OBJETIVO: Caracterizar la pancreatitis inducida por ácido valproico (AVP) en niños. PACIENTES Y MÉTODOS: Durante un período de 10 años se revisaron las historias clínicas de todos los pacientes con pancreatitis inducida por AVP, diagnosticada mediante criterios estrictos. Se extrajeron los resultados clínicos y de laboratorio. RESULTADOS: Durante el período de estudio se trataron 22 pacientes con pancreatitis inducida por AVP. Los síntomas fueron similares a los de pacientes con la entidad debida a otras etiologías e incluyeron dolor/hipersensibilidad abdominal 19/23 (83%), vómitos/arcadas 17/23 (74%), distensión abdominal 7/23 (30%) y fiebre/escalofríos 6/23 (26%). En todos los pacientes excepto en uno el nivel sérico de AVP se encontró dentro del intervalo terapéutico. Antes del inicio de la pancreatitis la duración media del tratamiento era de 32 meses. La lipasa sérica era de más de tres veces el límite superior de lo normal en todos los pacientes pero en un 39% de los examinados no se identificó un aumento significativo de la concentración sérica de amilasa. Los estudios de diagnóstico por imagen sólo alteraron el tratamiento clínico en un paciente. En general, la duración de la estancia hospitalaria fue breve (media, 8 días). Fallecieron 2 pacientes. En 4 de 5 pacientes sometidos a una nueva provocación se produjeron recidivas. CONCLUSIONES: La pancreatitis inducida por AVP no depende del nivel sérico de este fármaco y puede producirse en cualquier momento tras el inicio del tratamiento. Este proceso es grave o mortal con más frecuencia que el debido a otras causas. La concentración sérica de lipasa es más sensible que la de amilasa y debe obtenerse en caso de sospecha de la enfermedad. Es poco probable que los estudios de diagnóstico por imagen efectuados precozmente sean útiles en el tratamiento de los pacientes. FUNDAMENTO

British Journal of UrologyVolume 73, Issue 1 p. 105-106 Neoplastic Paneth cells in a mucinous adenocarcinoma of the bladder D. E. FISH, Corresponding Author D. E. FISH Departments of Histopathology, London, UK MRCP, MRCPath, Senior Registrar.St Mary's Hospital, Praed Street, London W2 1NY, UK.Search for more papers by this authorD. S. C. ROSE, D. S. C. ROSE Departments of Histopathology, London, UK BSc, MB, BS, Registrar.Search for more papers by this authorA. ADAMSON, A. ADAMSON *Departments of Urology, St Mary's Hospital, London, UK FRCS, Lecturer in Urology.Search for more papers by this authorR. D. GOLDIN, R. D. GOLDIN Departments of Histopathology, London, UK MD, MRCPath, Consultant Histopathologist.Search for more papers by this authorR. O. WITHEROW, R. O. WITHEROW *Departments of Urology, St Mary's Hospital, London, UK FRCS, Consultant Urologist.Search for more papers by this author D. E. FISH, Corresponding Author D. E. FISH Departments of Histopathology, London, UK MRCP, MRCPath, Senior Registrar.St Mary's Hospital, Praed Street, London W2 1NY, UK.Search for more papers by this authorD. S. C. ROSE, D. S. C. ROSE Departments of Histopathology, London, UK BSc, MB, BS, Registrar.Search for more papers by this authorA. ADAMSON, A. ADAMSON *Departments of Urology, St Mary's Hospital, London, UK FRCS, Lecturer in Urology.Search for more papers by this authorR. D. GOLDIN, R. D. GOLDIN Departments of Histopathology, London, UK MD, MRCPath, Consultant Histopathologist.Search for more papers by this authorR. O. WITHEROW, R. O. WITHEROW *Departments of Urology, St Mary's Hospital, London, UK FRCS, Consultant Urologist.Search for more papers by this author First published: January 1994 https://doi.org/10.1111/j.1464-410X.1994.tb07470.xCitations: 3 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume73, Issue1January 1994Pages 105-106 RelatedInformation

