Aging and heavy metal pollution are global challenges, and cadmium (Cd) may negatively affect aging. However, effective interventions for Cd toxicity among populations remain insufficient. Selenium (Se) is recognized for its protective effects against heavy metal toxicity and aging. This study utilized data from the National Health and Nutrition Examination Survey (2015-2018) to explore the individual and joint effects of Cd and Se on biological aging acceleration, measured by Klemera-Doubal method biological age acceleration (KDM-BA-Accel) (n = 7119) and Phenotypic age acceleration (PhenoAge-Accel) (n = 7433). Results showed that Cd was positively associated with KDM-BA-Accel (β = 0.57) and PhenoAge-Accel (β = 0.77), while Se had negative associations with both (β values were -4.01 and -5.30, respectively). Nonlinear analyses revealed J-shaped associations for Cd and L-shaped for Se with aging indicators. Moreover, inflammation significantly mediated the Cd-aging and Se-aging relationships. Most importantly, a significant negative interaction between Cd and Se on PhenoAge-Accel (β for interaction = -1.29) suggested an antagonistic effect, particularly among never smokers. Increasing Se content can mitigate the harmful effects of Cd on PhenoAge-Accel were demonstrated through three methods. Specifically, ⅰ) compared to "Cd (-) & Se (-)" group, "Cd (+) & Se (-)" group had β = 0.87, while "Cd (+) & Se (+)" group was non-significant; ⅱ) higher Se content was associated with a lower increase in PhenoAge-Accel as Cd content rose; ⅲ) there were no significant associations between Cd & Se mixture and aging indicators (both p > 0.310). These findings highlight Se supplementation as a potential strategy to counteract Cd-induced aging, offering a new direction for public health interventions in polluted populations.

Background Limited studies suggest that vitamin D or omega 3 fatty acids (n-3 FAs) supplementation may be beneficial for telomere maintenance, however, evidence from large randomized clinical trial is lacking. Objective We aimed to determine whether vitamin D or n-3 FAs supplementation reduce leukocyte telomere length (LTL) attrition over time by leveraging the VITamin D and OmegA-3 TriaL (VITAL) trial. Methods VITAL is a large, randomized, double-blind, placebo-controlled tr ial with a 2 x 2 factorial design of vitamin D3 (2,000 IU/day) and marine n-3 FAs (1 g/day) supplements for 5 years among a representative sample of 25,871 US females ≥55 and males ≥50 years of age. The VITAL Telomere study (NCT04386577) included 1054 participants who were evaluated in person at the Harvard Clinical and Translational Science Center. LTL was determined by the Absolute Human Telomere Length Quantification quantitative Polymerase Chain Reaction (PCR) method at baseline, Year 2, and Year 4. The pre-specified primary outcome measures were changes in LTL between baseline, Year 2 and Year 4. Analyses of intervention effect used mixed-effects linear regression models. Results LTL was measured in a total of 2,571 samples from the 1031 participants at baseline, year 2, and year 4. Compared to placebo, vitamin D3 supplementation significantly decreased LTL attrition by 0.14 kilo base pairs (kb) (95%CI: 0.007, 0.27) over 4 years (p = 0.039). Overall trend analysis showed that the vitamin D3 supplementation group had LTLs that were about 0.035 kb higher per year of follow-up compared to placebo group (95%CI: 0.002, 0.07, p=0.037). Marine n-3 FAs supplementation had no significant effect on LTL at either year 2 or year 4. Conclusion 4-years of supplementation with 2000 IU/day vitamin D3 reduced telomere attrition by 140 bp, suggesting that vitamin D3 daily supplementation with or without n-3 FAs might have a role in counteracting telomere erosion or cell senescence.

