Background There is an increased appreciation of the burden of cognitive impairment in persons with rheumatoid arthritis (RA). Research shows a gap between subjective and objective measures of cognitive impairment in persons with chronic diseases. Objectives This study explored the relationship between subjective cognitive dysfunction and computerized neuropsychological performance in Korean older adults with RA. Methods Individuals with RA were recruited by their rheumatologists during follow-up visits at one university hospital in Korea. After getting signed consents, a trained research nurse assessed participants with a range of physical, psychosocial, and biological metrics. Subjective cognitive dysfunction was assessed using the Perceived Deficits Questionnaire (PDQ; range 0–20, higher score=greater impairment). Objective cognitive impairment was assessed using a set of 6 computerized neurocognitive tests yielding 18 indices covering a range of cognitive domains. Subjects were classified as “impaired” if they performed 1 SD below age-based population norms on each test [1]. A total cognitive impairment score was calculated by summing the transformed scores (range: 0–18, higher score=greater impairment). Multiple regression analysis controlling for education, disease severity, and depression was conducted to identify the relationship between objective and subjective cognitive measures. Results Fifty four subjects with a mean (±SD) age of 63.6 (±10.5) years were included in the final analyses. 85% were female and 87% were married. Mean educational level was 10.2 (±4.9) years and mean disease duration was 8.9 (±8.5) years. 25.9% had depression and 55.6% had sleep problem. Mean PDQ score was 11.8 (±4.5, range 5–25) and mean total cognitive impairment score was 11.0 (±4.1, range=2–18). 92% were classified as cognitively impaired on five or more test indices. There was no significant correlation between PDQ score and total cognitive function score (r=.260, p=.068). However, psychological factors including depression (r=.621, p<.001) and sleep problem (r=.577, p<.001) were significantly correlated with PDQ score. In the multivariate analysis, there was no significant relationship between PDQ score and total cognitive impairment score. However, functional limitations and depression (=0.317, p=0.048; =0.334, p=0.019) were significantly associated with the PDQ score. Conclusions There was no significant relationship between subjective cognitive dysfunction and computerized neuropsychological performance in this cohort. Functional limitations and depression were significantly associated with perceived cognitive dysfunction. Findings emphasize the gap between subjective and objective measures of cognitive impairment and the importance of considering psychological factors in the context of cognitive complaints in clinical settings. References Kozora, E., Ellison, M. C., & West, S. (2004). Reliability and validity of the proposed American College of Rheumatology neuropsychological battery for systemic lupus erythematosus. Arthritis Care & Research, 51(5), 810–818. Acknowledgements This research was supported by the 2015 Inje University research grant (No.20151092). Disclosure of Interest None declared

Background For persons with chronic diseases such as rheumatoid arthritis (RA), intact cognitive function is crucial for performing main daily activities and adhering to self-management regimens. Persons with impaired cognitive function have decreased functional independence, reduced quality of life, and increased risk of mortality. Although several mechanisms may influence cognitive function in RA, it has not been well-studied in this population. Objectives This study explored the prevalence of cognitive impairment in persons with RA using a set of computerized neurocognitive tests and the factors that were significantly correlated with cognitive impairment. Methods Individuals with RA were recruited by their rheumatologists during follow-up visits at one university hospital in Korea. After getting signed consents, a trained research nurse assessed participants with a range of physical, psychosocial, and biological metrics. Cognitive function was assessed using a set of 6 computerized neurocognitive tests yielding 18 indices covering a range of cognitive domains. Subjects were classified as “impaired” if they performed 1 SD below age-based population norms on each test [1]. The total cognitive impairment score was calculated by summing the transformed scores, ranging from 0 (no impairment) to 18 (worst impairment). Pearson correlation coefficient analyses were conducted to identify the variables that might be significantly associated with cognitive impairment. Results Twenty three subjects with a mean (±SD) age of 64.9 (±12.4) years were included in preliminary analyses. 87% were female, 87% were married, and mean educational level was 9.7 (±5.2) years. Mean DAS-28 level was 2.6 (±1.2) and mean disease duration was 116.5 (±85.4) months. Mean HAQ score was 0.6 (±0.8) and mean cardiovascular disease (CVD) risk factors were 3.1 (±1.5). 35% had depression and 70% had sleep problems. The proportion of persons who were classified as cognitively impaired on each test were 34% in Card Sorting Test (executive function), 68% in Trail Making Test (visuo-motor coordination), 78% in Visual Span Test (language memory), 83% in Verbal Learning Test (visuo-spatial memory), 83% in Visual Continuous Performance Test (continuous attention), and 91% in Word-Color Test (selective attention). Mean total cognitive impairment score was 11.0 (±4.2), and ranged from 2–17. 95% were classified as cognitively impaired on five or more test indices. Education (r=-514, p<.05), income (r=-.638, p<.05), and CVD risk factors (r=.434, p<.05) were significantly correlated with total cognitive impairment score. Conclusions A significant number of RA patients were cognitively impaired. Low educational levels, low income, and increased CVD risk factors may be potential risks of cognitive impairment in this population. These findings suggest that the burden of cognitive impairment in RA is significant, and future studies identifying specific etiological contributors to cognitive impairment are warranted. References Kozora, E., Ellison, M. C., & West, S. (2004). Reliability and validity of the proposed American College of Rheumatology neuropsychological battery for systemic lupus erythematosus. Arthritis Care & Research, 51(5), 810–818. Acknowledgement This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (No.2014R1A1A1002988). Disclosure of Interest None declared

