Purpose and hypothesisSubsidence is a known reason for early failure of total hip arthroplasty (THA). In particular, cementless THA might be vulnerable to migration. The present study analysed femoral stem subsidence after primary cementless THA. Prosthetic and anatomical risk factors for early femoral stem subsidence were evaluated.MethodsTwo hundred thirty-one consecutive patients who underwent primary cementless THA in a single centre were retrospectively analysed. Post-operative results were evaluated in consideration of prosthetic and anatomical properties in correlation with subsidence on standing pelvic anteroposterior radiographs. Stem type and design, demographic data, BMI, canal flare index (CFI) and canal fill ratio (CFR) were evaluated.ResultsThe subsidence rate was significantly higher in collarless femoral stems [3.1mm (SD 2.8mm) vs. 1.9mm (SD 1.5mm); p=0.013] while the anatomical type of the proximal femur as described by the canal flare index did not influenced subsidence (p=0.050). Also, the canal fill ratio showed no significant correlation with subsidence at any level.ConclusionsIn the present study, stem subsidence was significantly higher in the collarless group compared to collared stems. No anatomical parameter (CFI and CFR) could be identified as risk factor for subsidence. Neither age nor BMI influenced subsidence in this cohort. Still, subgroup analysis indicated a sex-dependent role of BMI. Prospective studies of large cohorts should address the problem of subsidence in the future.Level of evidenceRetrospective therapeutic study, Level IV.

IntroductionConcerning biomechanical research, human specimens are preferred to achieve conditions that are close to the clinical situation. On the other hand, synthetic femurs are used for biomech...

IntroductionThis study was performed to investigate the failure mechanism of one specific hip arthroplasty cup design that has shown a high clinical failure rate. The aim of this study was to identify general design problems of this polyethylene inlay.Material and Methods55 consecutive retrievals of a cementless screw ring (Mecron) were collected. In any case a 32 mm ceramic head was used. All implants failed due to aseptic loosening. The follow-up of the implants was 3 to 16 years. We recorded backside wear, fatigue of the polyethylene at the flanges on the outer rim and at the cup opening (32 mm inner diameter). To assess the deformation of the inlay, the smallest and the median diameter of the cup opening were measured using a 3 dimensional coordinate measuring machine (Multisensor, Mahr, Germany).Results90% of the explants showed signs of wear on the backside of the inlay. Another typical and so far not described alteration was collar fatigue in 68%. 38% of the inlays showed rim creep: Examples for Ba...

Background:Total ankle replacements (TAR) are not as successful as total hip or total knee replacements. A three-time increased revision rate is reported in registry data [1]. Therefrom, wear associated revisions are frequent [2]. However, there is little knowledge about the wear behavior of TAR. This may be partly related to the fact, that currently no standard for wear testing of TAR exists.The aim of this study is to define a biomechanical valid, force-controlled test specification for level walking of TAR.Material and Methods:Basic requirements for force-controlled testing of TAR is the definition joint flexion, as well as active forces and torques acting on the joint and the definition of the ligamental stabilization of the joint.To specify flexion of the ankle, gait analysis was performed on patients treated with a TAR (HINTEGRA, Smith & Nephew) using skin mounted markers. Data about in-vivo forces is missing for TAR. Hence, determination of active forces and torques was based on mathematical models...

PURPOSE:Femoral defects often make it difficult to achieve sufficient fixation of the stem during revision surgery. No clinical studies comparing modular stems are available and differentiated recommendations are rare. The aim of this study was to compare the fixation of different revision stems in an experimental and standardised manner.METHODS:Segmental AAOS type I and III defects were reproduced in four femur pairs and two modular stems of different shape (cylindrical and conical) were implanted. Interfacial stem-bone movements were measured under axial torque application to analyze the stem fixation depending on defect extension.RESULTS:Both stems showed adequate fixation in AAOS type I defect. The defect extension significantly reduced the fixation of both implants. The fixation pattern changed significantly for the cylindrical-shaped stem but was maintained for the conical-shaped stem.CONCLUSIONS:Shape as well as the extension of femoral defect have an impact on primary fixation. A type I defect seems to be bridgeable for both stems albeit in a different way. In contrast, stem-demanding activities during the healing phase have to be avoided for the conical-shaped stem in a type III defect, whereas the cylindrical-shaped stem has already ceased to be sufficiently stable in this case.