Background Acute-on-chronic liver failure (ACLF) represents the terminal and most lethal phase of acute decompensated cirrhosis. Systemic inflammation plays a critical role in the pathogenesis of ACLF. Systemic inflammation reaction syndrome (SIRS) is a marker of ongoing inflammation. Therefore, we aim to evaluate the relationship of sterile SIRS with hepatitis B virus (HBV)-related ACLF (HBV-ACLF). Methods HBV-ACLF patients with sterile SIRS who were hospitalized between December 2016 and December 2018 were retrospectively analyzed. All patients were followed up until 90 days. Risk factors associated with 90-day mortality and sterile SIRS development were assessed. Results Among 151 HBV-ACLF patients without infection, 37 patients (24.5%) presented with or developed sterile SIRS. During the 90-day follow-up, 23 of the 37 patients with sterile SIRS died (62.2%), compared to 40 patients without sterile SIRS (35.1%, P = 0.004). Univariate analysis showed that age, total bilirubin (TBIL), international normalized ratio, ammonia, presence of sterile SIRS, model for end-stage liver disease score, presence of complications, and organ failures were associated with 90-day mortality. In multivariate analyses, the presence of sterile SIRS was an independent risk factor for 90-day mortality. Among SIRS components, heart rate (HR) was the most frequently met criterion (56 patients, 37.09%). Patients who met the HR or temperature criterion had lower 90-day survival rate than those who did not (46.4 vs 65.3%, P = 0.020; 16.7 vs 60.0%, P = 0.020). Conclusion The presence of sterile SIRS in HBV-ACLF patients was closely associated with prognosis.

Obesity is a major risk factor of hypertension, therefore quantifying the contribution of obesity to hypertension is necessary. The current study aimed to investigate the changes in population-attributable fractions (PAFs) of hypertension associated with general obesity and abdominal obesity over the recent 2 decades among the US population, as well as important sub-populations. This report was performed based on national-level cross-sectional data for 46,535 adults aged 18 years and older and 20,745 children aged 8–17 from the US National Health and Nutrition Examination Survey 1999–2018. The PAFs of hypertension due to general obesity and abdominal obesity were calculated by sex, race/ethnicity, and survey year. The linear regression analysis was used to evaluate the secular trends of PAFs over the years. The prevalence of general obesity and abdominal obesity presented significantly increasing trends during the past 2 decades in the US. The PAFs of hypertension due to general obesity increased steadily from 11.9 % to 15.1 % in women with a slope of 0.38 % (95 % CI: 0.31 – 0.45 %) and from 8.4 % to 13.4 % in men with a slope of 0.46 % (95 % CI: 0.36 – 0.56 %). Similar increasing trends were also observed for the PAFs due to abdominal obesity in both women and men. Additionally, there were significantly different trends of PAFs in various races/ethnicities. Over the past 2 decades, the contributions of obesity to hypertension were gradually rising among US population, which emphasizes the importance of controlling weight to further reduce the burden of hypertension.

Background Environmental noise is becoming increasingly recognized as an urgent public health problem, but the quality of current studies needs to be assessed. To evaluate the significance, validity and potential biases of the associations between environmental noise exposure and health outcomes. Methods We conducted an umbrella review of the evidence across meta-analyses of environmental noise exposure and any health outcomes. A systematic search was done until November 2021. PubMed, Cochrane, Scopus, Web of Science, Embase and references of eligible studies were searched. Quality was assessed by AMSTAR and Grading of Recommendations, Assessment, Development and Evaluation (GRADE). Results Of the 31 unique health outcomes identified in 23 systematic reviews and meta-analyses, environmental noise exposure was more likely to result in a series of adverse outcomes. Five percent were moderate in methodology quality, the rest were low to very low and the majority of GRADE evidence was graded as low or even lower. The group with occupational noise exposure had the largest risk increment of speech frequency [relative risk (RR): 6.68; 95% confidence interval (CI): 3.41-13.07] and high-frequency (RR: 4.46; 95% CI: 2.80-7.11) noise-induced hearing loss. High noise exposure from different sources was associated with an increased risk of cardiovascular disease (34%) and its mortality (12%), elevated blood pressure (58-72%), diabetes (23%) and adverse reproductive outcomes (22-43%). In addition, the dose-response relationship revealed that the risk of diabetes, ischemic heart disease (IHD), cardiovascular (CV) mortality, stroke, anxiety and depression increases with increasing noise exposure. Conclusions Adverse associations were found for CV disease and mortality, diabetes, hearing impairment, neurological disorders and adverse reproductive outcomes with environmental noise exposure in humans, especially occupational noise. The studies mostly showed low quality and more high-quality longitudinal study designs are needed for further validation in the future.

This study investigated the association between serum calcium levels and the prevalence of T2D using a cross‐sectional study and Mendelian randomization analysis.

