Human cognitive behavior arises from the interaction of specialized brain networks dedicated to distinct functions, such as language, logic, and social reasoning. Inspired by this organization, we propose Mixture of Cognitive Reasoners (MiCRo): a modular, transformer-based architecture post-trained with a curriculum that induces functional specialization across experts. Concretely, we partition the layers of a pretrained language model into four expert modules aligned with well-studied cognitive networks in the human brain. MiCRo offers three key advantages over standard language models. (1) The specialized experts are interpretable and causally meaningful---ablating a module causes substantial drops on benchmarks requiring its specialized domain. (2) MiCRo's behavior can be dynamically steered at inference time by routing tokens to particular experts (e.g., favoring social over logical reasoning), enabling fine-grained control over outputs. (3) MiCRo outperforms or matches comparable baselines on both machine-learning reasoning benchmarks (e.g., GSM8K, BBH) and alignment to human behavior (CogBench), while maintaining interpretability. Taken together, cognitively grounded functional specialization yields models that are both more human-like and more human-interpretable.

Creative thinking is a fundamental aspect of human cognition, and divergent thinking-the capacity to generate novel and varied ideas-is widely regarded as its core generative engine. Large language models (LLMs) have recently demonstrated impressive performance on divergent thinking tests and prior work has shown that models with higher task performance tend to be more aligned to human brain activity. However, existing brain-LLM alignment studies have focused on passive, non-creative tasks. Here, we explore brain alignment during creative thinking using fMRI data from 170 participants performing the Alternate Uses Task (AUT). We extract representations from LLMs varying in size (270M-72B) and measure alignment to brain responses via Representational Similarity Analysis (RSA), targeting the creativity-related default mode and frontoparietal networks. We find that brain-LLM alignment scales with model size (default mode network only) and idea originality (both networks), with effects strongest early in the creative process. We further show that post-training objectives shape alignment in functionally selective ways: a creativity-optimized preserves alignment with high-creativity neural responses while reducing alignment with low-creativity ones; a human behavior fine-tuned model elevates alignment with both; and a reasoning-trained variant shows the opposite pattern, suggesting chain-of-thought training steers representations away from creative neural geometry toward analytical processing. These results demonstrate that post-training objectives selectively reshape LLM representations relative to the neural geometry of human creative thought.

Nearby neurons in cortex share similar response profiles, producing systematic spatial organization across sensory and cognitive systems. Recent topographic models reproduce aspects of this structure but remain unimodal and spatially constrain each layer separately, yielding fragmented maps that capture neither the contiguity of cortical processing streams nor their integration across modalities. We introduce Topo-Omni, a topographic multimodal model in which visual, auditory, and language/cognitive processing share a single contiguous in-silico sheet. Built by fine-tuning a pretrained foundation model with a spatial smoothness objective, this architecture develops clusters across modalities that are consistent with human neuroimaging, from sensory to cognitive systems. Driving or suppressing a cluster selectively biases or impairs perception, paralleling human intervention studies. Finally, we use our model to screen for novel clusters in-silico and discover new natural landscape and animal networks which we validate in human data. A single spatial principle thus organizes representations across modalities and processing stages, yielding testable hypotheses about cortical organization.

Cultural evaluation of large language models has become increasingly important, yet current benchmarks often reduce culture to static facts or homogeneous values. This view conflicts with anthropological accounts that emphasize culture as dynamic, historically situated, and enacted in practice. To analyze this gap, we introduce a four-part framework that categorizes how benchmarks frame culture, such as knowledge, preference, performance, or bias. Using this lens, we qualitatively examine 20 cultural benchmarks and identify six recurring methodological issues, including treating countries as cultures, overlooking within-culture diversity, and relying on oversimplified survey formats. Drawing on established anthropological methods, we propose concrete improvements: incorporating real-world narratives and scenarios, involving cultural communities in design and validation, and evaluating models in context rather than isolation. Our aim is to guide the development of cultural benchmarks that go beyond static recall tasks and more accurately capture the responses of the models to complex cultural situations.

