To enhance the antimicrobial properties and cytocompatibility of a pure magnesium alloy, the alloy was subjected to ultrasonic micro-arc oxidation (UMAO) treatment loaded with berberine. The antibacterial activity and cytocompatibility of the magnesium alloy before and after the berberine-loaded UMAO coating treatment were investigated using plate counting, CCK-8 assays, and scanning electron microscopy (SEM) to evaluate the application potential of this composite coating as a surface bio-modification method for magnesium alloys. Surface microstructural characterization indicated that the coating had successfully incorporated the bioactive component. Plate count results showed that the berberine-loaded UMAO-coated magnesium alloy still exhibited strong antibacterial activity (>= 96%) against Escherichia coli and Staphylococcus aureus, indicating that the berberine-loaded UMAO coating endows the magnesium alloy with long-term antibacterial performance. cytocompatibility evaluation results showed that the berberine-loaded UMAO treatment did not induce cytotoxicity; rather, it improved the early adhesion of MC3T3-E1 cells and promoted the expression of BMP-2 and TGF-beta, providing important evidence for the development of a new generation of multifunctional magnesium-based implants.

The ceramic coating was in in-situ synthezed on the surface of the TA2 alloy substrate by the micro-arc oxidation technology. The silicate-aluminate solution was choosed as the electrolyte solution. The effects of in-situ micro-arc oxidation coatings thickenss on the wear resistance on TA2 alloy was investigated in details by means of pin-on-disk tester. The experimental results proved that MAO coatings were mainly consist of rutile TiO2 phase and the thickness and content of rutile TiO2 phase in the MAO coatings increased as the micro-arc oxidation voltage improved. The wear resistance of TA2 alloy was obviously improved when the thickness of MAO coating was closed to 10 mu m similar to 11 mu m.

Hardfacing layer was prepared by CO2 shielded welding with spraying optimizational Cr-Ti-Mn-B alloy powder.Rockwell hardness ( HRC) and microhardness ( HV) tests of hardfacing layer were opera-ted.Abrasion machine was used to study the wear resistance of hardfacing layer.The microstructure and phase composition were charactered by metallographic microscope and XRD.The results indicated that the appearance of weld welded by feeding powder in tube was beautiful.The utilization rate of alloy was higher and the alloy powder well distributed in weld seam to get the fine metallurgical structure.The hardness of hardfacing layer was HRC 65.At the same time, HV 730 and HV 810 were tested in surface and middle of hardfacing layer, respec-tively.The weight loss rate was less than 0.2%and the wear resistance of hardfacing layer obviously increased compared with that of feeding powder out tube.

The ultrasound was introduced in the micro-arc oxidation (MAO) on bio-magnesium alloy to enhance the corrosion resistance of magnesium alloy by the principles of sound electrochemistry. The 40 kHz frequncey and different powers, 0, 60, 90, 120, 150 and 180 W, of ultrasounds were used to produce ultrasound micro-arc oxidation coatings (UMAO). The effect of ultrasonic powers on corrosion resistance of the coating in the saline solution was studied. The hydrophilic and hydrophobic properties were studied by the contact angle of coatings. The potentiodyamic polarization was used to measure the potential, current density and linear polarization resistance of the magnesium alloy. Surface and section morphologies, Ca/P ratio of coating surface and corrosion surface of the coatings, phase composition of the corrosion products were extensively investigated by scanning electron microscope (SEM), energy-dispersive X-ray spectrometry (EDX) and X-ray diffraction (XRD). The results indicate that ultrasound increased Ca/P ratio of the coating and the corrosion layer to improve the bioactivity of the coatings. The corrosion resistance of MAO magnesium alloy was improved obviously. The contact angle was 91.950 at maxium when the ultrasound was 120 W, and the 120 W UMAO magnesium alloy was hydrophobic. The potential of the UMAO was 0.404 V, which inresased 1.032 V compared with that of the magnesium alloy, and the linear polarization resistance was maximum. The corrosion resistance of 120 W UMAO magnesium alloy was the best.

