Liger is a next-generation near-infrared (0.81 - 2.45 mu m) integral field spectrograph (IFS) and imaging camera for the W. M. Keck Observatory (WMKO) adaptive optics (AO) system. The instrument concept originated by coupling designs from WMKO AO instruments and the future Thirty Meter Telescope IRIS spectrograph. Liger is designed for the Keck I telescope to operate behind the upcoming Keck All-sky Precision Adaptive optics (KAPA) system. The imaging camera sequentially feeds an IFS that makes use of slicer assembly for the coarsest sampling (75 mas and 150 mas per spaxel) and lenslet array (14 mas and 31 mas per spaxel) for diffraction-limited sampling. The imaging camera makes use of off-axis parabolas and a Hawaii-2RG detector to achieve a 14 mas/pixel plate scale and 20.5 '' x20.5 '' field of view. The IFS offers a range of spectral resolving power of R=4,000 10,000 and yields large fields of view for an AO-fed IFS. Liger will enable new science by providing enhanced capabilities, including higher spectral resolving power, access to shorter wavelengths, and larger fields of view than any current or planned ground- or space-based IFS system. Liger will be able to unlock previously inaccessible science across a wide range of the cosmos, such as dark matter substructure, supermassive black holes, the Galactic Center, exoplanet atmospheres, and the time-variable Solar System. We present the overall design of the Liger subsystems and review unique science drivers.

Liger is an adaptive optics (AO) fed imager and integral field spectrograph (IFS) designed to take advantage of the Keck All-sky Precision Adaptive-optics (KAPA) upgrade to the Keck I telescope. Liger adapts the design of the InfraRed Imaging Spectrograph (IRIS) for the Thirty Meter Telescope (TMT) to Keck by implementing a new imager and re-imaging optics. The performance of the imager is critical as it sequentially feeds the spectrograph and contains essential components such as the pupil wheel, filter wheel, and pupil viewing camera. We present the design and structural analysis of the Liger imager optical assembly including static, modal, and thermal simulations. We present the fabrication as well as the full assembly and characterization plan. The imager will be assembled bench-top in a clean room utilizing a coordinate-measuring machine (CMM) for warm alignment. To ensure optimal performance, the imager will be characterized in a test cryostat before integration with the full Liger instrument. This comprehensive approach to characterization ensures the precision and reliability of the imager, enhancing the observational capabilities of Liger and W.M. Keck Observatory.

HISPEC is a new, high-resolution near-infrared spectrograph being designed for the W.M. Keck II telescope. By offering single-shot, R=100,000 between 0.98 - 2.5 um, HISPEC will enable spectroscopy of transiting and non-transiting exoplanets in close orbits, direct high-contrast detection and spectroscopy of spatially separated substellar companions, and exoplanet dynamical mass and orbit measurements using precision radial velocity monitoring calibrated with a suite of state-of-the-art absolute and relative wavelength references. MODHIS is the counterpart to HISPEC for the Thirty Meter Telescope and is being developed in parallel with similar scientific goals. In this proceeding, we provide a brief overview of the current design of both instruments, and the requirements for the two spectrographs as guided by the scientific goals for each. We then outline the current science case for HISPEC and MODHIS, with focuses on the science enabled for exoplanet discovery and characterization. We also provide updated sensitivity curves for both instruments, in terms of both signal-to-noise ratio and predicted radial velocity precision.

We present an overview of the design of IRIS, an infrared (0.85 - 2.5 micron) integral field spectrograph and imaging camera for the Thirty Meter Telescope (TMT). With extremely low wavefront error (<30 nm) and on-board wavefront sensors, IRIS will take advantage of the high angular resolution of the narrow field infrared adaptive optics system (NFIRAOS) to dissect the sky at the diffraction limit of the 30-meter aperture. With a primary spectral resolution of 4000 and spatial sampling starting at 4 milliarcseconds, the instrument will create an unparalleled ability to explore high redshift galaxies, the Galactic center, star forming regions and virtually any astrophysical object. This paper summarizes the entire design and basic capabilities. Among the design innovations is the combination of lenslet and slicer integral field units, new 4Kx4k detectors, extremely precise atmospheric dispersion correction, infrared wavefront sensors, and a very large vacuum cryogenic system.

Murine Sipa-1 (signal-induced proliferation associated protein) is a mitogen induced GTPase activating protein (GAP). While mapping candidate genes for multiple endocrine neoplasia type 1 (MEN1) at 11q13, we cloned the human homologue of Sipa-1. Herein, we report the complete cDNA sequence, expression, and genomic organization of SIPA-1. SIPA-1 consists of 16 exons with highly conserved exon–intron boundaries. The predicted SIPA-1 protein is highly homologous to the mouse protein, particularly in the region of the GAP-related domain at the amino terminus and the leucine zipper at the carboxy terminus. It is widely expressed, including in fetal tissues, but is most highly expressed in lymphoid organs. During the course of cloning SIPA-1, the MEN1 gene was identified, thus excluding human SIPA-1 as a candidate for this disease.