Repeated high-g shocks and whole-body vibration (WBV) as experienced by operators of High-Speed Craft (HSC) increase the risk of fatigue, back pain, and acute and chronic injuries, especially in the lumbar region of the spine. Studies on abdominal belts have suggested their beneficial effects on lumbar torso stabilisation and back pain mitigation in both weight lifting and HSC scenarios. This paper presents a human musculoskeletal model to simulate belt effects for occupants on HSC under high-g shocks. Parameters included the shock severity with peak acceleration ranging from 3 g to 10 g, human dimensions and muscle strengths, the belt width and belt forces are investigated. The results show an average of 120% increase in the intra-abdominal pressure (IAP), a 9% reduction in the transverse abdominis activities, and a 12% reduction in the spinal compressive force at the L4/L5 joints when the abdominal belt is added to the human model. In conclusion, wearing an abdominal belt significantly assists abdominal muscles and maintains a solid core during intense WBV generated in different shock severity levels. It may cause a small negative influence on the neck region with a 2.4% increase in the shear force at the C4/C5 joints.

Engineered tissues provide an alternative to graft material, circumventing the use of donor tissue such as autografts or allografts and non‐physiological synthetic implants. However, their lack of vasculature limits the growth of volumetric tissue more than several millimeters thick which limits their success post‐implantation. Perfused bioreactors enhance nutrient mass transport inside lab‐grown tissue but remain poorly customizable to support the culture of personalized implants. Here, a multiscale framework of computational fluid dynamics (CFD), additive manufacturing, and a perfusion bioreactor system are presented to engineer personalized volumetric tissue in the laboratory. First, microscale 3D printed scaffold pore geometries are designed and 3D printed to characterize media perfusion through CFD and experimental fluid testing rigs. Then, perfusion bioreactors are custom‐designed to combine 3D printed scaffolds with flow‐focusing inserts in patient‐specific shapes as simulated using macroscale CFD. Finally, these computationally optimized bioreactor‐scaffold assemblies are additively manufactured and cultured with pre‐osteoblast cells for 7, 20, and 24 days to achieve tissue growth in the shape of human calcaneus bones of 13 mL volume and 1 cm thickness. This framework enables an intelligent model‐based design of 3D printed scaffolds and perfusion bioreactors which enhances nutrient transport for long‐term volumetric tissue growth in personalized implant shapes. The novel methods described here are readily applicable for use with different cell types, biomaterials, and scaffold microstructures to research therapeutic solutions for a wide range of tissues.

Repeated High-G shocks and whole-body vibration (WBV) can increase the risk of fatigue and injuries in the lumbar region of the spine for crew and passengers on high-speed craft (HSC). Existing reviews have suggested the beneficial effects of abdominal belts regarding lumbar torso stabilization and spinal unloading. The paper provides a novel 3D seated human model with a virtual belt to simulate the belt effects for occupants on HSC. The model is built with AnyBody, a commercial software for musculoskeletal simulation based on the inverse dynamics method. The belt behaves like an additional force exerted in the lumbar region, and the force magnitude has been optimized to avoid discomfort during long journeys. The belt effects have been studied with different levels of wave shock, anthropometries, and belt design parameters such as belt width and position. Wave shocks exerted on seat surface are considered to be vertical acceleration and expressed with a half-sine pulse. The belt effects are evaluated with intra-abdominal pressure (IAP), transversus muscle activities, and spinal compressive force. The results have shown a combined increase of IAP (120%) and a decrease of spinal compressive force at the L4/L5 joint (13%) once the belt is applied under various circumstances. Transversus muscle activity is also reduced with belt application. The belt performs best when it covers the entire lumbar region. Reduction of belt width might lead to increased muscle activity for the muscle that is not covered by the belt, inducing over-recruited muscle. For the same belt width, belt position variations are irrelevant to the belt performance. It has been validated that the abdominal belt can significantly assist abdominal muscles and maintain a solid core during intense WBV generated in different sea states, reducing fatigue and the risk of injury to the lumbar. Therefore, the model can be a preliminary guide for designing the abdominal belt.

