RATIONALE:Primary central nervous system Burkitt lymphoma (PCNSBL) is a rare and aggressive malignancy, particularly challenging to diagnose in immunocompetent individuals due to its nonspecific presentation. PATIENT CONCERNS:A 38-year-old immunocompetent woman presented with a 1-week history of progressively severe headaches in the left frontotemporal region, without systemic symptoms or significant laboratory abnormalities. DIAGNOSES:Advanced magnetic resonance imaging revealed a nodular lesion in the left frontal area, initially diagnosed as meningioma. Postsurgical histopathological analysis confirmed the diagnosis of Burkitt lymphoma, characterized by diffuse infiltration of medium-sized lymphocytes, a high MIB1 proliferation index, and Myc gene rearrangement. INTERVENTIONS:The patient underwent complete surgical resection of the tumor and a 5-cycle chemotherapy regimen based on high-dose methotrexate, without the need for radiotherapy due to the localized nature of the tumor and complete surgical removal. OUTCOMES:Postoperatively, the patient's headaches resolved, and no evidence of tumor recurrence was observed on magnetic resonance imaging after 11 months of follow-up. Additional examinations, including fluorodeoxyglucose-18-positron emission computed tomography, bone marrow biopsy, and cerebrospinal fluid cytology, confirmed the absence of systemic involvement. LESSONS:This case highlights the importance of considering PCNSBL in the differential diagnosis of brain tumors, even in immunocompetent patients. Early diagnosis and a tailored chemotherapy regimen can lead to favorable treatment outcomes, emphasizing the need for a multimodality approach in managing PCNSBL.

Rationale: Nocardia infection is commonly regarded as an opportunistic pulmonary pathogen affecting debilitated or immunocompromised individuals. Brain abscesses caused by Nocardia farcinica are rare and pose a diagnostic challenge. Traditional diagnostic techniques for identifying Nocardia species, such as blood culture, microscopy, and pathology, have shown inadequate performance. In the reported case, we applied metagenomic next-generation sequencing (mNGS) to diagnose a case of brain abscess due to N. farcinica. Patient concerns: A 66-year-old female developed a brain abscess after sustaining a hand injury. The patient exhibited a gradual change in personality and experienced tremors in her right upper limb for a duration of 1 month. Diagnoses: The pathogen responsible for the multiple brain abscesses was identified in the cerebrospinal fluid as N. farcinica through mNGS. Interventions:Antibiotic treatment included trimethoprim-sulfamethoxazole, linezolid, amikacin, meropenem, and moxifloxacin. Outcomes: The patient's symptoms and signs improved significantly after administration of antibiotics to which the pathogen is known to be sensitive. After 5 months of follow-up, magnetic resonance imaging of the head showed that the abscess was basically cured. The patient lived a normal life with no adverse drug reactions. Lessons: Nocardia brain infection is characterized by an insidious onset and lacks distinctive clinical and imaging features. mNGS was advantageous for the timely identification and management of Nocardia-associated brain abscess in the present case and obviated the need for invasive brain surgery. Expeditious and precise diagnosis coupled with prompt antibiotic therapy can significantly reduce the mortality rate associated with this condition.

Mixed germ cell tumors (mGCTs) involving both the ovaries and sellar region have been rarely reported; thus, they pose significant challenges in clinical management. Our report of a case of a 26-year-old female with left ovarian mGCTs (dysgerminoma + yolk sac tumor) who presented with postoperative headaches and blurred vision contributes new information to the literature on treating mGCTs, which can lead to standardized regimens and sequencing guidelines. A physical examination revealed right temporal hemianopia, and elevated levels of alpha-fetoprotein were detected in serum and cerebrospinal fluid. Magnetic resonance imaging (MRI) of the sellar region revealed a space-occupying lesion. Pathological examination of the tumor after endoscopic transnasal resection confirmed the diagnosis of mGCTs (germinomas + yolk sac tumor). The patient received adjuvant chemotherapy and radiotherapy at reduced dosages. During follow-up, tumor markers remained within normal limits, and there was no evidence of tumor recurrence on sellar region MRI. This case highlights the rarity of the simultaneous occurrence of ovarian and sellar region mGCTs and emphasizes the importance of accurate diagnosis and multidisciplinary management.

