Clinical OtolaryngologyVolume 43, Issue 1 p. 328-332 CORRESPONDENCE: OUR EXPERIENCE Nasal compliance measurement for diagnosis of idiopathic non-allergic rhinitis: A prospective case-controlled study of 63 patients B. Louis, B. Louis INSERM, U955, E13, Créteil, France Faculté de Médecine, Université Paris-Est, Créteil, France CNRS, ERL 7240, Créteil, FranceSearch for more papers by this authorE. Bequignon, E. Bequignon orcid.org/0000-0002-5193-5776 INSERM, U955, E13, Créteil, France Faculté de Médecine, Université Paris-Est, Créteil, France CNRS, ERL 7240, Créteil, France Department of Otolaryngology–Head and Neck Surgery, APHP, Mondor Hospital, Créteil, France AP-HP, Hôpital Henri-Mondor – A Chenevier et Hôpital intercommunal, service d'ORL et de chirurgie cervico-faciale, Créteil, FranceSearch for more papers by this authorM. Devars du Mayne, M. Devars du Mayne Department of Otolaryngology–Head and Neck Surgery, APHP, Mondor Hospital, Créteil, France AP-HP, Hôpital Henri-Mondor – A Chenevier et Hôpital intercommunal, service d'ORL et de chirurgie cervico-faciale, Créteil, FranceSearch for more papers by this authorF. Zerah-Lancner, F. Zerah-Lancner INSERM, U955, E13, Créteil, France Faculté de Médecine, Université Paris-Est, Créteil, France Department of Otolaryngology–Head and Neck Surgery, APHP, Mondor Hospital, Créteil, France AP-HP, Hôpital Henri-Mondor – A Chenevier, service de physiologie et d'explorations fonctionnelles, Créteil, FranceSearch for more papers by this authorC. Larger, C. Larger Department of Otolaryngology–Head and Neck Surgery, APHP, Mondor Hospital, Créteil, France AP-HP, Hôpital Henri-Mondor – A Chenevier, service de physiologie et d'explorations fonctionnelles, Créteil, FranceSearch for more papers by this authorD. Isabey, D. Isabey INSERM, U955, E13, Créteil, France Faculté de Médecine, Université Paris-Est, Créteil, France CNRS, ERL 7240, Créteil, FranceSearch for more papers by this authorA. Coste, A. Coste INSERM, U955, E13, Créteil, France Faculté de Médecine, Université Paris-Est, Créteil, France CNRS, ERL 7240, Créteil, France Department of Otolaryngology–Head and Neck Surgery, APHP, Mondor Hospital, Créteil, France AP-HP, Hôpital Henri-Mondor – A Chenevier et Hôpital intercommunal, service d'ORL et de chirurgie cervico-faciale, Créteil, FranceSearch for more papers by this authorJ.F. Papon, Corresponding Author J.F. Papon jean-francois.papon@aphp.fr INSERM, U955, E13, Créteil, France Faculté de Médecine, Université Paris-Est, Créteil, France CNRS, ERL 7240, Créteil, France AP-HP, Hôpital Kremlin-Bicetre, service d'ORL et de chirurgie cervico-faciale, Le Kremlin-Bicetre, France Correspondence J.F. Papon, Faculte de Medecine, INSERM U955 Equipe 13, Creteil Cedex, France. Email: jean-francois.papon@aphp.frSearch for more papers by this author B. Louis, B. Louis INSERM, U955, E13, Créteil, France Faculté de Médecine, Université Paris-Est, Créteil, France CNRS, ERL 7240, Créteil, FranceSearch for more papers by this authorE. Bequignon, E. Bequignon orcid.org/0000-0002-5193-5776 INSERM, U955, E13, Créteil, France Faculté de Médecine, Université Paris-Est, Créteil, France CNRS, ERL 7240, Créteil, France Department of Otolaryngology–Head and Neck Surgery, APHP, Mondor Hospital, Créteil, France AP-HP, Hôpital Henri-Mondor – A Chenevier et Hôpital intercommunal, service d'ORL et de chirurgie cervico-faciale, Créteil, FranceSearch for more papers by this authorM. Devars du Mayne, M. Devars du Mayne Department of Otolaryngology–Head and Neck Surgery, APHP, Mondor Hospital, Créteil, France AP-HP, Hôpital Henri-Mondor – A Chenevier et Hôpital intercommunal, service d'ORL et de chirurgie cervico-faciale, Créteil, FranceSearch for more papers by this authorF. Zerah-Lancner, F. Zerah-Lancner INSERM, U955, E13, Créteil, France Faculté de Médecine, Université Paris-Est, Créteil, France Department of Otolaryngology–Head and Neck Surgery, APHP, Mondor Hospital, Créteil, France AP-HP, Hôpital Henri-Mondor – A Chenevier, service de physiologie et d'explorations fonctionnelles, Créteil, FranceSearch for more papers by this authorC. Larger, C. Larger Department of Otolaryngology–Head and Neck Surgery, APHP, Mondor Hospital, Créteil, France AP-HP, Hôpital Henri-Mondor – A Chenevier, service de physiologie et d'explorations fonctionnelles, Créteil, FranceSearch for more papers by this authorD. Isabey, D. Isabey INSERM, U955, E13, Créteil, France Faculté de Médecine, Université Paris-Est, Créteil, France CNRS, ERL 7240, Créteil, FranceSearch for more papers by this authorA. Coste, A. Coste INSERM, U955, E13, Créteil, France Faculté de Médecine, Université Paris-Est, Créteil, France CNRS, ERL 7240, Créteil, France Department of Otolaryngology–Head and Neck Surgery, APHP, Mondor Hospital, Créteil, France AP-HP, Hôpital Henri-Mondor – A Chenevier et Hôpital intercommunal, service d'ORL et de chirurgie cervico-faciale, Créteil, FranceSearch for more papers by this authorJ.F. Papon, Corresponding Author J.F. Papon jean-francois.papon@aphp.fr INSERM, U955, E13, Créteil, France Faculté de Médecine, Université Paris-Est, Créteil, France CNRS, ERL 7240, Créteil, France AP-HP, Hôpital Kremlin-Bicetre, service d'ORL et de chirurgie cervico-faciale, Le Kremlin-Bicetre, France Correspondence J.F. Papon, Faculte de Medecine, INSERM U955 Equipe 13, Creteil Cedex, France. Email: jean-francois.papon@aphp.frSearch for more papers by this author First published: 13 July 2017 https://doi.org/10.1111/coa.12935Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume43, Issue1February 2018Pages 328-332 RelatedInformation