Over the past decade, the use of AR has significantly increased over a wide range of applications. Although there are many good examples of AR technology being used in engineering, retail, and for entertainment, the technology has not been widely adopted for teaching in university engineering departments. It is generally accepted that the use of AR can complement the students’ learning experience by improving engagement and by helping to visualise complex engineering physics; however, several key challenges still have to be addressed to fully integrate the use of AR into a broader engineering curriculum. The presented paper reviews the uses of AR in engineering education, highlights the benefits of AR integration in engineering curriculums, as well as the barriers that are preventing its wider adoption.

Background Adverse neurological events associated with left ventricular assist devices (LVADs) have been suspected to be related to thrombosis. This study aimed to understand the risks of thrombosis with variations in the implanted device orientation. A severely dilated pulsatile patient-specific left ventricle, modelled with computational fluid dynamics, was utilised to identify the risk of thrombosis for five cannulation angles. With respect to the inflow cannula axis directed towards the mitral valve, the other angles were 25° and 20° towards the septum and 20° and 30° towards the free wall. Results Inflow cannula angulation towards the free wall resulted in longer blood residence time within the ventricle, slower ventricular washout and reduced pulsatility indices along the septal wall. Based on the model, the ideal inflow cannula alignment to reduce the risk of thrombosis was angulation towards the mitral valve and up to parallel to the septum, avoiding the premature clearance of incoming blood. Conclusions This study indicates the potential effects of inflow cannulation angles and may guide optimised implantation configurations; however, the ideal approach will be influenced by other patient factors and is suspected to change over the course of support.

Polyurethane foams have unique properties that make them suitable for a wide range of applications, including cushioning and seat pads. The foam mechanical properties largely depend on both the parent material and foam cell microstructure. Uniaxial loading experiments, X-ray tomography and finite element analysis can be used to investigate the relationship between the macroscopic mechanical properties and microscopic foam structure. Polyurethane foam specimens were scanned using X-ray computed tomography. The scanned geometries were converted to three-dimensional (3D) CAD models using open source, and commercially available CAD software tools. The models were meshed and used to simulate the compression tests using the implicit finite element method. The calculated uniaxial compression tests were in good agreement with experimental results for strains up to 30%. The presented method would be effective in investigating the effect of polymer foam geometrical features in macroscopic mechanical properties, and guide manufacturing methods for specific applications.

PURPOSE:Rotary blood pumps (RBPs) employed as ventricular assist devices are developed to support the ventricles of patients suffering from heart failure. Computational Fluid Dynamics (CFD) is frequently used to predict the performance and haemocompatibility of these pumps during development, however different simulation techniques employed by various research groups result in inconsistent predictions. This inconsistency is further compounded by the lack of standardised model validation, thus it is difficult to determine which simulation techniques are accurate. To address these problems, the US Food and Drug Administration (FDA) proposed a simplified centrifugal RBP benchmark model. The aim of this paper was to determine simulation settings capable of producing accurate predictions using the published FDA results for validation.METHODS:This paper considers several studies to investigate the impact of simulation options on the prediction of pressure and flow velocities. These included evaluation of the mesh density and interface position through steady simulations as well as time step size and turbulence models (k-ε realizable, k-ω SST, k-ω SST Intermittency, RSM ω-based, SAS and SBES) using a sliding mesh approach.RESULTS:The most accurate steady simulation using the k-ω turbulence model predicted the pressure to within 5% of experimental results, however experienced issues with unphysical velocity fields. A more computationally expensive transient simulation that used the Stress-Blended Eddy Simulation (SBES) turbulence model provided a more accurate prediction of the velocity field and pressure rise to within experimental variation.CONCLUSION:The findings of the study strongly suggest that SBES can be used to better predict RBP performance in the early development phase.