Rationale: Non-Hodgkin lymphoma affecting the brain, eyes, and cerebrospinal fluid without systemic spread is known as primary central nervous system lymphoma (PCNSL). While intracerebroventricular PCNSL is commonly found in the lateral ventricles and the third and fourth ventricles, the occurrence of PCNSL originating from the septum pellucidum is extremely rare. Patient Concerns: Two patients presented with recent memory loss and high cranial pressure. Diagnoses: Magnetic resonance imaging revealed a clear enhancing lesion in the septum pellucidum region. Pathological examination confirmed that both cases were primary large B-cell lymphoma GCB (germinal center B-cell-like) subtypes located in an “immune-privileged” area. Interventions: Both patients underwent total tumor resection, and the procedures were successfully completed without surgical complications. Outcomes: Over a 1-year period, treatment included four cycles of high-dose methotrexate combined with temozolomide. During the follow-up period (19–23 months), no recurrence of the lymphoma was observed. Lessons: In cases of PCNSL in the septum pellucidum, it is crucial to consider it as a potential differential diagnosis for intraventricular tumors. Surgical interventions should focus on maximizing tumor resection while ensuring the protection of critical structures like the fornix and peripheral neural components. The role of surgery compared to biopsy, as well as the long-term complications, necessitates extended follow-up. Additionally, an individualized treatment approach, considering factors such as age, Karnofsky performance score, and organ function assessment, can lead to positive outcomes.

Renal cell carcinoma (RCC) accounts for over 90% of primary renal tumors in adults. Although treatment approaches have steadily improved over the years, the prognosis outcome remains poor. With the aim of developing novel targets for RCC treatment, we explored the role of the circular RNA (circRNA) circ_001504 in the progression of RCC. We initially detected the expression of circ_001504 and microRNA (miRNA)-149 in RCC tissues and cells. RT-qPCR results showed that circ_001504 was highly expressed in RCC tissues, whereas miR-149 was poorly expressed. Interestingly, downregulation of circ_001504 suppressed malignant phenotypes in RCC cells, and upregulation of miR-149 exerted a similar effect. Bioinformatics analysis suggested potential binding sites between circ_001504 and miR-149, verified by a dual-luciferase reporter gene assay. Next, we identified nucleobindin 2 (NUCB2), a calcium-binding protein, as a target gene of miR-149. Furthermore, our data suggested that circ_001504 might serve as a competing endogenous RNA of miR-149, serving to elevate the expression of NUCB2. The silencing of circ_001504 resulted in decreased NUCB2 expression, which could be reversed by miR-149 inhibition. In addition, in vivo experiments demonstrated that circ_001504 depletion could suppress tumor growth in an established mouse RCC model. Collectively, reduced expression of circ_001504 lowered NUCB2 expression by sponging miR-149, thereby attenuating RCC progression, providing insight into circ_001504/miR-149/NUCB2 feedback loop into RCC treatment.

INTRODUCTION:LncRNA MALAT-1 expression is involved in regulating activities of non-small-cell lung cancer (NSCLC) cells. This study aimed to investigate the effects of lncRNA MALAT-1 on chemosensitivity of NSCLC cells by regulating autophagy. METHODS:We first validated the expression of lncRNA MALAT-1 in NSCLC cell lines. NSCLC cell lines with high lncRNA MALAT-1 expression were exposed to doxorubicin (DOX) to assess chemosensitivity. Further LncMAP database retrieval and ChIP, RIP and luciferase activity assays were conducted to explore interplay between lncRNA MALAT-1, RAD51, and E2F1. Immunofluorescence staining was performed to evaluate formation of autophagosomes in NSCLC cells. Ectopic expression and knockdown methods were used for in vitro mechanism experiments and in vivo substantiation. RESULTS:LncRNA MALAT-1 was overexpressed in NSCLC cells, and could promote NSCLC cell autophagy and inhibit its chemosensitivity. In vitro cell mechanism verification experiments showed that lncRNA MALAT-1 could recruit transcription factor E2F1 to bind to the promoter of RAD51, so as to promote the transcriptional expression of RAD51. In addition, cell function experiments in vitro showed that ectopically expressed lncRNA MALAT-1 promoted NSCLC cell autophagy and inhibited its chemosensitivity, while RAD51 knockdown negated its effect. Finally, in vivo animal experiments confirmed that lncRNA MALAT-1 silencing could impede the tumor growth. CONCLUSIONS:Taken together, this study revealed that silencing lncRNA MALAT-1 enhanced chemosensitivity of NSCLC cells by promoting autophagy, highlighting a feasible approach to prevent chemoresistance in NSCLC treatment.

