A novel wireless motion-detection device (WMDD) utilizes a low radio frequency (RF) emission/sensing system to isolate a patient's movement with high sensitivity and spatial resolution. The device was evaluated for detecting focal to bilateral tonic-clonic seizures (FBTCS) and respiratory changes. A prospective study of patients ≥18 years old admitted to a tertiary care epilepsy monitoring unit was conducted. Data from the WMDD was compared to video-EEG and respiratory inductive plethysmography (RIP) belts to assess the onset of convulsive seizures and to assess respiratory signals. Eighty-seven consecutive patients were enrolled, including 9 with RIP belts; 11 FBTCS were captured. The WMDD revealed identifiable RF signal changes in all FBTCS at the onset of motor activity. Higher total RF amplitude was seen during FBTCS, compared to non-seizure movements from interictal controls. The WMDD was able to detect respiratory changes that correlated with RIP changes. A contactless device using low-power RF that does not require a line-of-sight may be developed to detect FBTCS.

Clinical EEG interpretation requires reasoning over full EEG sessions and integrating signal patterns with clinical context. Existing EEG foundation models are largely designed for short-window decoding and do not incorporate clinical context. We introduce CLEF, a clinically grounded long-context EEG foundation model. CLEF represents EEG sessions as 3D multitaper spectrogram tokens, enabling tractable Transformer modeling at session scale, and aligns embeddings with neurologist reports and structured EHR data through contrastive objectives. We evaluate CLEF on a new 234-task benchmark spanning disease phenotypes, medication exposures, and EEG findings, with more than 260k EEG sessions from over 108k patients. CLEF outperforms prior EEG foundation models on 229 of 234 tasks, improving mean AUROC from 0.65 to 0.74. Reconstruction-only pretraining surpasses prior EEG foundation models, while report and EHR alignment yields further gains. Held-out concept and external-cohort experiments suggest that these representations transfer beyond observed alignment targets. These results support session-scale, clinically grounded representation learning as a promising foundation-model paradigm for clinical EEG.

Unifying text-image contrastive learning and text-to-image (T2I) generation in a single end-to-end model is challenging because the two objectives demand opposing masking regimes: contrastive alignment needs near-complete visible tokens, while masked generative modeling needs heavy corruption. We introduce DREAM, a unified framework that resolves this conflict through Masking Warmup, a schedule that shifts the center of the masking distribution over training, so low and high masking ratios coexist at every step. This co-exposure lets a single jointly-trained encoder serve both objectives. The resulting stable optimization unlocks Semantically Aligned Decoding at inference: the text encoder, trained against visual embeddings at all masking ratios, can score partially generated images and select the best trajectory with as little as 12.5

Token-based self-supervised learning (SSL) has emerged as a powerful paradigm for leveraging large-scale unlabeled data, yet it suffers from a previously overlooked challenge: token-class imbalance. We show that visual token distributions are highly skewed; a small subset of frequent tokens, often representing uninformative backgrounds, dominates the training process. Conversely, semantically rich but rare tokens are severely underrepresented. This imbalance distorts the learning objective, hindering the model’s ability to learn robust representations and impairing generalization. To address this, we introduce two solutions adapted from imbalanced learning: a class-balanced cross-entropy loss that re-weights the training signal based on token rarity, and semantic-aware label smoothing (SLS), a novel regularization technique that leverages token embedding similarity to create more meaningful soft targets. We validate our methods on MAGE for representation learning and MaskGIT for image generation. Our experiments demonstrate that these techniques significantly enhance both discriminative and generative performance, evidenced by improved linear separability of the representation space and better mode coverage in image synthesis, respectively. This study underscores the necessity of mitigating token-class imbalance, offering scalable solutions that contribute to more robust and generalizable visual learning.

