A total of 126 white male Wistar rats under subacute conditions were studied. Of them, 76 were perorally treated with AlCl3 in a dose of 3 mg/kg b.w. daily for 40 days. Activities of acid phosphatase (AP), succinate dehydrogenase (SDH), adenosine triphosphatase (ATP-ase) and the contents of glycogen, glucoproteins and RNA were dynamically followed-up in the liver and kidney. Serum activities of ASAT and ALAT were estimated by Borhringer's tests. Morphological changes were histochemically investigated. There was an initial elevation followed by reduction mostly manifested for SDH and ATP-ase and an increase of AP at the end of trial. Histochemical data argued for disorders of protein and carbohydrate metabolism. Morphological alterations more outlined in the liver became more severe until the end of the experiment.

The authors examined the lung lesions caused by peroral aluminium application as a 0,1 % solution of AlÐil3 in a dose of 3 mg Al3+/kg b. w. for 40 days in a total of 126 white male rats (70 experimental and 56 control). Visible structural alterations were established on the 15th day of the trial consisting in desquamation of bronchial epithelium, enhanced pmounts of acid glucosaminoglycans in the cell cytoplasm and irregular disposition of cells. Later on, the activity of SDH, alkaline phosphatase, and ATP-ase decreased but acid phosphatase activity increased. Connective-tissue fibres grew up in the wall of some bronchi. These morphological findings suggest that although perorally accepted, AlÐil3 induced structural lesions in the lungs as well as metabolic disturbances in the bronchial mucosa which depended on the duration of treatment.

The authors examined biochemically and histochemically the activity of alkaline phosphatase and adenosinetriphosphatase in lymph nodules of experimental animals, living under the conditions of continuous noise action (3 and 5 months) at a level of 95 decibels A for 3 hours daily in the morning. There were phase changes in the activity of the examined enzymes, which revealed considerable stability even after stopping the contact of the organism with noise factor. The manifested inhibition of the activity of alkaline phosphatase and partly of adenosinetriphosphatase suggested that the cells of lymph tissue revealed disturbances in the metabolic processes, which caused exhaustion of their protective function.