Methanol intoxication is a significant public health issue that can lead to serious complications such as metabolic acidosis and methanol-induced optic neuropathy. Early diagnosis is critical for reducing permanent vision loss and mortality. The pan-immune-inflammation value is a recently identified biomarker. It reflects the immune and inflammatory status and is rapid, inexpensive, and easy to calculate. In this study, we evaluated the diagnostic power of the pan-immune-inflammation value in patients who developed methanol-induced optic neuropathy. This retrospective, single-center study included 68 patients diagnosed with methanol intoxication between May 2020 and May 2025. Patients were divided into two groups based on the presence or absence of vision loss at admission. Demographic data, laboratory findings, and blood gas values were also analyzed. The pan-immune-inflammation value was calculated using the formula (platelet × neutrophil × monocyte) / lymphocyte. The diagnostic power of PIV in predicting vision loss was evaluated using ROC curve analysis. Among the 68 patients included in the study, 32 had vision loss, while 36 did not. In the group with vision loss, neutrophil (p = 0.007), platelet (p < 0.001), and the pan-immune-inflammation value levels (median: 1277.55 vs. 640.05, p < 0.001) were significantly higher, whereas lymphocyte and urea levels were lower. In the ROC analysis, with a cutoff value of 902.15 for the pan-immune-inflammation value, the sensitivity and specificity for predicting vision loss were 90.6

Hyperkalemia is a potentially life-threatening complication of acute kidney injury (AKI), but conventional electrocardiographic findings may be insensitive. We aimed to evaluate the association between hyperkalemia and ECG repolarization parameters in AKI patients undergoing their first hemodialysis session in the emergency department. This single-center prospective observational study included 144 adult AKI patients who underwent first-time hemodialysis. Baseline blood samples and ECGs were obtained before pharmacological hyperkalemia treatment and hemodialysis; post-hemodialysis (post-HD) measurements were obtained after a standard 2-hour session. QT, corrected QT (QTc), Tp-e, Tp-e/QT, and Tp-e/QTc were measured manually. Hyperkalemia was defined as potassium ≥ 5.5 mmol/L. ROC and multivariate logistic regression analyses were performed. Pre-hemodialysis (pre-HD) hyperkalemia was present in 51 patients (35.4

Evidence comparing different non–vitamin K antagonist oral anticoagulants (NOACs) in terms of intracranial hemorrhage (ICH) characteristics and clinical outcomes is limited. This study aimed to identify factors associated with mortality and morbidity in geriatric patients receiving different NOACs presenting to the emergency department with intracranial hemorrhage. This multicenter retrospective observational study. Geriatric patients (aged ≥ 65 years) who presented to the emergency department with ICH while receiving NOAC therapy were included. Clinical characteristics were extracted from electronic medical records. The primary outcome was in-hospital mortality, while secondary outcomes included hemorrhage volume, intraventricular hemorrhage, intensive care unit admission, and the effect of four-factor prothrombin complex concentrate administration. Statistical analyses were performed using the chi-square or Fisher’s exact tests for categorical variables and the Mann–Whitney U or t-test for continuous variables, with p < 0.05 considered statistically significant. A total of 47 patients were included; 57.4

Aim: Gastroenteritis, an inflammation of the stomach and small intestine, presents with symptoms such as diarrhea, abdominal pain, nausea, and vomiting. Salmonella Enteritidis, a significant bacterial pathogen commonly transmitted via poultry and eggs, can cause severe complications, particularly in immunocompromised individuals. Rapid diagnosis is crucial in emergency settings, highlighting the need for effective diagnostic tools. This study investigates the utility of the Systemic Immune-Inflammation Index in diagnosing SE infections. Materials and Methods: This retrospective study, conducted in the emergency department of an urban hospital from May 1 to June 1, 2024, included 29 adult patients with acute gastroenteritis. Data on demographics, clinical parameters, and laboratory test results were analyzed. SE-positive and SE-negative patients were compared regarding systemic inflammation markers and clinical features. Statistical analyses using SPSS version 26.0 assessed the diagnostic value of SIII and other parameters through ROC curve analysis. Results: SE was identified in 12 of the 29 patients. SE-positive individuals showed significantly higher levels of platelets, C-reactive protein, creatinine, and SIII compared to SE-negative patients (p<0.05). Specifically, SIII with a cutoff of 1209.17 had 100% sensitivity and 41.2% specificity (p=0.042). CRP with a cutoff of 27.50 showed 83.3% sensitivity and 64.7% specificity (p=0.010). NLR analysis was not statistically significant. Additionally, creatinine levels were notably higher in SE-positive patients. Discussion: SIII appears to be a valuable diagnostic parameter for SE in emergency department gastroenteritis cases. It may aid in rapid decision-making for suspected SE infections. Further multicenter studies are necessary to confirm and generalize these findings.