PURPOSE:In total hip arthroplasty fixation of revision stems can be demanding due to femoral bone loss. Strut grafts are often used for bone augmentation and stabilization of the newly inserted prosthesis. The aim of this study was to assess the effect of strut grafts on primary stability under various stem fixation conditions.METHODS:Two different revision stems (cylindrical and conical shape) were implanted into synthetic femora. Following a semicircular transfemoral osteotomy, three deficient femoral bearings were simulated (bony lid reattached with cable wires; weakened lid reattached with cable wires; strut grafts placed to the weakened lid with cable wires). Relative micro-movements were measured between prostheses and bones due to an axial moment applied to the stems.RESULTS:Relative movements correlated to the stem shape. The cylindrical stem showed higher movements increasing significantly with a weakened bony lid and portrayed a slight decrease of movements with strut graft application. No unequivocal influence of the weakened lid could be detected for the conical implant. Strut graft application did not show an additional stabilizing effect.CONCLUSIONS:The primary stability of the cylindrical fixation concept decreases with impaired fixation conditions of the femur. A clear restabilizing effect with strut grafts could not be proven. A decrease of primary stability due to the impaired bone could not be observed for the conical stem shape. Additionally, strut grafts do not enhance fixation for this stem shape. We conclude that surgeons should not rely on a stabilizing effect of strut grafts in revision hip surgery.

Ceramic-on-metal (CoM) bearings are considered to be a promising alternative to polyethylene-based bearings or hard-on-hard bearings (Ceramic-on-Ceramic (CoC) and Metal-on-Metal (MoM)). Although, CoM shows lower wear rates than MoM, in-vitro wear testing of CoM shows widely varying results. This may be related to limitations of wear-measuring methods. Therefore, the aim of this study was to improve the gravimetric measurement technique and to test wear behaviour of CoM bearings compared to CoC bearings. Level walking according to ISO-14242 was simulated for four CoM and four CoC bearings. Prior to simulation, errors in measurement of gravimetric wear were detected and improvements in measurement technique incorporated. The results showed no differences in mean wear rates between CoM and CoC bearings. However, the CoM bearings showed wear results over a wide range of wear performance. High reliability of wear results was recorded for the CoC bearings. Material transfer was observed on the ceramic heads of the CoM bearings. Therefore, for level walking a partial mixed or boundary lubrication has to be assumed for this type of bearing. CoM is a highly sensitive wear-couple. The reasons for the observed behaviour cannot be clarified from this study. Simulator studies have to be considered as an ideal loading condition. Therefore, high variations in wear rates as seen in this study, even at low levels, may have an adverse effect on the in-vivo wear behavior. Careful clinical use may be advisable until the reasons for the variation are fully clarified and understood.

Background The choice of implant design plays an important role for primary fixation of a TKA. Short-keeled tibial components allow implantation through a smaller approach with less femorotibial subluxation. Questions/purposes The purpose of this study was to detect early implant failure resulting from aseptic loosening after cemented short-keeled and standard tibial baseplate implantation. Methods Between 2008 and 2010, a group of 160 consecutive patients (with 80 standard and with 80 short-keeled tibial trays) received cemented TKAs. At 1-year followup, patients were examined clinically and radiographs were analyzed regarding aspects of radiolucency. The components were divided into five zones on each radiographic view and the measurements of the 10 zones were added. Results The mean sum of radiolucencies was increased significantly with the short-keeled baseplates. In the current study, short-keeled tibial trays revealed a revision rate of 6.3% after 1-year followup. In contrast, none of the standard tibial baseplates were revised. Conclusions The implantation of cemented, short-keeled tibial components is linked to an increased rate of early loosening. Therefore, the indication for cemented, short-keeled component implantation should be reviewed. Level of Evidence Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

Background: There is little knowledge about wear performance of total ankle arthroplasties (TAR). However, revisions rates are high for TAR [1] and wear associated revisions are frequent [2]. Therefore, the aim of this study is (1)To test the wear behavior of a TAR using a biomechanically valid testing scenario. (2)To test the influence of an alternative ceramic tibial component. (3)To test the long term wear performance of TAR. Material and Methods: In the first part of this study the HINTEGRA (Smith & Nephew) TAR has been used for wear testing. Wear testing was performed on a modified AMTI knee simulator. Level walking according to a previous described testing standard [see abstract: Development of a force controlled testing scenario for total ankle replacements] has been used. Level walking was simulated in three clinical relevant situations, first simulating the reduced loading after implantation, secondly simulating an increasing range of motion and at last a loading pattern orientating at the loadings in the native/healthy joint. Every simulation was run for 3 million cycles, resulting in 9 million total cycles. In the second part of this study the metal tibial plateau was replaced by a ceramic tibial component (Biolox® Delta, CeramTec). Simulation was run, as described above, for additional 9 million cycles. Termed as a long term test, in total 18 million cycles of testing are performed. Results: When simulating level walking with loadings assumed after implantation a wear rate of 19.5 ± 1,49 mg/Mc has been determined. Increasing the range of motion lead to a wear rate of 18.0 ± 2,56 mg/Mc and simulating loading as assumed in a healthy joint, a wear rate of 23.8 ± 1,47 mg/Mc was determined. When replacing the metal tibial component by a ceramic tray the wear rate decreased between 20–30% dependent on the tested scenario. No delamination occurred during 18 millon cycles of testing. Conclusion: In this study, high wear rates for TAR were determined. Compared to standardized wear testing of total knee replacements in our laboratory the wear rate of TAR was approximately 2.5 times increased. Ceramics seem to be an option to decrease the wear rate. The high wear rate of the polyethylene may be a factor contributing to the high revision rates seen in TARs.

