The transcapillary net exchanges of inulin, para-aminohippurate, thiocyanate and heavy water were determined in the renal circulation. It was found that the tracer substances larger than heavy water diffused more freely through renal than through previously studied peripheral or pulmonary capillaries. The results are consistent with the concept of a larger pore size in renal capillaries.
SPECIAL COMMUNICATIONSA Method for the Study of the Circulation in the Dog Using a Mechanical Left VentricleJohn C. Rose, Herbert P. Broida, Charles A. Hufnagel, John F. Gillespie, Pierre J. Rabile, and Edward D. FreisJohn C. Rose, Herbert P. Broida, Charles A. Hufnagel, John F. Gillespie, Pierre J. Rabile, and Edward D. FreisPublished Online:01 Mar 1955https://doi.org/10.1152/jappl.1955.7.5.580MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmailWeChat Previous Back to Top Download PDF FiguresReferencesRelatedInformationCited ByMechanical simulation of cardiac function by means of pulsatile blood pumpsJournal of Cardiothoracic and Vascular Anesthesia, Vol. 11, No. 3Cardiovascular responses to PGI2 (prostacyclin) in the dog.Circulation Research, Vol. 42, No. 2Systemic Blood Pressure Response to Changes in Right Ventricular FunctionCirculation Research, Vol. 14, No. 5Comparison of Effects of Angiotensin and Norepinephrine on Pulmonary Circulation, Systemic Arteries and Veins, and Systemic Vascular Capacity in the DogCirculation, Vol. 25, No. 1The sympathetic nervous system, the vascular volume and the venous return in relation to cardiovascular integrationThe American Journal of Medicine, Vol. 22, No. 2 More from this issue > Volume 7Issue 5March 1955Pages 580-584 https://doi.org/10.1152/jappl.1955.7.5.580PubMed14367248History Published online 1 March 1955 Published in print 1 March 1955 Metrics
ArticleEffects of Epinephrine and Nor-Epinephrine in Dogs Studied With a Mechanical Left VentricleDemonstration of Active Vasoconstriction in the Lesser CirculationJohn C. Rose, Edward D. Freis, Charles A. Hufnagel, and Edmund A. MassulloJohn C. RoseFrom the Departments of Medicine and Surgery, Georgetown University School of Medicine and the Cardiovascular Research and Experimental Surgical Laboratories, Georgetown University Hospital, Washington, D. C., Edward D. FreisFrom the Departments of Medicine and Surgery, Georgetown University School of Medicine and the Cardiovascular Research and Experimental Surgical Laboratories, Georgetown University Hospital, Washington, D. C., Charles A. HufnagelFrom the Departments of Medicine and Surgery, Georgetown University School of Medicine and the Cardiovascular Research and Experimental Surgical Laboratories, Georgetown University Hospital, Washington, D. C., and Edmund A. MassulloFrom the Departments of Medicine and Surgery, Georgetown University School of Medicine and the Cardiovascular Research and Experimental Surgical Laboratories, Georgetown University Hospital, Washington, D. C.Published Online:01 Jul 1955https://doi.org/10.1152/ajplegacy.1955.182.1.197MoreSectionsPDF (1 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformationCited ByCardiovascular Effects of Norepinephrine in Septic ShockDas chronische Cor pulmonaleReversal of experimental pulmonary hypertension with sodium nitroprussideThe Journal of Thoracic and Cardiovascular Surgery, Vol. 81, No. 4Experimentally Induced Changes in Pulmonary CirculationThe effects of an intravenous infusion of norepinephrine on pulmonary and systematic haemodynamics with and without propranolol pretreatment in dogsEuropean Journal of Pharmacology, Vol. 10, No. 1Orientierende ÜbersichtADRENERGIC DRUGSOrientierende ÜbersichtErgebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie, Vol. 58, No. 1Pulmonary pressor action of I-norepinephrine and angiotensinAmerican Heart Journal, Vol. 70, No. 1Der Novadraltest in der Diagnostik des kleinen VentrikelseptumdefektesSYMPATHOMIMETIC DRUGSEFFECT OF HISTAMINE AND OTHER ENDOGENOUS AMINES ON THE PERIPHERAL HEMODYNAMICS IN RABBITS UNDER THE CONTROLLED CARDIAC OUTPUTJapanese Journal of Pharmacology, Vol. 15, No. 4Pulmonary Capillary Flow Pulse and the Site of Pulmonary Vasoconstriction in the DogCirculation Research, Vol. 15, No. 2Comparison of Effects of Angiotensin and Norepinephrine on Pulmonary Circulation, Systemic Arteries and Veins, and Systemic Vascular Capacity in the DogCirculation, Vol. 25, No. 1Die Bedeutung des Gefäßtonus bei der chronischen pulmonalen Hypertonie, insbesondere bei der Mitralstenose, und seine BeeinflußbarkeitArchiv für Kreislaufforschung, Vol. 34, No. 4Pulmonary embolism and infarctionThe American Journal of Medicine, Vol. 24, No. 3 More from this issue > Volume 182Issue 1July 1955Pages 197-202 Copyright & PermissionsCopyright © 1955 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1955.182.1.197PubMed13248966History Received 25 January 1955 Published online 1 July 1955 Published in print 1 July 1955 Metrics
ArticleEffects of Varying the Output of a Mechanical Left Ventricle on the Circulation in the DogEdward D. Freis, Herbert P. Broida, Charles A. Hufnagel, and John C. RoseEdward D. FreisFrom the Cardiovascular Research Laboratory, Georgetown University Hospital, the Departments of Medicine and Surgery, Georgetown University School of Medicine, and the Heat and Power Division, National Bureau of Standards, Washington, D. C., Herbert P. BroidaFrom the Cardiovascular Research Laboratory, Georgetown University Hospital, the Departments of Medicine and Surgery, Georgetown University School of Medicine, and the Heat and Power Division, National Bureau of Standards, Washington, D. C., Charles A. HufnagelFrom the Cardiovascular Research Laboratory, Georgetown University Hospital, the Departments of Medicine and Surgery, Georgetown University School of Medicine, and the Heat and Power Division, National Bureau of Standards, Washington, D. C., and John C. RoseFrom the Cardiovascular Research Laboratory, Georgetown University Hospital, the Departments of Medicine and Surgery, Georgetown University School of Medicine, and the Heat and Power Division, National Bureau of Standards, Washington, D. C.Published Online:01 Jul 1955https://doi.org/10.1152/ajplegacy.1955.182.1.191MoreSectionsPDF (927 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation More from this issue > Volume 182Issue 1July 1955Pages 191-196 Copyright & PermissionsCopyright © 1955 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1955.182.1.191PubMed13248965History Received 13 December 1954 Published online 1 July 1955 Published in print 1 July 1955 Metrics
Single oral doses of 1-hydrazinophthalazine frequently lowered blood pressure particularly diastolic pressure in hypertensive patients. Prolonged therapy was less successful, apparently as a result of development of tolerance or side effects. The best long-term results were obtained when l-hydrazinophthalazine was alternated with hexamethonium.