 1.1. Tumor localizations were pelvic bones in 23, vertebras in 13 and thoracic bones in 5 and cranium in 3 patients. Tumor size was ≥8cm in 56.8% of patients. Distant metastases were present in 19 of the patients at the time of diagnosis (40.6%). All patients were treated with 12 weeks of neoadjuvant chemotherapy (IE-VAC) followed by surgery + radiation therapy (45 - 54 Gy) or radiation therapy alone (55.8 - 62 Gy). Postoperative radiation therapy was used in 16 and radiation therapy alone was used in 28 patients. Median follow-up was 49 months (9- 195). Local failures were developed in 7 patients (15.9%), and local control at 5 years was 81.7%. There were 3 local failures (10.7%) in the curative setting group and 4 local failures (25.0%) in the adjuvant group (p = N.S). Local control rates at 5 years were 83.0% in the curative setting group and 78.0% in the adjuvant group (p = N.S). All those patients with local failure experienced further distant metastases. Possible prognostic factors such as age (= <17 vs>17), tumor localization, tumor volume (= <8 cm vs>8 cm), M status at diagnosis (0 vs1) were not related with local control. Overall survival at 5 years was 45%. Radiation therapy, either alone or adjuvant to surgery provides local control in 80% of the non-extremity Ewing's sarcomas and plays an important role in the treatment.