Introduction Osteolysis and aseptic loosening in total hip replacement (THR) is often associated with polyethylene (PE) wear. This caused interest in alternative bearing surfaces. Since the mid nineties, research focused on hard-hard bearings like metal-on-metal (MOM) or ceramic-on-ceramic (COC). However, concerns remain about biological reactions to metallic wear debris or failure of the ceramic components. A new approach to reduce wear with a minimized risk of failure may be the use of a metallic cup in combination with a ceramic head, the so called ceramic-on-metal bearing (COM). The aim of this study was to estimate the wear behaviour at an early stage of this COM bearing type in comparison to COC bearings using a hip simulator. Material and Methods Simulator studies were carried out on a single station hip simulator (MTS 858 Mini Bionix II, Eden Prairie, USA) in accordance to ISO 14242-1. Bovine serum was used as the test medium. Four COM and four COC bearings were used, both 36mm in diameter. The heads were made of a mixed-oxid ceramic (Biolox Delta(r)) paired with a high carbon wrought CoCrMo cup in the COM group whereas both components were made of Biolox Delta(r) in the COC group. Simulation was run to a total of 2.4×10 6 cycles. Wear measurements were performed in intervals of 0.2x10 6 cycles using a gravimetric method (Sartorius Genius ME235S, measuring solution: 15 μg, Sartorius, Gottingen, Germany). Results Wear of the COM and COC pairings is shown in Figure 1. During the first 200,000 cycles a mean wear rate of 0.16mm 3 /10 6 cycles was found followed by a decreased wear rate of 0.04mm 3 /10 6 cycles for the COC bearings. The overall wear ranged from 0.08mm 3 to 0.17mm 3 , with a mean of 0.12 mm 3 . There was found a high variability in the wear progression between the four COM implants (Figure 1). A mean wear rate of 0.13mm 3 /10 6 cycles was determined during the first 200,000 cycles followed by a decreased wear rate of 0.05mm 3 /10 6 cycles. The overall wear of the COM implants ranged from 0.02mm 3 to 0.21mm 3 , with a mean of 0.13 mm 3 . All ceramic heads from the COM bearings showed metallic material transfer in form of stripes whereas no visible wear traces were found on the COC heads. Discussion and Conclusion The COM implants showed very low wear levels that were similar to the COC bearings and far below wear levels of conventional MOM bearings. However, there was a spreading up to the thirteen fold between lowest and highest wear volume of the COM at the end of the study. Concerning COM implants such high variability was also seen by other investigators. The simulator conditions are highly reproducible (as seen for the COC bearings). Considering the high variations in patients demand, the influence of patient related activity parameters should be further investigated in terms of wear. Moreover, this study was performed without implementing subluxation, impingement or malalignment which might also increase wear. These effects together with the influence of third body wear needs to be further considered.

Introduction: During hip stem revisions osteotomies allow to remove well-fixed components. Once removal has been done, cerclage wires should secure the osteotomy and support primary stability of the new stem. Stability is important for a bony ingrowth and therefore the longevity of a cementless revision stem. Tension wires seem to dominate revision surgery and studies only refer to the advantages of cable wires in general. This in-vitro study analyzed the infiuence of both, tension and cable wires on primary stability of cementless revision stems. We aimed to examine the effectivity of wiring a femoral osteotomy, differences achieved with each method, and whether one wire has advantages regarding the fixation concepts of revision stems (meta- and diaphyseal). Methods: We studied a Ti-tension- and a CoCrWNi-cable-wire. The Helios-stem stood for the meta- and the Wagner-SL-stem for the diaphyseal fixation concept. Each stem was implanted into 3 synthetic femurs and a standardized extended proximal femoral osteotomy was performed. Spatial movements of bones and stems at several sites were explored under axial torques using a high-resolution measuring device. Movement graphs subjected to the sites defined relative movements RM = ΔαZ/TZ [mdeg/Nm]. The osteotomies were locked consecutively with both wires and all compounds were measured again. Wiring was done by a proximal figure 8 and a diaphyseal circular loop. Results: Compared to the unlocked osteotomy the tension as well as the cable wires caused a changed RM for the stems (p=0.03). Both wires affect an increased stability within the proximal main fixation area of the Helios. Even for the Wagner-SL, usually fixating diaphyseally, a proximal fixation was reached with both wires. A significantly better stabilization could be observed for the Helios using cable wires (p=0.04). The overall RM reached with tension and cable wires was 16.6 and 11.1 mdeg/Nm. The Wagner-SL ® showed no difference in stability between tension and cable wire treatment (p=0.29). Discussion: Both, the tension and the cable wires support the revision stems in bridging the artificial defect of an extended proximal femoral osteotomy. Especially for the proximal fixating stem, RMs could largely be reduced, while cable wires seem to be advantageous. Preventing a circular constriction leading to an osseous malnutrition, the use of cable wires, however, should be impeded with regard to diaphyseal fixating stems and proximal osteotomies. Comparable results with both wires were reached and none of the wires showed any advantage in this situation. In conclusion, the wires should be chosen depending on the fixation concept of the revision stem.