HistopathologyVolume 23, Issue 6 p. 584-585 Gallbladder vasculitis: a report of two cases D.E. FISH, D.E. FISH Department of Histopathology, St Mary's Hospital, London, UKSearch for more papers by this authorD.J. EVANS, D.J. EVANS Department of Histopathology, St Mary's Hospital, London, UKSearch for more papers by this authorC.D. PUSEY, C.D. PUSEY Department of Medicine, Hammersmith Hospital, London, UKSearch for more papers by this author D.E. FISH, D.E. FISH Department of Histopathology, St Mary's Hospital, London, UKSearch for more papers by this authorD.J. EVANS, D.J. EVANS Department of Histopathology, St Mary's Hospital, London, UKSearch for more papers by this authorC.D. PUSEY, C.D. PUSEY Department of Medicine, Hammersmith Hospital, London, UKSearch for more papers by this author First published: December 1993 https://doi.org/10.1111/j.1365-2559.1993.tb01251.xCitations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1 Camilleri M, Pusey CD, Chadwick VS, Rees AJ. Gastrointestinal manifestations of systemic vasculitis. Q. J. Med. 1983; 206; 141–149. 2 Chen KTK. Gallbladder vasculitis. J. Clin. Gastroenterol. 1989; 11; 537–540. 3 Nohr M, Laustsen J, Falk E. Isolated necrotising panarteritis of the gallbladder. Acta Chir. Scand. 1989; 155; 485–487. 4 Gorevic PD, Kassab HJ, Levo Y et al.. Mixed cryoglobulinemia: clinical aspects and long-term follow-up of 40 patients. Am. J. Med. 1980; 69; 287–308. 5 Reza MJ, Roth BE, Pops MA, Goldberg LS. Intestinal vasculitis in essential mixed cryoglobulinaemia. Ann. Int. Med. 1974; 81; 633–634. Citing Literature Volume23, Issue6December 1993Pages 584-585 ReferencesRelatedInformation

The suggested link between angiogenesis in breast cancer and metastasis remains unsubstantiated. We tested this relationship in primary breast carcinomas from 37 patients with a median follow-up 9.5 years (Cohort 1) and 50 patients with a median follow-up of 1.5 years (Cohort 2). Angiogenesis was assessed by counting vessel density after immunohistochemical staining of vascular endothelium for factor VIII. Patients were grouped according to whether metastasis (defined as spread to axillary lymph nodes, distant sites or both) had occurred. The mean ± SD scores in Cohort 1 when metastasis was absent and present, respectively, were 15.6 ± 4.9 (n = 21) and 14.1 ± 3.7 (n = 16). In Cohort 2 the scores were 15.4 ± 5.8 (n = 26) and 14.5 ± 4.9 (ifn = 24). There was no significant difference between these scores in either cohort. Murtivariate analysis demonstrated lymph node involvement (P < 0.001) and tumour size (P < 0.001) but not angiogenesis score (P > 0.05) to predict distant metastasis. This evidence argues against any prognostic significance of angiogenesis in breast carcinoma.

Because the risk factors for human immunodeficiency virus (HIV) infection and hepatitis B (HBV) are similar and therefore coinfection is not uncommon, a detailed histological and immunohistochemical study of chronic hepatitis B infection in a group of 20 HIV positive Caucasian males (who did not have AIDS) and 30 HIV negative controls were undertaken. Using both the conventional histological classification and the Knodell histological activity index it was shown that HIV negative patients were more likely to have active disease and also more scarring than HIV positive patients. Hepatitis B surface antigen (HBsAg) expression was not significantly different between the two groups but expression of hepatitis Be antigen (HBeAg) and HBV-DNA polymerase was greater in those who were HIV positive. HIV positive patients are therefore more likely to have immunohistochemical markers of active viral replication, although histologically, liver disease is less severe. These findings have important implications for assessing the biopsy specimens in this group of patients and for treatment strategies aimed at improving their immune function.

HistopathologyVolume 17, Issue 5 p. 471-472 Combined endocrine cell carcinoma and adenocarcinoma of the gallbladder D.E. FISH, Corresponding Author D.E. FISH Department of Histopathology, St Mary's Hospital, LondonAddress for correspondence: Dr D.E. Fish, Department of Histopathology, St Mary's Hospital, Praed Street, London W2 1NY, UK.Search for more papers by this authorM. AL-IZZI, M. AL-IZZI Departments of Histopathology, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UKSearch for more papers by this authorP.P. GEORGE, P.P. GEORGE Departments of Surgery, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UKSearch for more papers by this authorB. WHITAKER, B. WHITAKER Departments of Surgery, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UKSearch for more papers by this author D.E. FISH, Corresponding Author D.E. FISH Department of Histopathology, St Mary's Hospital, LondonAddress for correspondence: Dr D.E. Fish, Department of Histopathology, St Mary's Hospital, Praed Street, London W2 1NY, UK.Search for more papers by this authorM. AL-IZZI, M. AL-IZZI Departments of Histopathology, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UKSearch for more papers by this authorP.P. GEORGE, P.P. GEORGE Departments of Surgery, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UKSearch for more papers by this authorB. WHITAKER, B. WHITAKER Departments of Surgery, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UKSearch for more papers by this author First published: November 1990 https://doi.org/10.1111/j.1365-2559.1990.tb00772.xCitations: 18AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume17, Issue5November 1990Pages 471-472 RelatedInformation