This paper introduces a novel cross-physiology translation task: synthesizing sleep electroencephalography (EEG) from respiration signals. To address the significant complexity gap between the two modalities, we propose a waveform-conditional generative framework that preserves fine-grained respiratory dynamics while constraining the EEG target space through discrete tokenization. Trained on over 28,000 individuals, our model achieves a 7

Wearable sensors enable the continuous acquisition of high-resolution physiological waveforms, such as photoplethysmography and accelerometry, under free-living conditions. However, inferring health-related phenotypes from these signals presents significant challenges due to high sampling frequencies, multimodal dependencies, and extreme sequence lengths (e.g., weeks of recordings), compounded by a scarcity of ground-truth labels. To address these challenges, existing self-supervised learning (SSL) methodologies typically follow two paradigms: (1) learning rich morphological representations from short waveform segments while collapsing longitudinal dynamics through simple aggregation, or (2) modeling behavioral patterns from coarse, hand-crafted features (e.g. heart rate, step counts) spanning longer horizons but foregoing subtle, predictive signatures in raw waveforms. To bridge this gap, we propose WavesFM, a foundation model utilizing a two-stage SSL framework for longitudinal physiological data. Specifically, we decompose the learning problem into two stages: first, a segment-level encoder is pretrained to extract local embeddings from short waveforms; subsequently, a temporal encoder is trained to model the sequence of these embeddings across a multi-day horizon. This hierarchical approach overcomes the computational complexity of high-resolution, long-sequence data, allowing the overall model to capture both local signal semantics and the complex circadian and inter-day variations governing physiological dynamics. Pretrained on over 6.8M hours (N=324k individuals) of recordings for the first stage and 5.3M hours (N=10k) for the second stage, WavesFM demonstrates superior performance across 58 diverse tasks spanning demographics, lifestyle, health conditions, and medications.

Knowledge Distillation (KD) aims to train a lightweight student model by transferring knowledge from a large, high-capacity teacher. Recent studies have shown that leveraging diverse teacher perspectives can significantly improve distillation performance; however, achieving such diversity typically requires multiple teacher networks, leading to high computational costs. In this work, we propose a novel cost-efficient knowledge augmentation method for KD that generates diverse multi-views by attaching multiple branches to a single teacher. To ensure meaningful semantic variation across multi-views, we introduce two angular diversity objectives: 1) $\textit{constrained inter-angle diversify loss}$, which maximizes angles between augmented views while preserving proximity to the original teacher output, and 2) $\textit{intra-angle diversify loss}$, which encourages an even distribution of views around the original output. The ensembled knowledge from these angularly diverse views, along with the original teacher, is distilled into the student. We further theoretically demonstrate that our objectives increase the diversity among ensemble members and thereby reduce the upper bound of the ensemble's expected loss, leading to more effective distillation. Experimental results show that our method surpasses an existing knowledge augmentation method across diverse configurations. Moreover, the proposed method is compatible with other KD frameworks in a plug-and-play fashion, providing consistent improvements in generalization performance.

Image tokenization, the process of transforming raw image pixels into a compact low-dimensional latent representation, has proven crucial for scalable and efficient image generation. However, mainstream image tokenization methods generally have limited compression rates, making highresolution image generation computationally expensive. To address this challenge, we propose to leverage language for efficient image tokenization, and we call our method Text-Conditioned Image Tokenization (TexTok). TexTok is a simple yet effective tokenization framework that leverages language to provide a compact, high-level semantic representation. By conditioning the tokenization process on descriptive text captions, TexTok simplifies semantic learning, allowing more learning capacity and token space to be allocated to capture fine-grained visual details, leading to enhanced reconstruction quality and higher compression rates. Compared to the conventional tokenizer without text conditioning, TexTok achieves average reconstruction FID improvements of 29.2% and 48.1% on ImageNet-256 and 512 benchmarks respectively, across varying numbers of tokens. These tokenization improvements consistently translate to 16.3% and 34.3% average improvements in generation FID. By simply replacing the tokenizer in Diffusion Transformer (DiT) with TexTok, our system can achieve a 93.5x inference speedup while still outperforming the original DiT using only 32 tokens on ImageNet-512. TexTok with a vanilla DiT generator achieves state-of-the-art FID scores of 1.46 and 1.62 on ImageNet-256 and -512 respectively. Furthermore, we demonstrate TexTok's superiority on the text-to-image generation task, effectively utilizing the off-the-shelf text captions in tokenization.