Recent progress in task-optimized neural networks has established encoding models as a powerful tool for predicting brain responses to naturalistic stimuli, yet most existing approaches rely on unimodal representations. The emergence of omni-modal foundation models and rich multimodal neural datasets enables encoding models that jointly integrate visual, auditory, and linguistic information across subjects. We introduce MIRAGE, a brain encoding framework for predicting whole-brain fMRI responses to naturalistic audiovisual stimuli. MIRAGE achieves state-of-the-art performance via a native multimodal backbone and adaptive feature gating across layers. These representations are then combined with a transformer-based brain encoder and a subject-specific linear head over the cortical parcels. Controlled comparisons show that natively multimodal features consistently outperform post-hoc aggregation of independent unimodal features, across architectural levels and backbones. Beyond predictive accuracy, the learned attention weights are directly inspectable to interpret the modality-specific gating profile over the backbone, and each modality traces a distinct anatomical pattern across cortex. Together, these results propose adaptive layer-wise aggregation of natively multimodal features as a generalizable, interpretable, and accurate approach for whole-brain encoding.

Dyslexia, a neurodevelopmental disorder characterized by persistent reading difficulties, is often linked to reduced activity of the visual word form area in the ventral occipito-temporal cortex. Traditional approaches to studying dyslexia, such as behavioral and neuroimaging methods, have provided valuable insights but remain limited in their ability to test causal hypotheses about the underlying mechanisms of reading impairments. In this study, we use large-scale vision-language models (VLMs) to simulate dyslexia by functionally identifying and perturbing artificial analogues of word processing. Using stimuli from cognitive neuroscience, we identify visual-word-form-selective (VWF-selective) units within VLMs and demonstrate that targeted ablation of these units, unlike ablation of random units, leads to selective impairments in reading tasks while general visual and language comprehension abilities remain intact. In particular, the resulting model matches dyslexic humans' phonological deficits without a significant change in orthographic processing. Additionally, the model’s VWF-selective units predict human-VWFA neural responses better than random units and the ablated model mirrors dyslexic behavior in font sensitivity. Taken together, our modeling results replicate key characteristics of dyslexia and establish a computational framework for investigating reading disorders.

Latent language identification is often used to argue that multilingual language models route computation through language-specific states, such as English pivots. However, existing probes infer latent language from different signals, such as the geometry of hidden states or what can be decoded from intermediate representations. Since such claims shape conclusions about how models share and route information across languages, we ask whether these probes measure the same phenomenon or expose distinct aspects of multilingual computation. We study this question across model families, training regimes, domains, tasks, checkpoints, and up to 27 languages. We find that identification probes systematically disagree: the GMM-based representation probe, which draws evidence from hidden state geometry, shows earlier cross-lingual mixing, whereas decoding-based probes, which rely on output-space decodability, retain sharper language-specific and more English-biased signals. These differences track model multilinguality and training progression, but are comparatively stable across domains. Our results suggest a more cautious interpretation of latent language identification, where current probes expose different aspects of multilingual processing, rather than directly revealing a single internal lingua franca.

Open LLMs enable AI practitioners to control development costs by building on an existing foundation for downstream applications. While offering substantial promise, current models often fail to meet the needs of users needing open solutions aligned with responsible AI principles, including data compliance, transparency, and inclusivity. In this work, we present Apertus, a fully open suite of large language models (LLMs) designed to address responsibility shortcomings in today’s open model ecosystem, namely data responsibility and global representation. Unlike many prior models that release weights without reproducible data pipelines or regard for content-owner rights, Apertus models are pretrained exclusively on openly available data, retroactively respecting robots.txt exclusions and filtering for non-permissive, toxic, and personally identifiable content. To mitigate risks of data memorization, we also adopt the Goldfish objective during pretraining, strongly suppressing verbatim recall of data while retaining downstream task performance. Apertus also drastically expands multilingual coverage, training on 15T tokens from over approximately 1800 languages, with about 40% of pretraining data allocated to non-English content. Released at 8B and 70B scales, Apertus approaches state-of-the-art results among fully open models on multilingual benchmarks, rivaling or surpassing open-weight counterparts.

