Supplementary Data from Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Prediagnostic Blood Measurements

PDF - 84KB, Joint effects of smoking and occupational exposure to aromatic amines and polycyclic aromatic hydrocarbons on the risk of bladder cancer (754 cases and 833 controls).

PDF - 84KB, Association of working in at-risk occupations with bladder cancer in men (609 cases and 665 controls) and women (145 cases and 168 controls) from EPIC.

Supplemental Table S1: ORs (95% CI) for risk of CRC by quartiles of baseline biomarkers of anti-LPS- and antiflagellin- IgA and IgG. Supplemental Table S2: ORs (95% CI) for risk of CRC by increasing levels of total bacterial exposure and high sensitivity C-reactive protein, waist circumference, BMI, total dietary fat, and alcohol intake; stratified by sex. Supplemenetal Table S3: ORs (95% CI) for risk of CRC by quartile of baseline biomarkers of anti-LPS- and antiflagellin- IgA and IgG after excluding cases and controls that occurred in the first 2 years of follow-up, stratified by sex

Supplementary Table S1. Adjusteda geometric mean prolactin levels, ng/ml (95% CI) by established correlates at the time of blood donation. Supplementary Table S2. Adjusteda geometric mean prolactin levels, ng/ml (95% CI) depending on the anthropometric factors. Supplementary Table S3. Adjusteda geometric mean prolactin levels, ng/ml (95% CI) depending on the lifestyle factors.

Perspective on This Article from Anthropometric Measures, Physical Activity, and Risk of Glioma and Meningioma in a Large Prospective Cohort Study

BACKGROUND In September 2015, the four-component, protein-based meningococcal serogroup B vaccine (4CMenB; Bexsero) became available for private purchase in Spain. METHODS We conducted a nationwide matched case-control study to assess the effectiveness of 4CMenB in preventing invasive meningococcal disease in children. The study included all laboratory-confirmed cases of invasive meningococcal disease in children younger than 60 months of age between October 5, 2015, and October 6, 2019, in Spain. Each case patient was matched with four controls according to date of birth and province. 4CMenB vaccination status of the case patients and controls was compared with the use of multivariate conditional logistic regression. RESULTS We compared 306 case patients (243 [79.4%] with serogroup B disease) with 1224 controls. A total of 35 case patients (11.4%) and 298 controls (24.3%) had received at least one dose of 4CMenB. The effectiveness of complete vaccination with 4CMenB (defined as receipt of at least 2 doses, administered in accordance with the manufacturer's recommendations) was 76% (95% confidence interval [CI], 57 to 87) against invasive meningococcal disease caused by any serogroup, and partial vaccination was 54% (95% CI, 18 to 74) effective. Complete vaccination resulted in an effectiveness of 71% (95% CI, 45 to 85) against meningococcal serogroup B disease. Vaccine effectiveness with at least one dose of 4CMenB was 64% (95% CI, 41 to 78) against serogroup B disease and 82% (95% CI, 21 to 96) against non-serogroup B disease. With the use of the genetic Meningococcal Antigen Typing System, serogroup B strains that were expected to be covered by 4CMenB were detected in 44 case patients, none of whom had been vaccinated. CONCLUSIONS Complete vaccination with 4CMenB was found to be effective in preventing invasive disease by serogroup B and non-serogroup B meningococci in children younger than 5 years of age.

PDF file - 172KB, Supplementary Figure 1. Cut-off points for categories of alcohol consumption by study included in the metaanalysis. Supplementary Table 1. Description of the BCAC studies. Supplementary Table 2. Characteristics of the SEARCH study by post-diagnosis alcohol consumption. Supplementary Table 3. Characteristics of the EPIC study by pre-diagnosis alcohol consumption. Supplementary Table 4. Distribution of alcohol consumption by country in the EPIC cohort. Supplementary Table 5. Characteristics of the BCAC studies. Supplementary Table 6. Association of alcohol consumption and mortality. Supplementary Table 7. Association of alcohol consumption and mortality in patients with stage I and II tumours compared to all patients in SEARCH.

