Luteoskyrin, a toxic metabolite ofPenicillium islandicum can be isolated by an acetone-Silica Gel chromatography column. A preliminary procedure separates the luteoskyrin and 2 other similar metabolites from the mycelial mat. The column used has the advantage of eluting the luteoskyrin as the first band from the source. A thin layer system utilizing CaHPO4 as stationary phase is also available to separate the components of the column and to verify isolation of luteoskyrin.

A comparison was made of the gastric absorption and distribution of sodium acetylsalicylate-7-14C with the absorption and distribution of sodium salts of other weakly acidic compounds. Each of the other compounds observed had an absorption pattern which was characteristic for the compound. Only sodium acetylsalicylate caused gastric lesions in the rat. The observations do not rule out the possibility that absorption characteristics of acetylsalicylic acid and its salts may be associated with their ability to cause gastric ulcers.