Background: The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) is a recently completed randomized, double-blind, placebo-controlled, 2x2 factorial trial of a multivitamin and cocoa extract supplement (containing 500 mg/d flavanols) in 21,442 older adults. In view of favorable effects of multivitamins on cognition and promising signals for cardiovascular risk reduction with cocoa extract, we conducted a pilot study to explore whether these interventions affected gut microbial composition and function. Methods: We conducted deep shotgun metagenomic sequencing in 30 COSMOS participants using fecal samples collected at baseline and year 2. We performed taxonomic profiling using MetaPhlAn2 and functional profiling using HUMAnN2. After proper quality filtering, we analyzed effects of both interventions on 2-year changes in microbial features, adjusting for age, sex, and body mass index. Results: Cocoa extract supplementation significantly altered the overall gut microbial taxonomic compositions from baseline to year 2, and explained 5.5% of the variance in the 2-year changes in relative abundance of all microbial species ( P =0.008). We further found that randomized cocoa extract supplementation altered the relative abundance of a few microbial species, including those previously linked to anti-inflammatory and cardiometabolic benefits (e.g., Akkermansia muciniphila , nominal P <0.05), and several microbial super pathways (including pyrimidine ribonucleotides de novo biosynthesis, FDR=0.03, and 28 other pathways with nominal P <0.05). Randomized multivitamin use did not significantly affect 2-year changes in alpha or beta diversity, but altered the abundance a few putative bacterial species and functional pathways (nominal P <0.05). Summary: Our pilot study suggests that cocoa extract and multivitamin supplementation in COSMOS may alter the gut microbiome and influence pathways relevant to health, emphasizing the need for larger studies that allow for more detailed investigations.

BACKGROUND:DNA methylation is associated with cardiovascular (CV) disease. However, in type 2 diabetes (T2D) patients, the role of gene methylation in the development of CV disease is under-studied. We aimed to identify the CV disease-related DNA methylation loci in patients with T2D and to explore the potential pathways underlying the development of CV disease using a two-stage design.METHODS:The participants were from the Jinan Diabetes Cohort Study (JNDCS), an ongoing longitudinal study designed to evaluate the development of CV risk in patients with T2D. In the discovery cohort, 10 diabetic patients with CV events at baseline were randomly selected as the case group, and another 10 diabetic patients without CV events were matched for sex, age, smoking status, and body mass index as the control group. In 1438 T2D patients without CV disease at baseline, 210 patients with CV events were identified after a mean 6.5-year follow-up. Of whom, 100 patients who experienced CV events during the follow-up were randomly selected as cases, and 100 patients who did not have CV events were randomly selected as the control group in the validation cohort. Reduced representation bisulfite sequencing and Targeted Bisulfite Sequencing were used to measure the methylation profiles in the discovery and validation cohort, respectively.RESULTS:In the discover cohort, 127 DMRs related to CV disease were identified in T2D patients. Further, we validated 23 DMRs mapped to 25 genes, of them, 4 genes (ARSG, PNPLA6, NEFL, and CRYGEP) for the first time were reported. There was evidence that the addition of DNA methylation data improved the prediction performance of CV disease in T2D patients. Pathway analysis identified some significant signaling pathways involved in CV comorbidities, T2D, and inflammation.CONCLUSIONS:In this study, we identified 23 DMRs mapped to 25 genes associated with CV disease in T2D patients, of them, 4 DMRs for the first time were reported. DNA methylation testing may help identify a high CV-risk population in T2D patients.

Background Pyrethroids have been widely used in the United States and worldwide. Few studies examined the effect of pyrethroids exposure on sleep problems among adolescents. Objectives This study investigated the associations between pyrethroids exposure and sleep problems in male and female adolescents. Methods The data were used from the National Health and Nutrition Examination Survey 2007–2014. In this study, 3-Phenoxybenzoic Acid (3-PBA) was used as a validated biomarker for pyrethroids exposure. The association between urinary 3-PBA and sleep problems was analyzed using logistic regression models. Results A total of 805 adolescents aged 16–20 years old were included in this study. The proportion of sleep problems was higher in females than in males (10.18% vs.7.35%, P = 0.154). A significant interaction was found between sex and 3-PBA ( P interaction = 0.021) in the risk of sleep problems. A positive association of 3-PBA exposure with sleep problems was observed in male adolescents after adjusting for all the other covariates (OR = 4.04, 95% CI 1.31, 12.42). No statistically significant association was observed in female adolescents. Conclusions A positive association was observed between pyrethroids exposure and sleep problems in male adolescents, but not in female adolescents. More studies are required to confirm our findings.