Knee wear simulator studies are performed to evaluate wear behavior of implants.Simulation of the human gait cycle is often carried out continuously, without considering resting periods as they are part of patient’s daily live. In addition to dynamic activities like walking, daily activities also consist of static periods like standing, sitting or lying. During the day dynamic activities alternate continuously with static periods and most of the day is spent in passive periods, where no joint motion occurs. Such resting periods have not yet been considered in prosthetic knee wear tests. Implementing resting periods may cause an increase in friction and thus increased wear of the implant. The aim of the current study was to determine if the implementation of resting periods would increase polyethylene (PE) wear in total knee replacement (TKR).Two wear studies were conducted using a force controlled AMTI knee simulator on a conventional bicondylar TKR. For the first study, simulation was carried out continu...

Introduction: Postoperative periprosthetic fractures are difficult to investigate clinically in scientifically and statistically valid study samples because they are uncommon. However, the combination of advanced age and poor bone quality has been associated with these fractures in conjunction with cementless hip stems. So far, these speculations have neither been supported by clinical evidence nor been investigated experimentally. The purpose of the present study was to analyze in-vitro if the treatment with cementless hip stems increases the risk of suffering a periprosthetic fracture for older patients compared to younger patients. Regarding this manner, we aimed to clarify parameters which possibly can be used preoperatively to assess age related fracture risk and whether the femoral bone quality really plays a role in fracture development. Methods: An established biomechanical setup was used to provide an investigation on 16 femoral specimens of different age. Prior, the BMDs were measured in 5 ROIs and a cementless hip stem was implanted into each femur. The load bearing of “normal walking” was applied quasistatically under standardized conditions until the fracture occurred. The specimens were arranged by age in ascending order to divide them in the middle. A group of under septuagenarians ( Results: The elderly specimens fractured at significantly lower forces ( Discussion: In patients with advanced age treated with cementless hip stems the risk of suffering a periprosthetic fracture is significantly higher. The identification of specific fracture development variables in geriatric populations can be extended to a preoperative check list to aid clinicians in practicing effective risk assessment. Criteria such as BMD, BMI and CCD angle should be included: A fracture risk remains in patients around 80 years of age or older, with a Ward’s triangle BMD below a value of 0.500g/cm2, or a BMI >33kg/m2. Depending on patient activity, one single factor should not be viewed as an exclusion criterion for a cementless hip stem, whereas the cumulation of them should alert the surgeon.

Background: Cerclage wires are widely used in revision hip surgery to reattach the lid of a femoral osteotomy. The present study compared the influence of multifilaments and monofilaments on primary stability of revision hip stems with different fixation principles.Methods: A standardized extended proximal femoral osteotomy was performed in the anterior cortex of 6 synthetic femora. We used a high-resolution measuring device to explore spatial micromovements of a diaphyseal and a metaphyseal fixating revision stem. Both of these were implanted in 3 femora. The specimens were measured again after consecutive restabilization of osteotomies with multifilaments and monofilaments. The movement graphs generated defined relative micromovements between stems and bones and the stabilizing effect of the two wire systems compared.Findings: Both multifilaments and monofilaments effected a major reduction of relative micromovements for both fixation principles. There were no differences in relative movements between the multifilament and monofilament treatments for the diaphyseal fixating stem. Yet for the metaphyseal fixating stem a significantly better restabilization was observed with multifilaments.Interpretation: Both multifilaments and monofilaments can support the revision hip stem in bridging the extended proximal femoral osteotomy. Yet, which wiring system should be chosen depends on the fixation principle of the revision stem. Multifilaments seem to be advantageous when used with metaphyseal fixating stems. However, the use of multifilaments with diaphyseal fixating components should be reconsidered as this might constrict the periosteal vascularity. (c) 2010 Elsevier Ltd. All rights reserved.