Neurons in the brain are spatially organized such that neighbors on tissue often exhibit similar response profiles. In the human language system, experimental studies have observed clusters for syntactic and semantic categories, but the mechanisms underlying this functional organization remain unclear. Here, building on work from the vision literature, we develop TopoLM, a transformer language model with an explicit two-dimensional spatial representation of model units. By combining a next-token prediction objective with a spatial smoothness loss, representations in this model assemble into clusters that correspond to semantically interpretable groupings of text and closely match the functional organization in the brain's language system. TopoLM successfully predicts the emergence of a spatially organized cortical language system as well as the organization of functional clusters selective for fine-grained linguistic features empirically observed in human cortex. Our results suggest that the functional organization of the human language system is driven by a unified spatial objective, and provide a functionally and spatially aligned model of language processing in the brain.Neurons in the brain are spatially organized such that neighbors on tissue often exhibit similar response profiles. In the human language system, experimental studies have observed clusters for syntactic and semantic categories, but the mechanisms underlying this functional organization remain unclear. Here, building on work from the vision literature, we develop TopoLM, a transformer language model with an explicit two-dimensional spatial representation of model units. By combining a next-token prediction objective with a spatial smoothness loss, representations in this model assemble into clusters that correspond to semantically interpretable groupings of text and closely match the functional organization in the brain's language system. TopoLM successfully predicts the emergence of a spatially organized cortical language system as well as the organization of functional clusters selective for fine-grained linguistic features empirically observed in human cortex. Our results suggest that the functional organization of the human language system is driven by a unified spatial objective, and provide a functionally and spatially aligned model of language processing in the brain.

This work adapts a neuroscientific contrast localizer to pinpoint causally relevant units for Theory of Mind (ToM) and mathematical reasoning tasks in large language models (LLMs) and vision-language models (VLMs). Across 11 LLMs and 5 VLMs ranging in size from 3B to 90B parameters, we localize top-activated units using contrastive stimulus sets and assess their causal role via targeted ablations. We compare the effect of lesioning functionally selected units against low-activation and randomly selected units on downstream accuracy across established ToM and mathematical benchmarks. Contrary to expectations, low-activation units sometimes produced larger performance drops than the highly activated ones, and units derived from the mathematical localizer often impaired ToM performance more than those from the ToM localizer. These findings call into question the causal relevance of contrast-based localizers and highlight the need for broader stimulus sets and more accurately capture task-specific units.

Large language models (LLMs) exhibit remarkable similarity to neural activity in the human language network. However, the key properties of language underlying this alignment—and how brain-like representations emerge and change across training—remain unclear. We here benchmark 34 training checkpoints spanning 300B tokens across 8 different model sizes to analyze how brain alignment relates to linguistic competence. Specifically, we find that brain alignment tracks the development of formal linguistic competence—i.e., knowledge of linguistic rules—more closely than functional linguistic competence. While functional competence, which involves world knowledge and reasoning, continues to develop throughout training, its relationship with brain alignment is weaker, suggesting that the human language network primarily encodes formal linguistic structure rather than broader cognitive functions. Notably, we find that the correlation between next-word prediction, behavioral alignment, and brain alignment fades once models surpass human language proficiency. We further show that model size is not a reliable predictor of brain alignment when controlling for the number of features. Finally, using the largest set of rigorous neural language benchmarks to date, we show that language brain alignment benchmarks remain unsaturated, highlighting opportunities for improving future models. Taken together, our findings suggest that the human language network is best modeled by formal, rather than functional, aspects of language.

Large Language Models (LLMs) have been shown to be effective models of the human language system, with some models predicting most explainable variance of brain activity in current datasets. Even in untrained models, the representations induced by architectural priors can exhibit reasonable alignment to brain data. In this work, we investigate the key architectural components driving the surprising alignment of untrained models. To estimate LLM-to-brain similarity, we first select language-selective units within an LLM, similar to how neuroscientists identify the language network in the human brain. We then benchmark the brain alignment of these LLM units across five different brain recording datasets. By isolating critical components of the Transformer architecture, we identify tokenization strategy and multihead attention as the two major components driving brain alignment. A simple form of recurrence further improves alignment. We further demonstrate this quantitative brain alignment of our model by reproducing landmark studies in the language neuroscience field, showing that localized model units -- just like language voxels measured empirically in the human brain -- discriminate more reliably between lexical than syntactic differences, and exhibit similar response profiles under the same experimental conditions. Finally, we demonstrate the utility of our model's representations for language modeling, achieving improved sample and parameter efficiency over comparable architectures. Our model's estimates of surprisal sets a new state-of-the-art in the behavioral alignment to human reading times. Taken together, we propose a highly brain- and behaviorally-aligned model that conceptualizes the human language system as an untrained shallow feature encoder, with structural priors, combined with a trained decoder to achieve efficient and performant language processing.