Background Loss to follow-up can occur with many reasons, which influenced the outcomes of longitudinal cohort studies. Objectives To compare the characteristics of patients who lost to follow-up and patients who completed the 2 years of follow-up, and examine the associated factors for early loss to follow-up (ELTF). Methods The study subjects consisted of the KORONA cohort which is a multicenter longitudinal RA cohort. After excluding 1,119 patients who did not complete the 2 years of follow-up but still are actively participating, we divided the patients (n=4,257) into two groups; patients who lost to follow-up within 2 years (ELTF group), and patients who completed the 2 years of follow-up (FU group). Multivariate analysis was performed using the variables significant in univariate analyses and institutional factor. Institutions were divided in 3 groups based on the number of patients enrolled; A (largest) and C (smallest). Results ELTF group patients (n=1,674, 39%) were older (p=0.04) and less educated (p<0.01). In a multivariate analysis, higher disease activity (OR 1.09, CI 1.02-1.16) and cardiovascular disease (CVD, OR 1.66, CI 1.17-2.34) at enrollment were risk factors for ELTF, whereas longer disease duration (OR 0.98, CI 0.97-0.99) and MTX use (OR 0.59, CI 0.49-0.70) were protective. Patients recruited from institutions of smaller numbers are likely to ELTF (C: OR. 7.65, CI 5.43-10.79, B: OR 3.27, CI 2.73-3.92, for A). Conclusions RA Patient who have higher disease activity and CVD at enrollment are likely to ELTF, while longer disease duration and MTX use were protective. In addition, institutional factor should be considered as one of main factors for ELTF. References Iannaccone CK, Fossel A, Tsao H, Cui J, Weinblatt M, Shadick N. Factors associated with attrition in a longitudinal rheumatoid arthritis registry. Arthritis Care Res (Hoboken). 2013;65(7):1183-9. Disclosure of Interest None declared

Windows have significant effects on heating and cooling energy in buildings due to the fact that windows are the thermally weak parts among the building constructions and that they can directly transmit the solar radiation into the room space. Therefore, proper selection of window materials and blind operation type is an essential factor for energy saving. One of the advanced window systems that has been actively applied these days is low-E windows, whose thermal efficiencies are improved compared to the conventional clear windows by applying the low emissivity coating, resulting in lower solar heat gain coefficient and U-value. In addition, proper operation of blinds can also significantly reduce the thermal load and energy consumption in buildings. In this study, experimental research was performed to evaluate the inside air and surface temperature characteristics of six small-scale test chambers during cooling period, since those temperatures can be good indicators for the indirect assessment of the cooling effects of different window types and blind locations.

The demand for NO x after-treatment system has increased dramatically due to the stricter NO x emission regulations for diesel vehicles. The urea-SCR system is one of the NO x after-treatment methods found to be quite effective to meet the regulation requirement enforced by various authorities including the Euro-6. In order to develop an effective urea-SCR system, it is critical to establish an even distribution of reductant over the catalyst surface since this favorable distribution can increase reduction reaction and in turn, improve NO x conversion efficiencies. In the current study, a number of design variations of the urea-SCR system which included two mixer types and three decomposition pipe lengths, were evaluated systematically using CFD analysis and experimental measurements. The purpose of the CFD analysis was to estimate the distribution of reductant within the urea-SCR system with a specific configuration and the purpose of the engine emission test was to measure the amount of NO x reduction, respectively. The results from the systematic analysis revealed the relation between the reductant distribution over the SCR and the performance of the NO x reduction.