Background: Supraventricular tachycardia (SVT) is a common arrhythmia requiring effective rate control. As a cardiac glycoside Digoxin is mostly utilized in infants for this indication. However, factors influencing its efficacy in managing SVT in adult patients are not thoroughly evaluated. Our study investigates the impact of hemoglobin and renal function on digoxin's ability to achieve rate control in adult SVT patients. Methods: We conducted a retrospective, single-center observational study with 167 adult patients presenting with SVT and treated with digoxin. Patients were categorized into Rate Control Group (RCG, n=58) and Non-Rate Control Group (N-RCG, n=109) based on the success of rate control. Clinical and laboratory parameters, including hemoglobin, renal function (GFR, renal failure), and patient outcomes (discharge, hospital/ICU admission) of both patient groups were analyzed and compared. Results: Patients achieving rate control (RCG) exhibited significantly higher hemoglobin levels (13.6 ± 2.5 g/dL vs. 12.7 ± 2.5 g/dL, p=0.010) and GFR (60.7 ± 27.3 vs. 58.7 ± 25.5 ml/min/1.73m2, p=0.015), with lower incidence of renal failure (3.4% vs. 17.4%, p=0.009) compared to N-RCG. Multivariate logistic regression revealed that hemoglobin remained a significant independent positive predictor of rate control (Adjusted OR: 1.154, 95% CI: 1.009-1.321, p=0.037), while renal failure and GFR did not retain statistical significance. No significant difference was observed in overall patient outcomes (discharge, hospital/ICU admission) between the groups (p=0.302). Conclusion: Higher hemoglobin levels independently predict successful rate control with digoxin in adult SVT patients. While renal function is still critical for digoxin pharmacokinetics, its direct influence on rate control success may be confounded by other factors. Further research is warranted to explore the mechanisms linking hemoglobin and GFR to digoxin efficacy and the long-term clinical implications of rate control.

Some of the professions that require the knowledge and the ability to perform cardiopulmonary resuscitation (CPR) include physicians, nurses, paramedics, and firefighters. While firefighters are expected to meet certain criteria for body mass index (BMI), height, and weight to be recruited, medical professionals are not expected to meet such criteria. However, some studies have demonstrated that anthropometric variables affect the quality of CPR. The aim of our study was to investigate the effect of sex, age, BMI, and smoking habits in CPR practitioners on the quality of CPR. This study was planned as a prospective study. It was conducted with 104 nurses in the emergency department of a tertiary hospital. Participants were randomly assigned to groups of 2 members. Each of the 2 members in the group took turns to perform CPR for 2 minutes. Participants' performance of CPR was recorded using the TrueCPR device. Of the 70 participants who were performed suboptimal CPR, 40 were in the nonsmoking group. Furthermore, 34 participants who were found to perform optimal CPR had a mean BMI of 23.6 (21.2-26.0) kg/m2. Height, weight, and BMI values were found to have statistical significance in optimal CPR. According to the study, low BMI is associated with suboptimal CPR.

Heart failure is one of the common reasons for presentations to emergency departments. Heart failure, which has an increasing prevalence and high mortality rate, significantly affects the health system. Therefore, it is important to predict mortality in emergency department. This study investigated the performance of the Emergency Heart Failure Mortality Risk Grade (EHMRG) score. In this study, we retrospectively examined the data of patients who presented to our emergency department with heart failure symptoms and were diagnosed with decompensated heart failure. The ability of the EHMRG score to determine hospitalization/discharge status and predict 7- and 30-day mortality was investigated. The study included 469 patients with a mean age of 73.09 ± 11.82 years. Patients admitted to the hospital and those who died within 7 or 30 days had higher EHMRG scores compared to those who were discharged and those who survived beyond these timeframes (P < .05). The score had a sensitivity of 69.48% and a specificity of 53.91% for making hospitalization/discharge decisions; a sensitivity and specificity of 50% and 88.96%, respectively, for the prediction of 7-day mortality; and a sensitivity and specificity of 60.98% and 74.53%, respectively, for the prediction of 30-day mortality. The EHMRG score is a useful tool for assessing disease severity, making hospital admission decisions, and predicting 7- and 30-day mortality. However, it is not a discriminatory scoring system for determining whether admitted patients require ward or intensive care. The EHMRG score can be utilized without any reservations in countries where metolazone is not available.