In order to improve the corrosion resistance and bioactivity of magnesium alloy coated by ultrasound micro-arc oxidation (UMAO), different content of n-TiO 2 was added into silicate electrolyte. Electrochemical corrosion and simulated body fluid (SBF) soaking were conducted, and the surface morphology, phase structure and composition also were analyzed. The results indicated that Ecorr and Icorr of UMAO biocoatings with n-TiO 2 increased and decreased an order of magnitude with increase of n-TiO 2 , respectively. The corrosion resistance of coatings with adding 4.8g/L n-TiO 2 into electrolyte was the best. After soaking in SBF, the samples increased loose weight firstly and then increased weight to form Mg 3 Ca (CO 3 ) 4 , Mg1 0 Cl (OH) 18 ·5H 2 O and Na 4 Mg 2 (PO 4 ) ·2H 2 O new phases and Mg, MgO, MgSiO 3 were still exit, which showed that good bioactivity of the UMAO coatings with n-TiO 2 .

采用超声微弧氧化技术,在硅酸盐电解液中添加n-SiO2,研究不同添加量对纯镁生物涂层组织结构及性能的影响.分析涂层形貌及相结构,测定涂层厚度、涂层结合力、摩擦系数、电化学腐蚀性能.结果表明:添加n-SiO2粒子,涂层表面形成更多均匀细小孔,形成了含n-SiO2粒子涂层,随着n-SiO2含量从0 g/L增加到7.5 g/L,涂层主相MgO向MgSiO3变化,涂层Si含量增多,涂层厚度从10.26 μm增加到13.32 μm,结合强度从4.9N增大到7.4N,摩擦系数从1.1下降到0.6.其中,添加n-SiO2含量为7.5 g/L时,超声微弧氧化涂层与基体有最高结合强度,且耐摩擦系数最小,耐蚀性最好.

Ultrasonic was introduced into the micro-arc oxidation MAO process to prepare coating on magnesium alloy in order to improve the corrosion resistance of magnesium alloy.Ultrasonic effect on corrosion resistance of(MAO) magnesium alloy in two kinds of simulated body fluid(SBF) was studied.The rate of hydrogen evolution of magnesium alloy in SBF was operated to get the corrosion rate of magnesium alloy.The potential,current density and linear polarization resistance of magnesium alloy were tested by potentiodyamic polarization.The results indicate that corrosion resistance of magnesium alloy by different surface treatment is as follows: ultrasonic micro arc oxidationmicro arc oxidationmagnesium alloy.Ultrasonic micro arc oxidation effectively enhances the corrosion resistance of magnesium alloy compared with conventional micro arc oxidation.

The ultrasonic micro-arc oxidation (UMAO) was used to fabricate ceramic coatings on magnesium alloy. UMAO coatings were produced at 60 W input ultrasonic. The effects of the ultrasound on the microstructure, phase composition, elemental distribution and corrosion resistance of the coatings were extensively investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), energy-dispersive X-ray spectrometry (EDX) and electrochemical workstation. The results showed that ultrasound improved the homogeneous distribution of micro-porous structure. The coatings were mainly composed of MgO ceramic and small amount of calcium and phosphorus with porous structure. The Ca/P ratio of the coatings increased when 60 W ultrasonic was used. The corrosion potential in simulated body fluid (SBF) changed from −1.583 V of bare magnesium alloy to −0.353 V of magnesium alloy coated under 60 W ultrasonic. The corrosion resistance of UMAO coatings was better than that of MAO coatings.

Electrochemical deposition method was applied to fabricate the composite coatings on magnesium alloy by ultrasonic micro-arc oxidation. The electrochemical deposition coating of composite coatings was acicular calcium phosphate dibasic. The rate of hydrogen evolution of magnesium alloy in simulated body fluid was studied to obtain the corrosion rate of two kinds of magnesium alloys. The potentiodynamic polarization was used to test the potential, current density and linear polarization resistance of magnesium alloys. The results indicated that corrosion resistance of both ultrasonic micro-arc oxidation and ultrasonic micro arc oxidation-electrochemical deposition magnesium alloys in 10 d is in the range of 0.0006-0.0001 mg/(cm 2·h -1) and the latter is less than the former, which indicated that the corrosion resistance of composite coatings is better than that of single coating.

Based on the characteristic of the subject of materials science and engineering,the construction of the innovation base included the materials preparation and processing,materials analysis test,materials design and simulation to achieve the integration studies of the materials design,preparation and analysis.Innovation base conforms to the principle of the function,open sharing and mutual support.According to the subject development,the biomedical materials and the wear-resistant metal material platform were built in priority.After several years' construction,a multi-level contracture and a well-development tendency have formed.Now,outstanding innovative results of graduated and undergraduate students were obtained.The training creative,practical and comprehensive coordination ability have been improved,the academic research and social service capabilities were also improved.