EDITORIAL article Front. Public Health, 10 June 2022Sec. Environmental health and Exposome https://doi.org/10.3389/fpubh.2022.895576

SESSION TITLE: Airways Function Measurement and Treatment Outcomes SESSION TYPE: Rapid Fire Original Inv PRESENTED ON: 10/19/2022 11:15 am - 12:15 pm PURPOSE: Small airways disease (SAD) is a key risk in developing obstructive lung diseases (OLD), including chronic obstructive lung disease (COPD)[1]. These diseases in farmworkers are understudied. A review of 14 studies reported wide ranging COPD prevalence in farmworkers from 3% to 68%[2]. Recent meta-analysis showed associations between non-smoking farmworkers[3]. However, horticulture was not included. Our study investigated the prevalence and risk factors for SAD and OLD among horticulture farmworkers. METHODS: 182 farmworkers (41% female; 67% Hispanics) were surveyed in rural Southeastern US from 2013 to 2017. Smoking status was self-reported. Pulmonary function tests were obtained with SAD defined as FEF25-75% predicted < 0.65 per literature and OLD defined as FEV1/FVC ratio < 0.7 per GOLD criteria[4]. RESULTS: 32% of overall population smoked and within that population, 36% and 27% had SAD and OLD respectively. 28% and 24% of non-smoking population had SAD and OLD respectively (Table 1). 49% of males and 10% of females smoked. 22% of males and 39% of females had SAD. 14% of males and 20% females had OLD. 63%, 73% and 15% of whites, blacks and Hispanics smoked respectively (Table 2). 32%, 29% and 29% of whites, blacks, and Hispanics respectively had SAD. 14% whites, 24% blacks and 15% Hispanics respectively had OLD. Logistics regression showed that sex and age were significantly associated with SAD and OLD respectively; while, tobacco use and race were not (Table 3). CONCLUSIONS: This is a relatively young and healthy adult population. However, the prevalence of SAD and OLD in this farmworker population, particularly among non-smokers, females and Hispanics, were high, indicating possible etiologies including occupational risks. The high prevalence of SAD in all races further increases risk for developing OLD later. Based on self-reported questionnaire, females smoked less than males; while, blacks smoked the most and Hispanics smoked the least. Despite this, female and Hispanics had high disease prevalence. Nationally, OLD prevalence is higher in males. Regarding race, whites have the highest prevalence and Hispanics have the lowest without considering occupation. In this cohort, blacks had the highest OLD prevalence and whites had the lowest. CLINICAL IMPLICATIONS: Farmworkers are understudied regarding lung diseases. It may be important to screen farmworkers for SAD and OLD, even if they do not smoke. Early detection of these diseases can lead to timely interventions including use of bronchodilators to improve lung function. Sex was a significant predictor but race was not in our analyses. Females and Hispanics both had low smoking but higher disease prevalence. Further research is warranted to assess for sex and race-specific screening and treatment guidelines for lung diseases. DISCLOSURES: No relevant relationships by Li Chen No relevant relationships by Pamela Cromer No relevant relationships by Yutong Dong No relevant relationships by Deborrah Layman no disclosure on file for Andrew Mazzoli; No relevant relationships by Haidong Zhu

This analysis aims to investigate the association between household pesticide exposure and hypertension risk, and to determine whether smoking plays a role in this association. We used data from the National Health and Nutrition Examination Survey (NHANES) for the years 1999-2014, including a total of 32,309 U.S. adult participants who were 20 years or older. Smoking status and pesticide exposure were self-reported. Blood pressure was measured by trained personnel using a mercury sphygmomanometer, according to a standardized protocol. We observed an increased risk of hypertension (OR [odds ratio] = 1.10, 95% confidence intervals [CI]: 1.01-1.18) in participants with exposure to household pesticides. Moreover, a significant interaction between smoking status and pesticide exposure on hypertension was observed (P = 0.022). Stratified analysis showed that household pesticide exposure was associated with a 29% higher risk of hypertension (OR = 1.29, 95% CI: 1.08-1.53) in smokers. However, for non-smokers, this association was not significant. Similar trends were found for systolic and diastolic blood pressures. In addition, we investigated the associations between pesticide metabolites in urine/serum and hypertension and found that several metabolites of dioxins, furans, and coplanar polychlorinated biphenyls were significantly associated with a higher risk of hypertension. This study suggests that household pesticide exposure is associated with an elevated risk of hypertension. We also report that smoking may accentuate the effect of pesticide exposure on hypertension.

