A recent analysis of the Fermi Large Area Telescope data provided evidence for a high-intensity emission of high-energy gamma rays with a E−2 spectrum from two large areas, spanning 50° above and below the Galactic centre (the “Fermi bubbles”). A hadronic mechanism was proposed for this gamma-ray emission making the Fermi bubbles promising source candidates of high-energy neutrino emission. In this work Monte Carlo simulations regarding the detectability of high-energy neutrinos from the Fermi bubbles with the future multi-km3 neutrino telescope KM3NeT in the Mediterranean Sea are presented. Under the hypothesis that the gamma-ray emission is completely due to hadronic processes, the results indicate that neutrinos from the bubbles could be discovered in about one year of operation, for a neutrino spectrum with a cutoff at 100TeV and a detector with about 6km3 of instrumented volume. The effect of a possible lower cutoff is also considered.

Detection of high-energy neutrinos from distant astrophysical sources will open a new window on the Universe. The detection principle exploits the measurement of Cherenkov light emitted by charged particles resulting from neutrino interactions in the matter containing the telescope. A novel multi-PMT digital optical module (DOM) was developed to contain 31 3-inch photomultiplier tubes (PMTs). In order to maximize the detector sensitivity, each PMT will be surrounded by an expansion cone which collects photons that would otherwise miss the photocathode. Results for various angles of incidence with respect to the PMT surface indicate an increase in collection efficiency by 30% on average for angles up to 45° with respect to the perpendicular. Ray-tracing calculations could reproduce the measurements, allowing to estimate an increase in the overall photocathode sensitivity, integrated over all angles of incidence, by 27% (for a single PMT). Prototype DOMs, being built by the KM3NeT consortium, will be equipped with these expansion cones.

To measure variations of zenith dependence of sedimentation/bio-fouling on the optical modules (OMs) as considered by the KM3NeT consortium in the deep sea, we have used a grid of photodiodes distributed inside the glass sphere to measure the light intensity of two light sources located outside the glass sphere on a fixed position. The method is described and the data collected during the last three years in depths from 3100 m down to 5100 m, in the southeast Ionian sea, at sites near Pylos, Peloponnese, Greece, are discussed.

The long optical base transmissometer (LAMS—Long Arm Marine Spectrophotometer) constructed in 2008 by NESTOR group is described. The data of the recent water transparency measurements in the NESTOR site and in the Capo Passero site in the wavelength range 378–522nm are presented

A long optical base line spectrophotometer designed to measure light transmission in deep sea waters is described. The variable optical path length allows measurements without the need for absolute or external calibration. The spectrophotometer uses eight groups of uncollimated light sources emitting in the range 370–530nm and was deployed at various depths at two locations in the Ionian Sea that are candidate sites for a future underwater neutrino telescope. Light transmission spectra at the two locations are presented and compared.

LAERTIS, designed to collect environmental data from the deep-sea, is operated since 1999 and has been deployed several time at 4000m depth at the NESTOR site. Power and data were transferred through a 30-km electro-optical cable to the Shore Station. In this report, we describe briefly the LAERTIS instrumentation and present typical data that were collected successfully during those deployment demonstrating the importance of a deep-sea station permanently connected to shore.

The key component of NESTOR, the deep-sea Cherenkov neutrino telescope, built in the Mediterranean, NW of Greece, is the optical module. The NESTOR Optical Module employs a PhotoMultiplier Tube (PMT) in a transparent glass pressure housing. The Hamamatsu PMT R8055-01, 13in. photomultiplier was selected for NESTOR to replace the old 15′′ Hamamatsu PMTs (R2018-03). Extensive tests have been made on the sensitivity, uniformity, time resolution and noise rates of 162 R8055-01 13in. PMTs

A module of the NESTOR underwater neutrino telescope, was deployed, in March 2003, at a depth of 3800m in order to test the overall detector performance and particularly that of the data acquisition systems. A prolonged period of running under stable operating conditions made it possible to measure the cosmic ray muon flux, I0cosa(θ).

NESTOR is a deep-sea neutrino telescope that is under construction in the Ionian Sea off the coast of Greece at a depth of about 4000m. This paper briefly reviews the detector structure and deployment techniques before describing in detail the calibration and engineering run of a test detector carried out in 2003. The detector was operated for more than 1 month and data was continuously transmitted to shore via an electro-optical cable laid on the sea floor. The performance of the detector is discussed and analysis of the data obtained shows that the measured cosmic ray muon flux is in good agreement with previous measurements and with phenomenological cosmic ray models.

NESTOR is a deep-sea neutrino telescope that is currently under construction in the Ionian Sea, off the coast of Pylos, Southwestern Greece, at a depth of approximately 4000 m. We outline briefly the layout of the telescope and summarize the present status of the project. The results of a one month continuous operation of a test unit using our standard detector modules is discussed. Data of the cosmic ray muon flux acquired with the help of an electro-optical cable during this period is presented. The data are in good agreement with earlier experiments at comparable, depth. In addition we discuss our results of bioluminescence measurements and other site and technical aspects.