BACKGROUND:The objective was to investigate the predictive ability of traditional clinical, radiological scores, and combined grading systems for 28-day mortality in patients with nontraumatic subarachnoid hemorrhage (SAH). METHODS:This multicenter cohort study enrolled 451 adults who presented to the emergency departments of six major tertiary care hospitals in Istanbul with nontraumatic aneurysmal SAH. Demographic data; clinical characteristics; and traditional clinical grading scores were recorded, including the Glasgow Coma Scale (GCS), Hunt and Hess scale (HHS), World Federation of Neurological Surgeons (WFNS) scale, modified Fisher scale (mFS), and two combined grading systems, the VASOGRADE and Ogilvy-Carter scales. These data were compared between survivors and nonsurvivors. RESULTS:A total of 451 patients were included, comprising 242 males (53.7%) and 209 females (46.3%), with a mean ± SD age of 54.8 ± 14.1 years. The overall mortality rate was 28.2% (n = 127). Nonsurvivors had significantly lower mean GCS scores and higher HHS, WFNS, mFS, and Ogilvy-Carter scores compared to survivors (all p < 0.001). A significantly higher proportion of nonsurvivors were categorized in the red group based on VASOGRADE (p < 0.001). Multivariable logistic regression analysis identified age, sex, HHS, mFS, WFNS, and VASOGRADE as independent predictors of mortality. The WFNS scale emerged as the most reliable predictor of mortality with an area under the curve of 0.878. CONCLUSIONS:Although the GCS and Ogilvy-Carter scales effectively distinguished survivors from nonsurvivors, they were not independent predictors of mortality. The WFNS scale was identified as the most reliable predictor of mortality in aneurysmal SAH patients, followed by the mFS and HHS.

PurposeMedicines derived from natural sources have been used for thousands of years throughout the world. Because natural compounds are thought to have less toxic effects and fewer side effects, these products are becoming more popular by the day.Case ReportIn this case report, we presented a case of acute kidney injury, rhabdomyolysis, and hepatotoxicity after ingestion of black seed oil. Although black seed oil is widely used around the world, there is currently limited knowledge on its adverse effects.ConclusionIt is important to keep in mind that rhabdomyolysis, acute renal damage, and hepatotoxicity might occur following the use of black seed oil. Black seed oil ingestion should be considered when making a differential diagnosis for these conditions in patients suspected of taking herbal products.

Aim: Blunt abdominal traumas (BAT), which account for a large proportion of traumatic injuries, form a significant proportion of patients in emergency departments and are the leading cause of death in people under 45 years of age. In this study, we aimed to present the results of our patients who were admitted to our emergency department with BAT and underwent packing procedures during damage control laparotomy. Material and Methods: The patients aged >= 18 years who underwent emergency laparotomy for BAT and underwent packing with damage control surgery between 01.01.2021 and 31.12.2023 in our tertiary care hospital, a level 1 trauma center, were retrospectively analyzed in this study. Results: Of the15 patients included in the study, 11 (73.3 %) were male. The mean age of the patients was 36.13 +/- 1 4.16 years. Traffic accidents and occupational injuries were the most common causes of blunt trauma. The median duration of hospitalization was 14 (1-124) days, and mortality was observed in 3 patients (20%). In 13 patients (87.7%), both ultrasonography and computed tomography imaging were performed. Shock index, Glasgow Coma Scale (GCS), Injury Severity Score (ISS), Revised Trauma Score (RTS), and Trauma and Injury Severity Score (TRISS) values were calculated. The mean ISS was found to be 37.2 +/- 9.4. Discussion: Damage control surgery, which is an essential approach for reducing mortality and morbidity rates in blunt abdominal trauma, remains crucial. The formation of multidisciplinary trauma teams with well-equipped trauma centers is necessary to achieve successful treatment outcomes in trauma patients.