Fundamento. Desde septiembre de 2020, los centros escolares permanecieron abiertos bajo medidas de prevención de la infección por COVID-19 y una estrecha vigilancia y control por parte de Salud Pública. Métodos. Se describió la organización y el procedimiento de rastreo escolar durante la pandemia de COVID-19 en Navarra. Se estudió el alumnado rastreado, cuarentenas escolares, transmisión en el aula, e impacto en la actividad educativa. Resultados. El rastreo fue desarrollado por el Departamento de Salud en coordinación con el Departamento de Educación. Durante el curso 2020/21, la incidencia en escolares fue similar o inferior a la población general y las ondas epidémicas no mostraron relación con los periodos lectivos. El 26% del alumnado, mayormente de educación infantil y primaria, estuvo en cuarentena. La tasa de ataque secundaria (TAS) en las aulas fue inferior al 5%. En el curso 2021/22, la incidencia aumentó con la entrada de la variante Ómicron. Se indicó cuarentena en el 17% del alumnado de infantil y primaria durante el primer trimestre, y en el 11% durante el segundo. La TAS ascendió al 18% en el primer trimestre, y la transmisión alcanzó niveles muy altos en el segundo, con grandes brotes. Las cuarentenas tuvieron un gran impacto en la actividad lectiva. Conclusiones. La gestión de casos y contactos en el ámbito escolar resultó de suma importancia para mantener un balance equilibrado entre la seguridad y el control de la pandemia en las aulas, y asegurar las garantías pedagógicas y el bienestar de la infancia.

PDF - 80KB, Association of smoking and occupational exposure with bladder cancer by NAT2 acetylation in cases and controls from EPIC.

BACKGROUND: Iron is an essential micronutrient with differing intake patterns and metabolism between men and women. Epidemiologic evidence on the association of dietary iron and its heme and non-heme components with colorectal cancer (CRC) development is inconclusive. METHODS: We examined baseline dietary questionnaire-assessed intakes of total, heme, and non-heme iron and CRC risk in the EPIC cohort. Sex-specific multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were computed using Cox regression. We modelled substitution of a 1 mg/day of heme iron intake with non-heme iron using the leave one-out method. RESULTS: Of 450,105 participants (318,680 women) followed for 14.2 +/- 4.0 years, 6162 (3511 women) developed CRC. In men, total iron intake was not associated with CRC risk (highest vs. lowest quintile, HRQ5vs.Q1:0.88; 95%CI:0.73, 1.06). An inverse association was observed for non-heme iron (HRQ5vs.Q1:0.80, 95%CI:0.67, 0.96) whereas heme iron showed a non-significant association (HRQ5vs.Q1:1.10; 95%CI:0.96, 1.27). In women, CRC risk was not associated with intakes of total (HRQ5vs.Q1:1.11, 95%CI:0.94, 1.31), heme (HRQ5vs.Q1:0.95; 95%CI:0.84, 1.07) or non-heme iron (HRQ5vs.Q1:1.03, 95%CI:0.88, 1.20). Substitution of heme with non-heme iron demonstrated lower CRC risk in men (HR:0.94; 95%CI: 0.89, 0.99). CONCLUSIONS: Our findings suggest potential sex-specific CRC risk associations for higher iron consumption that may differ by dietary sources.

PDF file - 100K, Relative risks (RR-s) and 95% confidence intervals (CI-s) of colon, rectal and colorectal cancer according to sex-specific quintiles of baseline leptin concentrations, in men and women , the European Prospective Investigation into Cancer and Nutrition (EPIC), 1992-2003

PDF file - 101K, Relative risks (RR-s) and 95% confidence intervals (CI-s) of colon, rectal and colorectal cancer according to sex-specific quintiles of baseline soluble leptin receptor (sOB-R) concentrations, in men and women, the European Prospective Investigation into Cancer and Nutrition (EPIC), 1992-2003

Fundamento. Desde septiembre de 2020, los centros escolares permanecieron abiertos bajo medidas de prevención de la infección por COVID-19 y una estrecha vigilancia y control por parte de Salud Pública. Métodos. Se describió la organización y el procedimiento de rastreo escolar durante la pandemia de COVID-19 en Navarra. Se estudió el alumnado rastreado, cuarentenas escolares, transmisión en el aula, e impacto en la actividad educativa. Resultados. El rastreo fue desarrollado por el Departamento de Salud en coordinación con el Departamento de Educación. Durante el curso 2020/21, la incidencia en escolares fue similar o inferior a la población general y las ondas epidémicas no mostraron relación con los periodos lectivos. El 26% del alumnado, mayormente de educación infantil y primaria, estuvo en cuarentena. La tasa de ataque secundaria (TAS) en las aulas fue inferior al 5%. En el curso 2021/22, la incidencia aumentó con la entrada de la variante Ómicron. Se indicó cuarentena en el 17% del alumnado de infantil y primaria durante el primer trimestre, y en el 11% durante el segundo. La TAS ascendió al 18% en el primer trimestre, y la transmisión alcanzó niveles muy altos en el segundo, con grandes brotes. Las cuarentenas tuvieron un gran impacto en la actividad lectiva. Conclusiones. La gestión de casos y contactos en el ámbito escolar resultó de suma importancia para mantener un balance equilibrado entre la seguridad y el control de la pandemia en las aulas, y asegurar las garantías pedagógicas y el bienestar de la infancia.