Reinforcement learning (RL) has recently emerged as a compelling approach for enhancing the reasoning capabilities of large language models (LLMs), where an LLM generator serves as a policy guided by a verifier (reward model). However, current RL post-training methods for LLMs typically use verifiers that are fixed (rule-based or frozen pretrained) or trained discriminatively via supervised fine-tuning (SFT). Such designs are susceptible to reward hacking and generalize poorly beyond their training distributions. To overcome these limitations, we propose Tango, a novel framework that uses RL to concurrently train both an LLM generator and a verifier in an interleaved manner. A central innovation of Tango is its generative, process-level LLM verifier, which is trained via RL and co-evolves with the generator. Importantly, the verifier is trained solely based on outcome-level verification correctness rewards without requiring explicit process-level annotations. This generative RL-trained verifier exhibits improved robustness and superior generalization compared to deterministic or SFT-trained verifiers, fostering effective mutual reinforcement with the generator. Extensive experiments demonstrate that both components of Tango achieve state-of-the-art results among 7B/8B-scale models: the generator attains best-in-class performance across five competition-level math benchmarks and four challenging out-of-domain reasoning tasks, while the verifier leads on the ProcessBench dataset. Remarkably, both components exhibit particularly substantial improvements on the most difficult mathematical reasoning problems.

The ability to assess sleep at home, capture sleep stages, and detect the occurrence of apnea (without on-body sensors) simply by analyzing the radio waves bouncing off people's bodies while they sleep is quite powerful. Such a capability would allow for longitudinal data collection in patients' homes, informing our understanding of sleep and its interaction with various diseases and their therapeutic responses, both in clinical trials and routine care. In this article, we develop an advanced machine-learning algorithm for passively monitoring sleep and nocturnal breathing from radio waves reflected off people while asleep. Validation results in comparison with the gold standard (i.e. polysomnography; n = 880) demonstrate that the model captures the sleep hypnogram (with an accuracy of 80.5% for 30-second epochs categorized into wake, light sleep, deep sleep, or REM), detects sleep apnea (AUROC = 0.89), and measures the patient's Apnea-Hypopnea Index (ICC = 0.90; 95% CI = [0.88, 0.91]). Notably, the model exhibits equitable performance across race, sex, and age. Moreover, the model uncovers informative interactions between sleep stages and a range of diseases including neurological, psychiatric, cardiovascular, and immunological disorders. These findings not only hold promise for clinical practice and interventional trials but also underscore the significance of sleep as a fundamental component in understanding and managing various diseases.

Chronic itch affects 13 underlies many medical conditions. A major challenge in clinical care and new therapeutics development is the lack of an objective measure for quantifying itch, leading to reliance on subjective measures like patients' self-assessment of itch severity. In this paper, we show that a home radio device paired with artificial intelligence (AI) can concurrently capture scratching and evaluate its impact on sleep quality by analyzing radio signals bouncing in the environment. The device eliminates the need for wearable sensors or skin contact, enabling monitoring of chronic itch over extended periods at home without burdening patients or interfering with their skin condition. To validate the technology, we conducted an observational clinical study of chronic pruritus patients, monitored at home for one month using both the radio device and an infrared camera. Comparing the output of the device to ground truth data from the camera demonstrates its feasibility and accuracy (ROC AUC = 0.997, sensitivity = 0.825, specificity = 0.997). The results reveal a significant correlation between scratching and low sleep quality, manifested as a reduction in sleep efficiency (R = 0.6, p < 0.001) and an increase in sleep latency (R = 0.68, p < 0.001). Our study underscores the potential of passive, long-term, at-home monitoring of chronic scratching and its sleep implications, offering a valuable tool for both clinical care of chronic itch patients and pharmaceutical clinical trials.

The National Center on Sleep Disorders Research of the National Heart, Lung, and Blood Institute at the National Institutes of Health hosted a 2-day virtual workshop titled Big Data Approaches for Novel Mechanistic Insights on Disorders of Sleep and Circadian Rhythms on May 2nd and 3rd, 2024. The goals of this workshop were to establish a comprehensive understanding of the current state of sleep and circadian rhythm disorders research to identify opportunities to advance the field by using approaches based on artificial intelligence and machine learning. The workshop showcased rapidly developing technologies for sensitive and comprehensive remote analysis of sleep and its disorders that can account for physiological, environmental, and social influences, potentially leading to novel insights on long-term health consequences of sleep disorders and disparities of these health problems in specific populations.