Introduction: Vascular aging, starting from youth, encompasses arterial degeneration and hardening that impairs vascular function, and ultimately causes end-organ damage, predominantly in the heart, brain, and kidney. Leucine (Leu) is an essential amino acid in the biosynthesis of proteins. It is initially catalyzed to α-ketoisocaproate (α-KIC), and then further metabolized to β-hydroxy-β-methylbutyrate (HMB). Our prior work showed a significant decrease in circulating HMB in response to additional sodium intake, a key risk factor for accelerated vascular aging. Hypothesis: We aimed to test the hypotheses that Leu/α-KIC/HMB metabolic activity declines with chronological aging, and that Leu/α-KIC/HMB metabolism is inversely associated with vascular aging in a young population. Methods: Global metabolomic profiling was performed in blood samples from 65 black adolescents and young adults, aged 25.9 ± 9.4 yrs and 85% were female. Blood levels of leucine, α-KIC, and HMB were extracted and log-transformed. Associations of leucine, α-KIC, and HMB with age, carotid-femoral pulse wave velocity (cfPWV), and intima-media thickness (IMT) were determined by pairwise correlations. A p -value smaller than 0.05 was considered significant. Results: Among 65 subjects with an age range of 13 to 45 yrs, older age was associated with lower levels of HMB (r=-0.37, P =0.002) and α-KIC (r=-0.30, P =0.016), but not leucine (r=-0.22, P =0.078). Higher levels of HMB and α-KIC, but not leucine, were associated with lower cfPWV (HMB: r=-0.33, P =0.010; α-KIC r=-0.31, P =0.018). Metabolites in the Leu/α-KIC/HMB metabolism pathway were also inversely associated with IMT, but only HMB showed a borderline statistical significance (r=-0.23, P =0.072). Conclusions: Our findings indicated a potential role of Leu/α-KIC/HMB metabolism in vascular aging, even in a young black population.

Background: Vitamin D is considered to modulate T-cell function, which has been implicated in the treatment of inflammatory conditions. However, there is limited knowledge on the effects of vitamin D and its influences on circulating T-cell profiles in humans, particularly in overweight Black individuals who are more likely to be vitamin D insufficient (serum 25(OH)D concentrations of ≤20 ng/mL). Thus, this study tested the hypothesis that vitamin D supplementation modulates T-cell composition, which is in a dose-dependent manner. Methods: A 16-week randomized, double-blinded, placebo-controlled trial of vitamin D3 supplementation was undertaken in 70 overweight/obese Black people (mean age = 26 years, 82% female) with 25 hydroxyvitamin D ≤ 20 ng/mL at baseline. Subjects were randomly assigned a supervised monthly oral vitamin D3 equivalent to approximately 600 IU/day (n = 17), 2000 IU/day (n = 18), 4000 IU/day (n = 18), or a placebo (n = 17). Fresh peripheral whole blood was collected and CD3+, CD4+ and CD8+ cell counts and percentages were determined by flow cytometry at baseline and at 16 weeks, among 56 subjects who were included in the analyses. Results: A statistically significant increase in CD3+% in the 2000 IU/day vitamin D3 supplementation group, and increases in CD4+% in the 2000 IU/day and 4000 IU/day vitamin D3 supplementation groups were observed (p-values < 0.05) from the changes in baseline to 16 weeks. Further adjustments for age, sex and BMI showed that 2000 IU/day vitamin D3 supplementation increased in CD3+ count, CD3%, CD4 count, and CD4%, as compared to the placebo group (p-values < 0.05). Moreover, the highest serum 25(OH)D quantile group had the highest CD3% and CD4%. Conclusions: Sixteen-week vitamin D3 supplementation increases peripheral blood T-cell numbers and percentages in overweight/obese Black patients with vitamin D insufficiency. This resulting shift in circulating T-cell composition, particularly the increase in T helper cells (CD4+ cells), suggests that vitamin D supplementation may improve immune function in Black individuals.