Design methods for large industrial pumps are well developed, but they cannot be relied upon when designing specialised miniature pumps, due to scaling issues. Therefore, the design and development phase of small pumps demand numerous experimental tests to ensure a viable prototype. Of initial interest is hydraulic design in the form of pump performance and efficiency curves. This project aimed to produce an automated test rig capable of generating both the performance (P-Q - pressure vs. flow rate) and efficiency curves that are reliable and repeatable. The apparatus is largely customizable and suitable for a range of smaller pump sizes. The pump impeller and volute were 3D printed, allowing for design flexibility and rapid prototyping and testing. The test loop was automated which allowed the flow rate to be incremented from 0 L/min to the maximum flow rate. At each step the pressure, flow rate, voltage and current were recorded to generate the P - Q and efficiency curves. Repeatability results showed low variations of +/- 3 mmHg (400 Pa) in pressure and +/- 2% in hydraulic efficiency. The given setup can be used to compare and evaluate the hydraulic performance of various pump designs. (C) 2020 The Author(s). Published by Elsevier Ltd.

Buoyancy-driven turbulent dispersion in a maturation pond is studied using a combination of field measurements and computational fluid dynamics. Modelling flow in maturation ponds requires turbulent closure models because of the large physical size and the need to model on diurnal timescales. Simulation results are shown to be more sensitive to the inclusion of a buoyancy production term appearing in the turbulent transport equations than to the model choice. Comparisons with experimental thermal profiles show that without this term, thermal mixing is over-predicted. When including the term, stratification occurs but thermal mixing is under-predicted in the lower water column. In terms of pond performance, the effect of this term is to cause increased surface die-off of Escherichia coli during sunlight hours due to the generation of stratification. It is recommended that future modelling consider and implement this term.

The flow regime around a hexagonal polygon with low Reynolds numbers Re < 200 is numerically investigated in two different orientations namely face- and corner oriented. The basic flow characteristics, including drag coefficient, lift coefficient, Strouhal number and critical Reynolds number of the hexagonal cylinders, are calculated by solving the Navier–Stokes and mass conservation (continuity) equations, using the Simple (semi-implicit method for pressure-linked equations) algorithm. Within the studied range of Re, the predicted lift coefficient and Strouhal number of the face-oriented hexagon were higher than those of the corner-oriented hexagon. In contrast, the predicted drag coefficient and critical Reynolds number of the corner-oriented hexagon were greater than those of the face-oriented one. Flow characteristics of a novel textured geometry are also studied using three-dimensional transient analysis. The Strouhal number St of the textured geometry was found to be in between the St of both the hexagonal cylinders, and its lift coefficient is lower than that of the hexagonal cylinders. The computational fluid dynamics results show that, within the studied Reynolds number range, the drag coefficient of the textured pipe is almost equal to that of the circular cylinder while its lift coefficient is substantially smaller than that of circular and face- and corner-oriented hexagon pipes.

Left ventricular assist devices are associated with thromboembolic events, which are potentially caused by altered intraventricular flow. Due to patient variability, differences in apical wall thickness affects cannula insertion lengths, potentially promoting unfavourable intraventricular flow patterns which are thought to be correlated to the risk of thrombosis. This study aimed to present a 3D multiscale computational fluid dynamic model of the left ventricle (LV) developed using a commercial software, Ansys, and evaluate the risk of thrombosis with varying inflow cannula insertion lengths in a severely dilated LV. Based on a HeartWare HVAD inflow cannula, insertion lengths of 5, 19, 24 and 50 mm represented cases of apical hypertrophy, typical ranges of apical thicknesses and an experimental length, respectively. The risk of thrombosis was evaluated based on blood washout, residence time, instantaneous blood stagnation and a pulsatility index. By introducing fresh blood to displace pre-existing blood in the LV, after 5 cardiac cycles, 46.7%, 45.7%, 45.1% and 41.8% of pre-existing blood remained for insertion lengths of 5, 19, 24 and 50 mm, respectively. Compared to the 50 mm insertion, blood residence time was at least 9%, 7% and 6% higher with the 5, 19 and 24 mm insertion lengths, respectively. No instantaneous stagnation at the apex was observed directly after the E-wave. Pulsatility indices adjacent to the cannula increased with shorter insertion lengths. For the specific scenario studied, a longer insertion length, relative to LV size, may be advantageous to minimise thrombosis by increasing LV washout and reducing blood residence time.

