Novel anthranilamides were surprisingly found to exert additional activity on B-RAF. Corresponding thiophene, pyrazole, and thiazole core analogs were prepared as VEGFR-2 inhibitors with c-KIT, and B-RAF activity. Compounds in the phenyl, thiophene, and thiazole series are in vivo active.
A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-alpha and PPAR-delta ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-delta over PPAR-alpha.
Philip Wickens合作论文数12Chih-Yuan Chuang合作论文数7Julie Dixon合作论文数5charles kreiman合作论文数4Zhenqiu Hong合作论文数4Louis-David Cantin合作论文数4Catherine A. Brennan合作论文数4barton phillips合作论文数3harold c e kluender合作论文数3susanne greschat合作论文数3martin hentemann合作论文数3
Hartmut Beck合作论文数3m patel合作论文数3
Paulus Patrick合作论文数Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt3Boyer Stephen合作论文数3Lei Wang合作论文数3Uday Khire合作论文数3Robert W. Schoenleber合作论文数3Karl-Heinz Thierauch合作论文数3
Holger Hess-Stumpp合作论文数Research Laboratories of Schering AG, Berlin, Germany3Peter Ellinghaus合作论文数3Ajay Bhargava合作论文数3Tatiana Shelekhin合作论文数2Istvan Enyedy合作论文数2William Bullock合作论文数2Sidney Liang合作论文数2William J Scott合作论文数2Jeffrey Shapiro合作论文数2James N. Livingston合作论文数2benjamin jones合作论文数2Michael Burns合作论文数2Bierer D E合作论文数2
Chris Town合作论文数J. Craig Venter Institute2Chengzhi Zhang合作论文数2Miao Dai合作论文数2Qian Zhao合作论文数2Xin Ma合作论文数2Rico Lavoie合作论文数2Herbert Ogutu合作论文数2Manami Tsutsumi合作论文数2Jeffrey S. Johnson合作论文数Dept Chem, Univ N Carolina2Zhonghua Zhang合作论文数2Sidney X. Liang合作论文数2Michael Härter合作论文数2Thomas H. Claus合作论文数2Jacques Dumas合作论文数2
Derek B. Lowe合作论文数CNS/CV Chemical Research, Schering-Plough Research Institute2Christiana I. Iwuagwu合作论文数2Frederick J. Ehrgott合作论文数2