A module of the NESTOR underwater neutrino telescope was deployed at a depth of 3800 m in order to test the overall detector performance and particularly that of the data acquisition systems. A prolonged period of running under stable operating conditions made it possible to measure the cosmic ray muon flux, I-0 (.) cos(alpha)(theta), as a function of the zenith angle theta. Measured values of index alpha and the vertical intensity I-0(Graphics)are in good agreement with previous measurements and phenomenological predictions. (c) 2005 Elsevier B.V. All rights reserved.

A module of the NESTOR underwater neutrino telescope was deployed at a depth of 3800 m in order to test the overall detector performance and particularly that of the data acquisition systems. A prolonged period of running under stable operating conditions made it possible to measure the cosmic ray muon flux, I0 cosðhÞ, as a function of the zenith angle h. Measured values of index a and the vertical intensity I0 0927-6505/$ see front matter 2005 Elsevier B.V. All rights reserved. doi:10.1016/j.astropartphys.2005.02.001 * Corresponding author. Tel./fax: +30 210 7276948. E-mail address: eanason@cc.uoa.gr (E.G. Anassontzis). ðsystÞ cm 2 s 1 sr 1 378 G. Aggouras et al. / Astroparticle Physics 23 (2005) 377–392 a 1⁄4 4:7 0:5ðstatÞ 0:2ðsystÞ I0 1⁄4 9:0 10 9 0:7 10 ðstatÞ 0:4 10 are in good agreement with previous measurements and phenomenological predictions. 2005 Elsevier B.V. All rights reserved. PACS: 95.55.Vj; 29.40.Ka; 13.15.+g

NESTOR is a submarine high-energy muon and neutrino telescope, now under construction for deployment in the Mediterranean close to Greek shores. The first floor of NESTOR with 12 optical modules was deployed successfully in March 2003 together with the electronics system. All systems and the associated environmental monitoring units are operating properly and data are being recorded. The status of the NESTOR project is presented. We outline briefly the construction of the deepwater neutrino telescope, properties of the NESTOR site, infrastructure of the project, the deployment of the first floor, and its current operation. The first data are presented and plans for the next steps are summarized.

and ~1 HS are correlates of CMI, levels of these proteins may be as importan z as T-cell levels as indices of host systemic immune competence.The lower T-cell levels during irradiation suggest that systemic immune competence declines with treatment, while the lower levels of APP, and increase in ~zHS indicate improvement in systemic immunity.Therefore, the data indicate that effects of radiation therapy on systemic inune competence may not parallel changes in T-cell levels and other in vitro correlates of CMI.Determination of the effects on host immunec?@%? tence may require a matrix of assays of both cellular and humoral factors which influence CMI.

Preoperative plasma CEA levels were measured by radioimmunoassay for 149 patients with bronchogenic carcinoma. The data were used to determine the prognostic value of the CEA assay in these patients. The relationship of preoperative CEA levels with stage of disease, histology and resectability was also examined. All of the patients with CEA levels >6 ng/ml died in less than 3 years while all of the patients who survived 3 to 5 years had preoperative CEA levels ≤ 6 ng/ml. The CEA assay had no prognostic significance for patients with undifferentiated large or small cell carcinomas since all of the patients with undifferentiated large cell carcinoma had CEA levels ≤ 6.0 ng/ml and all of the patients with small cell carcinoma have died regardless of their initial preoperative plasma CEA value. The number of patients in these two histologic groups was small and perhaps the study of additional patients will show a critical CEA level for these patients as well. There was no correlation observed between CEA levels ≤ 6 ng/ml vs. >6 ng/ml and resectability of the primary tumor. The studies indicate, however, that preoperative CEA levels are of prognostic value in patients with epidermoid and adenocarcinoma who have values >6 ng/ml since all of these patients have died and all of the long term survivors had levels ≤ 6 ng/ml.

Immunoprofile studies consisting of the measurement of de novo sensitization with DNCB, skin testing with microbial antigens, WBC and differential blood cell counts, enumeration of peripheral blood T and B lymphocytes and stimulation of lymphocytes with the plant mitogens PHA, Con A, and PWM were performed prior to irradiation therapy for 141 patients with bronchogenic carcinoma. The data from these studies were examined, with the addition of the variables stage of disease, histologic type of tumor, age and sex, by multivariate analysis for correlation with survival. Although stage of disease was shown to be a significant factor in the survival of these patients, the results of this analysis indicate that significant additional information relative to survival may be obtained from the measurement of: (1) patients' response to DNCB; (2) response to skin test antigens; and (3) the proportion of peripheral T lymphocytes. There was little gain in survival forecasting efficiency with the addition of the remaining variables.