This work will also have a great value to help designers to evaluate the product's performance, few metrics were created for the main issues in the Internet of Things. With the metrics, manufacturers can analyze in a more critical manner the usage of sensors, find alternatives to deliver the same function with less cost and decide how is the best way to handle the implications of changing it. It will also help them to evaluate what are the points of vulnerability and how the product is regarding its safety and privacy. Besides all that there is also the need to meet the needs of the user and designed products will have to provide seamless integration with other enterprise data, applications and environment. Also overcome battery challenges that limit computation, display resolution and connectivity. The term Internet of Things might have been present for a long time now, but still there are plenty of work ahead to be done to transform this "term" into this success that everybody has been expecting.

Cancer is a condition in which the unwanted cells spilt up excessively and penetrate neighboring tissues.By the blood and lymph system cancer cells can transmit to other parts of the body.If left untreated cancer may leads to death.If diagnosed early and treated it is curable.Trabectedin is an anticancer agent used for the treatment of cancer.This review focuses on Trabectedin as an anticancer agent and the recently developed analytical techniques in Trabectedin.In this review the analytical techniques in Trabectedin include RP-HPLC, LC-MS method.In RP-HPLC method was developed according to ICH guidelines, for quantifying Trabectedin drug substance and the method is validated.The drugs were injected into a Zorbax SB, C18 (150x4.6mm);3.5m column kept at room temperature, and the effluent was measured at 215nm.The mobile phase was composed of phosphate buffer (pH 3.0) and acetonitrile in a 70:30 V/V ratio.The flow rate was kept constant at 0.8 ml/min.Trabectedin's calibration curve was linear from 50 to 175 g/ml (r2 for Trabectedin = 1).For the determination of Trabectedin in bulk and pharmaceutical dosage forms, the proposed method was adequate, sensitive, reproducible, accurate, and precise.In LC-MS method was validated in accordance with US Food and Drug Administration guidelines.Linearity, LLOQ, intra-and inter-day accuracy and precision, recovery, matrix effect, selectivity, and stability were among the parameters studied.

This paper explores different strategies and tools for migrating non cloud-native or legacy applications to cloud. The approach taken involves studying the existing migration strategies and experimenting them on different types of non cloud-native applications to identify the strengths and challenges associated with each of them. Some of the commonly used platforms, tools and features currently available for supporting these migrations are also studied for their efficacy towards migration of the chosen applications. The paper concludes with a consolidated set of steps for each migration strategy, while factoring in the range of applications they are best suited for, considering their complexity and scope.

We described a novel and eco-friendly approach to remove toxic heavy metal of Pb(II) by using dimercaptosuccinic acid (DMSA) anchored Fe3O4 magnetic nanorods (MNRs) which were synthesized via facile method utilizing Punica Granatum rind extract which was a non toxic waste material. The DMSA@Fe3O4 MNRs were characterized by X-ray diffraction (XRD), Fourier transformed infrared analysis (FT-IR), thermogravimetric analysis (TGA), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX), nitrogen adsorption and desorption techniques, and vibrating sample magnetometer (VSM). These DMSA@Fe3O4 MNRs have been used for the removal of Pb(II) from aqueous solution. The adsorption isotherm data fitted well with Langmuir isotherm and Freundlich model, the monolayer adsorption capacity was found to be 46.18 mg/g at 301 K. The experimental kinetic data fitted very well with the pseudo-second-order model. The results indicate that the biogenic synthesized DMSA@Fe3O4 MNRs act as significant adsorbent material for removal of Pb (II) from aqueous environment. (C) 2014 King Saud University. Production and hosting by Elsevier B.V.

Orthohydroxypropiophenoneisonicotinoylhydrazone ligand(L) has been synthesized from orthohydroxypropiophenone and isonicotinicacid hydrazide. The Cu(II) complex is prepared and structurally characterized. The structure of the ligand(L) is proposed based on elemental analysis, IR and mass spectra and Cu(II) complex is characterized from the studies of electronic spectra, EPR spectra, powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). On the basis of electronic and EPR studies, rhombically distorted octahedral environment has been proposed for the Cu(II) ion. The powder X-ray diffraction data indicate triclinic structure with the unit cell parameters: a=9.4734Å, b=6.1588Å, c=3.9254Å, and V=195.6Å3 for the complex. The ligand and Cu(II) complex have been tested for in vitro antibacterial, antioxidant and cytotoxic activities. The results reveal that the Cu(II) complex exhibits greater activity than the free ligand.