Fundamento. Desde septiembre de 2020, los centros escolares permanecieron abiertos bajo medidas de prevención de la infección por COVID-19 y una estrecha vigilancia y control por parte de Salud Pública. Métodos. Se describió la organización y el procedimiento de rastreo escolar durante la pandemia de COVID-19 en Navarra. Se estudió el alumnado rastreado, cuarentenas escolares, transmisión en el aula, e impacto en la actividad educativa. Resultados. El rastreo fue desarrollado por el Departamento de Salud en coordinación con el Departamento de Educación. Durante el curso 2020/21, la incidencia en escolares fue similar o inferior a la población general y las ondas epidémicas no mostraron relación con los periodos lectivos. El 26% del alumnado, mayormente de educación infantil y primaria, estuvo en cuarentena. La tasa de ataque secundaria (TAS) en las aulas fue inferior al 5%. En el curso 2021/22, la incidencia aumentó con la entrada de la variante Ómicron. Se indicó cuarentena en el 17% del alumnado de infantil y primaria durante el primer trimestre, y en el 11% durante el segundo. La TAS ascendió al 18% en el primer trimestre, y la transmisión alcanzó niveles muy altos en el segundo, con grandes brotes. Las cuarentenas tuvieron un gran impacto en la actividad lectiva. Conclusiones. La gestión de casos y contactos en el ámbito escolar resultó de suma importancia para mantener un balance equilibrado entre la seguridad y el control de la pandemia en las aulas, y asegurar las garantías pedagógicas y el bienestar de la infancia.

Supplemental Table 1 shows associations between candidate biomarkers and breast cancer risk in women postmenopausal at blood collection using 5-year risk from Pfeiffer's model as a regression offset. ORs are estimated per doubling of concentration (from log2-transformed measurements) Supplemental Table 2 shows the estimated biomarker effects on risk of breast cancer, per doubling of concentration, in women postmenopausal at blood collection. The estimates provided are adjusted for Pfeiffer's risk score from the common model (i.e. mutually adjusted) and in the selected model. Supplemental Table 3 shows the performance of the full and selected models in women postmenopausal at blood collection in terms of concordance-statistic ("C"), integrated discrimination improvement index (IDI), and net-reclassification improvement (NRI continuous), each with 95%-Confidence interval and optimism-correction from 1000 bootstrap-samples.

Background Previous studies had limited power to assess the associations of circulating insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) with clinically relevant prostate cancer as a primary endpoint, and the association of genetically predicted IGF-I with aggressive prostate cancer is not known. We aimed to investigate the associations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 concentrations with overall, aggressive and early-onset prostate cancer. Methods Prospective analysis of biomarkers using the Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset (up to 20 studies, 17 009 prostate cancer cases, including 2332 aggressive cases). Odds ratios (OR) and 95% confidence intervals (CI) for prostate cancer were estimated using conditional logistic regression. For IGF-I, two-sample Mendelian randomization (MR) analysis was undertaken using instruments identified using UK Biobank (158 444 men) and outcome data from PRACTICAL (up to 85 554 cases, including 15 167 aggressive cases). Additionally, we used colocalization to rule out confounding by linkage disequilibrium. Results In observational analyses, IGF-I was positively associated with risks of overall (OR per 1 SD = 1.09: 95% CI 1.07, 1.11), aggressive (1.09: 1.03, 1.16) and possibly early-onset disease (1.11: 1.00, 1.24); associations were similar in MR analyses (OR per 1 SD = 1.07: 1.00, 1.15; 1.10: 1.01, 1.20; and 1.13; 0.98, 1.30, respectively). Colocalization also indicated a shared signal for IGF-I and prostate cancer (PP4: 99%). Men with higher IGF-II (1.06: 1.02, 1.11) and IGFBP-3 (1.08: 1.04, 1.11) had higher risks of overall prostate cancer, whereas higher IGFBP-1 was associated with a lower risk (0.95: 0.91, 0.99); these associations were attenuated following adjustment for IGF-I. Conclusions These findings support the role of IGF-I in the development of prostate cancer, including for aggressive disease.

PDF file - 80K, Relative risks (RR-s) and 95% confidence intervals (CI-s) of colon, rectal and colorectal cancer according to quintiles of free leptin index (FLI), the European Prospective Investigation into Cancer and Nutrition (EPIC), 1992-2003