Purpose: With its six member Networks, Connecting Organisations for Regional Disease Surveillance (CORDS – www.cordsnetwork.org) aims to contain outbreaks at the source and keep communities safe from the spread of infectious diseases in animals and humans. One of its strategies is to promote innovations that strengthen event-based surveillance (EBS) at community level. Supported by a grant from The Rockefeller Foundation, and a collaboration with Ending Pandemics, the CORDS member Networks have started to assess EBS systems and practices, with a focus on cross border sites in selected countries in Sub-Saharan Africa, Southeast Asia, the Middle East and Southeast Europe, in order to share current collection methods of human and animal health events and identify areas of improvement. Methods & Materials: A mixed methods design was employed. A standardised assessment tool was developed in web and paper-based formats to include quantitative and qualitative indicators to be assessed at national, regional and local levels. The tool assessed multiple domains in relation to EBS systems and processes, data collection tools and sources, event verification and response and inter-sectoral collaboration and cross border surveillance. Supplementary data collection methods of structured interviews with key stakeholders, document reviews and observations were used to obtain information. Networks received online training on the tool and trained data collectors within their Networks. Pre-testing and piloting of the tool was undertaken within Networks and experiences shared at a Network wide meeting. The main implementation phase is currently underway. Results: Fifty-three cross border sites are included in the assessment across 14 countries (Indonesia, Laos, Thailand, Vietnam, Burundi, Kenya, Tanzania, Uganda, Israel, Jordan, Palestinian territories, Albania, Kosovo and Macedonia). We present the results of the process of implementing this methodology at a multi-country level and the opportunities and challenges of this approach and potential for scale-up at a wider level. Conclusion: Cross border areas remain particularly at risk from disease outbreaks, however there is poor understanding of EBS practices within these settings. This research provides a standardised methodology to assess EBS systems across regions of the world with a focus on One Health and the use of digital tools.