CuInSe2 was fabricated via mechanical milling of Cu, In, Se and self-propagating high temperature synthesis (SHS). The latter materials were thermally evaporated to obtain nanostructured thin films. The ball milled powders are obtained using a rotational disk speed of 300 rpm and a milling time of 15 and 30 min. On the other hand, the SHS process was carried out on the mixed cold pressed powder of Cu, In and Se, owing to a graphite plate heated by a high intensity electrical current. The investigated materials were analyzed by X-ray diffraction. They exhibited a chalcopyrite like-structure. Rietveld method combined with Fourier analysis using Maud program was exploited to fit X-ray diffraction data. The chemical bounding is studied by X-ray photoelectron spectroscopy (XPS). SEM analysis revealed that the obtained thin films were nanostructured.

Nasal compliance is a measure related to the blood volume in the nasal mucosa. The objective of this study was to better understand the vascular response in vasomotor rhinitis by measuring nasal cross-sectional area and nasal compliance before and after mucosal decongestion in 10 patients with vasomotor rhinitis compared with 10 healthy subjects. Nasal compliance was inferred by measuring nasal area by acoustic rhinometry at pressures ranging from atmospheric pressure to a negative pressure of -10 cmH(2)O. Mucosal decongestion was obtained with one puff per nostril of 0.05% oxymetazoline. At atmospheric pressure, nasal cross-sectional areas were similar in the vasomotor rhinitis group and the healthy subject group. Mucosal decongestion did not induce any decrease of nasal compliance in patients with vasomotor rhinitis in contrast with healthy subjects. Our results support the hypothesis, already proposed, of an autonomic dysfunction based on a paradoxical response of the nasal mucosa in vasomotor rhinitis. Moreover, the clearly different behavior between healthy subjects and vasomotor rhinitis subjects suggests that nasal compliance measurement may therefore represent a potential line of research to develop a diagnostic tool for vasomotor rhinitis, which remains a diagnosis of exclusion.