Objective: Trauma is a leading cause of morbidity and mortality in children.One in every four patients with trauma has abdominal trauma.Abdominal trauma is the third leading cause of death associated with trauma.Mortality increases in patients with inflammation because of the body's reaction to trauma.The systemic immune-inflammation index (SIII) is a test indicative of body inflammation based on complete blood count alone.Index value may indicate prognosis of pediatric patients with blunt abdominal trauma. Materials and Methods:The present study was designed as a retrospective, single-center research.The study included pediatric patients with isolated blunt abdominal trauma who were admitted to the emergency department between June 01, 2021 and June 01, 2022 and met the inclusion criteria.Patient demographic data; medical history; leukocytes, platelet, and neutrophil count; SIII; and outcome status were captured in the case form. Results:The study included 103 patients, of whom 64.1% were male and the mean age was 7.32±5.12years.Mortality was noted in 6.8% of the patients included in the study.The sensitivity and specificity for a cut-off value of 890.47×10 3 /L SIII were 95.7% and 62.5%, respectively (area under the curve: 0.832; 95% confidence interval: 0.820-0.944,p<0.003), in pediatric patients with blunt abdominal trauma. Conclusion:High SIII scores, a rapid, inexpensive, reliable, and radiation-free test, could be used as a predictor of mortality in pediatric patients admitted to the emergency department with blunt abdominal trauma.

PURPOSE:This study had two main goals: to determine which rhabdomyolysis patients need haemodialysis; and to highlight the significance of blood gas parameters, particularly base excess, as predictors of the need for haemodialysis. METHOD:A total of 270 patients were included in this multicentre, retrospective study. Among the patients who were transferred in from the earthquake region and developed rhabdomyolysis, those with creatine kinase (CK) values >1000 U/L were included in our study. The need for renal replacement in these patients was determined via laboratory tests, urine output monitoring and clinical follow-up. FINDINGS:A total of 270 patients were included in our study. Univariate and multivariate regression analyses of laboratory parameters were performed to identify predictors of HD treatment. According to the univariate regression analysis, BE, HCO3, creatinine, CK, lactate, alanine transaminase (ALT) and aspartate transaminase (AST) levels were found to be significantly associated with receiving HD treatment. According to multivariate regression analysis, only BE (p = 0.003) was found to be a significant predictor of HD treatment. ROC analysis revealed that the optimal cutoff value for BE was -2.6; at this value, the sensitivity and specificity of BE for predicting HD treatment were 89% and 77.1%, respectively (AUC: 0.912; 95% CI: 0.872-0.943; p < 0.001). CONCLUSION:Base excess is an effective predictor of the need for haemodialysis in patients with crush-related injuries that cause rhabdomyolysis and in patients who develop acute renal failure due to elevated CK.

Acute pain in the right lower quadrant during pregnancy is difficult to approach and acute appendicitis must be excluded. The complication rate in pregnant acute appendicitis increases as a result of delayed diagnosis due to physiological and anatomic changes. The systemic immune inflammatory index (SII), which includes several inflammatory tests, is considered to be a good indicator of acute inflammation. The aim of the present study was to investigate the diagnostic value of SII in the diagnosis of acute appendicitis and complicated appendicitis in pregnant women. This was designed as a retrospective, single-center case-control study. This study was performed in pregnant women over 12 weeks of gestation who were diagnosed with acute appendicitis as indicated by pathology report and met the inclusion criteria. Vital parameters, demographic characteristics, laboratory values, presence of complicated appendicitis, and pathology reports were taken into analysis. The present study was performed with 76 pregnant women, including 38 pregnant women with acute appendicitis and 38 pregnant women with healthy controls. SII had a sensitivity of 82.0

ObjectivesAcute respiratory distress syndrome (ARDS) is a respiratory disease characterized by a high rate of mortality. Determining the prognosis of this disease is therefore important. Lung ultrasonography has found increased use, especially in the recent years. This study aimed to score patients diagnosed with ARDS at the emergency department using point‐of‐care ultrasound (POCUS)‐Lung and to investigate the prognosis of patients with ARDS using a scoring system.MethodsThis study was designed as a single‐center prospective study. The study was performed in patients admitted to the emergency department and were diagnosed with ARDS pursuant to the Berlin criteria for ARDS and who met the inclusion criteria. The patients underwent lung ultrasonography at the emergency department and were scored (A line: 0; B1 line: 1; B2 line: 2; and C line: 3 points) accordingly.ResultsThe study included 100 patients with ARDS. The mortality rate was 52% in the patients in the study. The lung ultrasonography score in the mortality group (25.48 ± 3.64) was higher than that in the survivors (8.46 ± 3.61). For a cut‐off value of 17.5 for the lung ultrasonography score, the sensitivity and specificity with regard to mortality indicators were 92.8% and 90.9%, respectively (the area under the curve: 0.901; 95% confidence interval: 0.945–0.985: P < .001).ConclusionThe findings suggested that scoring based on POCUS‐Lung at the time of initial presentation at the emergency department in patients diagnosed with ARDS according to the Berlin criteria could help determine the prognosis. As POCUS‐Lung proved to be an important imaging method in investigating the affected alveolar capacity, we recommend its possible use as a prognostic indicator.