Nowadays, global warming caused by greenhouse gases, is a serious problem worldwide. IPCC (Intergovernmental Panel on Climate Change) suggested preparation plan such as emission factor of greenhouse gases and equation of emission in 1996. Horticulture facilities are taking the biggest blow due to the increasing heating bills as they mostly use fossil fuel but in turn they are generating huge amounts of greenhouse gases. Therefore, this paper accurately quantifies the amount of electricity consumed by fan coil unit using various heat sources in largescale horticulture facilities based on IPPC data. Also analysis of economic feasibility accomplishment, efficiency and gas consumption in gas boiler, which is commonly used in large-scale horticulture facilities, is done. Calculation of heating bills in each case has been done based on recent gas and electricity prices in Korea to find the economic feasibility for setting up of heat pump system. The most economic and environment-friendly heating system to be used in the large-scale greenhouses is suggested in this study.

Greenhouses use low U-value skin, such as glass and vinyl, and thus they need to be significantly heated 24 hours as per characteristic of crops, using more heating energy than normal buildings. Recently government has planned to set large scale controlled horticulture, above 100ha in South Korea. Problem in large scale controlled horticulture is large amounts of fossil fuel being used for heating and the increase in the price of oil 10% annually. This paper conducts simulation study of a large scale greenhouse using EnergyPlus simulation program in order the investigate the effects of pipe network parameters on the large-scale horticulture facility heating system performance. The parameters under consideration in this study are pipe diameter and fluid flow rate. Both the distance between heat source and green house and the heat gain and heat loss through the pipe were considered.

Background Pulmonary arterial hypertension (PAH) is a major cause of mortality in connective tissue disease (CTD). Objectives The survival rates and mortality-predictive factors of a nationwide registry of Korean patients with CTD-PAH were determined. Methods Patients with CTD-PAH were enrolled between April 2008 and December 2012. Hemodynamic parameters and clinical data (WHO-functional class [FC], organ involvement, laboratory tests, and treatment agents) were recorded. Survival rates were calculated by using the Kaplan–Meier method. Mortality-associated factors were examined by Cox proportional hazards regression analysis. Results In total, 174 incident PAH cases (61 with systemic lupus erythematosus, 50 with systemic sclerosis, 10 with mixed CTD, 22 with rheumatoid arthritis [RA], and 31 with other CTDs) were diagnosed by right heart catheterisation or Doppler echocardiography. Of these, 25 (14%) died during the 3.8±2.7 year follow-up period after PAH diagnosis. The 1 and 3 year survival rates were 90.7% and 87.3%, respectively. Compared to the other CTD-PAHs, RA-PAH had the lowest survival rates (56% 3 year survival; p=0.022). Multiple regression analysis revealed that low DLCO, pleural effusion, and diabetes mellitus were poor prognostic factors (p=0.008, 0.04, and 0.009, respectively). Anti-UI-RNP antibody positivity was protective (p=0.022). In patients with WHO-FC III/IV, patients who received vasodilators had lower mortality than those who did not (p=0.038). Conclusions In Korean patients with CTD-PAH, the 3 year survival rate was 87%. Low DLCO, pleural effusion, and DM were independent poor prognostic factors. Anti-UI-RNP antibody was protective. Prompt PAH-specific vasodilator therapy may improve the survival of patients with severe CTD-PAH. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.1271