We have developed a discrete multisegmental model describing the coupling between inspiratory flow and nasal wall distensibility. This model is composed of 14 individualized compliant elements, each with its own relationship between cross-sectional area and transmural pressure. Conceptually, this model is based on flow limitation induced by the narrowing of duct due to collapsing pressure. For a given inspiratory pressure and for a given compliance distribution, this model predicts the area profile and inspiratory flow. Acoustic rhinometry and posterior rhinomanometry were used to determine the initial geometric area and mechanical characteristics of each element. The proposed model, used under steady-state conditions, is able to simulate the pressure-flow relationship observed in vivo under normal conditions ( 4 subjects) and under pathological conditions ( 4 vasomotor rhinitis and 3 valve syndrome subjects). Our results suggest that nasal wall compliance is an essential parameter to understand the nasal inspiratory flow limitation phenomenon and the associated increase of resistance that is well known to physiologists. By predicting the functional pressure-flow relationship, this model could be a useful tool for the clinician to evaluate the potential effects of treatments.

STUDY OBJECTIVES To assess whether the dual anatomic origin of exhaled nitric oxide (NO), namely alveolar and bronchial, could explain the link between exhaled NO and airway responsiveness, and could participate in the bronchodilatory effect of deep inspiration (DI) that may be evidenced during methacholine challenge. DESIGN AND SETTING Prospective study in a laboratory performing pulmonary function tests of an academic hospital. PATIENTS AND INTERVENTIONS Patients underwent multiple flow analysis of exhaled NO, allowing calculation of total maximum airway NO flux (J'awno) and NO concentration of expansible compartment (CAno), and received a cumulative methacholine dose of 2,000 microg. DI effect was assessed by continuous measurement of the resistance of respiratory system using the forced oscillation technique before and after DI. RESULTS In a first phase involving 23 patients, a positive correlation between log values of J'awno and CAno was demonstrated with the degree of airway responsiveness (percentage of FEV(1) decrease). In a second phase involving 38 patients, only log CAno was correlated with responsiveness, and no significant relationship was demonstrated between J'awno or CAno and the effect of DI. Patients with smaller airways and/or distal airflow limitation exhibited a constrictive response to DI. CONCLUSION Airway responsiveness is mainly associated with an increase in distal origin of NO output, and no relationship between exhaled NO and the effect of DI was evidenced.

To explore the determinants of possible collapse of the nasal valve region, a common cause of nasal obstruction, we evaluated the mechanical properties of the nasal wall. In this study, we determined the nasal cross-sectional area-to-negative pressure ratio (nasal wall compliance) in the anterior part of the nose in six healthy subjects by measuring nasal area by acoustic rhinometry at pressures ranging from atmospheric pressure to a negative pressure of -10 cmH(2)O. Measurements were performed at baseline and after nasal mucosal decongestion (oxymetazoline). At baseline, nasal wall compliance increased progressively from the nasal valve (0.031 +/- 0.016 cm2/cmH(2)O, mean +/- SD) to the anterior and medial part of the inferior turbinate (0.045 +/- 0.024 cm2/cmH(2)O) and to the middle meatus region (0.056 +/- 0.029 cm2/cmH(2)O). After decongestant, compliances decreased and became similar in the three regions. On the basis of these results, we hypothesize that compliance of the nasal wall is partly related to mucosal blood volume and quantity of vascular tissue, which differ in the three regions, increasing from the nasal valve to the middle meatus.