Journal Article Vitamin A in Osteo- and Rheumatoid Arthritis Get access ANGELA FAIRNEY, ANGELA FAIRNEY Department of Chemical Pathology, St. Mary's Hospital Medical School, and Department of RheumatologySt. Mary's Hospital, Paddington, London W2 1PG Search for other works by this author on: Oxford Academic PubMed Google Scholar K. V. PATEL, K. V. PATEL Department of Chemical Pathology, St. Mary's Hospital Medical School, and Department of RheumatologySt. Mary's Hospital, Paddington, London W2 1PG Search for other works by this author on: Oxford Academic PubMed Google Scholar D. E. FISH, D. E. FISH Department of Chemical Pathology, St. Mary's Hospital Medical School, and Department of RheumatologySt. Mary's Hospital, Paddington, London W2 1PG Search for other works by this author on: Oxford Academic PubMed Google Scholar M. H. SEIFERT M. H. SEIFERT Department of Chemical Pathology, St. Mary's Hospital Medical School, and Department of RheumatologySt. Mary's Hospital, Paddington, London W2 1PG Search for other works by this author on: Oxford Academic PubMed Google Scholar Rheumatology, Volume 27, Issue 4, August 1988, Pages 329–330, https://doi.org/10.1093/rheumatology/27.4.329 Published: 01 August 1988 Article history Received: 23 March 1988 Published: 01 August 1988

FEBS LettersVolume 117, Issue 1-2 p. 28-32 Full-length articleFree Access Investigation into the sulphoconjugation of 5α-androst-16-en-3β-ol by porcine liver Correction(s) for this article Investigation into the sulphoconjugation of 5α-androst-16-en-3β-ol by porcine liver (1980) Volume 120Issue 1FEBS Letters pages: 157-157 First Published online: November 14, 2001 D.E. Fish, D.E. Fish Department of Biochemistry and Chemistry, Guy's Hospital Medical School, London SE1 9RT, EnglandSearch for more papers by this authorG.M. Cooke, G.M. Cooke Department of Biochemistry and Chemistry, Guy's Hospital Medical School, London SE1 9RT, EnglandSearch for more papers by this authorD.B. Gower, Corresponding Author D.B. Gower Department of Biochemistry and Chemistry, Guy's Hospital Medical School, London SE1 9RT, EnglandAddress correspondence and reprints requests to: D. B. G.Search for more papers by this author D.E. Fish, D.E. Fish Department of Biochemistry and Chemistry, Guy's Hospital Medical School, London SE1 9RT, EnglandSearch for more papers by this authorG.M. Cooke, G.M. Cooke Department of Biochemistry and Chemistry, Guy's Hospital Medical School, London SE1 9RT, EnglandSearch for more papers by this authorD.B. Gower, Corresponding Author D.B. Gower Department of Biochemistry and Chemistry, Guy's Hospital Medical School, London SE1 9RT, EnglandAddress correspondence and reprints requests to: D. B. G.Search for more papers by this author First published: August 11, 1980 https://doi.org/10.1016/0014-5793(80)80906-9Citations: 9AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References 1 D.B. Gower, J. Steroid Biochem., 3, (1972), 45– 103. 2 D.R. Melrose, H.C.B. Reed, R.L.S. Patterson, Brit. Vet. J., 127, (1971), 497– 501. 3 Y.A. Saat, PhD Thesis (1973), University of London 136– 4 R.S. Bandurski, L.G. Wilson, C.L. Squires, J. Am. Chem. Soc., 78, (1956), 6408– 6409. 5 M.C. Lebeau, A. Alberga, E.E. Baulieu, Biochem. Biophys. Res. Comm., 17, (1964), 570– 572. 6 A. Ruokonen, J. Steroid Biochem., 9, (1978), 939– 946. 7 T. Katkov, D.B. Gower, Biochem. J., 117, (1970), 533– 538. 8 W.M. Allen, S.J. Hayward, A. Pinto, J. Clin. Endocrinol. Metab., 10, (1950), 54– 70. 9 N.B. Colthup, J. Opt. Soc. Am., 40, (1950), 397– 400. 10 J.N. Labows, G. Preti, E. Hoelzle, J. Leyden, A. Kligman, Steroids, 34, (1979), 249– 258. 11 F. Gasparini, R. Hochberg, S. Lieberman, Biochemistry, 15, (1976), 3969– 3975. 12 O.H. Lowry, N.J. Rosebrough, A.L. Farr, R.J. Randall, J. Biol. Chem., 193, (1951), 265– 275. 13 G.M. Cooke, D.B. Gower, Biochim. Biophys. Acta, 498, (1977), 265– 271. 14 R.H. DeMeio, M. Wizerhaniuk, I. Schreibman, J. Biol. Chem., 213, (1955), 439– 443. 15 J. Schneider, M. Lewbart, J. Biol. Chem., 222, (1956), 787– 794. 16 J.B. Adams, Biochim. Biophys. Acta, 82, (1964), 572– 580. 17 Y. Nose, F. Lippman, J. Biol. Chem., 233, (1958), 1348– 1351. 18 A.B. Roy, Biochem. J., 63, (1956), 294– 300. Citing Literature Volume117, Issue1-2August 11, 1980Pages 28-32 ReferencesRelatedInformation