Pulmonary embolism requires careful differential diagnosis as it is associated with a wide range of symptoms that may suggest different diseases such as chest pain, shortness of breath and syncope. Since the disease can be fatal, especially in cases where right ventricular failure and hemodynamic instability develop, prognostic markers are great importance in terms of monitoring the patient during the treatment process. We aimed in our study to compare the relationship between the ratio of D-dimer and High Sensitive Troponin T (HsTnT) values ​​with short-term mortality and to compare this relationship with Pulmonary Embolism Severity Index (PESI) scoring. Our study was conducted with patients who applied to the emergency department of our hospital between 01/01/2022 and 01/01/2023 and were definitively diagnosed with Pulmonary thromboembolism after their evaluation. Findings. The success of D-dimer/HsTroponin, D-dimer/CK-MB and troponin/D-dimer indices calculated from the laboratory test results of the cases in predicting mortality was examined, and a comparison was made with the success of the PESI score in predicting mortality. Among these indices, D-dimer/CK-MB was found to be the most successful index in predicting 7-day mortality (AUC: 0.734; 95

Aim: Sepsis is a condition that results in mortality as a result of multiorgan failure associated with infection. Therefore, a number of parameters are used to determine the prognosis of sepsis. Accordingly, the ratio of procalcitonin and albumin found recent use for the above purpose. The present study aimed to investigate the value of the procalcitonin/albumin ratio to determine the prognosis of sepsis patients. Material and Methods: The present study was designed as a single -center, prospective research. The study included patients admitted to the intensive care unit upon diagnosed with pneumosepsis and met the inclusion criteria. Patients with pneumonic infiltration in the lungs supported by computed tomography images and a qSOFA score >= 2 were considered to have pneumosepsis. Results: The present study included 299 patients, who were admitted to the intensive care unit upon pneumosepsis diagnosis. The procalcitonin/albumin ratio in the mortality group and survivors was 0.42 and 0.004, respectively. The sensitivity and specificity for mortality were 87.4% and 77.6%, respectively, for a cut-off value of 0.010 for the procalcitonin/albumin ratio. Discussion: The results of the present study were indicative of the fact that elevated procalcitonin/albumin ratio was significant in predicting prognosis in patients, who were admitted to the intensive care unit upon pneumosepsis diagnosis. This suggested that procalcitonin/albumin ratio might serve as a prognostic indicator on the grounds that the severity of sepsis was associated with the change in acute phase reactants.

Background: Preeclampsia is a serious complication of pregnancy with negative consequences for the mother and fetus. It was aimed to investigate whether the systemic immune inflammation index is a parameter that will facilitate the diagnosis of preeclampsia. Methods: This retrospective and single -center study included patients diagnosed with preeclampsia after admission to the emergency department and those who met the inclusion criteria. Vital parameters, demographic data, medical history, white blood cell count, platelet count, neutrophil count, systemic immune -inflammation index values, biochemical parameters, and gestational weeks were analyzed in each patient. Results: A total of 40 patients with preeclampsia (preeclampsia group) and 40 normal pregnant women (control group) were included. Laboratory tests revealed that the mean WBC, neutrophil, and lymphocyte counts were significantly higher in the preeclampsia group than in the control group, whereas the preeclampsia group had a significantly lower mean platelet count than the control group (p < 0.001). The sensitivity and specificity for the cut-off value of 758.39 x 10 (9) /L systemic immune -inflammation index in pregnant patients with preeclampsia was 77.5% and 67.5%, respectively (AUC: 0.705; 95% CI: 0.587 -0.823; p 1 / 4 0.002 ). No significant difference was observed between the mean neutrophil-to-lymphocyte ratio in preeclampsia diagnosis. Conclusion: The systemic immune -inflammation index may be used as a marker to help in establishing the diagnosis of preeclampsia. We believe that this index is an important prognostic indicator because it concurrently evaluates neutrophil and lymphocyte values -which indicate the inflammation process -and platelet count, i.e., an indicator of coagulopathy.

