AllergyVolume 54, Issue 3 p. 296-297 Isoniazid-induced bullous skin reaction P Scheid, P Scheid *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this authorG Kanny, Ph. Tréchot, G Kanny, Ph. Tréchot *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this authorV Rosner, V Rosner *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this authorO Ménard, O Ménard *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this authorJM Vignaud, JM Vignaud *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this authorD Anthoine, D Anthoine *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this authorY Martinet, Y Martinet *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this author P Scheid, P Scheid *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this authorG Kanny, Ph. Tréchot, G Kanny, Ph. Tréchot *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this authorV Rosner, V Rosner *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this authorO Ménard, O Ménard *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this authorJM Vignaud, JM Vignaud *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this authorD Anthoine, D Anthoine *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this authorY Martinet, Y Martinet *Service de Pneumologie A Hôpital de Brabois Rue du Morvan 54511 Vandœuvre-lès-Nancy Cedex France Tel. (33) 3 83 15 34 00 Fax: (33) 3 83 15 35 41Search for more papers by this author First published: 24 December 2001 https://doi.org/10.1034/j.1398-9995.1999.00049.xCitations: 9Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume54, Issue3March 1999Pages 296-297 RelatedInformation

Cardiac angiosarcoma is a rare tumour with very poor prognosis especially in patients with metastatic disease. We present the case of a 43 year old patient with angiosarcoma revealed by open lung biopsy for multiple pulmonary metastases. Cardiac symptoms were limited to a moderate pericarditis and no echocardiographic sign of heart tumour was observed. The clinical outcome was rapidly fatal despite chemotherapy. The cardiac primary tumour was diagnosed at autopsy. We emphasize the difficulties of diagnosing cardiac angiosarcoma and confirm the limited value of echocardiography for this diagnosis.

Radon is a natural radioactive gas, with worldwide distribution, deriving from uranium decay products, which can be inhaled, weather in mining condition (extraction and management of uranium ores) or in domestic condition (in some high risk homes or geographic areas). The main epidemiologic studies on uranium mining workers have all confirmed an excess in relative risk of primary lung cancer. Epidemiologic studies on indoor exposure suggest a role of radon in the genesis of a certain number of primary lung cancer, although these results remain controversial and need to be confirmed. An overview of the main actual problems related to this bronchial carcinogen is presented in this paper.

Radon is a natural radioactive gas, with worldwide distribution, deriving from uranium decay products, which can be inhaled, eather in mining condition (extraction and management of uranium ores) or in domestic condition (in some high risk homes or geographic areas). The main epidemiologic studies on uranium mining workers have all confirmed an excess in relative risk of primary lung cancer.

Two cases of diabetes insipidus revealing a pituitary metastasis from a lung cancer are reported. One patient was an 81 year old female with small cell carcinoma of the lung and a large pituitary metastasis. The other was a 62 year old male with a history of surgery for epidermoid lung cancer who had diabetes insipidus antagonized by concomitant corticotropin deficiency. Endocrine manifestations of pituitary metastases are infrequent and usually denote invasion of the posterior pituitary lobe. The primary tumor is usually breast cancer in females and lung cancer in males. In some patients, concomitant corticotropin deficiency masks the diabetes insipidus. Management rests on irradiation to the pituitary, if needed with systemic chemotherapy and hormone replacement therapy.

Following a reminder of anatomy, the semiology of standard radiology and modern imaging methods is described. The authors then deal with the phrenic-supraphrenic thoracic pathologies (air and liquid effusions, neighbourhood atelectasis, etc.) and with the phrenic-infraphrenic pathologies (transdiaphragmatic hernias, hepatic pathology, subphrenic abscess and pleural effusions). In each of these chapters, the often complex elements of standard radiology and modern imaging methods are detailed.

In a prospective study the level of carcinoembryonic antigen (ACE) were simultaneously measured in plasma and bronchoalveolar lavage liquid (LBA), in fifteen patients suffering from bronchopulmonary cancer and fifteen patients suffering from non-malignant pulmonary disease. In these two groups the level of ACE in LBA liquid (cancer 8,990 +/- 4,050 ng/ml; controls 2,510 +/- 1,060 ng/ml) were clearly more elevated than the corresponding plasma levels (cancer 1,931 +/- 1,760 ng/ml; controls 8.2 +/- 2 ng/ml) and the plasma levels of ACE were more elevated in the cancer group; in the same group the ACE levels in the LBA liquid were more elevated in the tumour group (4,770 +/- 2,180 ng/ml versus 808 +/- 300 ng/ml). This study has also shown the elevated levels of ACE in the LBA liquid in patients suffering from chronic bronchial inflammation (2,510 +/- 1,060 ng/ml) and during the course of acute bacterial pneumonia. The contribution of the ACE level in LBA liquid in relation to the plasma levels in the diagnosis of bronchopulmonary cancer would thus appear to have no clinical value, but the exact relationships between the phenomenon of chronic bronchial inflammation and metaplasia of the bronchial epithelium merit further study.

The authors report two cases of diabetes insipidus due to pituitary metastasis of lung neoplasm. The endocrine clinical manifestations of pituitary metastasis are rare, and usually the fact of involvement of the posterior pituitary.

The authors report one case of polymyositis, discovered among a 59 years old man, by appearence of dyspnea, revealing a bilateral pulmonary fibrosis. A respiratory localisation is following 10 % of the polymyositis and usually presenting as a non specific fibrosis. This fibrosis can exceptionnally reveal a polymyositis.

Chemoprophylaxis of tuberculosis may be primary or secondary. Primary chemoprophylaxis is intended for infants and children with negative tuberculin tests and exposed to contagion, in order to avoid primary tuberculosis. It lasts for three months and consists of oral isoniazide in one single daily dose of 5 to 10 mg/kg. Secondary chemoprophylaxis applies to all subjects, but principally to children, with a tuberculin test that has recently become positive in the absence of BCG vaccination. Its purpose is to protect against clinical tuberculosis. It lasts for six months and consists of isoniazid combined with rifampicin.

Chemoprophylaxis of tuberculosis may be primary or secondary. Primary chemoprophylaxis is intended for infants and children with negative tuberculin tests and exposed to contagion, in order to avoid primary tuberculosis. It lasts for three months and consists of oral isoniazide in one single daily dose of 5 to 10 mg/kg. Secondary chemoprophylaxis applies to all subjects, but principally to children, with a tuberculin test that has recently become positive in the absence of BCG vaccination. Its purpose is to protect against clinical tuberculosis. It lasts for six months and consists of isoniazid combined with rifampicin.

The authors present all the chest imaging techniques that are currently available to pneumologists and detail their indications and advantages. They suggest that in each major chest disease clinicians should use the technique that is most useful to the diagnosis and least costly, thereby avoiding overlaps of expensive techniques.

The antero-posterior X-ray film of the chest is still a basic examination in everyday clinical practice. It supplies multiple data but reading of the image is difficult and requires much accuracy and method. In this review paper we examine all the artefacts, pitfalls and diagnostic problems we have encountered in many years of experience, irrespective of their cause (technical, iatrogenic) or origin (parietal, intrathoracic, pleural, vascular, gastrointestinal, mediastinal, pulmonary). We consider that all pneumologists should have in mind these problems when faced with doubtful or abnormal radiographs of the chest.