GR-TiO2 nanocomposite was prepared by simple chemical method using graphene oxide and titanium isopropoxide (Ti [OCH (CH3)(2)](4)) precursors. The crystalline nature of the composite was characterised by powder X-ray diffraction and the intercalation was explained by Raman spectroscopy. The morphology of the composite was analysed by field emission scanning electron microscopy. The elemental and quantitative measurement of the composite was determined by electron dispersive spectroscopy. The shape and size of the particle was measured by transmission electron spectroscopy and high resolution spectroscopy. The surface area and elemental composition of the composite was studied by using Brunauer-Emmett-Teller (BET) method and X-ray photoelectron spectroscopy. Photo-generated electrons were studied by photoluminescence spectra. The photocatalytic activity of nanocomposite was investigated by the degradation of Rhodamine-B (Rh-B) in an aqueous solution under solar light irradiation. The GR-TiO2 demonstrates photocatalytic activity in the degradation with a removal rate of 98% under solar light irradiation as compared with pure TiO2 (42%), graphite oxide (19%), and mechanical mixture GR + TiO2 (60%) due to the increased light absorption intensity and reduction of electron-hole pair recombination with the intercalation of graphene and TiO2. The results indicated that the GR-TiO2 could be used as a catalyst to degrade Rh-B from coloured wastewater.

Synthesis, characterization and anti-trypanosomal activity of R-(-)carvone and arylketones-thiosemi carbazones and toxicity against Artemia salina LeachBienvenu Glinma, Salome D. S. Kpoviessi, Raymond H. Fatondji, Fernand A. Gbaguidi, Coco N. Kapanda, Joanne Bero, Didier M. Lambert, Veronique Hannaert, Joëlle Quetin-Leclercq, Mansourou Moudachirou, Jacques Poupaert, Georges C. Accrombessi

We described a novel and eco-friendly method for preparing Fe3O4-Ag core shell nanoparticles (CSNPs) with high magnetism and potent antibacterial activity. The Fe3O4-Ag CSNPs were obtained using waste material of Vitis vinifera (grape) stem extract as the green solvent, reducing and capping agent. The result recorded from X-ray powder diffraction (XRD), UV–vis spectrum, energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FT-IR) supports the biosynthesis and characterization of Fe3O4-Ag CSNPs. From transmission electron microscopy (TEM) the size of the Fe3O4-Ag nanoparticles was measured below 50nm; high-resolution TEM (HRTEM) indicates the core shell structure; and selected area electron diffraction (SAED) has revealed polycrystalline nature. Vibrating sample magnetometer (VSM) shows the ferromagnetic nature of Fe3O4-Ag CSNPs at room temperature with saturation magnetization of 15.74emu/g. Further, these biogenic nanoparticles were highly hazardous to microorganisms. The antibacterial activity of biogenic Fe3O4-Ag CSNPs showed potent inhibitory activity against both Gram-positive and Gram-negative pathogens. These nanoparticles may also be reusable because of its excellent ferromagnetic property.

A new cis-palladium(II)diaqua(3,4-difluoroacetophenonethiosemicarbazone complex (Pd(II) complex) is synthesized using 3,4-difluoroacetophenonethiosemicarbazone(L). The L and its Pd(II) complex are characterized and confirmed by elemental analyses, electrochemical analyses, FT-IR, FT-Raman, UV-Vis, HRMS and LC-MS techniques. Ligand L is further characterized by H-1, C-13 and F-19 NMR spectroscopy. The crystal structure of L is unambiguously characterized by single X-ray crystallography. The ligand (L) belongs to monoclinic system with P2(1)/C space group and the unit cell parameters are a(angstrom) = 9.1144(7), b(angstrom) = 13.7928(7), c(angstrom) = 8.4174(5), alpha(degrees)= 90, beta(degrees) = 100.715, gamma(degrees) = 90 and volume V(A(3))= 1039.73(11). The Raman bands observed for the L and its Pd(II) complex are in good agreement with the FT-IR spectral data. The Pd(II) complex is found to be highly efficient in inhibiting the growth of human pathogens like Salmonella typhimurium and Klebsiella pneumonia with MIC value 10.0 mu g/mL whose inhibition zones are almost comparable with the standard antibiotic. The synthesized compounds have shown antiproliferative activity against the human breast cancer cell lines MDA-MB231 by intermitting the regular pathway of ribonucleotidereductase. (C) 2013 Elsevier B.V. All rights reserved.