Background Rheumatoid arthritis (RA) requires multiple drug regimens, because of its chronic, progressive disease nature. Drug adherence is defined as patients take medications as prescribed. Previous studies have reported that adherence of RA patients was about 30% to 80%. However, factors affecting nonadherence has not been well documented. Objectives The current study aimed to assess adherence in RA patients and to identify risk factors for nonadherence. Methods Rheumatoid arthritis patients over the age 18 who satisfied the 1987 ACR criteria were included from the KORean Observational study Network for Arthritis (KORONA). We selected 3,523 patients who answered the self-report questionnaire at enrollment. We classified patients into two groups. Patients who failed to take their medications for more than 5 days in total over the preceding 60 days were included in the nonadherence group and their reasons for nonadherence was investigated. T-test and Chi-square were used to compare two groups and logistic regression was used to identify risk factors. Results The adherence rate was 90.4% (3,184 out of 3,523 patients). The reasons for nonadherence were: forgetfulness (36.9%), feeling asymptomatic (23.3%), side effects (12.4%), and taking alternative treatment (10.3%). Nonadherence patients were younger (50.9 years vs. 54.6 years, p≤0.01), reported side effects (44.2% vs. 33.3%, p≤0.01) and had lower Health Assessment Questionnaire (HAQ) score (0.57 vs. 0.68, p<0.01). Multivariate analyses were performed to identify the risk factors for nonadherence (n=3,094). It showed that young age (OR =1.02, 95% CI 1.01 to 1.03), having experience of side effects (OR=1.82, 95% CI 1.41 to 2.34) and lower HAQ score (OR=1.48, 95% CI 1.13 to 1.90) were associated with nonadherence. We did subgroup analysis to identify risk factors for nonadherence due to forgetfulness, young age (OR=1.04, 95% CI 1.02 to 1.06), having experience of side effects (OR=1.72, 95% CI 1.14 to 2.60) and low HAQ score (OR=1.80, 95% CI 1.12 to 2.89) were found to be also associated with forgetfulness. Conclusions In this study, relatively low proportion of 9.6% of the RA patients showed nonadherence. The major reason of nonadherence was forgetfulness. Young age, experience of drug side effects, and low HAQ score were commonly associated with nonadherence and forgetfulness. To improve adherence for RA treatment, further studies for impact of adherence and patient-physician communication on improving outcomes of RA should be conducted. Acknowledgements This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020). Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.3965

Background The importance of tight control is supported by solid clinical evidence. While treating RA with the aim of achieving remission or a low disease activity-as determined by disease activity score employing 28 joints count (DAS28) or the simplified and the clinical disease activity index (SDAI, CDAI) -is reasonable and important, this approach is not widely accepted in the clinical situation. Objectives To identify the effects of tight control of rheumatoid arthritis (RA) on various disease outcomes in a large observational study. Methods We selected 1900 RA patients with a baseline DAS28-ESR of more than 3.2 and who had 1 year of follow-up data. The patients were divided into two groups: (1) disease-modifying antirheumatic drugs (DMARDs)-changed group (patients who changed the types or amounts of their DMARDs) and (2) DMARDs-unchanged group (patients who maintained their DMARDs). We measured various disease outcomes, including the Health Assessment Questionnaire–Disability Index (HAQ-DI), DAS28-ESR, C-reactive protein (CRP), ESR, and global health assessments by both physicians and patients. The t-test was used to identify the effects of tight control of RA on various disease outcomes. Results Patients in the DMARDs-changed group were younger, had a shorter disease duration, used less leflunomide, used more biologic agents. At baseline, they had higher DAS28-ESR (4.62±0.96 in DMARDs-changed group versus 4.42±0.90 in DMARDs-unchanged group, p<0.001), CRP (1.15±1.62 versus 0.81±1.14, p<0.001), global health assessment by both physician (34.05±20.00 versus 26.94±18.16, p<0.001) and patient (48.96±25.34 versus 46.18±24.74, p=0.016). In the comparison between baseline and the 1-year follow-up, the DMARDs-changed group showed greater improvements in HAQ-DI (–0.76±1.43 versus –0.59±1.22, p=0.006), CRP (–0.39±1.71 versus –0.11±1.37 mg/dl, p=0.001), and the global health assessment by a physician (–11.21±24.18 versus –8.10±19.20, p=0.002). Image/graph Conclusions Immediate changes in DMARDs according to disease activity can improve disease outcomes, especially DAS28-ESR, CRP, and the global health assessment by a physician. Disclosure of Interest None Declared