In the realm of Parkinson's disease (PD) research, NLRP3 inflammasome-mediated pyroptosis has recently garnered significant attention as a potential novel form of dopaminergic neuronal death. Our previous research revealed the activation of innate immune-related genes, such as the TLR4 signaling pathway and interferon regulatory factor 7 (IRF7), although the specific mechanism remains unclear. Our current study shed light on whether the TLR4 signaling pathway and IRF7 can affect the pyroptosis of dopaminergic nerve cells and thus participate in the pathogenesis of PD. The PD model was constructed by MPP + treatment of PC12 cells or stereotactic injection of the striatum of SD rats, and the expression of genes were detected by RT-qPCR and Western Blotting. Lentivirus, siRNA and (5Z)-7-Oxozeaenol were used to validate the regulation of this pathway on pyroptosis. The expression of TLR4, TAK1, IRF7 and pyroptosis molecular markers was upregulated after MPP + treatment. IRF7 could affect dopaminergic neural cells pyroptosis by targeted regulation of NLRP3. Furthermore, inhibition of the TLR4/TAK1 signaling pathway led to a decrease in the expression of both IRF7 and NLRP3, while overexpression of IRF7 reversed the reduction in pyroptosis and increase in TH expression. TLR4/TAK1/IRF7 axis can promote PD by influencing pyroptosis through NLRP3.

Rationale: Erdheim-Chester disease (ECD) is a rare progressive disease affecting multiple systems. It has recently been recognized as a neoplastic disease following the discovery of activating mutations in the MAPK pathway. There are several striking signs of ECD, such as the long bone involvement, as well as the hairy kidney appearance on computed tomography scan. It is rare for ECD to manifest neurological symptoms. Central nervous system involvement is a strong prognostic factor and independent predictor of death. ECD is characterized by the overproduction and accumulation of foamy histiocytes and Touton’s giant cells in various tissues and organs. ECD is a multisystem disorder in which any organ may be affected. Patient concerns: This case report describes a 57-year-old woman with headaches and ataxia as the first clinical manifestation, without characteristic bone pain, but with delayed enuresis. In addition to the renal involvement, this patient had rarer splenic involvement. Diagnoses: The imaging presentation of this patient was similar to that of a “multiple meningiomas”. A combination of clinical, imaging and pathology for the diagnosis of ECD. Interventions: Patients were given INF-α therapy. Outcomes: Fortunately, the patient responded well to INF-α treatment. Lessons: ECD patient with neuro-endocrine symptoms.

目的 探讨脑功能区胶质瘤切除术应用术中磁共振成像(intraoperative magnetic resonance imaging,iMRI)联合神经电生理监测对脑功能区的保护作用.方法 2022年6-12月吉林大学第一医院诊治脑功能区胶质瘤患者26例,均行手术治疗.术前行多模态MRI检查,图像融合后导入神经导航系统,拟定手术切口及入路.全身麻醉下开颅,术中唤醒麻醉行皮层/皮层下直接电刺激定位运动、语言和感觉区皮层及皮下通路后切除肿瘤,肿瘤切除满意、脑移位明显、肿瘤边缘达到电生理预警(＜5 mm)时恢复全身麻醉行iMRI检查判断肿瘤残留情况.如发现肿瘤残留,将残留肿瘤重新标记并投射在显微镜下切除残留肿瘤至满意,然后再次行皮层下电刺激确定弓状束、锥体束的完整性.术后常规给予降颅压、营养神经及对症治疗,术后组织病理证实高级别胶质瘤患者于术后2～3周行替莫唑胺同步放化疗.记录术中iMRI显示的肿瘤全切除、次全切除率;记录术后并发症发生情况;比较术前及术后1、3个月KPS评分;随访至2023年4月,行MRI检查观察肿瘤复发情况.结果(1)26例中首次iMRI显示肿瘤全切20例,6例肿瘤残留者二次切除,再次iMRI显示4例肿瘤全切、2例肿瘤次全切除,首次肿瘤全切率为76.9％(20/26),再次肿瘤全切率为92.3％(24/26).(2)术后发生一过性语言加重3例,运动障碍加重5例,癫痫发作2例,给予尼莫地平、甲泼尼龙、甘露醇及丙戊酸钠治疗后逐渐恢复,无感染、颅内出血、癫痫持续状态及死亡发生.(3)随访至2023年4月,26例肿瘤均未复发.术前[(83.02± 4.76)分]及术后 1、3 个月 KPS 评分[(90.31±5.76)、(95.23±6.71)分]比较差异有统计学意义(F=4.845,P=0.010),术后1、3个月KPS评分均高于术前(t=4.975,P＜0.001;t=7.568,P＜0.001).结论 脑功能区胶质瘤切除术应用iMRI联合神经电生理监测可在保护神经功能的前提下最大化切除肿瘤,高级别胶质瘤患者术后行替莫唑胺同步放化疗可改善预后.