In the present work, Fe3O4 magnetic nanoparticles (MNPs) are synthesized via plantain peel extract by the biogenic method. The reaction process is simple, eco-friendly and convenient to handle. These MNPs are characterized by X-ray diffraction, transmission electron microscopy, energy-dispersive spectroscopy, Fourier transform infrared spectroscopy, Brunauer Emmett and Teller surface area analyzer and vibrating sample magnetometer techniques. The Fe3O4 MNPs possess high Brunauer, Emmett and Teller (BET) surface area which is found to be 11.31m2/g and well-dispersed Fe3O4 MNPs have spherical morphology. The size below 50nm are seen in transmission electron microscopic image. In addition, the MNPs present in higher saturation magnetization (15.8emu/g) show excellent magnetic response behavior.

A complexing agent, 2,3,4-trihydroxyaceto-phenonephenylhydrozone (THAPPH) was prepared and developed a selective and sensitive kinetic direct spectrophotometric method for the determination of thorium(IV) at nano levels. The method sensitivity is calculated in terms of molar absorptivity (3.246x10(5) L mol(-1) cm(-1)) and Sandell's sensitivity (0.0007153 mu g cm(-2)), which explains that the method is more sensitive. The developed method is more precise and accuracy, which is found by standard deviation (0.0018), relative standard deviation (0.55%), absolute error(0.008) and confidence limit(+/- 0.0019). The metal and ligand forms 1:1 (M:L)complex and its stability constant is calculated by Asumu's and Edmonds and Birnbaum's method. This developed method was applied for the determination of thorium(IV) from thorite ore and checked the validity of the method by comparing the obtained results with AAS method.

Mn(II) and Co(II) complexes of benzyloxybenzaldehyde-4-phenyl-3-thiosemicarbazone have been synthesized and characterized by the investigations of electronic and EPR spectra and X-ray diffraction. Based on the spectral studies, an octahedral geometry is assigned for the Mn(II) and Co(II) complexes. X-ray powder diffraction studies reveal that Mn(II) and Co(II) complexes have triclinic crystal lattices. The unit cell parameters of the Mn(II) complex are a=11.0469Å, b=6.2096Å, c=7.4145Å, α=90.646°, β=95.127°, γ=104.776°, V=489.7Å3 and those of Co(II) complex are a=9.3236Å, b=10.2410Å, c=7.8326Å, α=90.694°, β=99.694°, γ=100.476°, V=724.2Å3. When the free ligand and its metal complexes are subjected to antibacterial activity, the metal complexes are proved to be more active than the ligand. However with regard to in vitro antioxidant activity, the ligand exhibits greater antioxidant activity than its metal(II) complexes.

Stability constant ofmetal complexes of gallacetophenone phenylhydrazone (GPPH) are determined using spectrophotometricmethod. Stability constant of complexes are determined at 300C, bymaintaining the ionic strength constant using 0.1MNaNO3. The stoichiometry of the complexes is determined by JobÂ’s method. It has been verified thoroughly byAsmus method. For the metals, the order of stability constant is found to be Fe(II) > Ti (IV) >Mo (VI) >Al (III).The log k values of the complexes of Fe (II), Ti (IV),Mo (VI) andAl (III) are calculated to be 8.84, 8.44, 7.17 and 3.50 respectively by Asmus method.

