We report on the controlled manipulation of 5-20 nm-sized Au colloidal particles deposited on Si-based substrates using the tip of an atomic force microscope (AFM) operated at room temperature and under ambient conditions. This work is aiming at the step-by-step assembly of granular prototype nanometer-scale devices.For device fabrication and electrical transport measurements, respectively, different particle arrangements were assembled into a 10-40 nm wide gap region separating two Au nanoelectrodes.Decomposition of previously assembled devices allows to repeatedly synthesize new patterns of arbitrary shape using the same set of particles. This opportunity reflects the very high degree of flexibility of our approach in assembling novel functional devices.