Purpose of the study. It has already been emphasized that occupational cancers are underreported in France. A study was conducted in the Ile-de-France region on bladder cancer cases and sinonasal cancers aiming to evaluate the frequency of exposure to occupational carcinogens, to identify related sectors of activity and to facilitate compensation as occupational diseases (OD) and finalize a routine tool for the identification of relevant occupational exposures.Method. All incident cases of sinonasal cancer living in Ile-de-France and bladder cancer in workers living in three districts of Ile-de-France fully covered by social insurance as long-term diseases between 2005 and 2007 were eligible. Volunteer subjects answered a detailed occupational questionnaire. Evaluation of exposure to aromatic amines and polycyclic aromatic hydrocarbons was performed by two experts in occupational diseases, with information returned to the usual doctor, and suggestion of claim for compensation as OD when appropriate. The number of claims for OD and/or compensation as OD was studied.Results. Among 1162 eligible cases of bladder cancer, 58% volunteered to participate. Claim for compensation as OD was proposed to 7% of the subjects, but only 22% of them did. Among 151 eligible cases of sinonasal cancer, 48% participated. Claim for compensation as OD was proposed to 35% of the subjects and only 53% of them did. All claims for compensation as OD were accepted.Conclusion. A substantial fraction of patients with bladder cancer or sinonasal cancer could claim for compensation as OD in this series, but few of them did. As individual and collective medico-social issues of compensation for OD are important, information of physicians and patients should be reinforced. Moreover, systematic identification of occupational exposure should be proposed to incident cases of bladder or sinonasal cancer cases. (c) 2012 Elsevier Masson SAS. All rights reserved.

L’activité agricole est en interaction avec d’autres activités anthropiques potentiellement émettrices de Polluants Organiques Persistants (POP). Ces molécules posent des problèmes de transfert dans la chaîne alimentaire, notamment vers les produits animaux. Les POP sont caractérisés par une forte rémanence, une volatilité élevée et une lipophilicité marquée entraînant leur accumulation potentielle dans les tissus adipeux. Ce groupe de molécules potentiellement toxiques pour l’homme et l’environnement fait l’objet d’une attention internationale. L’objectif de cette synthèse est d’aborder le devenir de trois familles de composés POP, de type hydrocarbures polycycliques: les dioxines-furanes (PCDD/F), les polychlorobiphényls (PCB) et les hydrocarbures aromatiques polycycliques (HAP). Les résultats de recherche montrent une contamination significative des fourrages situés en zones exposées aux polluants par comparaison avec des zones isolées. Ils mettent également en évidence un transfert différentiel de ces molécules toxiques vers les matrices biologiques dont le lait.Human activities produce polluting compounds such as the Persistent Organic Pollutants group (POPs) which may interact with agriculture. These molecules raised concern about risk of transfer through the food chain via the animal product. The POPs are characterised by a strong persistence in the environment, a high volatility and a lipophilicity which lead to their accumulation in fat tissues. These compounds are enlisted in international conventions to organise the information about their potential toxicity for humans and the environment. The aim of this paper is to study transfer in the food chain of three groups of POPs: the dioxins-furans (PCDD/F), the polychlorobiphenyls (PCB) and the Polycyclic Aromatic Hydrocarbons (PAH). The results show that the contamination of fodder by these compounds is observed when they are exposed to emission sources compared to remote areas. They also show that a differential transfer of the molecules is detected towards biological matrices (milk).

SAA1-O-04 The aim of this multicentric case-control study was to evaluate the frequency of occupational causes of bladder cancer and the distribution of exposure situations. Between 1998 and 2004, 316 male incident cases of bladder cancer and 316 male controls matched on age were recruited in 5 hospitals. Each subject had a face-to-face interview to collect information on tobacco consumption and on the complete job history occupational exposure to polycyclic aromatic hydrocarbon (PAH), aromatic amines (AA), and nitrosamines (NA) evaluated by 2 occupational experts, blindly according to the case/control status. For each subject, a cumulative exposure index (CEI) to PAH, AA, and NA was calculated, taking into account probability, frequency, and exposure level for all job periods during the working life. Logistic regression analyses were performed to calculate odds ratios (OR) with corresponding 95% confidence intervals (CI) for bladder cancer occurrence and PAH, AA, and NA exposures, adjusted for age and tobacco smoking. As expected, this study shows a dose-effect relationship between tobacco consumption levels and risk of bladder cancer (OR = 1.97; 95% CI, 1.14–3.41) for low tobacco consumption level (1–20 pack-years [PY], 5.36; 95% CI, 3.14–9.16) for high tobacco consumption level (21–40 PY and 11.66; 95% CI, 6.63–20.48) for very high tobacco consumption level (>40 PY). A dose-response relationship was observed between probability of exposure to PAH or cumulative exposure index to PAH and risk of bladder cancer after adjustment on age and tobacco consumption (OR = 2.31; 95% CI, 1.39–3.85) for definite exposure and OR = 1.93 (95% CI, 1.08–3.43) for higher CEI). By contrast, no relationship was identified between AA or NA and bladder cancer in this series. Excess bladder cancer risks were observed in various occupations, such as motor vehicle drivers (P < 0.0002), earthmoving plant or material handling drivers (P < 0.002), and sheet-metal workers (P < 0.0006) and in various industries, such as wood industry (P < 0.0002), ship building and repairing and manufacture of railroad equipment, motor vehicles and aircraft (P < 0.0005), freight transport by road (P < 0.006), and retail trade (P < 0.004). The lack of dose-response relationship between bladder cancer AA or NA exposures and bladder cancer could reflect a decrease of exposures to AA and NA in a few decades. By contrast, the relationship between PAH exposure and bladder cancer justifies going deeply into exposure situations identified of this study in order to propose specific prevention programs.