Journal of the American Geriatrics SocietyVolume 12, Issue 11 p. 1037-1044 SENSITIVITY TO PAIN IN RELATIONSHIP TO AGE* E. DAVID SHERMAN M.D., F.A.C.P., Corresponding Author E. DAVID SHERMAN M.D., F.A.C.P. Montreal, Canada The Institute of Gerontology, University of Montreal, and the Annie Lauterman Geriatric Research Laboratory, Maimonides Hospital and Home for the Aged, Montreal, Canada.4330 Hampton Avenue, Montreal 28, P.Q., Canada.Search for more papers by this authorEUGÈNE ROBILLARD M.D., Corresponding Author EUGÈNE ROBILLARD M.D. Montreal, Canada Department of Physiology, University of Montreal.4330 Hampton Avenue, Montreal 28, P.Q., Canada.Search for more papers by this author E. DAVID SHERMAN M.D., F.A.C.P., Corresponding Author E. DAVID SHERMAN M.D., F.A.C.P. Montreal, Canada The Institute of Gerontology, University of Montreal, and the Annie Lauterman Geriatric Research Laboratory, Maimonides Hospital and Home for the Aged, Montreal, Canada.4330 Hampton Avenue, Montreal 28, P.Q., Canada.Search for more papers by this authorEUGÈNE ROBILLARD M.D., Corresponding Author EUGÈNE ROBILLARD M.D. Montreal, Canada Department of Physiology, University of Montreal.4330 Hampton Avenue, Montreal 28, P.Q., Canada.Search for more papers by this author First published: November 1964 https://doi.org/10.1111/j.1532-5415.1964.tb00652.xCitations: 33 † Presented at the Sixth International Congress of Gerontology, Copenhagen, Denmark, August 14, 1963. Based on a continuing study described in a previously published report (3). Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume12, Issue11November 1964Pages 1037-1044 RelatedInformation

Synthetic L-alpha-lecithin was administered by inhalation to 11 infants suffering from respiratory distress. The L-alpha-lecithin was delivered by microaerosolization, at a concentration of 0.25% in a mixture of equal volumes of propylene glycol and water. This was done with the aim of decreasing the alveolar surface tension. In eight of the treated infants who survived, the respiratory distress was alleviated. The results are inconclusive but they justify further investigation.

Volume–pressure curves obtained from isolated atelectatic guinea pig lungs under normal controlled conditions are compared with those obtained from animals having inhaled fine aluminum or iron oxide particles. After particles inhalation, the inflation curves are deviated to the right, showing a constricting effect. Previous exposure to low concentration of isoproterenol aerosol fails to reverse completely the constricting effect induced by a prior inhalation of aluminum oxide particles although in combination with diphenhydramine or at a higher concentration an antagonistic action appears. Cyproheptadine aerosolation also prevents the constricting effect of inhaled aluminum oxide particles The constricting effect of iron oxide was not prevented by those dilating aerosols at concentrations used.

Volume–pressure curves obtained from isolated atelectatic rat lungs under normal control conditions were compared with those obtained from lungs of animals previously exposed to inhalation of submicronic aluminum oxide particles for various periods of time. A dilating effect was recorded in rat lungs after aluminum oxide particle inhalation contrasting with the constricting effect reported by many authors in guinea pig, dog, cat, and man. Inhalation of fine aluminum particles before or after inhalation of sympathomimetic aerosol resulted in a more intense dilatation. The constricting effect of carbachol was antagonized by prior inhalation of fine aluminum oxide dust and enhanced when the order of inhalations was reversed.

In previous experiments, the inhalation of aluminum or iron oxide submicronic particles was shown to possess strong constricting properties, using the method of volume–pressure curves with atelectatic guinea pig lung. The constricting effect of aluminum was prevented by cyproheptadine, an antihistaminic and antiserotonin substance. In the present experiments, determinations of serotonin and histamine in dust-treated lungs were undertaken; the content of serotonin and of histamine was found to be increased after aluminum and after iron oxide particle inhalation respectively. Serotonin and histamine given as aerosols to guinea pigs reproduced the characteristic volume–pressure curves obtained after aluminum or iron oxide microparticle inhalation, respectively.

Rats were exposed to an atmosphere containing submicronic aluminum oxide particles or to aerosols of carbachol or isoproterenol. The static pressure – volume curves of their lungs, rendered gas-free and removed after exposure, were then compared to those of normal rats studied similarly. The lungs were filled and emptied gradually both with air and with saline so that in every case the force due to tissue elasticity, as well as that due to the surface tension of the alveolar lining, could be determined. Carbachol aerosol (1%) inhalation for 7 minutes produced an increase in the force due to tissue elasticity. The inhalation of aluminum oxide particles, less than one micron in diameter, for half an hour also increased the force due to tissue elasticity slightly, but it greatly decreased the force due to the surface tension of the alveolar lining.

Quebec,18 whereas in Ontario it occurred relatively infrequently following its dominance during 1958. Coxsackie B2 was dominant in Quebec during 1960, but it was the principal enterovirus in Toronto during 1959, and it occurred relatively abundantly in Illinois in 1958.19 Following the virtuial absence of paralytic poliomyelitis from Toronto during 1960, two cases of Poliovirus Type I infection were encountered during mid-winter and a further eight cases, all due to Poliovirus Type I, occurred during summer. The reason for development of paralytic disease in two fully vaccinated children six weeks and six months after receiving the last dose of vaccine probably resides in failure of antibody production in response to vaccination, owing to the relatively low level of antibody to Poliovirus Type I in the early serum sample; but in the child who became paralyzed five years after vaccination it is possible that the antibody level had fallen to an amount too low to induce protection. All produced antibody after stimulation by living virus acquired naturally.

On a étudié l'incorporation du P32 et le contenu de phosphore dans certaines fractions de phosphore du coeur, chez des rats âgés d'un an et de deux ans, à l'état de repos et suivant un exercice vigoureux. Le taux d'incorporation du P32 se montra plus fort dans le phosphate de créatine que dans le triphosphate d'adénosine durant la phase d'augmentation de l'absorption du phosphore chez les rats d'un an à l'état de repos, mais non pas chex ceux de deux ans. On ne trouva aucune différences les deux groupements d'age après l'exercice, sauf qu'il fallait une plus grosse charge de travail pour épuiser les animaux d'un an que pour ceux de deux ans.