BACKGROUND:Lymphomatoid granulomatosis (LyG) is a rare extralymphatic lymphoproliferative disease characterized by lymphocytic invasion into vascular walls and damage to blood vessels. The lungs are affected in 90% of LyG cases, followed by the skin, central nervous system (CNS), kidneys and liver.CASE PRESENTATION:Here we report a case of a young woman with LyG, with CNS involvement as the initial clinical manifestation. Computer tomography (CT) scans showed multiple nodular, patchy and flocculent high-density shadows in both lungs without mediastinal lymph node enlargement. Magnetic resonance imaging (MRI) scans showed multiple abnormal signal intensities in the right cerebellar hemisphere, frontal, parietal and temporal lobes, and dorsal brainstem, which became patchy and annular after enhancement. The post-operative pathological analysis of lesion samples confirmed the diagnosis of grade II LyG.CONCLUSIONS:LyG should be concerned in young adults showing multiple radiological brain and lung lesions. Resection and postoperative medication of steroid hormones and IFN-α may be effective in the treatment of LyG.

Over the past decade, repeated studies demonstrated that the vertebrate brain had a specialized lymphatic transport pathway, which overturned the traditional concept of central nervous system (CNS) immune privilege. Despite the lack of lymphatic vessels, the glymphatic system and the meningeal lymphatic vessels provide a unique pathway for solutes transport and metabolites clearance in the brain. Sleep, circadian rhythm, arterial pulsation, and other physiological factors modulate this specialized lymphatic drainage pathway. It has also changed significantly under pathological conditions. These modulatory mechanisms may arise critical targets for the therapeutic of CNS disorders. This review highlights the latest research progress on the modulation of lymphatic transport in the CNS under physiological and pathological conditions. Furthermore, we examined the possible upstream and downstream relation networks between these regulatory mechanisms.

目的 对某三甲医院131I治疗场所辐射水平进行检测,了解其辐射水平.方法 25名甲癌患者共服用82880MBq的131I.患者服药后用X、γ射线测量仪检测病房周围剂量当量率;出院后用α、β表面污染仪检测病房表面污染;治疗期间和出院当天对131I治疗场所及办公区进行空气采样,用高纯锗γ能谱仪测量空气样品,数据处理后得到空气中131I浓度.结果 131I治疗病房周围剂量当量率为0.15～0.46 μSv/h.病房清理前表面污染为0.53～40.1 Bq/cm2,其中马桶最高.患者服药后4 h内,131I治疗场所及办公区走廊空气中131I浓度分别为1.74 Bq/m3和0.66 Bq/m3.131I治疗场所排风速率为0.50 m/s.患者治疗期间及出院当天,因通风导致空气中的131I浓度分别较前一天下降29.7％、79.7％和53.3％.结论 该场所外照射辐射水平较低且屏蔽效果较好;131I治疗病房清理前表面污染除马桶略高于标准要求外,其余均低于标准限值;通风是降低该场所空气中131I浓度的主要途径.

目的 了解某金矿作业矿工的健康状况,为改善金矿工人健康水平以及有针对性地制定有效保障金矿作业矿工健康的防治措施提供科学依据.方法 收集某金矿577名矿工职业健康体检数据,对体检结果进行分析与评价.结果 高血压检出率为41.9％(242/577),高血糖检出率为12.8％(74/577),心率异常检出率为24.6％(124/577),肝功能异常检出率为28.1％(162/577).且该金矿职工的高血压、高血糖检出率随年龄的增加呈现上升趋势,差异均有统计学意义(P＜0.05).结果 显示,女性发生高血压的危险性是男性的0.502倍,从事地下采掘工作者是从事地面工作者的2.353倍(P＜0.05);不同作业年限、工种的金矿职工高血糖检出率比较,差异有统计学意义(P＜0.05),从事地下采掘和其他工作者高血糖检出率明显高于地面工作者(P＜0.05).心率异常可能与粉尘接触和年龄有关,结果表明,暴露于地下粉尘因素者更易出现心率异常;随着年龄增加,心率异常检出率增加.肝功能异常与工作年限有关(P＜0.05),其中≥30 a工龄组肝功能异常检出风险是≤14a工龄组的1.683倍.结论 该金矿工人血压,血糖,心率以及肝功能均存在异常,其危险因素可能为年龄,工作年限,性别以及工种等.

