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1Treatment of Herpers Viral Retinopathies in Babies with Severe Immune Deficiency

E. Adjadj,Matthieu P. Robert,Caroline Séghir,Sebastien Héritier, Barham Bodaghi,J.L. Dufier,Olivier Roche

2012Investigative Ophthalmology & Visual Science（2012）引用：23

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2Delta1-pyrroline-5-carboxylate Synthase Deficiency: Histological Study of the Crystalline Lens

Olivier Roche,E. Adjadj,Matthieu Robert,Christophe Orssaud,Jean‐Michel Rozet,Josseline Kaplan,J.L. Dufier

2012Investigative Ophthalmology & Visual Science（2012）引用：22

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3[Dosage and Kinetics of MMC Release of a Collagen Implant Used As a Delivery Device in Glaucoma Surgery in the Rabbit Eye].

E Adjadj, S Roy,C Zimmermann,T Shaarawy,J Flammer,A Mermoud,J Drewe

PURPOSE:To determine the absorption and the release of mitomycin-C from a collagen implant and tissue impregnation in the anterior structures of the rabbit eye.METHODS:Determining the quantity of mitomycin-C that a collagen implant can absorb with the difference between dry and soaked weight. Mitomycin-C release was measured in vitro using spectrophotometry. The measurement was repeated using a bioassay. Ocular tissue impregnation was determined in 12 eyes of six rabbits. Sclera, implant, aqueous, and ciliary body specimens were collected for concentration measurement using HPLC from 1 to 6 h after surgery.RESULTS:The mean mitomycin-C quantity absorbed in the implant was 3.22+/-0.2 microg. In vitro release was 0.13 mg/ml after 10 min and 0.05 microg/ml at 6 h. The bioassay showed almost no antifibrotic activity in sclera. In vivo release of mitomycin-C was high from the first to the sixth hour.CONCLUSION:After filtering surgery, mitomycin-C in the collagen implant is clearly released and ocular tissues are effectively impregnated.

2006Journal francais d'ophtalmologie（2006）引用：27

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4Dosage Et Cinétique De Libération De Mitomycine C D’un Implant De Collagène Utilisé Comme Moyen D’administration Lors D’une Chirurgie Filtrante Chez Le Lapin

E. Adjadj, S. Roy,C. Zimmermann,T. Shaarawy,J. Flammer,A. Mermoud,J. Drewe

Purpose: To determine the absorption and the release of mitomycin-C from a collagen implant and tissue impregnation in the anterior structures of the rabbit eye.Methods: Determining the quantity of mitomycin-C that a collagen implant can absorb with the difference between dry and soaked weight. Mitomycin-C release was measured in vitro using spectrophotometry. The measurement was repeated using a bioassay. Ocular tissue impregnation was determined in 12 eyes of six rabbits. Sclera, implant, aqueous, and ciliary body specimens were collected for concentration measurement using HPLC from 1 to 6 h after surgery.Results: The mean mitomycin-C quantity absorbed in the implant was 3.22 +/- 0.2 mu g. In vitro release was 0.13 mg/ml after 10 min and 0.05 mu g/ml at 6 h. The bioassay showed almost no antifibrotic activity in sclera. In vivo release of mitomycin-C was high from the first to the sixth hour.Conclusion: After filtering surgery, mitomycin-C in the collagen implant is clearly released and ocular tissues are effectively impregnated.

2006Journal français d'ophtalmologie（2006）引用：5

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5Single–piece Acrylic Intraocular Lens in Pediatric Cataracts