Surface modifications of dental implants to provide optimal conditions for osseointegration remains an urgent task in modern dental implantology. A few publications demonstrate that the surface of the dental implants modified by plasma electrolytic oxidation (PEO) possess a combination of several important features that promote osteointegration: optimal micro roughness within 1-7 microns, high chemical purity, and mechanical strength [8,20].The aim. To evaluate the clinical efficacy of IRIS implants with a new surface modified by the PEO method (hereinafter referred to as IRIS PEO).Materials and methods. Based on the Patrice Lumumba RUDN Medical Center and the Center of Medical Care for Dental Diseases, FGBU «Central Clinical Hospital with Polyclinic» of the Presidential Affairs Department of the Russian Federation, 60 patients aged 27 to 52 years with partial tooth loss were examined and treated. The patients received 1 IRIS-PEO implant each on the upper or lower jaw. All implants were placed with the force from 35 to 50 N/cm2, with gingiva shapers. Prosthetics were performed after 2 months on the lower jaw and after 4 months on the upper jaw. Before taking impressions, the stability of implants was measured using the Penguin RFA (Integration Diagnostic Sweden AB, Sweden). One year after prosthetics, the neck resorption of the implants was evaluated.Results. Because of the treatment, all prosthetic constructions met the functional and aesthetic requirements. The stability indices of implants in ISQ units on the upper jaw averaged 75±3.4, on the lower jaw 79±2.4. Bone resorption in the implants’ neck area 1 year after the end of the treatment was not observed. The pilot clinical study of the IRIS-PEO implants allowed to optimize the terms of rehabilitation and to obtain high functional and esthetic result in the treatment of patients with tooth loss.Conclusions. Pilot clinical implementation of the implants of the IRIS system with the surface modified by plasma electrolytic oxidation demonstrated the possibility of open management of the implants with the gingiva shaper, to carry out prosthetics in 2 months on the lower jaw and 4 months on the upper jaw. No neck resorption was observed one year after prosthetics.

This work presents a comparative study on the bioresorption of samples based on natural biopolymers, such as polyhydroxybutyrate, polylactide, polycaprolactone, and chitosan, in living systems and an evaluation of the tissue response to these samples. A histological examination of the polylactide-containing tissue samples revealed that the material possesses good supporting functions for connective, bone, and granulation tissues and causes no pronounced inflammatory infiltration with lymphocytes, neutrophils, and giants cells of foreign bodies. The resorption of the material proceeds slowly, and metabolites released during the resorption have no negative effect on the reparative osteogenesis. These materials seem to be quite promising in veterinary medicine.

We studied biocompatibility and bioresorption of 3D-printed polylactide and polyglycolide tissue membranes. Ultrasound microscopy and histological examination showed that membranes fabricated of a copolymer of lactic and glycolic acids in a mass ratio of 1:9 are bioresorbed and have good biocompatibility with soft tissues (connective tissue, adipose tissue, and epithelium). An important feature of the copolymer membranes, which differs them from pure polylactide membranes, is the formation of a thin fibrous capsule that did not interfere its destruction by the mechanism of hydrolytic resorption.