Ischemic brain injury (IBI) is a common acute cerebral vessel disease that occurs secondary to blockage in arteries, mainly characterized by insufficient blood supply to the brain. The transcription factor c-Myc in IBI continues to be implicated in numerous studies. This study was conducted with emphasis placed on the underlying mechanism of c-Myc in IBI. Clinical samples were collected from IBI patients. Middle cerebral artery occlusion (MCAO) was induced in mice by inserting a suture from the external carotid artery to the anterior cerebral artery through the internal carotid artery to mechanically block the blood supply at the origin of the middle cerebral artery, and cortical neurons from mice were exposed to oxygen glucose deprivation (OGD) conditions for IBI model in vitro construction. RT-qPCR was performed to determine microRNA-23b (miR-23b) expression. TUNEL staining and Western blot analysis was conducted to detect apoptosis. The regulatory relationship was analyzed by dual-luciferase reporter gene assay. After loss- and gain-of-function assays, triphenyltetrazolium chloride staining was carried out to detect the area of cerebral infarction, after which the spatial memory in mice was evaluated with Morris water maze test. As per our findings, miR-23b was upregulated in the serum of IBI patients and OGD-treated murine primary neurons. Silencing of miR-23b resulted in reduced OGD-induced neuronal apoptosis. miR-23b inversely targeted nuclear factor erythroid 2-related factor 2 (Nrf2) and c-Myc negatively regulated miR-23b expression. Overexpression of c-Myc and inhibition of miR-23b led to reduced neurological scores of infarction area, neuronal apoptosis, shortened platform arrival time and significantly increased the time spent on the platform quadrant and the times of crossing the platform in vivo. Collectively, downregulated miR-23b by c-Myc might alleviate IBI by upregulating Nrf2.

Objective To investigate the efficacy and safety of intraoperative high⁃field MRI combined with fluorescence⁃guided glioma resection. Methods A total of 53 patients with glioma admitted to The Fisrt Bethune Hospital of Jilin University from June 2017 to June 2018 were enrolled, including 33 patients (62.26%) whose tumors were located in important brain functional areas (17 cases in motor area, 11 cases in language area, 5 cases in thalamus). Glioma resection was performed under fluorescence⁃guided (fluorescence guidance group, n=28) and intraoperative high⁃field MRI combined with fluorescence⁃guided glioma resection (combined group, n=25). Results Total tumor resection was performed in 42 cases (79.25%) and subtotal tumor resection in 11 cases (20.75%). Of the 33 patients whose tumors were located in important brain functional areas, total resection was performed in 25 cases (75.76%) and subtotal resection in 8 cases (24.24%). There were 12 cases (22.64%) of astrocytoma (WHO grade Ⅱ), 17 cases (32.08%) of anaplastic astrocytoma (WHO grade Ⅲ) and 24 cases (45.28%) of glioblastoma (WHO grade Ⅳ) were confirmed by postoperative pathology. There were 16 cases of speech disorder (30.19%), 21 cases of transient limb movement disorder (39.62%), 6 cases of mental disorder (11.32%), 8 cases of intracranial infection (15.09%), 2 cases of small epidural hemorrhage (3.77%), and no death after the operation. The operation time of combined group was longer than that of fluorescence guidance group [(3.79±1.14) h vs. (2.53±1.04) h; t=⁃4.718, P=0.000]. The tumor total resection rate in the combined group was higher than that in fluorescent guidance group [92% (23/25) vs. 67.86% (19/28); χ2=4.681, P=0.031], the WHO grade had significant difference between 2 groups (χ2=2.041, P=0.036), but the tumor total resection rate in important brain functional areas [88.89% (16/18) vs. 60% (9/15); Fisher's exact probability: P=0.101] and the incidence of postoperative complications [37.73% (20/53) vs. 62.26% (33/53); χ2=0.179, P=1.000] were no significant difference between 2 groups. In the mean follow⁃up of 9 months, 11 patients (20.75%) had tumor recurrence. There was no significant difference in the recurrence rate between combined group and fluorescence guidance group [12% (3/25) vs. 28.57% (8/28); χ2=2.205, P=0.138]. Conclusions Intraoperative high⁃field MRI combined with fluorescence guidance can significantly improve the total resection rate of glioma, while preserving important brain functional areas and neural structures as much as possible, improving the quality of life and prolonging the progression⁃free survival of patients.