Recent significant advances in text-to-image models unlock the possibility of training vision systems using synthetic images, potentially overcoming the difficulty of collecting curated data at scale. It is unclear, however, how these models behave at scale, as more synthetic data is added to the training set. In this paper we study the scaling laws of synthetic images generated by state of the art text-to-image models, for the training of supervised models: image classifiers with label supervision, and CLIP with language supervision. We identify several factors, including text prompts, classifier-free guidance scale, and types of text-to-image models, that significantly affect scaling behavior. After tuning these factors, we observe that synthetic images demonstrate a scaling trend similar to, but slightly less effective than, real images in CLIP training, while they significantly underperform in scaling when training supervised image classifiers. Our analysis indicates that the main reason for this underperformance is the inability of off-the-shelf text-to-image models to generate certain concepts, a limitation that significantly impairs the training of image classifiers. Our findings also suggest that scaling synthetic data can be particularly effective in scenarios such as: (1) when there is a limited supply of real images for a supervised problem (e.g., fewer than 0.5 million images in ImageNet), (2) when the evaluation dataset diverges significantly from the training data, indicating the out-of-distribution scenario, or (3) when synthetic data is used in conjunction with real images, as demonstrated in the training of CLIP models.

Unconditional generation -- the problem of modeling data distribution without relying on human-annotated labels -- is a long-standing and fundamental challenge in generative models, creating a potential of learning from large-scale unlabeled data. In the literature, the generation quality of an unconditional method has been much worse than that of its conditional counterpart. This gap can be attributed to the lack of semantic information provided by labels. In this work, we show that one can close this gap by generating semantic representations in the representation space produced by a self-supervised encoder. These representations can be used to condition the image generator. This framework, called Representation-Conditioned Generation (RCG), provides an effective solution to the unconditional generation problem without using labels. Through comprehensive experiments, we observe that RCG significantly improves unconditional generation quality: e.g., it achieves a new state-of-the-art FID of 2.15 on ImageNet 256x256, largely reducing the previous best of 5.91 by a relative 64%. Our unconditional results are situated in the same tier as the leading class-conditional ones. We hope these encouraging observations will attract the community's attention to the fundamental problem of unconditional generation. Code is available at [https://github.com/LTH14/rcg](https://github.com/LTH14/rcg).

As artificial intelligence (AI) rapidly approaches human-level performance in medical imaging, it is crucial that it does not exacerbate or propagate healthcare disparities. Prior research has established AI's capacity to infer demographic data from chest X-rays, leading to a key concern: do models using demographic shortcuts have unfair predictions across subpopulations? In this study, we conduct a thorough investigation into the extent to which medical AI utilizes demographic encodings, focusing on potential fairness discrepancies within both in-distribution training sets and external test sets. Our analysis covers three key medical imaging disciplines: radiology, dermatology, and ophthalmology, and incorporates data from six global chest X-ray datasets. We confirm that medical imaging AI leverages demographic shortcuts in disease classification. While correcting shortcuts algorithmically effectively addresses fairness gaps to create "locally optimal" models within the original data distribution, this optimality is not true in new test settings. Surprisingly, we find that models with less encoding of demographic attributes are often most "globally optimal", exhibiting better fairness during model evaluation in new test environments. Our work establishes best practices for medical imaging models which maintain their performance and fairness in deployments beyond their initial training contexts, underscoring critical considerations for AI clinical deployments across populations and sites.

Parkinson's Disease is a progressive neurodegenerative disorder afflicting almost 12 million people. Increased understanding of its complex and heterogenous disease pathology, etiology and symptom manifestations has resulted in the need to design, capture and interrogate substantial clinical datasets. Herein we advocate how advances in the deployment of artificial intelligence models for Federated Data Analysis and Federated Learning can help spearhead coordinated and sustainable approaches to address this grand challenge.

We introduce SynCLR, a novel approach for learning visual representations exclusively from synthetic images and synthetic captions, without any real data. We synthesize a large dataset of image captions using LLMs, then use an off-the-shelf text-to-image model to generate multiple images corresponding to each synthetic caption. We perform visual representation learning on these synthetic images via contrastive learning, treating images sharing the same caption as positive pairs. The resulting representations transfer well to many downstream tasks, competing favorably with other general-purpose visual representation learners such as CLIP and DINO v2 in image classification tasks. Furthermore, in dense prediction tasks such as semantic segmentation, SynCLR outperforms previous self-supervised methods by a significant margin, e.g., improving over MAE and iBOT by 6.2 and 4.3 mIoU on ADE20k for ViT-B/16.