Annals of the New York Academy of SciencesVolume 452, Issue 1 p. 409-409 The Hypothesis of the Model of Insulin Synthesis Regulation D. P. SHRAER, D. P. SHRAERSearch for more papers by this author D. P. SHRAER, D. P. SHRAERSearch for more papers by this author First published: October 1985 https://doi.org/10.1111/j.1749-6632.1985.tb30037.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume452, Issue1Sixth International Conference on Collective Phenomena: Reports from the Moscow Refusnik SeminarOctober 1985Pages 409-409 RelatedInformation

The possibility of eliminating the drug resistance determinants in penicillinase-producing staphylococci under the effect of an acridine "dimer", synthesized by French scientists was studied. Comparison of the eliminating activity of a number of acridine compounds, such as acrichin, acriflavine, proflavine and "dimer" showed that the new derivative of acridine as well as the other acridines used in the experiments induced elimination of the penicillinase plasmids when used in the sublethal concentrations.

A modified quantitative nephelometric method was used. It was shown that production of extracellular plasmocoagulase was depressed in the development of acridine-sensitive and acridine-resistant cultures of Staph. aureus in the fluid nutrient medium containing 3,6-diaminoacridines: acriflavine, proflavine, acridine yellow, acridine orange, acridine No. 40 and acridine No. 56; 3,6-diaminoacridines failed to lead to noncompetitive inhibition of staphylococcus plasmocoagulase. A disturbance of the regulation of the enzyme exit into the external environment can serve as the cause of depression of the extracellular plasmocoagulase production by Staph. aureus.

Während bei der Umsetzung der 9-Aminoacridine (I) mit N-Acety1glutaminsäureanhydrid (II) in Dimethylformamid die N-acylierten Derivate (III) entstehen, wird aus dem unsubstituierten 9-Aminoacridin (IV) mit (II) unter den gleichen Bedingungen das Salz (V) gebildet.

In infection of mice with small doses ofM.tuberculosis the concomitant staphylococcal infection, especially that developing in advance, leads to attenuation of the tuberculous process.