Background Methotrexate (MTX) is well known as the anchor drug for treatment of rheumatoid arthritis (RA). It is recommended that MTX should be administered as soon as the diagnosis of RA is made and the dose should be escalated to tolerable adequate higher dose. Objectives We aimed to investigate the difference in outcomes according to the weekly dose of MTX. Methods A total of 4,393 patients enrolled in KORONA (Korean Observational Study Network for Arthritis), after excluding 973 patients who were not receiving MTX and 10 patients with inadequate information on their MTX dosage, were assessed for demographic factors, disease outcome measurements (DAS28, HAQ, EQ-5D, fatigue, sleep, pain, general condition, radiographic damage, surgery), comorbidities, medication, and adverse events. A total of 4,361 patients were assessed for outcomes according to MTX dose in relation to body weight after excluding 32 patients with body weight data missing. Patients receiving more or less than 10mg weekly dose of MTX were compared. In patients receiving more than 10mg weekly dose of MTX, patients with more or less than 0.25mg/kg were compared and in those receiving less than 10mg weekly, 0.16mg/kg was the cut-off for comparison. Results More patients were receiving more than 10mg weekly dose of MTX (62.4%) compared to less than 10mg (37.6%). Patients in the more than 10mg weekly dose group were younger (p<0.01), had shorter disease duration (p<0.01), better general condition (p<0.01), had less hypertension (p<0.01) and other cardiovascular comorbidities (p<0.01), received more steroids (p<0.01) and NSAIDs (p<0.01), and had more radiographic damage at diagnosis and follow up (p<0.01) and surgery (p<0.01). When weekly MTX dose more or less than 0.25mg/kg were compared in the more than 10mg weekly group, the more than 0.25mg/kg group were more female (p<0.01), younger (p<0.01), longer disease duration (p<0.01), higher HAQ score (p<0.01), more pain (p<0.01), lower EQ-5D score (p<0.01), higher DAS28 (p<0.01), less hypertension (p<0.01), other cardiovascular (p<0.01), and gastrointestinal comorbidities (p<0.01), more radiographic damage at diagnosis (p<0.01) and follow up (p<0.01), and more surgery (p<0.01). Conclusions Higher doses of MTX were used in younger patients with worse prognostic factors at diagnosis. The high-dose group had significantly higher disease activity, more pain, higher HAQ score, lower EQ-5D score, more radiographic damage and surgery, and more gastrointestinal comorbidities. But they had significantly less hypertension and other cardiovascular comorbidities, showed no significant difference in interstitial lung disease and adverse events. Acknowledgements This study is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065). Disclosure of Interest None Declared

Background Use of complementary and alternative medicine (CAM) is not uncommon in patients with rheumatoid arthritis (RA), but patient characteristics and the factors influencing and predicting its use is not well known. Objectives We aimed to assess the characteristics and outcomes of CAM in patients with RA and to analyze the predicting factor for its use. Methods A total of 5,360 RA patients from the KORONA (Korean Observational Study Network for Arthritis) prospective multicenter cohort were assessed for use of CAM and characteristics including age, sex, disease duration, delay in diagnosis, family history, comorbidities, socioeconomic status, fatigue, sleep, pain, exercise, smoking, HAQ, EQ-5D, DAS28, medication, radiographic damage, surgery, and adverse events. Multiple logistic regression was used to analyze the predicting factors for CAM use. Results Of the 5,360 patients, 2,468 (46.0%) patients responded that they have used CAM. Acupuncture was most common (73.3%) followed by herbal medicine (60.4%), moxibustion (30.7%), bee venom (19.1%), others (7.7%), and placenta injection (3.9%). Female used CAM significantly more and CAM users were significantly younger at onset (p<0.01), had longer disease duration (p<0.01), more family history (p=0.02), lower income (p<0.01), and lower education status (p<0.01). CAM users reported significantly more fatigue (p<0.01), more sleep disturbance (p<0.01), more pain (p<0.01), worse general condition (p<0.01), higher HAQ score (p<0.01), and lower EQ-5D score (p<0.01). They also had significantly higher disease activity (p<0.01, more use of steroids (p<0.01) and NSAIDs (p<0.01), had more radiographic damage (p<0.01), underwent more surgery (p<0.01), and had more adverse events (p<0.01). One or more problem in any of the dimensions of EQ-5D was significantly associated with the use of CAM. Factors significantly predicting the use of CAM were female gender (OR, 95%CI, 1.71, 1.30-2.45), older age, steroids (1.49, 1.29-1.72), adverse events (1.43, 1.26-1.63), radiographic damage (1.40, 1.21-1.62), regular exercise (1.35, 1.19-1.53), surgery (1.31, 1.10-1.55), high income (1.30, 1.06-1.60), and high DAS28 (1.07, 1.07-1.15). Conclusions Patients with higher disease activity and lower health-related quality of life and higher functional disability used CAM significantly more frequently. Acknowledgements This study is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065). Disclosure of Interest None Declared