Being prompted to engage in reasoning has emerged as a core technique for using large language models (LLMs), deploying additional inference-time compute to improve task performance. However, as LLMs increase in both size and adoption, inference costs are correspondingly becoming increasingly burdensome. How, then, might we optimize reasoning's cost-performance tradeoff? This work introduces a novel approach based on computational models of metareasoning used in cognitive science, training LLMs to selectively use intermediate reasoning steps only when necessary. We first develop a reward function that incorporates the Value of Computation by penalizing unnecessary reasoning, then use this reward function with Expert Iteration to train the LLM. Compared to few-shot chain-of-thought prompting and STaR, our method significantly reduces inference costs (20-37% fewer tokens generated across three models) while maintaining task performance across diverse datasets.

The intricate relationship between language and culture has long been a subject of exploration within the realm of linguistic anthropology. Large Language Models (LLMs), promoted as repositories of collective human knowledge, raise a pivotal question: do these models genuinely encapsulate the diverse knowledge adopted by different cultures? Our study reveals that these models demonstrate greater cultural alignment along two dimensions -- firstly, when prompted with the dominant language of a specific culture, and secondly, when pretrained with a refined mixture of languages employed by that culture. We quantify cultural alignment by simulating sociological surveys, comparing model responses to those of actual survey participants as references. Specifically, we replicate a survey conducted in various regions of Egypt and the United States through prompting LLMs with different pretraining data mixtures in both Arabic and English with the personas of the real respondents and the survey questions. Further analysis reveals that misalignment becomes more pronounced for underrepresented personas and for culturally sensitive topics, such as those probing social values. Finally, we introduce Anthropological Prompting, a novel method leveraging anthropological reasoning to enhance cultural alignment. Our study emphasizes the necessity for a more balanced multilingual pretraining dataset to better represent the diversity of human experience and the plurality of different cultures with many implications on the topic of cross-lingual transfer.

Instruction-tuning is a widely adopted method of finetuning that enables large language models (LLMs) to generate output that more closely resembles human responses to natural language queries, in many cases leading to human-level performance on diverse testbeds. However, it remains unclear whether instruction-tuning truly makes LLMs more similar to how humans process language. We investigate the effect of instruction-tuning on LLM-human similarity in two ways: (1) brain alignment, the similarity of LLM internal representations to neural activity in the human language system, and (2) behavioral alignment, the similarity of LLM and human behavior on a reading task. We assess 25 vanilla and instruction-tuned LLMs across three datasets involving humans reading naturalistic stories and sentences, and discover that instruction-tuning generally enhances brain alignment by an average of 6%, but does not have a similar effect on behavioral alignment. To identify the factors underlying LLM-brain alignment, we compute the correlation between the brain alignment of LLMs and various model properties, such as model size, performance ability on problem-solving benchmarks, and ability on benchmarks requiring world knowledge spanning various domains. Notably, we find a strong positive correlation between brain alignment and model size (r = 0.95), as well as performance on tasks requiring world knowledge (r = 0.81). Our results suggest that making world knowledge in LLMs more accessible via instruction-tuning also yields neural representations more similar to those of the human language system.

Abstract Large language and multimodal models (LLMs and LMMs) will transform access to medical knowledge and clinical decision support. However, the current leading systems fall short of this promise, as they are either limited in scale, which restricts their capabilities, closed-source, which limits the extensions and scrutiny that can be applied to them, or not sufficiently adapted to clinical settings, which inhibits their practical use. In this work, we democratize large-scale medical AI systems by developing MEDITRON: a suite of open-source LLMs and LMMs with 7B and 70B parameters adapted to the medical domain. MEDITRON extends pretraining on a comprehensively curated medical corpus that includes biomedical literature and internationally recognized clinical practice guidelines. Evaluations using standard medical reasoning benchmarks show significant improvements over all current open-access models and several state-of-the-art commercial LLMs that are orders of magnitude larger, more expensive to host, and closed-source. Enhanced with visual processing capabilities, our MEDITRON-V model also outperforms all open-access models and much larger closed-source models on multimodal reasoning tasks for various biomedical imaging modalities. Beyond traditional benchmarks, we also create a novel and physician-driven adversarial question dataset grounded in real-world clinical settings, and a comprehensive 17-metric evaluation rubric to assess alignment and contextualization to real-world clinical practice. Applying this framework to MEDITRON-70B's responses, sixteen independent physicians found a high level of alignment across all metrics, including medical accuracy, safety, fairness, communication, and interpretation. The MEDITRON suite is a significant step forward in closing the technological gap between closed- and open-source medical foundation models. By releasing our methodologies, models, and real-world clinical practice benchmarks, we aim to drive the open-source development of more capable, representative, accessible, and transparent medical AI assistants.

