COVID-19 was declared a pandemic in March 2020. For case management, Mali has created several treatment sites including the site of the CHU Gabriel Touré.AIMS:The objective of the study was to analyse drug prescriptions for the COVID-19 treatment at the CHU Gabriel Touré.METHODS:We performed a retrospective and descriptive study from April to September 2020. Drug prescriptions and hospital records were used to collect data. Prescriptions and hospital records were used to collect data.RESULTS:A total of 29 patients were hospitalized. The median age was 44 years, 75.90% of patients had at least one pathology associated with COVID-19. The number of prescriptions was 333 comprising 870 lines of prescriptions including 33.21% for standard treatments, and 66.79% for associated pathologies. with 86.23% available at the Hospital Pharmacy. Chloroquine, dosed at 250mg, was administered at 500mg twice a day. The national guidelines from the treatment of COVID-19 recommends 200mg of chloroquine in two doses. Vitamin C was prescribed for all patients although not included in the national guidelines. The class of drugs for the blood and blood-forming organs was the most prescribed (31.49%). The average cost of treatments was 65,602 ± 106,858 FCFA with a maximum of 567,860 FCFA. An evaluation of prescriptions in other treatment sites is necessary.

Le tuberculome est l'une des rares causes infectieuses de compression médullaire. Il est responsable de troubles neurologiques importants avec des séquelles considérables. L'objectif était de discuter des aspects physiopathologiques et la conduite thérapeutique du tuberculome intramédullaire. Patient et méthode : Le patient de 32 ans sans antécédents particuliers a présenté un syndrome de compression médullaire lente. La chirurgie associée à l'examen anatomopathologique ont permis de poser le diagnostic. Une antibiothérapie antituberculeuse a été instaurée en traitement de fond. Après 15 mois, l'évolution était marquée par la persistance des troubles neurologiques. Conclusion : La prise en charge précoce et adéquate du tuberculome intramédullaire limite le risque de complication mais ne garantis pas une évolution sans séquelles

Introduction : Les abcès cérébraux peuvent devenir graves s'ils sont non ou insuffisamment traités. La prise en charge inclue le traitement correct de la porte d'entrée. Celle-ci n'est pas toujours retrouvée. Nous rapportons notre expérience sur la prise en charge des abcès cérébraux à porte d'entrée non retrouvée à l'issue duquel nous proposerons un algorithme décisionnel de traitement. Patients et méthode : Il s'agit d'une étude retrospective et descriptive allant de novembre 2014 à décembre 2016. Elle a concerné les patients de tous âges traités dans le service de neurochirurgie du CHU Gabriel Touré pour un abcès cérébral chez qui le foyer initial n'a pas été retrouvé. Les paramètres cliniques, radiologiques et thérapeutiques ont été étudiés. Résultats :Durant notre période d'étude, les abcès cérébraux à point de départ non trouvé ont représenté 33,3% de tous les abcès cérébraux et 63,6% des abcès cérébraux opérés. L'âge moyen des patients était de 45 ans avec un sex ratio de 0,7. Tous nos patients étaient immunocompétents. La fièvre et l'hypertension intracranienne étaient les principaux signes. La lésion était de siège frontal et temporal principalement. Tous les patients ont bénéficié d'une ponction chirurgicale avec drainage d'abcès associé à une triantibiothérapie. L'évolution était défavorable dans 28,6% des cas (recollection d'abcès) et satisfaisante dans 71,4% des cas. La mortalité était nulle. Conclusion : La très bonne évolution clinique et radiologique après le traitement n'est une gage de la guérison d'un abcès du cerveau tant que le foyer infectieux initial n'est retrouvé et convenablement traité

INTRODUCTION:Healthcare-associated infections or nosocomial infections are a public health problem due to their frequency, severity and economic impact. They cause an increase of the morbidity, the mortality, the hospital stay and the expenses of taking care of the patients. According to the WHO, 7.1 million people are affected each year, of which about 100,000 die.AIM OF STUDY:The aim of this study was to determine the frequency of healthcare-associated infections in the Neurosurgery Department of Gabriel Touré University teaching Hospital and to identify the risk factors associated with these infections.MATERIAL AND METHODS:This was an epidemiological, descriptive, analytic, cross-sectional and prospective study lasting 6 months from May 29 to November 30, 2016. The study focused on patients who stayed more than 48 hours in the Neurosurgical department Gabriel Touré teaching hospital. The collected data focused on the clinical and biological characteristics of the patients during their hospitalization. The maximum size of the sample was 200 patients. A sample was taken for each type of infection. The criteria used for the diagnosis of Healthcare-associated infections were those of the CDC (Center for Disease Control) and the realization of a thick drop in our context. The chi-square test was used for the comparison of qualitative variables and Kruskal Wallis and Anova for quantitative variables. The materiality threshold has been set to a value of p less than 0.05.RESULTS:At the end of our study, we had 34 infected patients out of 200, a rate of 17%. The significant risk factors found in our study were: high age (p = 0.04), ASA class (p = 0.002), pre-surgical shaving (p = 0.02), long duration surgical intervention (p = 0.002) and long hospital stay (p = 0.004). The types of infections associated with the care found were: urinary in 18 (53%) cases, respiratory in 9 (26%) cases, operative site in 6 (18%) cases and 1 (3%) cases of bacteremia. The bacterial spectrum of these infections was dominated by Negative Gram Bacilli, among which Escherichia coli in 11 (32.3%) cases. The clinical course of patients treated for these infections was marked by healing in 31 (91.2%) cases, complications in 2 (5.9%) cases, and death in 1 (2.9%) case.CONCLUSION:The prevalence of Healthcare-associated infections in our department remains high compared to that found in developed countries. This study allowed us to identify the main risk factors associated with these infections. A stricter adherence to the rules of hygiene and prevention of Healthcare-associated infections is needed to reduce this rate.