Background Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular diseases (CVD). RA disease activity and inflammation contributes to the increase in risk, but traditional risk factor such as hypertension and dyslipidemia also plays a significant role. Objectives We investigated the influence of hypertension and its management on cardiovascular risk and RA-related outcomes in patients with RA. Methods RA patients from the KORONA (Korean Observational Study Network for Arthritis) prospective multicenter cohort were assessed for demographic factors, RA-related outcomes (DAS28, HAQ, EQ-5D), traditional risk factors for CVD, and cardiovascular risks. Systemic Coronary Risk Evaluation (SCORE) risk score and Korean 10-year CVD risk score were used to assess the CVD risk. Patients with no hypertension and those with either diagnosis of hypertension or high blood pressure were compared. Among the hypertension group, patients with blood pressure below the target (140/90mmHg) and those above the target were compared. Patients with no hypertension and those with hypertension and blood pressure below target with treatment were also compared. Results From the 5,376 patients enrolled in KORONA, 4,232 patients were included in the analysis after excluding 1,144 patients with missing information on cholesterol, smoking status, or blood pressure. Patients with hypertension or had high blood pressure were significantly younger (p<0.01), had longer disease duration (p<0.01), longer delay in diagnosis (p<0.01), higher HAQ score (p<0.01), lower EQ-5D score (p<0.01), higher disease activity (p<0.01), higher BMI (p<0.01), and more dyslipidemia (p<0.01). SCORE risk as well as the Korean 10-year CVD risk score were significantly higher in patients with hypertension and high blood pressure (p<0.01). Among the patients with hypertension, those still showing blood pressure above the target were older (p=0.47), had shorter disease duration (p=0.01), and higher SCORE risk (p<0.01) and Korean 10-year CVD risk score. When patients with no hypertension and those with hypertension but blood pressure below target with treatment were compared, patients with being treated for hypertension had higher HAQ score (p<0.01), lower EQ-5D score (p<0.01), higher disease activity (p<0.01), higher BMI (p<0.01), higher SCORE risk (p<0.01) and Korean 10-year CVD risk (p<0.01), and more dyslipidemia (p<0.01). Conclusions Patient with hypertension are at increased risk for CVD and the risk remained higher than the patients with no hypertension even after reaching the recommended target for blood pressure control. Acknowledgements This study is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065). Disclosure of Interest None Declared

Background Early and aggressive treatment offers better outcomes in early rheumatoid arthritis (RA). The long-term effect of early treatment and effect of early treatment on functional disability have not been studied. Objectives To determine whether early diagnosis and treatment have long-term benefits for disease activity and functional disability in patients with RA enrolled in the KORean Observational study Network for Arthritis (KORONA). Methods A total of 4540 rheumatoid arthritis patients completed questionnaires to establish their demographic profile, medical history, disease-specific outcomes, and RA-related information. We defined early and delayed RA diagnoses as lag-times of shorter than and at least 1 year. Disease activity was measured with the DAS28–ESR, and it was dichotomized using a score of 2.6. Functional disability was measured with the Korean HAQ-DI, and was dichotomized using a score of 1. We used the chi-square test and t-test to identify differences between male and female patients, and crude and multiadjusted models to identify the impacts of early diagnosis on disease activity and functional disability. Results In crude and multiadjusted models, early diagnosis was not associated with a higher remission rate (OR 1.10, CI 0.94-1.28 in crude model, OR 1.05, CI 0.83-1.32 in multiadjusted model). We performed subgroup analysis according to disease duration; there was no association between early diagnosis and remission rate. Early diagnosis was associated with functional disability in crude model (OR 0.79, CI 0.68-0.91) but not in multiadjusted model (OR 0.85, CI 0.72-1.002). In subgroup analysis according to disease duration and disease activity, early diagnosis was independently associated with functional disability for a shorter disease duration (OR 0.78, CI 0.63-0.96 in disease duration <10 years) and the presence of moderate-to-severe disease activity (OR 0.83, CI 0.69-0.99 in DAS28-ESR ≥3.2). Image/graph Conclusions Early diagnosis is associated with functional disability especially with a disease duration of less than 10 years and the presence of moderate-to-severe disease activity. Disclosure of Interest None Declared