Language Models pretrained on large textual data have been shown to encode different types of knowledge simultaneously. Traditionally, only the features from the last layer are used when adapting to new tasks or data. We put forward that, when using or finetuning deep pretrained models, intermediate layer features that may be relevant to the downstream task are buried too deep to be used efficiently in terms of needed samples or steps. To test this, we propose a new layer fusion method: Depth-Wise Attention (DWAtt), to help re-surface signals from non-final layers. We compare DWAtt to a basic concatenation-based layer fusion method (Concat), and compare both to a deeper model baseline -- all kept within a similar parameter budget. Our findings show that DWAtt and Concat are more step- and sample-efficient than the baseline, especially in the few-shot setting. DWAtt outperforms Concat on larger data sizes. On CoNLL-03 NER, layer fusion shows 3.68-9.73% F1 gain at different few-shot sizes. The layer fusion models presented significantly outperform the baseline in various training scenarios with different data sizes, architectures, and training constraints.

While today's large language models exhibit impressive abilities in generating human-like text, they require massive amounts of data during training. We here take inspiration from human cognitive development to train models in limited data conditions. Specifically we present a self-synthesis approach that iterates through four phases: Phase 1 sets up fundamental language abilities, training the model from scratch on a small corpus. Language is then associated with the visual environment in phase 2, integrating the model with a vision encoder to generate descriptive captions from labeled images. In the "self-synthesis" phase 3, the model generates captions for unlabeled images, that it then uses to further train its language component with a mix of synthetic, and previous real-world text. This phase is meant to expand the model's linguistic repertoire, similar to humans self-annotating new experiences. Finally, phase 4 develops advanced cognitive skills, by training the model on specific tasks such as visual question answering and reasoning. Our approach offers a proof of concept for training a multimodal model using a developmentally plausible amount of data.

Diacritization plays a pivotal role in improving readability and disambiguating the meaning of Arabic texts. Efforts have so far focused on marking every eligible character (Full Diacritization). Comparatively overlooked, Partial Diacritzation (PD) is the selection of a subset of characters to be marked to aid comprehension where needed. Research has indicated that excessive diacritic marks can hinder skilled readers – reducing reading speed and accuracy. We conduct a behavioral experiment and show that partially marked text is often easier to read than fully marked text, and sometimes easier than plain text. In this light, we introduce Context-Contrastive Partial Diacritization (CCPD) – a novel approach to PD which integrates seamlessly with existing Arabic diacritization systems. CCPD processes each word twice, once with context and once without, and diacritizes only the characters with disparities between the two inferences. Further, we introduce novel indicators for measuring partial diacritization quality, essential for establishing this as a machine learning task. Lastly, we introduce TD2, a Transformer-variant of an established model which offers a markedly different performance profile on our proposed indicators compared to all other known systems.

Instruction-tuning is a widely adopted finetuning method that enables large language models (LLMs) to generate output that more closely resembles human responses. However, no studies have shown that instruction-tuning actually teaches LLMs to process language in a similar manner as humans. We investigate the effect of instruction-tuning on aligning LLM and human language processing mechanisms in two ways: (1) brain alignment, the similarity of LLM internal representations to neural activity in the human language system, and (2) behavioral alignment, the similarity of LLM and human behavior on a reading task. We assess 25 vanilla and instruction-tuned LLMs on three datasets involving humans reading naturalistic stories and sentences, and find that instruction-tuning generally enhances brain alignment (~6%), but has no similar effect on behavioral alignment. To identify factors underlying this improvement in brain alignment, we compute correlations between brain alignment and various LLM properties, such as model size, problem-solving, and world knowledge understanding. Notably, we find a strong positive correlation between brain alignment and model size (r = 0.95), as well as performance on tasks requiring world knowledge (r = 0.81). Our results demonstrate that instruction-tuning LLMs improves both world knowledge representations and brain alignment, suggesting that the mechanisms that encode world knowledge in LLMs also improve representational alignment to the human brain.