It is shown that vitamin E (tocopherol) and arachidonic acid are antagonists at the cellular level in regulation of Ca-calmodulin-dependent acetylcholine-induced current in molluscan neurons.
Characteristics (amplitude, latent period) of two types of evoked potentials arising in response to acoustic stimulation, namely the action potential of the auditory nerve and sonomotor evoked potential derived from skin of the postauricular region and back, were studied in guinea pigs. Correlation-regression analysis revealed the degree and type of association between the parameters of these potentials. For action potentials and sonomotor potentials (irrespective of from where the latter were recorded) close correlation was found (r = 0.93). Similar close correlation (r = 0.91) also was found when latent periods of the action potential and sonomotor evoked potentials recorded from skin of the postauricular region, but not from skin of the back, were compared. As a result of mathematical modeling data were obtained for pathogenetically based correction of disturbed functions of the auditory system.
Electrical responses of the fenestra cochleae to stimulation by clicks of different intensity, polarity, and frequency, were studied in anesthetized cats. The absolute values of amplitude and latent period of the neural component of the response reflect the physiological state of the auditory nerve. Besides ordinary potentials characterized by peaks N1 and N2, specific responses were observed when clicks with an intensity of 85 dB or "rarefaction" clicks were used. Dependence of the amplitude of these responses on the intensity of acoustic stimuli of different polarity was investigated during a change in the rhythm of the stimulation; the effect of different rhythms of stimulation on the gradient of the curve reflecting this relationship was examined. The possible mechanisms of the effect of stimulus frequency are discussed.
The parameters of the cochlear round window responses to stimulation by acoustic clicks of different intensity, polarity and frequency were studied in experiments on anesthetized cats. The intensity function reflecting the dependence of the amplitude of potential change upon the level of stimulating click included two parts differing in slope. The dependence of the electric responses on the stimulus intensity and frequency was also studied. A specific form of the reaction was found in some cases. The study of all these parameters gives us some reasons to make a conclusion on the function of the auditory nerve.
A complex setup for diagnosing affections involving the auditory system of man is described. The algorhythm of the setup functioning is depicted in detail, its main task consisting in segregation of the signal produced by the potential from the noise--the background activity of the human brain cortex. The functioning of the complex setup in dynamics by following the given algorhythm is shown.