Background: Adult studies have suggested that magnesium intake may regulate C-reactive protein (CRP) and muscle mass, known risk factors for cardiometabolic diseases. Given the large deficiencies in magnesium intake in adolescents, we aimed to investigate sex and race differences in dietary magnesium intake and test the hypothesis that lower magnesium intake is associated with higher CRP and lower muscle mass. Methods: A total of 766 black and white adolescents, 14 to 18 years old (51% black; 50% female) were previously recruited. Diet was assessed with four to seven independent 24-h recalls. Body composition was measured by dual-energy X-ray absorptiometry. High-sensitivity CRP (hs-CRP), leptin, resistin, and adiponectin were measured using fasting blood samples by ELISA. Results: There were sex and race differences in the daily consumption of magnesium. The average daily magnesium intakes were 200.66 ± 7.09 mg and 205.03 ± 7.05 mg for males and females, respectively, far below the recommended amounts of 410 mg for males and 360 mg for females. White subjects (217.95 ± 6.81 mg/day) consumed more than black subjects (187.75 ± 6.92 mg/day). Almost none of the adolescents met the recommendations. Adjusted multiple linear regressions revealed that lower magnesium intake was associated with higher hs-CRP and lower fat-free mass (FFM) (p-values < 0.05). Higher hs-CRP was associated with lower FFM. Moreover, an interaction between magnesium intake and hs-CRP on FFM was identified (p-value < 0.05). Lower magnesium intake amplified the inverse relationships between hs-CRP and FFM (p-values < 0.05). Conclusion: Magnesium consumption in our adolescents was far below daily recommended levels with male and black subjects consuming less than female and white subjects. Lower magnesium intake was associated with higher CRP and lower muscle mass. Low magnesium intake may also augment the inverse relationship between CRP and FFM.

AIMS:To examine the longitudinal association between transportation noise exposure (road traffic, aircraft, and railway noise) and T2D in a meta-analysis.MATERIALS AND METHODS:We systematically searched PubMed, Embase, Scopus, Cochrane, and Web of Science published up to February 2022. The GRADE approach was used to evaluate the study quality, and the pooled effect estimate was calculated by the fixed-effects model or the random-effects model.RESULTS:We included 10 prospective studies with a total of 4,994,171 participants and 417,332 T2D cases in the meta-analysis. According to the Navigation guide, 8 studies out of 10 were rated as having a probably high or high risk of bias. For road noise, the pooled relative risk (RR) per 10 dB higher Lden for developing T2D was 1.06 (95% CI:1.03, 1.09) with high heterogeneity (I2  = 90.1%, p < 0.001). Similar associations were also observed in aircraft and railway noise: the pooled RR were separately were: 1.01 (1.00, 1.01) and 1.02 (1.01, 1.03) separately. A 'dose-response' analysis found a similar linear association between road noise exposure and the risk of T2D.CONCLUSIONS:An overall 6% increase in the risk of T2D per 10 dB increase in road exposure was observed. Further studies are needed to confirm our findings, especially for aircraft and railway noise, and to identify the mechanisms involved.

Background Epidemiologic evidence linking environmental noise to obesity and hypertension remains scarce, especially in children, and the results remain inconclusive. This study aims to examine the cross-sectional associations of self-reported residential noise exposure with obesity and hypertension in children and adolescents. Methods As an ongoing study, a representative sample of the children aged 6–9 years in Chongqing were selected in 2014. In 2019, self-reported residential noise (answer categories: “very quiet,” “moderately quiet,” “slightly quiet,” and “not at all quiet”) data were collected, and 3,412 participants with completed data were included in the analyses. Results Participants living in a quieter area had a significantly lower risk of obesity than those living in a noisy area (very quiet: OR = 0.50, 95%CI: 0.29–0.88, P = 0.015; moderately quiet: OR = 0.61, 95%CI: 0.36–1.02, P = 0.059). Similar associations were observed for abdominal obesity, although did not reach statistical significance. Consistently, residential noise exposure was significantly associated with body mass index (BMI) and waist-to-height ratio. Self-reported residential noise exposure was positively associated with systolic blood pressure (β = −1.808; 95%CI = −3.495, −0.110; P = 0.037). When sleep quality, study stress, BMI, and vegetable/fruits consumption were further adjusted, all effect estimates decreased, and no statistical association was observed between noise exposure and blood pressure. Furthermore, we found that the mediating effects of obesity on the associations of self-reported residential noise exposure with hypertension were 6.8% (% of total effect mediated = 0.068, 95%CI: −2.58, 3.99), although did not reach statistical significance. Conclusions Self-reported residential noise exposure was associated with a higher risk of obesity or abdominal obesity. Also, self-reported residential noise exposure was positively associated with hypertension, and obesity may partially mediate this association, but did not reach statistical significance.