Journal Article How the ‘HAMMER’ can help in effectively treating skin cancer Get access W. Hussain, W. Hussain Department of Mohs Micrographic and Reconstructive Surgery Search for other works by this author on: Oxford Academic Google Scholar C. Morris, C. Morris Division of Mohs Histotechnology, Leeds Centre for Dermatology, Leeds General Infirmary, Leeds LS1 3EX, U.K. E‐mail: dr_w_hussain@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar J. Christian J. Christian Division of Mohs Histotechnology, Leeds Centre for Dermatology, Leeds General Infirmary, Leeds LS1 3EX, U.K. E‐mail: dr_w_hussain@hotmail.com Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 167, Issue 2, 1 August 2012, Pages 454–455, https://doi.org/10.1111/j.1365-2133.2012.10930.x Published: 01 August 2012
TLC and liquid scintillation spectrometry were used to determine the identities and relative quantities of aspirin and its metabolites in the gastric juice, blood plasma, rumen (non- glandular portion), and corpus (glandular portion) of the rat stomach 4min. after the oral administration of aspirin-7-14C. It was found that aspirin and salicylic acid are the major components in the gastric juice, blood plasma, and rumen and corpus tissues. Trace levels of a compound with an Rce_ value corresponding to that of salicyluric acid was found in the fluids and tissues analyzed. No glucuronide conjugates of salicylic acid or polyhy- droxy metabolites of aspirin were found. The level of salicylic acid was fourfold higher in the corpus tissue than in the rumen tissue.
When albino rats were orally administered aspirin in buffer at pH 4.60 at a dose level of 50.0 mg./kg. body weight, all of the animals developed gastric erosions and bleeding within 2 hr. Under the same conditions and at the same dosage, Mongolian gerbils failed to develop these lesions. At higher dose levels of 100 and 200 mg./kg., some gerbils developed mild to moderate gastric lesions with some bleeding.
A comparison was made of the gastric absorption and distribution of sodium acetylsalicylate-7-14C with the absorption and distribution of sodium salts of other weakly acidic compounds. Each of the other compounds observed had an absorption pattern which was characteristic for the compound. Only sodium acetylsalicylate caused gastric lesions in the rat. The observations do not rule out the possibility that absorption characteristics of acetylsalicylic acid and its salts may be associated with their ability to cause gastric ulcers.
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