Head trauma is a leading cause of mortality and morbidity in pediatric patients. The trauma itself leads to the activation of a biomolecular cascade of damage. Purinergic receptors and ATP release play an important role in the activation of astroglia, microglia, monocyte-macrophages, neutrophils, and T cells in this process. The systemic immune inflammation index can be easily calculated, cheap, only requires hemogram parameters, and does not include any subjective findings. Therefore, we believe that it could be a prognostic predictor and a diagnostic marker for pediatric head trauma cases. Our study was designed as a retrospective and single-center study. The study was conducted with pediatric patients who presented to the emergency department with isolated head trauma between June 15, 2022, and December 15, 2022. Demographic data, medical history, white blood count, platelet count, neutrophil count, systemic immune inflammation index (SIII), Glasgow Coma Score, and the presence of pathology on brain computed tomography were recorded on the case report form. The study was conducted with 112 cases. In cases with bleeding, the median value of GCS was significantly lower (p<0.001), while WBC, Neutrophil, Platelet, NLR and SIII were significantly higher (p=0.008, p=0.001, p<0.001, p=0.011, and p<0.001, respectively). There was no significant difference between lymphocyte values and bleeding status. We believe that a higher SIII may be associated with persistent pericontusional inflammation in the brain and may be a good marker for predicting intracranial pathology and prognosis of the pathology caused by head trauma.

INTRODUCTION:Recently, telemedicine has become a widely used method worldwide for the treatment of patients with acute ischemic stroke in hospitals where neurologists are unavailable. The purpose of this study was to determine the accuracy and reliability of treatment decisions made by remote neurologists via teleconference assisted by emergency physicians in acute stroke cases and to determine whether the use of teleconsultation would lead to any delays in assessment and treatment decisions.METHODS:This single-center and prospective study was performed with 104 patients who met the inclusion criteria. Patients were concurrently assessed by a teleneurologist (TN) experienced in stroke and an on-site neurologist (OS-N). The TN performed their assessment via teleconference and assisted by an emergency physician for test results and physical examination. NIHSS (The National Institutes of Health Stroke Scale) scores, assessment times, treatment decisions by the two neurologists, and patient outcomes were recorded separately. The TN was asked to rate the quality of communication.RESULTS:Of the 104 patients in the study, 59.6% (n = 62) were men and the median age was 66 (interquartile range = 56-78) years. The median duration of assessment by the OS-N was 30 (18-45) min and the median duration of assessment by the TN was 6 (5-8) min; the duration of assessment by the TN was significantly shorter (6.56 min vs. 33.35 min; Z = 8.669; p < 0.001). The median rating assigned by the TN to the quality of teleconsultation was 5.0 (4.25-5.0) (Table 1). The NIHSS scores assigned by both neurologists showed significant correlation (p < 0.001). Analysis of the agreement between the OS-N and TN in their treatment decisions yielded a Kappa value of 74.3% for interrater agreement.CONCLUSIONS:Teleconsultation was a successful and reliable strategy in assessing patients with ischemic stroke and making decisions for IV-tPA. Moreover, patient assessment via teleconsultation was less time consuming. The results of the study are promising for the use of teleconsultation in the future.

Aim: Right ventricular failure can develop in patients with pulmonary embolism (PE) and is associated with increased mortality. Mid-regional pro-atrial natriuretic peptide (MR-proANP), a natriuretic peptide, is secreted due to the increased atrial wall tension caused by right heart failure. In this study, we aimed to investigate the diagnostic value of MR-proANP in patients who presented to the emergency department with a pre-diagnosis of pulmonary embolism.Material and Methods: Among patients with a preliminary diagnosis of PE, 100 patients who were confirmed to have PE by computed tomography pulmonary angiography (CTPA) were determined as the case group. As a control group, 50 patients were randomly identified, in whom the diagnosis of PE was excluded. Echocardiography was performed in all patients in the case group immediately after the diagnosis was confirmed, and the presence of right ventricular dysfunction was investigated. This study was designed as a prospective observational study.Results: The median value of MR-proANP (645.8 (66.37-3313.08) pmol/L) in the case group was found to be significantly higher than median value of MR-proANP (442.9 (226.73-774.78) pmol/L) in the control group (p:0.003). MR-proANP was found to be significantly higher in the differential diagnosis of PE.Discussion: In addition to clinical signs and symptoms, MR-proANP levels seem to be a useful variable that may improve diagnostic accuracy in patients with suspected pulmonary embolism in the emergency department.