Calcium phosphate biocoatings were fabricated on the surface of magnesium alloy by micro-arc oxidation (MAO) technique. The properties of biocoatings related with MAO technics parameters and the electrolyte constitute. The surface morphology, constitute and friction coefficient were studied by SEM XRD and fret test machine. The results indicated that the optimum electrolyte was CaCO3-Na3PO4 contained 20g/L phosphate ions and 1.5 Ca/P ratio, and the optimum technics parameters was 350V oxidation voltage for10min, 500HZ pulse frequency and 1:10 in duty cycle. The main phase constitutes of the porous biocoatings contained were Mg, MgO, Mg3(PO4)2 and CaNaPO4. The anode polarization potential of the coating was -1.36V and enhanced about 0.29V compared with that of magnesium alloy substrate, which indicated that the biocoatings had better corrosion resistant properties. The friction coefficient of the biocoatings was 0.23 and decreased 0.15 compared with that of magnesium alloy substrate, which indicated that the biocoatings had better wear resistant properties. The biocoatings could induce hydroxyapatite to form on its surface after soaked in body fluid, which showed that the composite coatings owned good bioactivity.

Non fluorine and fluorine-carrying magnesium based biocoating were made by ultrasonic and micro-arc oxidation method. Determined the coating properties by SEM, EDAX, ImageJ software and eddy current thickness meter. The coating wear resistance in simulated body fluid was determined by the ball-disc type friction and wear tester. The results show that the biocoating is composed of the compact layer and the loose layer with porous on its surface, the average porous aperture is 5~20 μm; the non-fluorine biocoating surface porosity is 23%, and the coating thickness is 16.64 μm. The porosity and thickness of fluorine-carrying biocoating are 23%~27% and 20.82~28.44 μm, respectively. The friction coefficient of the non-fluorine biocoating is 0.52, compared with that of the fluorine-carrying biocoating decreases by 0.15~0.34, the main mechanism of friction and wear is abrasive wear, and the wear resistance of fluorine-carrying biocoating is effectively improved.

Chinese medicine Drynariae Rhizoma extract (DR) was introduced into porcine bone hydroxyapatite (PBHA) and chitosan (CS) for the preparation of scaffold by the Vacuum freeze drying method in order to accelerate bone growth and weak bone adhesion in the early healing stage of scaffold. The microscopic morphology and composition of the scaffolds were analyzed by SEM, XRD and IR. Compressive strength of the scaffold and the porosity was tested. Biological activity of the scaffolds was studied by immersed in Simulated Body Fluid (SBF). The scaffolds were a high porosity of 80% and compressive strength of 1.2MPa. Carbonate containing bone-like HA was formed on the surface of the scaffold after immersion in SBF, showing that the scaffold materials have good bone-like apatite forming ability. The scaffolds of DR -PBHA- CS have good physical and chemical properties, good biological activity and low price.

The fluorine-carrying magnesium based biocoating materials were made by ultrasonic and micro-arc oxidation. Determined the coating properties by SEM, EDAX and ImageJ software, etc. Based on the GB/T21866-2008 and AATCC100-2004 standards, determined the biocoating antibacterial resistance. The potentiodynamic polarization test determined the corrosion resistance of biocoating in simulated body fluid. The results show that biocoating is composed of the compact and loose layer and the average diameter of micropores on the surface is 5~20 μm. The porosity of the fluorine-carrying biocoating is 23%~27%, and its thickness is 20.82~28.44 μm. The antibacterial rate of the fluorine-carrying biocoating is 61%~76%. The E corr and I corr of the fluorine-carrying coatings increases by 95~170 mV and decreased by about two orders of magnitude compared with that of non fluorine-carrying biocoating, respectively. It could effectively improve the antibacterial and corrosion resistance of the magnesium based biocoating.