Rotary left ventricular assist devices (LVADs) are commonly operated at a constant speed, attenuating blood flow pulsatility. Speed modulation of rotary LVADs has been demonstrated to improve vascular pulsatility and pump washout. The effect of LVAD speed modulation on intraventricular flow dynamics is not well understood, which may have an influence on thromboembolic events. This study aimed to numerically evaluate intraventricular flow characteristics with a speed modulated LVAD. A severely dilated anatomical left ventricle was supported by a HeartWare HVAD in a three-dimensional multiscale computational fluid dynamics model. Three LVAD operating scenarios were evaluated: constant speed and sinusoidal co- and counter-pulsation. In all operating scenarios, the mean pump speed was set to restore the cardiac output to 5.0 L/min. Co- and counter-pulsation was speed modulated with an amplitude of 750 rpm. The risk of thrombosis was evaluated based on blood residence time, ventricular washout, kinetic energy densities, and a pulsatility index map. Blood residence time for co-pulsation was on average 1.8 and 3.7% lower than constant speed and counter-pulsation mode, respectively. After introducing fresh blood to displace preexisting blood for 10 cardiac cycles, co-pulsation had 1.5% less old blood in comparison to counter-pulsation. Apical energy densities were 84 and 27% higher for co-pulsation in comparison to counter-pulsation and constant speed mode, respectively. Co-pulsation had an increased pulsatility index around the left ventricular outflow tract and mid-ventricle. Improved flow dynamics with co-pulsation was caused by increased E-wave velocities which minimized blood stasis. In the studied scenario and from the perspective of intraventricular flow dynamics, co-pulsation of rotary LVADs could minimize the risk of intraventricular thrombosis.

Swimming resistance gearis aimed at conditioning competitive swimmers. As part of a training program,competitive swimmers are typically cycled through training strokes withelements of additional resistance to build strength, resilience and simulate fatigue.The challenge is provide variable resistance levels within a single session,dependent on specific needs and training objectives. In this paper variedconcepts were created that make use of remote wireless control systems and werecompared in a criteria weighted Pugh Matrix. The winning concept, a tetheredcone device, scored highly for its simplicity and cost. Although the product isinitially aimed at elite athletes, it is likely that the design will have utilityin recreational swimming and rehabilitation.; ;

Background: Implantation of a rotary blood pump (RBP) can cause non-physiological flow fields in the left ventricle (LV) which may trigger thrombosis. Different inflow cannula geometry can affect LV flow fields. The aim of this study was to determine the effect of inflow cannula geometry on intraventricular flow under full LV support in a patient specific model.Methods: Computed tomography angiography imaging of the LV was performed on a RBP candidate to develop a patient-specific model. Five inflow cannulae were evaluated, which were modelled on those used clinically or under development. The inflow cannulae are described as a crown like tip, thin walled tubular tip, large filleted tip, trumpet like tip and an inferiorly flared cannula. Placement of the inflow cannula was at the LV apex with the central axis intersecting the centre of the mitral valve. Full support was simulated by prescribing 5 l/min across the mitral valve. Thrombus risk was evaluated by identifying regions of stagnation. Rate of LV washout was assessed using a volume of fluid model. Relative haemolysis index and blood residence time was calculated using an Eulerian approach.Results: The inferiorly flared inflow cannula had the lowest thrombus risk due to low stagnation volumes. All cannulae had similar rates of LV washout and blood residence time. The crown like tip and thin walled tubular tip resulted in relatively higher blood damage indices within the LV.Conclusion: Changes in intraventricular flow due to variances in cannula geometry resulted in different stagnation volumes. Cannula geometry does not appreciably affect LV washout rates and blood residence time. The patient specific, full support computational fluid dynamic model provided a repeatable platform to investigate the effects of inflow cannula geometry on intraventricular flow.