Craniopharyngioma is a slow-growing benign tumor, accounting for 5.6%-13% of primary intracranial tumors in children. The present patient showed a huge cyst, and computed tomography scan of the brain revealed a 9.2- × 8.7- × 7.0-cm giant cystic lesion with calcification located in the suprasellar cistern. A review of the literature showed the present case is the biggest craniopharyngioma reported. After the tumor was removed, vasospasm appeared in the surgical area. The surgical field was soaked in diluted nimodipine solution for 12 minutes, including the exposed nerve and blood vessel, especially the optic nerve and middle cerebral artery, which led to vasospasm recovery. At 3-month follow-up, there was slight subdural hygroma; contrast magnetic resonance imaging scan did not reveal any residual tumor or recurrence.

Abstract Rationale: Bronchogenic cysts refer to congenital anomalies derived from the primitive foregut. Spinal bronchogenic cysts are uncommon entities, and those occurring in the intramedullary sites are extremely rare. Bronchogenic cysts involving the foramen magnum region have only been described in 2 cases; however, intramedullary bronchogenic cysts with syringomyelia have not yet been reported. Patient concerns: A 46-year-old woman presented with a 6-month history of pain in the posterior neck region and a 1-month history of numbness in the upper extremities. Neurological examination revealed a loss of sensation in bilateral upper extremities and sensory dissociation. Magnetic resonance imaging (MRI) showed an intramedullary cystic lesion in the foramen magnum region and syringomyelia. Diagnosis: Histopathological findings were consistent with a bronchogenic cyst. Interventions and outcomes: A surgical resection of the cystic lesion was performed via a posterior midline approach. Under neurophysiological monitoring, the cyst was punctured, yielding gelatinous liquid. The dorsal part of the cystic wall was removed. One month postoperatively, the symptoms were resolved completely. Three months after operation, MRI showed no recurrence of the cyst and the syringomyelia disappeared. Lessons: Intramedullary bronchogenic cysts with syringomyelia are extremely rare. Preoperative identification is challenging and definitive diagnosis depends on histopathological evidence. Timely surgical resection should be highlighted.

Rationale: Intracranial schwannomas most frequently arise from the trigeminal nerve and the vestibular nerve. Schwannomas within the cerebral parenchyma are exceedingly rare. Additionally, calcification is an uncommon histopathological and radiological characteristic in schwannomas. Patient concerns: A 46-year-old man presented to us with sudden onset epileptic seizure and a 3-month history of intermittent headache. After admission, the physical and neurological examinations were all normal. Brain CT revealed an irregular, well-defined, hyperdense mass in the right temporal lobe. MRI showed a solid mass appearing iso- to hypointensity on T1-weighted imaging and heterogeneous intensity on T2-weighted imaging in the right temporal lobe; after Gd-DTPA administration, the lesion showed heterogeneous enhancement. Diagnosis: Histopathological examination revealed hyperchromatic nuclei and loose intercellular matrix with calcification. Immunohistochemical analysis demonstrated that the tumor was strongly positive for S100 protein but negative for GFAP and CK, which was consistent with a schwannoma. Interventions and outcomes: A surgical resection via the right temporal approach was performed. Intraoperatively, we noticed that the tumor was grayish yellow, capsuled, and located entirely within the temporal parenchyma. A gross total resection was achieved. The postoperative course was uneventful, and there was no epileptic seizure. Lessons: Intraparenchymal schwannoma with calcification is an uncommon histopathological and radiological characteristic in schwannomas. Intraparenchymal schwannoma with calcification is extremely rare. The early identification and appropriate surgical treatment should be highlighted.

Thiol-functionalized metal-organic frameworks (MIL-101-SH and UiO-66-SH) were synthesized by a post-synthetic modification method as the proper adsorbents for Hg (II) removal from water. This facile method for the synthesis of UiO-66-SH was developed via a condensation reaction between cysteamine and carboxyl groups present in the framework of UiO-66-COOH. MIL-101 was functionalized by grafting amine group of cysteamine on coordinatively unsaturated chromium ions centres, yielding to MIL-101-SH adsorbents. These two types of thiol-functionalized MOFs samples by cysteamine-modified were characterized by XRD, XPS, FTIR and N-2 adsorption-desorption isotherms respectively, which prove the successful modification of the thiol groups. The maximum adsorption capacities of mercury ions for UiO-66-SH and MIL-101-SH adsorbents were 110 and 250 mg/g at pH of 5, respectively. Moreover, the acidic medium could effectively elute Hg (II) and the adsorbents can be well reusable. [GRAPHICS]