Ti/bioglass were sprayed on Ti6Al4V substrate by high velocity flame spraying, then the coatings underwent crystallization treatment at 700°C. Microstructure, phase composition and residual stress of the coatings were characterized by SEM, XRD and GIXRD (grazing incidence X-ray diffraction), respectively. Results showed that after the coatings were hea-treated at 700°C, flake TiO 2 crystals precipitated from the cracks in the coatings, which played a role of healing up the cracks. The precipitation of needle Na 2Ti 6O 13 crystals on the surface of the coatings helped to improve the bioactivity of the coatings, possibly contributing to increase the value of residual compressive stress. All the residual stress of Ti/Bioglass coatings prepared was compressive stress in direct proportion of the bioglass content. The occurrence of residual compressive stress was due to the spraying impact phenomena by high velocity of the flame spraying and great kinetic energy of the particles. The existence of spraying impact stress had a positive significance of the increase in the bond strength of the coatings.

Chelate pyrophosphate titanate coupling agent(NDZ-311)is used as modified agent to modify chitosan(CS).Porous HA-TCP/CS biomaterials are prepared by vacuum freeze drying method.Influence of the amount of coupling agent NDZ-311 on the relationship between compressive strength and porosity of the porous biomaterials is investigated.Analyses of the composite materials are carried out by means of SEM,XRD and IR.The results show that the-O-catenarian aether bond function group in NDZ-311 can induce many types of ester-based transformation reactions to make NDZ-311 and CS filler crosslinking,therefore,the compressive strength of porous biomaterials can be improved by adding NDZ-311 to CS.The addition of CS filler can be more than 50% and can not be separated from phase.Compressive strength of the porous biomaterials decreases with the increase of the content of NDZ-311,and then increases with further increase of the content of NDZ-311.Porosity of the porous biomaterials increases with the increase of the content of NDZ-311,and then decreases with further increase of the content of NDZ-311.Matching of compressive strength and porosity of the porous biomaterials is the best with the mass ratio of HA-TCP to CS 7∶3,the content of NDZ-311 is 1wt% when compressive strength and porosity of the porous biomaterials are 2.3MPa and 84.8%,respectively.Pore shape is stacking fault lath lapping and distribution of pore was comparative uniform.HA-TCP particles are uniformly dispersed on CS templates.The added coupling agent of NDZ-311 has little change on the phase structure of the materials,only the intensity of characteristic diffraction peaks in each phase of the materials has a little enhancement.

Calcium phosphate coating was made on the Ti-6Al-4V surface which was treated by micro-arc oxidation (MAO) by means of electrochemical deposition.Uniformity pores,which owned regular salience around pores,were formed on the Ti-6Al-4V,followed by deposited at different deposition time.Anode oxidation was used at 300V voltage for 1min.Electrochemical deposition was conducted at current densities of 25-30 mA/cm2 and 310K～315K for 10min and 60min,respectively.The surface morphology was observed by scanning electron microscopy(JSM-6360LV).The phases of coatings were analyzed by X-ray Diffraction(XRD).As the result,the coatings soaked by simulated body fluid composed of hydroxyapatite,Anatase,Rutile.Coatings by MAO-electrochemical deposition are superior in resisting wear compared with coatings by electrochemical deposition.SEM observation of the morphologies indicates that deposition time was shortened.

The porous glasses of molybdic tailing were prepared by melt quenching methods.By investigating influence of different pore-forming agents on the properties of porous glass of molybdic tailing,the optimal pore-forming agent was determined.The influence of the content of optimal pore-forming agent on the porosity and bending strength of porous glass of molybdic tailing were analyzed.The results showed that BaCO3 in this system was the best pore-forming agent,the porosity and bending strength of porous glass of molybdic tailing both were changed with the increase of the content of BaCO3,and the highest porosity is 16.8% when the content of BaCO3 attained 10%.It was found that a small amount of quartz was residue in porous glass of molybdic tailing by XRD techniques,and the pore structure was not connected on the whole,it was closed-cell material.

This study examined the bioactive and stability of calcium phosphate- polypyrrole(ppy) composite coatings on titanium alloys by electrochemically deposition in simulated body fluid (SBF). Change of coatings mass and SBF pH during coatings soaked in SBF indicated that ppy reduces the decomposition of coatings. The surface morphology of coatings characterized by SEM showed that the stability of composition coating was superior to that of single coating. XRD indicated that ppy induces CO3 2- enter calcium phosphate coating, which showed that the composite coatings possess better bioactive. Thus, this electrochemical deposition provides an effective method of ppy incorporation at physiological temperature, which can offer excellent bioactive and stability of coatings, with a potential for sustained release of therapeutic agents as required for metallic implant fixation.