A new catalytic and kinetic spectrophotometric method for the determination of vanadium(V) was studied using 2,3,4-trihydroxyacetophenonephenylhydrazone (THAPPH) as an analytical reagent. The present method was developed on the catalytic effect of vanadium on oxidation of THAPPH by hydrogen peroxide in hydrochloric acid–potassium chloride buffer (pH=2.8) at the 20th minute. The metal ion has formed 1:2 (M:L) complex with THAPPH. Beer’s law was obeyed in the range 20–120ng/mL of V(V) at λmax 390nm. The sensitivity of the method was calculated in terms of molar absorptivity (1.999×105 Lmol−1cm−1) and Sandell’s sensitivity (0.000254μgcm−2), shows that this method is more sensitive. The standard deviation (0.0022), relative standard deviation (0.56%), confidence limit (±0.0015) and standard error (0.0007) revealed that the developed method has more precision and accuracy. The stability constant was calculated with the help of Asmu’s (9.411×10−11) and Edmond’s & Birnbaum’s (9.504×10−11) methods at room temperature. The interfering effect of various cations and anions was also studied. The present method was successfully applied for the determination of vanadium(V) in environmental and alloy samples. The method’s validity was checked by comparing the results obtained with atomic-absorption spectrophotometry and also by evaluation of results using F-test.

Benzyloxybenzaldehyde-4-phenyl-3-thiosemicarbazone ligand (L) has been synthesized from benzyloxybenzaldehyde and 4-phenyl-3-thiosemicarbazide. Complexes of this ligand with chlorides of Cu(II) and Ni(II) have been prepared. The structure of the ligand (L) is proposed based on elemental analysis, IR and 1H NMR spectra. Its complexes with Cu(II) and Ni(II) ions are characterized from the studies of electronic as well as EPR spectra. On the basis of electronic and EPR studies, rhombically distorted octahedral structure has been proposed for Cu(II) complex while the Ni(II) complex has been found to acquire an octahedral structure. The ligand and their metal complexes have been tested in vitro for their biological effects. Their antibacterial activities against Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae) and Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) have been investigated. The prepared metal complexes exhibit higher antibacterial activities than the parent ligand. The in vitro antioxidant activity of free ligand and its metal(II) complexes have also been investigated and the results however reveal that the ligand exhibits greater antioxidant activity than its complexes.

The synthesis of Cu(II) and Ni(II) complexes with 2,6-diacetylpyridine bis(4-phenyl-3-thiosemicarbazone) (L) ligand have been reported. The ligand was characterized by elemental analysis and spectral (IR and (1)H NMR) studies and its complexes were characterized by electronic, UV/VIS, EPR and IR studies. The room-temperature EPR spectrum of CLOD complex was recorded and the analysis of its spectrum gave {g} tensor with g(1) = 2.25, g(2) = 2.15, and g(3) = 2.07 which were of distorted octahedral structure. The electronic spectrum of Ni(II) complex indicated the octahedral geometry around the Ni(II) ion. Their antibacterial activities were evaluated by the diameter of zone of inhibition (mm) against four bacteria such as B. subtilis, S. aureus, E. coli and K. pneumonia. The ligand and the 6-coordinate Ni(II) complex did not inhibit the growth of the test organisms, while the Cu(II) complex showed good antibacterial activity than parent ligand against the same bacteria. The free ligand and its metal complexes have been tested for in vitro - antioxidant activity by reduction of 1,1-diphenyl-2-picryl hydrazyl (DPPH) and iron induced lipid peroxidation using rat brain homogenate. The ligand exhibited potent in vitro - antioxidant activity than its Ni(II) and Cu(II)complexes.

A simple, rapid, highly sensitive and new simultaneous spectrophotometric method is proposed for the analysis of chromium(VI) and vanadium(V) without separation by using 3,4-dihydroxybeznaldehyde isonicotinoyl hydrazone (3,4-DHBINH). The reagent reacts with the two metal ions in acetic acid-sodium acetate buffer of pH 5.5 and gives maximum absorbances at 400 nm and 360 nm for chromium(VI) and vanadium(V), respectively. Both the metal ions gives 1:1 (M:L) complexes with the reagent. Effect of various diverse ions also studied. The instability constants for the two complexes were also evaluated. This method was successfully applied for the determination of chromium(VI) and vanadium(V) in various spiked samples. The validity of the method was checked by comparing with the results obtained by atomic absorption spectrophotometry.